Ontology type: schema:ScholarlyArticle
2019-06-28
AUTHORSAntonio Ponti, Guglielmo Ronco, Elsebeth Lynge, Mariano Tomatis, Ahti Anttila, Nieves Ascunce, Mireille Broeders, Jean-Luc Bulliard, Isabella Castellano, Patricia Fitzpatrick, Alfonso Frigerio, Solveig Hofvind, Ondřej Májek, Nereo Segnan, Stephen Taplin
ABSTRACTPurposeNuclear grade is an important indicator of the biological behaviour of ductal carcinoma in situ (DCIS). De-escalation of treatment has been suggested for low-grade DCIS. Our aim is to estimate the relative rate of progression of DCIS by nuclear grade by analysing the distribution of nuclear grade by detection at initial or subsequent screening.MethodsWe asked International Cancer Screening Network sites to complete, based on their screening and clinical databases, an aggregated data file on DCIS detection, diagnosis and treatment.ResultsEleven screening programs reported 5068 screen-detected pure DCIS in nearly 7 million screening tests in women 50–69 years of age. For all programs combined, low-grade DCIS were 20.1% (range 11.4–31.8%) of graded DCIS, intermediate grade 31.0% and high grade 48.9%. Detection rates decreased more steeply from initial to subsequent screening in low compared to high-grade DCIS: the ratios of subsequent to initial detection rates were 0.39 for low grade, 0.51 for intermediate grade, and 0.75 for high grade (p < 0.001).ConclusionsThese results suggest that the duration of the preclinical detectable phase is longer for low than for high-grade DCIS. The findings from this large multi-centre, international study emphasize that the management of low-grade DCIS should be carefully scrutinized in order to minimize overtreatment of screen-detected slow-growing or indolent lesions. The high variation by site in the proportion of low grade suggests that further pathology standardization and training would be beneficial. More... »
PAGES761-765
http://scigraph.springernature.com/pub.10.1007/s10549-019-05333-6
DOIhttp://dx.doi.org/10.1007/s10549-019-05333-6
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PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/31250357
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