Extracellular volume fraction in dilated cardiomyopathy patients without obvious late gadolinium enhancement: comparison with healthy control subjects View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-01-30

AUTHORS

Yoo Jin Hong, Chul Hwan Park, Young Jin Kim, Jin Hur, Hye-Jeong Lee, Sae Rom Hong, Young Joo Suh, Andreas Greiser, Mun Young Paek, Byoung Wook Choi, Tae Hoon Kim

ABSTRACT

To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 − hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 − pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (−) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (−) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = −0.551, P = 0.008), Group B (r = −0.525, P = 0.021), and Group A + B (r = −0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients. More... »

PAGES

115-122

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10554-015-0595-0

DOI

http://dx.doi.org/10.1007/s10554-015-0595-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001405011

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25634119


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    "description": "To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV\u00a0=\u00a0[(\u0394R1 of myocardium/\u0394R1 of LV blood pool)]\u00a0\u00d7\u00a0(1\u00a0\u2212\u00a0hematocrit), where R1\u00a0=\u00a01/T1, \u0394R1\u00a0=\u00a0post-contrast R1\u00a0\u2212\u00a0pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (\u2212) segments in Group A\u00a0+\u00a0B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (\u2212) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n\u00a0=\u00a041, 568 segments, 30.7\u00a0%\u00a0\u00b1\u00a05.9) was significantly higher (P\u00a0<\u00a00.001) than that of the control group (n\u00a0=\u00a010, 157 segments, 25.6\u00a0%\u00a0\u00b1\u00a03.2). The ECV was inversely related to LVEF in Group A (r\u00a0=\u00a0\u22120.551, P\u00a0=\u00a00.008), Group B (r\u00a0=\u00a0\u22120.525, P\u00a0=\u00a00.021), and Group A\u00a0+\u00a0B (r\u00a0=\u00a0\u22120.550, P\u00a0<\u00a00.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.", 
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32 schema:description To evaluate whether the extracellular volume fraction (ECV) measured using cardiac magnetic resonance (CMR) imaging can detect myocardial tissue changes in dilated cardiomyopathy (DCM) without late gadolinium enhancement (LGE). Forty-one DCM patients and 10 healthy volunteers underwent pre- and post-T1 mapping using a modified Look-Locker Inversion recovery sequence, LGE, and cine MRI on a 3-T CMR system. LGE-MR findings were used to divide DCM patients into two groups: Group A had no apparent LGE, and Group B had LGE apparent in at least one segment. The ECV of the left ventricle (LV) myocardium (16 segments) was calculated in the short-axis view as follows: ECV = [(ΔR1 of myocardium/ΔR1 of LV blood pool)] × (1 − hematocrit), where R1 = 1/T1, ΔR1 = post-contrast R1 − pre-contrast R1. The LV ejection fraction (LVEF) was obtained from cine MRI images. The mean myocardial ECV in LGE (−) segments in Group A + B was compared to that of controls. The mean myocardial ECV in Group A was compared to that of LGE (−) segments in Group B. The correlation between LV systolic function and the mean myocardial ECV of the whole myocardium was evaluated in all groups. Among the 41 DCM patients, 22 were in Group A, and 19 were in Group B. The mean ECV of DCM patents (n = 41, 568 segments, 30.7 % ± 5.9) was significantly higher (P < 0.001) than that of the control group (n = 10, 157 segments, 25.6 % ± 3.2). The ECV was inversely related to LVEF in Group A (r = −0.551, P = 0.008), Group B (r = −0.525, P = 0.021), and Group A + B (r = −0.550, P < 0.001). The ECV measured by MRI could be a useful parameter in evaluating diffuse myocardial changes in DCM patients.
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39 CMR system
40 DCM patients
41 LGE segments
42 LV ejection fraction
43 LV systolic function
44 Look-Locker inversion recovery sequence
45 MRI
46 MRI images
47 R1
48 T1
49 cardiac magnetic resonance imaging
50 cardiomyopathy patients
51 changes
52 cine MRI images
53 comparison
54 control
55 control group
56 control subjects
57 correlation
58 diffuse myocardial changes
59 ejection fraction
60 enhancement
61 extracellular volume fraction
62 findings
63 fraction
64 function
65 gadolinium enhancement
66 group
67 group A
68 group B
69 group B.
70 healthy control subjects
71 healthy volunteers
72 images
73 imaging
74 inversion recovery sequence
75 late gadolinium enhancement
76 left ventricle myocardium
77 magnetic resonance imaging
78 mapping
79 mean ECV
80 myocardial changes
81 myocardial extracellular volume fraction
82 myocardial tissue changes
83 myocardium
84 parameters
85 patents
86 patients
87 recovery sequence
88 resonance imaging
89 segments
90 sequence
91 short-axis view
92 subjects
93 system
94 systolic function
95 tissue changes
96 useful parameter
97 ventricle myocardium
98 view
99 volume fraction
100 volunteers
101 whole myocardium
102 ΔR1
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