Evaluation of postmortem MDCT and MDCT-angiography for the investigation of sudden cardiac death related to atherosclerotic coronary artery disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2012-01-12

AUTHORS

Katarzyna Michaud, Silke Grabherr, Francesco Doenz, Patrice Mangin

ABSTRACT

The goal of this study was to evaluate the diagnostic value of postmortem multi-computed tomography (MDCT) and MDCT-angiography for sudden cardiac deaths related to ischemic heart disease. Twenty three cases were selected based on clinical history and the results of native MDCT, multiphase post-mortem CT-angiography and conventional autopsy were compared. Radiological examination showed calcification of coronary arteries in 78% of the cases, most of which were not detailed at autopsy. MDCT-angiography allowed better visualization of the coronary arteries than MDCT and permitted the evaluation of stenoses and occlusions. Of the 14 cases of coronary thrombosis detected at conventional autopsy, 11 were visible as stop of perfusion with CT-angiography and three were found to be partly perfused. One case had an old thrombosis with collateral circulation. One case had a coronary artery postmortem clot found with MDCT-angiography. Coronary artery calcifications are more easily detected and documented with radiological examination than with conventional autopsy. MDCT is of limited diagnostic value for ischemic heart disease. MDCT-angiography, when correctly interpreted, is a reasonable tool to view the morphology of coronary arteries, rule out significant coronary artery stenoses, identify occlusions and direct sampling for histological examination. More... »

PAGES

1807-1822

References to SciGraph publications

  • 2011-05-20. Influence of coronary artery disease prevalence on predictive values of coronary CT angiography: a meta-regression analysis in EUROPEAN RADIOLOGY
  • 2007-10-20. Guidelines for autopsy investigation of sudden cardiac death in VIRCHOWS ARCHIV
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  • 2011-02-24. Targeted post-mortem computed tomography cardiac angiography: proof of concept in INTERNATIONAL JOURNAL OF LEGAL MEDICINE
  • 2011-04-19. Immediate computed tomography coronary angiography versus delayed outpatient stress testing for detecting coronary artery disease in emergency department patients with chest pain in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • 2010-12-12. Post-mortem computed tomography angiography: past, present and future in FORENSIC SCIENCE, MEDICINE AND PATHOLOGY
  • 2011-09-16. Prognostic value of coronary artery calcium score and coronary CT angiography in patients with intermediate risk of coronary artery disease in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • 2010-07-20. Magnetic resonance imaging goes postmortem: noninvasive detection and assessment of myocardial infarction by postmortem MRI in EUROPEAN RADIOLOGY
  • 1999-12. Harmonisation of Medico-Legal Autopsy Rules in INTERNATIONAL JOURNAL OF LEGAL MEDICINE
  • 2010-11-07. Multi-phase post-mortem CT angiography: development of a standardized protocol in INTERNATIONAL JOURNAL OF LEGAL MEDICINE
  • 2008-05-27. Coronary artery calcium screening: current status and recommendations from the European Society of Cardiac Radiology and North American Society for Cardiovascular Imaging in THE INTERNATIONAL JOURNAL OF CARDIOVASCULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10554-012-0012-x

    DOI

    http://dx.doi.org/10.1007/s10554-012-0012-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1032549392

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22238022


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