Dyspnea predicts mortality among patients undergoing coronary computed tomographic angiography View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-02

AUTHORS

Rine Nakanishi, Heidi Gransar, Alan Rozanski, Jamal S. Rana, Victor Y. Cheng, Louise E. J. Thomson, Romalisa Miranda-Peats, Damini Dey, Sean W. Hayes, John D. Friedman, James K. Min, Daniel S. Berman

ABSTRACT

The prognostic implications of dyspnea and typical angina in patients referred for coronary CT angiography have not been examined. We examined features associated with incident mortality risk among individuals undergoing coronary computed tomographic angiography (CCTA) presenting with dyspnea, typical angina, and neither of these symptoms. 1147 consecutive individuals without known CAD (mean 61 years, 61.6 %men) undergoing CCTA comprised the study population 132 with dyspnea, 218 with typical angina, and 797 without dyspnea or typical angina (reference group). Mortality risk in relation to dyspnea or typical angina was evaluated with multivariable Cox proportional hazards models compared to reference. In addition, the prognosis associated with dyspnea or typical angina was assessed among age matched subgroups. Patients with dyspnea had a greater prevalence of C70 % stenosis (p\0.001) and coronary segments with plaque (p = 0.02) compared to the other two groups. During a follow-up of 3.1 years, 52 individuals died. By multivariable Cox models, compared to patients in reference group, dyspnea patients experienced higher mortality (HR 2.0, 95 % CI 1.0–4.0, p = 0.049) while typical angina patients did not (HR 1.1, 95 % CI 0.6–2.3, p = 0.76). In the matched group, the patients with dyspnea (HR 2.2, 95 % CI 1.1–4.3, p = 0.03) still had significantly reduced survival compared to the other two groups, while those with typical angina did not (HR 1.2, 95 % CI 0.6–2.6,p = 0.62). Dyspnea is associated with increased mortality ate compared to patients with typical angina and those with neither of these symptoms among patients undergoing CCTA. More... »

PAGES

329-337

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10554-015-0769-9

DOI

http://dx.doi.org/10.1007/s10554-015-0769-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1026975424

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26467171


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