T-bet+ lymphocytes infiltration as an independent better prognostic indicator for triple-negative breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2019-05-08

AUTHORS

Hitomi Mori, Makoto Kubo, Masaya Kai, Mai Yamada, Kanako Kurata, Hitomi Kawaji, Kazuhisa Kaneshiro, Tomofumi Osako, Reiki Nishimura, Nobuyuki Arima, Masayuki Okido, Junji Kishimoto, Yoshinao Oda, Masafumi Nakamura

ABSTRACT

PurposeT-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.MethodsThis study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expression on tumor-infiltrating lymphocytes (TILs) was defined as ≥ 30 per 6.25 × 10−3 mm2.ResultsOf the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors. T-bet expression was significantly correlated with CD8 expression (p < 0.0001). Patients with T-bet+ tumors had longer overall survival (OS) compared with patients with T-bet− tumors (p = 0.047). The combination of CD8+ and T-bet+ was associated with a better recurrence-free survival (RFS) and OS compared to CD8+/T-bet− tumors (p = 0.037 and p = 0.024, respectively). Adjuvant chemotherapy provided significantly greater benefit to patients with T-bet+ tumors (p = 0.031 for RFS, p = 0.0003 for OS). Multivariate analysis revealed that T-bet expression on TILs was an independent and positive prognostic indicator (HR = 0.36, 95% confidence interval (CI) 0.12–0.94, p = 0.037 for RFS, HR = 0.30, 95% CI 0.07–0.95, p = 0.039 for OS).ConclusionsOS was significantly improved for patients with high T-bet-expressing TILs in TNBC. Thus, T-bet may be a predictive indicator for survival and various immunotherapy strategies in TNBC. More... »

PAGES

569-577

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  • Identifiers

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    http://scigraph.springernature.com/pub.10.1007/s10549-019-05256-2

    DOI

    http://dx.doi.org/10.1007/s10549-019-05256-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1113995874

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/31069590


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        "description": "PurposeT-box transcription factor 21 (T-bet), which is the master regulator of effector T-cell activation, is derived by stimulation of T-cell receptors. In this study, we focused on T-bet and examined the function of activated T cells.MethodsThis study included 242 patients with primary triple-negative breast cancer (TNBC) who underwent resection without neoadjuvant chemotherapy between January 2004 and December 2014. The immunohistochemistry scoring for CD8 and T-bet expression on tumor-infiltrating lymphocytes (TILs) was defined as\u2009\u2265\u200930 per 6.25\u2009\u00d7\u200910\u22123\u00a0mm2.ResultsOf the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors. T-bet expression was significantly correlated with CD8 expression (p\u2009<\u20090.0001). Patients with T-bet+ tumors had longer overall survival (OS) compared with patients with T-bet\u2212 tumors (p\u2009=\u20090.047). The combination of CD8+ and T-bet+ was associated with a better recurrence-free survival (RFS) and OS compared to CD8+/T-bet\u2212 tumors (p\u2009=\u20090.037 and p\u2009=\u20090.024, respectively). Adjuvant chemotherapy provided significantly greater benefit to patients with T-bet+ tumors (p\u2009=\u20090.031 for RFS, p\u2009=\u20090.0003 for OS). Multivariate analysis revealed that T-bet expression on TILs was an independent and positive prognostic indicator (HR\u2009=\u20090.36, 95% confidence interval (CI) 0.12\u20130.94, p\u2009=\u20090.037 for RFS, HR\u2009=\u20090.30, 95% CI 0.07\u20130.95, p\u2009=\u20090.039 for OS).ConclusionsOS was significantly improved for patients with high T-bet-expressing TILs in TNBC. Thus, T-bet may be a predictive indicator for survival and various immunotherapy strategies in TNBC.", 
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