Body size over the life-course and the risk of endometrial cancer: the California Teachers Study View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-12

AUTHORS

Pamela L. Horn-Ross, Alison J. Canchola, Leslie Bernstein, Dennis Deapen, James V. Lacey, Eunjung Lee, David O. Nelson, Peggy Reynolds

ABSTRACT

PURPOSE: Obesity is a public health epidemic and a major risk factor for endometrial cancer. Here, we identify key aspects of body size which jointly, over the life-course (since adolescence), are associated with endometrial cancer risk. METHODS: Among 88,142 participants in the California Teachers Study, 887 were diagnosed with invasive type 1 endometrial cancer between 1997-1998 and 2012. Multivariable Cox proportional hazards models provided estimates of hazard rate ratios (HR) and 95% confidence intervals (CI) for endometrial cancer associated with life-course body size phenotypes, which incorporated validated measures. RESULTS: Among women currently using hormone therapy, endometrial cancer risk was only associated with height (HR 1.78, 95% CI 1.32-2.40 for ≥67 vs. <67 inches). Among women not using hormone therapy, tall women who were overweight/obese in adolescence (HR 4.33, 95% CI 2.51-7.46) or who became overweight/obese as adults (HR 4.74, 95% CI 2.70-8.32) were at greatest risk. CONCLUSIONS: Considering absolute body mass, changes in adiposity over time, and body fat distribution together, instead of each measure alone, we identified lifetime obesity phenotypes associated with endometrial cancer risk. These results more clearly define specific risk groups, and may explain inconsistent findings across studies, improve risk prediction models, and aid in developing targeted interventions for endometrial cancer. More... »

PAGES

1419-1428

References to SciGraph publications

  • 2014-03. Body weight in early adulthood, adult weight gain, and risk of endometrial cancer in women not using postmenopausal hormones in CANCER CAUSES & CONTROL
  • 2012-06. Postmenopausal endometrial cancer risk and body size in early life and middle age: prospective cohort study in BRITISH JOURNAL OF CANCER
  • 2012-03. Body size and the risk of postmenopausal breast cancer subtypes in the California Teachers Study cohort in CANCER CAUSES & CONTROL
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  • 1998-08. Selection of anthropometric indicators for classification of abdominal fatness— a critical review in INTERNATIONAL JOURNAL OF OBESITY
  • 2014-09. Body size across the life course and risk of premenopausal and postmenopausal breast cancer in Black women, the Carolina Breast Cancer Study, 1993–2001 in CANCER CAUSES & CONTROL
  • 1988-02. The dose-effect relationship between 'unopposed' oestrogens and endometrial mitotic rate: its central role in explaining and predicting endometrial cancer risk in BRITISH JOURNAL OF CANCER
  • 2002-09. High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States) in CANCER CAUSES & CONTROL
  • 2007-05. Anthropometric factors and risk of endometrial cancer: the European prospective investigation into cancer and nutrition in CANCER CAUSES & CONTROL
  • 2011-08. Circulating sex hormones and breast cancer risk factors in postmenopausal women: reanalysis of 13 studies in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10552-016-0820-8

    DOI

    http://dx.doi.org/10.1007/s10552-016-0820-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026507153

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/27804057


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    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10552-016-0820-8'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10552-016-0820-8'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10552-016-0820-8'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10552-016-0820-8'


     

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