Pharmacometabolomics reveals a role for histidine, phenylalanine, and threonine in the development of paclitaxel-induced peripheral neuropathy View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-10

AUTHORS

Yihan Sun, Jae Hyun Kim, Kiran Vangipuram, Daniel F. Hayes, Ellen M. L. Smith, Larisa Yeomans, N. Lynn Henry, Kathleen A. Stringer, Daniel L. Hertz

ABSTRACT

PURPOSE: Approximately 25% of breast cancer patients experience treatment delays or discontinuation due to paclitaxel-induced peripheral neuropathy (PN). Currently, there are no predictive biomarkers of PN. Pharmacometabolomics is an informative tool for biomarker discovery of drug toxicity. We conducted a secondary whole blood pharmacometabolomics analysis to assess the association between pretreatment metabolome, early treatment-induced metabolic changes, and the development of PN. METHODS: Whole blood samples were collected pre-treatment (BL), just before the end of the first paclitaxel infusion (EOI), and 24 h after the first infusion (24H) from sixty patients with breast cancer receiving (80 mg/m2) weekly treatment. Neuropathy was assessed at BL and prior to each infusion using the sensory subscale (CIPN8) of the EORTC CIPN20 questionnaire. Blood metabolites were quantified from 1-D-1H-nuclear magnetic resonance spectra using Chenomx® software. Metabolite concentrations were normalized in preparation for Pearson correlation and one-way repeated measures ANOVA with multiple comparisons corrected by false discovery rate (FDR). RESULTS: Pretreatment histidine, phenylalanine, and threonine concentrations were inversely associated with maximum change in CIPN8 (ΔCIPN8) (p < 0.02; FDR ≤ 25%). Paclitaxel caused a significant change in concentrations of 2-hydroxybutyrate, 3-hydroxybutyrate, pyruvate, o-acetylcarnitine, and several amino acids from BL to EOI and/or 24H (p < 0.05; FDR ≤ 25%), although these changes were not associated with ΔCIPN8. CONCLUSIONS: Whole blood metabolomics is a feasible approach to identify potential biomarker candidates of paclitaxel-induced PN. The findings suggest that pretreatment concentrations of histidine, phenylalanine, and threonine may be predictive of the severity of future PN and paclitaxel-induced metabolic changes may be related to disruption of energy homeostasis. More... »

PAGES

657-666

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-018-4862-3

DOI

http://dx.doi.org/10.1007/s10549-018-4862-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1105141735

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29946863


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomarkers", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Histidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Magnetic Resonance Spectroscopy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metabolomics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paclitaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Peripheral Nervous System Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phenylalanine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Threonine", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA", 
            "The NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sun", 
        "givenName": "Yihan", 
        "id": "sg:person.011241612665.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011241612665.96"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA", 
            "The NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kim", 
        "givenName": "Jae Hyun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vangipuram", 
        "givenName": "Kiran", 
        "id": "sg:person.013451710662.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013451710662.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayes", 
        "givenName": "Daniel F.", 
        "id": "sg:person.013712224532.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712224532.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Health Behavior and Biological Sciences, University of Michigan School of Nursing, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Ellen M. L.", 
        "id": "sg:person.01063523362.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063523362.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA", 
            "The NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yeomans", 
        "givenName": "Larisa", 
        "id": "sg:person.01000320163.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000320163.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Huntsman Cancer Institute", 
          "id": "https://www.grid.ac/institutes/grid.479969.c", 
          "name": [
            "Huntsman Cancer Institute, University of Utah Health Care, Salt Lake City, UT, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henry", 
        "givenName": "N. Lynn", 
        "id": "sg:person.01042733643.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA", 
            "The NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stringer", 
        "givenName": "Kathleen A.", 
        "id": "sg:person.01135222576.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135222576.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA", 
            "Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hertz", 
        "givenName": "Daniel L.", 
        "id": "sg:person.0750251511.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750251511.14"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.pain.2006.01.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001816843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.pain.2006.01.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001816843"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.1995.05020081.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003336273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1525-1438.1995.05020081.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003336273"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-012-1428-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007025860", 
          "https://doi.org/10.1007/s00520-012-1428-5"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-1278-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007967397", 
          "https://doi.org/10.1007/s10549-010-1278-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00115550-200703000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011677547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00115550-200703000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011677547"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/01480545.2014.981753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012116679"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-009-2690-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015338024", 
          "https://doi.org/10.1007/s00216-009-2690-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-009-2690-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015338024", 
          "https://doi.org/10.1007/s00216-009-2690-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-009-2690-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015338024", 
          "https://doi.org/10.1007/s00216-009-2690-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00216-009-2690-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015338024", 
          "https://doi.org/10.1007/s00216-009-2690-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.12-3-312", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016956599"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.xphs.2016.12.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017848518"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jnnp.63.6.754", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017976916"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-09-1452", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018246250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018638902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp287", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018638902"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neuroscience.2011.10.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020350699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.02.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022157621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.rapm.2006.11.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025177254"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2005.04.028", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025968980"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2013.00156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026201925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2004.11.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026713349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/clpt.2013.217", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028195960", 
          "https://doi.org/10.1038/clpt.2013.217"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1214/aos/1074290335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029214550"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpain.2016.02.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034579451"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034607621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.54.0914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034693245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s12264-013-1316-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035106951", 
          "https://doi.org/10.1007/s12264-013-1316-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphar.2013.00001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035400571"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.44.8738", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036235280"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2014.56.3296", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039146854"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0010883", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041881927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2125.2011.04111.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042765826"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.1530509100", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044620917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ki.2010.440", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046344518", 
          "https://doi.org/10.1038/ki.2010.440"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0085732", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047793096"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkv380", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047923881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11136-013-0379-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048142516", 
          "https://doi.org/10.1007/s11136-013-0379-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0145816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048264034"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btq048", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048288630"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-1590", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049803552"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dju044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049886151"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jop.2012.000863", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051413541"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11065-007-9021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052709721", 
          "https://doi.org/10.1007/s11065-007-9021-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s11065-007-9021-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052709721", 
          "https://doi.org/10.1007/s11065-007-9021-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008211226339", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056302604"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/01621459.1955.10501294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1058299235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdw290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059394806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-0586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-0586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224919"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.07.061", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203025"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1203/00006450-199812000-00013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064214056", 
          "https://doi.org/10.1203/00006450-199812000-00013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074813213", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1077383385", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/acs.analchem.7b00171", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084121430"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1373/clinchem.2016.254649", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084311139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djx098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085225753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/j.pain.0000000000000939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085349479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/j.pain.0000000000000939", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085349479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-017-3780-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086107563", 
          "https://doi.org/10.1007/s00520-017-3780-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-017-3780-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1086107563", 
          "https://doi.org/10.1007/s00520-017-3780-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev-biochem-061516-044952", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090279551"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100012713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100012713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/fpc.0000000000000318", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100012713"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1538-7445.sabcs17-p6-11-03", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101066139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-18-0656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103670717"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-18-0656", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103670717"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-10", 
    "datePublishedReg": "2018-10-01", 
    "description": "PURPOSE: Approximately 25% of breast cancer patients experience treatment delays or discontinuation due to paclitaxel-induced peripheral neuropathy (PN). Currently, there are no predictive biomarkers of PN. Pharmacometabolomics is an informative tool for biomarker discovery of drug toxicity. We conducted a secondary whole blood pharmacometabolomics analysis to assess the association between pretreatment metabolome, early treatment-induced metabolic changes, and the development of PN.\nMETHODS: Whole blood samples were collected pre-treatment (BL), just before the end of the first paclitaxel infusion (EOI), and 24 h after the first infusion (24H) from sixty patients with breast cancer receiving (80\u00a0mg/m2) weekly treatment. Neuropathy was assessed at BL and prior to each infusion using the sensory subscale (CIPN8) of the EORTC CIPN20 questionnaire. Blood metabolites were quantified from 1-D-1H-nuclear magnetic resonance spectra using Chenomx\u00ae software. Metabolite concentrations were normalized in preparation for Pearson correlation and one-way repeated measures ANOVA with multiple comparisons corrected by false discovery rate (FDR).\nRESULTS: Pretreatment histidine, phenylalanine, and threonine concentrations were inversely associated with maximum change in CIPN8 (\u0394CIPN8) (p\u2009<\u20090.02; FDR\u2009\u2264\u200925%). Paclitaxel caused a significant change in concentrations of 2-hydroxybutyrate, 3-hydroxybutyrate, pyruvate, o-acetylcarnitine, and several amino acids from BL to EOI and/or 24H (p\u2009<\u20090.05; FDR\u2009\u2264\u200925%), although these changes were not associated with \u0394CIPN8.\nCONCLUSIONS: Whole blood metabolomics is a feasible approach to identify potential biomarker candidates of paclitaxel-induced PN. The findings suggest that pretreatment concentrations of histidine, phenylalanine, and threonine may be predictive of the severity of future PN and paclitaxel-induced metabolic changes may be related to disruption of energy homeostasis.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-018-4862-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2423333", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.5053793", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6809870", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6809964", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "171"
      }
    ], 
    "name": "Pharmacometabolomics reveals a role for histidine, phenylalanine, and threonine in the development of paclitaxel-induced peripheral neuropathy", 
    "pagination": "657-666", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "46b0362785dcefcd07846df00aac0e76efc0c2c38f214a7de068305505111acb"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29946863"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-018-4862-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1105141735"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-018-4862-3", 
      "https://app.dimensions.ai/details/publication/pub.1105141735"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8663_00000572.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10549-018-4862-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4862-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4862-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4862-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4862-3'


 

This table displays all metadata directly associated to this object as RDF triples.

373 TRIPLES      21 PREDICATES      100 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-018-4862-3 schema:about N04143d8d8eab470996eb1ad0fd29dbe5
2 N2e4b8d0bf11e48299d2ec367d04a83ce
3 N2f8dd50ff24d4e9db6e26f9c1d47b667
4 N35034e553e464f40b85fc507d7e48e86
5 N54fa1faebe3c4484a45ac53b92d60199
6 N678ca2b7db074546b46e4f79e53ed96a
7 N7b48709dfde8478c9830c30f5d0495d7
8 N924900aed4764365b9e95444430731fc
9 N9c14b5dc9850426cb4728ae2eb4cfb54
10 Na55f835c648048c7bacbe6ff60288b82
11 Nd3d876db34e7453dba58d5598a9651b9
12 Nd52d6790225e4e01a59b98c94aa10a7d
13 Nd5c85b1fff3045f38527e30648963b91
14 Ne9e90ee17d7d48b6a63bbaac7232664a
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N25b20b2b28584dd1882f8aa3c41a369e
18 schema:citation sg:pub.10.1007/s00216-009-2690-3
19 sg:pub.10.1007/s00520-012-1428-5
20 sg:pub.10.1007/s00520-017-3780-y
21 sg:pub.10.1007/s10549-010-1278-0
22 sg:pub.10.1007/s11065-007-9021-2
23 sg:pub.10.1007/s11136-013-0379-8
24 sg:pub.10.1007/s12264-013-1316-0
25 sg:pub.10.1038/clpt.2013.217
26 sg:pub.10.1038/ki.2010.440
27 sg:pub.10.1203/00006450-199812000-00013
28 https://app.dimensions.ai/details/publication/pub.1074813213
29 https://app.dimensions.ai/details/publication/pub.1077383385
30 https://doi.org/10.1016/j.clon.2004.11.014
31 https://doi.org/10.1016/j.ejca.2005.02.012
32 https://doi.org/10.1016/j.ejca.2005.04.028
33 https://doi.org/10.1016/j.jpain.2016.02.011
34 https://doi.org/10.1016/j.neuroscience.2011.10.010
35 https://doi.org/10.1016/j.pain.2006.01.037
36 https://doi.org/10.1016/j.rapm.2006.11.009
37 https://doi.org/10.1016/j.xphs.2016.12.009
38 https://doi.org/10.1021/acs.analchem.7b00171
39 https://doi.org/10.1023/a:1008211226339
40 https://doi.org/10.1046/j.1525-1438.1995.05020081.x
41 https://doi.org/10.1073/pnas.1530509100
42 https://doi.org/10.1080/01621459.1955.10501294
43 https://doi.org/10.1093/annonc/mdp287
44 https://doi.org/10.1093/annonc/mdw290
45 https://doi.org/10.1093/bioinformatics/btq048
46 https://doi.org/10.1093/jnci/dju044
47 https://doi.org/10.1093/jnci/djx098
48 https://doi.org/10.1093/nar/gkv380
49 https://doi.org/10.1097/00115550-200703000-00006
50 https://doi.org/10.1097/fpc.0000000000000318
51 https://doi.org/10.1097/j.pain.0000000000000939
52 https://doi.org/10.1111/j.1365-2125.2011.04111.x
53 https://doi.org/10.1136/jnnp.63.6.754
54 https://doi.org/10.1146/annurev-biochem-061516-044952
55 https://doi.org/10.1158/1078-0432.ccr-09-1452
56 https://doi.org/10.1158/1078-0432.ccr-10-2474
57 https://doi.org/10.1158/1078-0432.ccr-12-1590
58 https://doi.org/10.1158/1078-0432.ccr-15-0586
59 https://doi.org/10.1158/1078-0432.ccr-18-0656
60 https://doi.org/10.1158/1538-7445.sabcs17-p6-11-03
61 https://doi.org/10.1200/jco.2002.07.061
62 https://doi.org/10.1200/jco.2012.44.8738
63 https://doi.org/10.1200/jco.2013.54.0914
64 https://doi.org/10.1200/jco.2014.56.3296
65 https://doi.org/10.1200/jop.2012.000863
66 https://doi.org/10.1214/aos/1074290335
67 https://doi.org/10.1371/journal.pone.0010883
68 https://doi.org/10.1371/journal.pone.0085732
69 https://doi.org/10.1371/journal.pone.0145816
70 https://doi.org/10.1373/clinchem.2016.254649
71 https://doi.org/10.1634/theoncologist.12-3-312
72 https://doi.org/10.3109/01480545.2014.981753
73 https://doi.org/10.3389/fphar.2013.00001
74 https://doi.org/10.3389/fphar.2013.00156
75 schema:datePublished 2018-10
76 schema:datePublishedReg 2018-10-01
77 schema:description PURPOSE: Approximately 25% of breast cancer patients experience treatment delays or discontinuation due to paclitaxel-induced peripheral neuropathy (PN). Currently, there are no predictive biomarkers of PN. Pharmacometabolomics is an informative tool for biomarker discovery of drug toxicity. We conducted a secondary whole blood pharmacometabolomics analysis to assess the association between pretreatment metabolome, early treatment-induced metabolic changes, and the development of PN. METHODS: Whole blood samples were collected pre-treatment (BL), just before the end of the first paclitaxel infusion (EOI), and 24 h after the first infusion (24H) from sixty patients with breast cancer receiving (80 mg/m2) weekly treatment. Neuropathy was assessed at BL and prior to each infusion using the sensory subscale (CIPN8) of the EORTC CIPN20 questionnaire. Blood metabolites were quantified from 1-D-1H-nuclear magnetic resonance spectra using Chenomx® software. Metabolite concentrations were normalized in preparation for Pearson correlation and one-way repeated measures ANOVA with multiple comparisons corrected by false discovery rate (FDR). RESULTS: Pretreatment histidine, phenylalanine, and threonine concentrations were inversely associated with maximum change in CIPN8 (ΔCIPN8) (p < 0.02; FDR ≤ 25%). Paclitaxel caused a significant change in concentrations of 2-hydroxybutyrate, 3-hydroxybutyrate, pyruvate, o-acetylcarnitine, and several amino acids from BL to EOI and/or 24H (p < 0.05; FDR ≤ 25%), although these changes were not associated with ΔCIPN8. CONCLUSIONS: Whole blood metabolomics is a feasible approach to identify potential biomarker candidates of paclitaxel-induced PN. The findings suggest that pretreatment concentrations of histidine, phenylalanine, and threonine may be predictive of the severity of future PN and paclitaxel-induced metabolic changes may be related to disruption of energy homeostasis.
78 schema:genre research_article
79 schema:inLanguage en
80 schema:isAccessibleForFree false
81 schema:isPartOf Nb0b51ee862764299817ab2b652d18d21
82 Ncafcd7f5318c4a4da33bab4c6eeda810
83 sg:journal.1092777
84 schema:name Pharmacometabolomics reveals a role for histidine, phenylalanine, and threonine in the development of paclitaxel-induced peripheral neuropathy
85 schema:pagination 657-666
86 schema:productId N2410ac848da3462e82a8a71a5a5b5ec3
87 N8bb6c1656acb4d678ab0e8a92e983036
88 N93b956d23cbd416b9339ddb69e226210
89 N9b6455eed06f4649801234a17051ce09
90 Na42e4ae727a643eabc4bb1468ea0355c
91 schema:sameAs https://app.dimensions.ai/details/publication/pub.1105141735
92 https://doi.org/10.1007/s10549-018-4862-3
93 schema:sdDatePublished 2019-04-10T15:10
94 schema:sdLicense https://scigraph.springernature.com/explorer/license/
95 schema:sdPublisher Ne7d2dd0679f543aaa5d6f00be84df88f
96 schema:url https://link.springer.com/10.1007%2Fs10549-018-4862-3
97 sgo:license sg:explorer/license/
98 sgo:sdDataset articles
99 rdf:type schema:ScholarlyArticle
100 N04143d8d8eab470996eb1ad0fd29dbe5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Peripheral Nervous System Diseases
102 rdf:type schema:DefinedTerm
103 N1445c6d910d6427ca4ebe99b6fde5a7b schema:affiliation https://www.grid.ac/institutes/grid.214458.e
104 schema:familyName Kim
105 schema:givenName Jae Hyun
106 rdf:type schema:Person
107 N158b99eb223942c4bba422859c6ef15f rdf:first sg:person.0750251511.14
108 rdf:rest rdf:nil
109 N2410ac848da3462e82a8a71a5a5b5ec3 schema:name readcube_id
110 schema:value 46b0362785dcefcd07846df00aac0e76efc0c2c38f214a7de068305505111acb
111 rdf:type schema:PropertyValue
112 N25b20b2b28584dd1882f8aa3c41a369e rdf:first sg:person.011241612665.96
113 rdf:rest N69a643f484234f1c8c10ffd84173f5b0
114 N2c155859006b40829e48ff01e54ea86b rdf:first sg:person.013451710662.49
115 rdf:rest Nf6106c1b1ce34482bdfe3ab87da1f231
116 N2e4b8d0bf11e48299d2ec367d04a83ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 N2f8dd50ff24d4e9db6e26f9c1d47b667 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Biomarkers
121 rdf:type schema:DefinedTerm
122 N35034e553e464f40b85fc507d7e48e86 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Histidine
124 rdf:type schema:DefinedTerm
125 N54fa1faebe3c4484a45ac53b92d60199 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Paclitaxel
127 rdf:type schema:DefinedTerm
128 N56eb5dfedba044e1b7851e28a1b47684 rdf:first sg:person.01135222576.49
129 rdf:rest N158b99eb223942c4bba422859c6ef15f
130 N678ca2b7db074546b46e4f79e53ed96a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Metabolomics
132 rdf:type schema:DefinedTerm
133 N69a643f484234f1c8c10ffd84173f5b0 rdf:first N1445c6d910d6427ca4ebe99b6fde5a7b
134 rdf:rest N2c155859006b40829e48ff01e54ea86b
135 N7b48709dfde8478c9830c30f5d0495d7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Magnetic Resonance Spectroscopy
137 rdf:type schema:DefinedTerm
138 N8bb6c1656acb4d678ab0e8a92e983036 schema:name dimensions_id
139 schema:value pub.1105141735
140 rdf:type schema:PropertyValue
141 N924900aed4764365b9e95444430731fc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Threonine
143 rdf:type schema:DefinedTerm
144 N93b956d23cbd416b9339ddb69e226210 schema:name pubmed_id
145 schema:value 29946863
146 rdf:type schema:PropertyValue
147 N9b6455eed06f4649801234a17051ce09 schema:name doi
148 schema:value 10.1007/s10549-018-4862-3
149 rdf:type schema:PropertyValue
150 N9c14b5dc9850426cb4728ae2eb4cfb54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Female
152 rdf:type schema:DefinedTerm
153 Na42e4ae727a643eabc4bb1468ea0355c schema:name nlm_unique_id
154 schema:value 8111104
155 rdf:type schema:PropertyValue
156 Na55f835c648048c7bacbe6ff60288b82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Breast Neoplasms
158 rdf:type schema:DefinedTerm
159 Nb0b51ee862764299817ab2b652d18d21 schema:volumeNumber 171
160 rdf:type schema:PublicationVolume
161 Nbc2c6f5f4e8c4d418e7743244c61c294 rdf:first sg:person.01000320163.82
162 rdf:rest Nc76ba477ece741bc8026301a27d0a679
163 Nc76ba477ece741bc8026301a27d0a679 rdf:first sg:person.01042733643.27
164 rdf:rest N56eb5dfedba044e1b7851e28a1b47684
165 Ncafcd7f5318c4a4da33bab4c6eeda810 schema:issueNumber 3
166 rdf:type schema:PublicationIssue
167 Ncf26faa5a0a64eedaeed4ab501240587 rdf:first sg:person.01063523362.92
168 rdf:rest Nbc2c6f5f4e8c4d418e7743244c61c294
169 Nd3d876db34e7453dba58d5598a9651b9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Aged
171 rdf:type schema:DefinedTerm
172 Nd52d6790225e4e01a59b98c94aa10a7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
173 schema:name Adult
174 rdf:type schema:DefinedTerm
175 Nd5c85b1fff3045f38527e30648963b91 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Phenylalanine
177 rdf:type schema:DefinedTerm
178 Ne7d2dd0679f543aaa5d6f00be84df88f schema:name Springer Nature - SN SciGraph project
179 rdf:type schema:Organization
180 Ne9e90ee17d7d48b6a63bbaac7232664a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
181 schema:name Middle Aged
182 rdf:type schema:DefinedTerm
183 Nf6106c1b1ce34482bdfe3ab87da1f231 rdf:first sg:person.013712224532.50
184 rdf:rest Ncf26faa5a0a64eedaeed4ab501240587
185 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
186 schema:name Medical and Health Sciences
187 rdf:type schema:DefinedTerm
188 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
189 schema:name Oncology and Carcinogenesis
190 rdf:type schema:DefinedTerm
191 sg:grant.2423333 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-018-4862-3
192 rdf:type schema:MonetaryGrant
193 sg:grant.5053793 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-018-4862-3
194 rdf:type schema:MonetaryGrant
195 sg:grant.6809870 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-018-4862-3
196 rdf:type schema:MonetaryGrant
197 sg:grant.6809964 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-018-4862-3
198 rdf:type schema:MonetaryGrant
199 sg:journal.1092777 schema:issn 0167-6806
200 1573-7217
201 schema:name Breast Cancer Research and Treatment
202 rdf:type schema:Periodical
203 sg:person.01000320163.82 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
204 schema:familyName Yeomans
205 schema:givenName Larisa
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01000320163.82
207 rdf:type schema:Person
208 sg:person.01042733643.27 schema:affiliation https://www.grid.ac/institutes/grid.479969.c
209 schema:familyName Henry
210 schema:givenName N. Lynn
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27
212 rdf:type schema:Person
213 sg:person.01063523362.92 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
214 schema:familyName Smith
215 schema:givenName Ellen M. L.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01063523362.92
217 rdf:type schema:Person
218 sg:person.011241612665.96 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
219 schema:familyName Sun
220 schema:givenName Yihan
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011241612665.96
222 rdf:type schema:Person
223 sg:person.01135222576.49 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
224 schema:familyName Stringer
225 schema:givenName Kathleen A.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01135222576.49
227 rdf:type schema:Person
228 sg:person.013451710662.49 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
229 schema:familyName Vangipuram
230 schema:givenName Kiran
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013451710662.49
232 rdf:type schema:Person
233 sg:person.013712224532.50 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
234 schema:familyName Hayes
235 schema:givenName Daniel F.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712224532.50
237 rdf:type schema:Person
238 sg:person.0750251511.14 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
239 schema:familyName Hertz
240 schema:givenName Daniel L.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750251511.14
242 rdf:type schema:Person
243 sg:pub.10.1007/s00216-009-2690-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015338024
244 https://doi.org/10.1007/s00216-009-2690-3
245 rdf:type schema:CreativeWork
246 sg:pub.10.1007/s00520-012-1428-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007025860
247 https://doi.org/10.1007/s00520-012-1428-5
248 rdf:type schema:CreativeWork
249 sg:pub.10.1007/s00520-017-3780-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1086107563
250 https://doi.org/10.1007/s00520-017-3780-y
251 rdf:type schema:CreativeWork
252 sg:pub.10.1007/s10549-010-1278-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007967397
253 https://doi.org/10.1007/s10549-010-1278-0
254 rdf:type schema:CreativeWork
255 sg:pub.10.1007/s11065-007-9021-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052709721
256 https://doi.org/10.1007/s11065-007-9021-2
257 rdf:type schema:CreativeWork
258 sg:pub.10.1007/s11136-013-0379-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048142516
259 https://doi.org/10.1007/s11136-013-0379-8
260 rdf:type schema:CreativeWork
261 sg:pub.10.1007/s12264-013-1316-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035106951
262 https://doi.org/10.1007/s12264-013-1316-0
263 rdf:type schema:CreativeWork
264 sg:pub.10.1038/clpt.2013.217 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028195960
265 https://doi.org/10.1038/clpt.2013.217
266 rdf:type schema:CreativeWork
267 sg:pub.10.1038/ki.2010.440 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046344518
268 https://doi.org/10.1038/ki.2010.440
269 rdf:type schema:CreativeWork
270 sg:pub.10.1203/00006450-199812000-00013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064214056
271 https://doi.org/10.1203/00006450-199812000-00013
272 rdf:type schema:CreativeWork
273 https://app.dimensions.ai/details/publication/pub.1074813213 schema:CreativeWork
274 https://app.dimensions.ai/details/publication/pub.1077383385 schema:CreativeWork
275 https://doi.org/10.1016/j.clon.2004.11.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026713349
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.ejca.2005.02.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022157621
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/j.ejca.2005.04.028 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025968980
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1016/j.jpain.2016.02.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034579451
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1016/j.neuroscience.2011.10.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020350699
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1016/j.pain.2006.01.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001816843
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1016/j.rapm.2006.11.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025177254
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1016/j.xphs.2016.12.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017848518
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1021/acs.analchem.7b00171 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084121430
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1023/a:1008211226339 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056302604
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1046/j.1525-1438.1995.05020081.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003336273
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1073/pnas.1530509100 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044620917
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1080/01621459.1955.10501294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1058299235
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1093/annonc/mdp287 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018638902
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/annonc/mdw290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059394806
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/bioinformatics/btq048 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048288630
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/jnci/dju044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049886151
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/jnci/djx098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085225753
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/nar/gkv380 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047923881
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1097/00115550-200703000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011677547
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1097/fpc.0000000000000318 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100012713
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1097/j.pain.0000000000000939 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085349479
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1111/j.1365-2125.2011.04111.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1042765826
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1136/jnnp.63.6.754 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017976916
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1146/annurev-biochem-061516-044952 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090279551
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1158/1078-0432.ccr-09-1452 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018246250
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1158/1078-0432.ccr-10-2474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034607621
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1158/1078-0432.ccr-12-1590 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049803552
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1158/1078-0432.ccr-15-0586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224919
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1158/1078-0432.ccr-18-0656 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103670717
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1158/1538-7445.sabcs17-p6-11-03 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101066139
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1200/jco.2002.07.061 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203025
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1200/jco.2012.44.8738 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036235280
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1200/jco.2013.54.0914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034693245
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1200/jco.2014.56.3296 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039146854
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1200/jop.2012.000863 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051413541
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1214/aos/1074290335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029214550
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1371/journal.pone.0010883 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041881927
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1371/journal.pone.0085732 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047793096
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1371/journal.pone.0145816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048264034
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1373/clinchem.2016.254649 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084311139
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1634/theoncologist.12-3-312 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016956599
358 rdf:type schema:CreativeWork
359 https://doi.org/10.3109/01480545.2014.981753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012116679
360 rdf:type schema:CreativeWork
361 https://doi.org/10.3389/fphar.2013.00001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035400571
362 rdf:type schema:CreativeWork
363 https://doi.org/10.3389/fphar.2013.00156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026201925
364 rdf:type schema:CreativeWork
365 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
366 schema:name Department of Clinical Pharmacy, University of Michigan College of Pharmacy, Ann Arbor, MI, USA
367 Department of Health Behavior and Biological Sciences, University of Michigan School of Nursing, Ann Arbor, MI, USA
368 Rogel Cancer Center, University of Michigan Medical School, Ann Arbor, MI, USA
369 The NMR Metabolomics Laboratory, College of Pharmacy, University of Michigan, Ann Arbor, MI, USA
370 rdf:type schema:Organization
371 https://www.grid.ac/institutes/grid.479969.c schema:alternateName Huntsman Cancer Institute
372 schema:name Huntsman Cancer Institute, University of Utah Health Care, Salt Lake City, UT, USA
373 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...