Age at first full-term birth and breast cancer risk in BRCA1 and BRCA2 mutation carriers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-09

AUTHORS

Joanne Kotsopoulos, Jacek Gronwald, Henry T. Lynch, Andrea Eisen, Susan L. Neuhausen, Nadine Tung, Peter Ainsworth, Jeffrey N. Weitzel, Tuya Pal, William D. Foulkes, Charis Eng, Christian F. Singer, Leigha Senter, Ping Sun, Jan Lubinski, Steven A. Narod, the Hereditary Breast Cancer Clinical Study Group

ABSTRACT

PURPOSE: In the general population, an early age at first full-term birth confers protection against the risk of developing breast cancer. The relationship between age at first birth and breast cancer risk is not clear for women with a mutation in the BRCA1 or BRCA2 gene. Thus, we undertook a case-control study of women with a BRCA1 or BRCA2 mutation to study the effects of age at first full-term birth matched for other reproductive factors. METHODS: Information about reproductive factors, including age at first birth as well as medical history, was collected from a routinely administered research questionnaire. There were 2,295 matched pairs of women with a BRCA1 or BRCA2 mutation included in the final analysis. RESULTS: There was no significant difference in the mean age at first full-term birth among the BRCA1 (24.9 vs. 25.2; P = 0.10) or BRCA2 mutation carriers (26.5 vs. 26.6 years; P = 0.80). Findings were similar in the analysis limited to cases who were diagnosed with breast cancer prior to age 45. CONCLUSION: This matched analysis of a large number of BRCA mutation carriers suggests that age at first birth has little influence on BRCA1 or BRCA2 breast cancer risk. More... »

PAGES

421-426

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-018-4822-y

DOI

http://dx.doi.org/10.1007/s10549-018-4822-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1104043812

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29774471


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HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4822-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4822-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4822-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-4822-y'


 

This table displays all metadata directly associated to this object as RDF triples.

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335 schema:name Women’s College Research Institute, Women’s College Hospital, 76 Grenville St., 6th Floor, M5S 1B2, Toronto, ON, Canada
336 rdf:type schema:Organization
 




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