Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-02-12

AUTHORS

Constantinos Savva, Karen De Souza, Reem Ali, Emad A. Rakha, Andrew R. Green, Srinivasan Madhusudan

ABSTRACT

PURPOSE: MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in about 15% of breast cancers and linked to aggressive phenotypes. MYC overexpression also induces oxidative stress and replication stress in cells. ATM signalling and ATR-mediated signalling are critical for MYC-induced DNA damage response. Whether ATM and ATR expressions influence clinical outcomes in MYC overexpressed breast cancers is unknown. METHODS: We investigated ATM, ATR and MYC at the transcriptional level [Molecular Taxonomy of Breast Cancer International Consortium cohort (n = 1950)] and at the protein level in the Nottingham series comprising 1650 breast tumours. We correlated ATM, ATR and MYC expressions to clinicopathological features and survival outcomes. RESULTS: In MYC over expressed tumours, high ATR or low ATM levels were associated with aggressive breast cancer features such as higher tumour grade, de-differentiation, pleomorphism, high mitotic index, high-risk Nottingham Prognostic Index, triple negative and basal-like breast cancers (all adjusted p values < 0.05). Tumours with low ATM or high ATR levels in conjunction with MYC overexpression also have worse overall breast cancer-specific survival (BCSS) (p value < 0.05). CONCLUSIONS: We conclude that ATR/ATM-directed stratification and personalisation of therapy may be feasible in MYC overexpressed breast cancer. More... »

PAGES

1-11

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-018-05113-8

DOI

http://dx.doi.org/10.1007/s10549-018-05113-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112070604

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30746633


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Nottingham University Hospitals NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.240404.6", 
          "name": [
            "Department of Oncology, Nottingham University Hospitals, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Savva", 
        "givenName": "Constantinos", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Nottingham University Hospitals NHS Trust", 
          "id": "https://www.grid.ac/institutes/grid.240404.6", 
          "name": [
            "Department of Oncology, Nottingham University Hospitals, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Souza", 
        "givenName": "Karen", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, Academic Unit of Oncology, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ali", 
        "givenName": "Reem", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Department of Pathology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rakha", 
        "givenName": "Emad A.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Department of Pathology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG5 1PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Green", 
        "givenName": "Andrew R.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Nottingham", 
          "id": "https://www.grid.ac/institutes/grid.4563.4", 
          "name": [
            "Department of Oncology, Nottingham University Hospitals, NG5 1PB, Nottingham, UK", 
            "Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, Academic Unit of Oncology, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Madhusudan", 
        "givenName": "Srinivasan", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.bbagrm.2014.03.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002432260"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1586/14737140.8.10.1689", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006893274"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a014241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007687362"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1756-9966-32-95", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008494380", 
          "https://doi.org/10.1186/1756-9966-32-95"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ctrv.2013.03.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009647529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.neo.2014.09.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010194222"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.18632/oncotarget.9156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010462800"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a014266", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012215524"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a014407", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013716777"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature10983", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014607335", 
          "https://doi.org/10.1038/nature10983"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-11-1198", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020248092"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)00188-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023269017"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji237", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023556722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molonc.2014.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029363924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034137455", 
          "https://doi.org/10.1038/onc.2013.275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/onc.2013.275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034137455", 
          "https://doi.org/10.1038/onc.2013.275"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1054/bjoc.2000.1522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034175533", 
          "https://doi.org/10.1054/bjoc.2000.1522"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jsbmb.2015.02.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035035687"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-10-3776", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035089351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2319-4170.125655", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035298410"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.2016.46", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037190454", 
          "https://doi.org/10.1038/bjc.2016.46"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a014423", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038032174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0507367103", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038586376"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.gde.2009.11.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040524318"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041078054", 
          "https://doi.org/10.1038/sj.onc.1209873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1209873", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041078054", 
          "https://doi.org/10.1038/sj.onc.1209873"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043987722"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1747-1028-7-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044903023", 
          "https://doi.org/10.1186/1747-1028-7-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601910378691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047096408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/1947601910378691", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047096408"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2012.03.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047284773"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1101/cshperspect.a014357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047723058"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm3546", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047891925", 
          "https://doi.org/10.1038/nrm3546"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-15-0945", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053421694"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-15-0479", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063224904"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1182/blood-2015-05-644872", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064122721"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2011-1037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064328688"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1535-7163.mct-16-0378", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083395494"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.dnarep.2017.06.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085962157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm.2017.67", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091217755", 
          "https://doi.org/10.1038/nrm.2017.67"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41392-018-0008-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101130554", 
          "https://doi.org/10.1038/s41392-018-0008-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41392-018-0008-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101130554", 
          "https://doi.org/10.1038/s41392-018-0008-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41392-018-0008-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101130554", 
          "https://doi.org/10.1038/s41392-018-0008-7"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-02-12", 
    "datePublishedReg": "2019-02-12", 
    "description": "PURPOSE: MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in about 15% of breast cancers and linked to aggressive phenotypes. MYC overexpression also induces oxidative stress and replication stress in cells. ATM signalling and ATR-mediated signalling are critical for MYC-induced DNA damage response. Whether ATM and ATR expressions influence clinical outcomes in MYC overexpressed breast cancers is unknown.\nMETHODS: We investigated ATM, ATR and MYC at the transcriptional level [Molecular Taxonomy of Breast Cancer International Consortium cohort (n\u2009=\u20091950)] and at the protein level in the Nottingham series comprising 1650 breast tumours. We correlated ATM, ATR and MYC expressions to clinicopathological features and survival outcomes.\nRESULTS: In MYC over expressed tumours, high ATR or low ATM levels were associated with aggressive breast cancer features such as higher tumour grade, de-differentiation, pleomorphism, high mitotic index, high-risk Nottingham Prognostic Index, triple negative and basal-like breast cancers (all adjusted p values\u2009<\u20090.05). Tumours with low ATM or high ATR levels in conjunction with MYC overexpression also have worse overall breast cancer-specific survival (BCSS) (p value\u2009<\u20090.05).\nCONCLUSIONS: We conclude that ATR/ATM-directed stratification and personalisation of therapy may be feasible in MYC overexpressed breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-018-05113-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }
    ], 
    "name": "Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers", 
    "pagination": "1-11", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c08a8aee5fd1541e65faf8ae2ac33560eb6bd686f16592146716c0c75b949040"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30746633"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-018-05113-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1112070604"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-018-05113-8", 
      "https://app.dimensions.ai/details/publication/pub.1112070604"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T09:04", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000334_0000000334/records_127812_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10549-018-05113-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-05113-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-05113-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-05113-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-018-05113-8'


 

This table displays all metadata directly associated to this object as RDF triples.

221 TRIPLES      21 PREDICATES      64 URIs      18 LITERALS      7 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-018-05113-8 schema:about anzsrc-for:11
2 anzsrc-for:1112
3 schema:author N606a9901fe35498a86a73c71d271334c
4 schema:citation sg:pub.10.1038/bjc.2016.46
5 sg:pub.10.1038/nature10983
6 sg:pub.10.1038/nrm.2017.67
7 sg:pub.10.1038/nrm3546
8 sg:pub.10.1038/onc.2013.275
9 sg:pub.10.1038/s41392-018-0008-7
10 sg:pub.10.1038/sj.onc.1209873
11 sg:pub.10.1054/bjoc.2000.1522
12 sg:pub.10.1186/1747-1028-7-6
13 sg:pub.10.1186/1756-9966-32-95
14 https://doi.org/10.1016/j.bbagrm.2014.03.013
15 https://doi.org/10.1016/j.cell.2012.03.003
16 https://doi.org/10.1016/j.ctrv.2013.03.002
17 https://doi.org/10.1016/j.dnarep.2017.06.010
18 https://doi.org/10.1016/j.gde.2009.11.001
19 https://doi.org/10.1016/j.jsbmb.2015.02.004
20 https://doi.org/10.1016/j.molonc.2014.10.013
21 https://doi.org/10.1016/j.neo.2014.09.009
22 https://doi.org/10.1016/s0092-8674(00)00188-4
23 https://doi.org/10.1073/pnas.0507367103
24 https://doi.org/10.1093/jnci/dji237
25 https://doi.org/10.1101/cshperspect.a014241
26 https://doi.org/10.1101/cshperspect.a014266
27 https://doi.org/10.1101/cshperspect.a014357
28 https://doi.org/10.1101/cshperspect.a014407
29 https://doi.org/10.1101/cshperspect.a014423
30 https://doi.org/10.1158/0008-5472.can-10-3776
31 https://doi.org/10.1158/1078-0432.ccr-10-2567
32 https://doi.org/10.1158/1078-0432.ccr-11-1198
33 https://doi.org/10.1158/1078-0432.ccr-15-0479
34 https://doi.org/10.1158/1535-7163.mct-15-0945
35 https://doi.org/10.1158/1535-7163.mct-16-0378
36 https://doi.org/10.1177/1947601910378691
37 https://doi.org/10.1182/blood-2015-05-644872
38 https://doi.org/10.1210/me.2011-1037
39 https://doi.org/10.1586/14737140.8.10.1689
40 https://doi.org/10.18632/oncotarget.9156
41 https://doi.org/10.4103/2319-4170.125655
42 schema:datePublished 2019-02-12
43 schema:datePublishedReg 2019-02-12
44 schema:description PURPOSE: MYC transcription factor has critical roles in cell growth, proliferation, metabolism, differentiation, transformation and angiogenesis. MYC overexpression is seen in about 15% of breast cancers and linked to aggressive phenotypes. MYC overexpression also induces oxidative stress and replication stress in cells. ATM signalling and ATR-mediated signalling are critical for MYC-induced DNA damage response. Whether ATM and ATR expressions influence clinical outcomes in MYC overexpressed breast cancers is unknown. METHODS: We investigated ATM, ATR and MYC at the transcriptional level [Molecular Taxonomy of Breast Cancer International Consortium cohort (n = 1950)] and at the protein level in the Nottingham series comprising 1650 breast tumours. We correlated ATM, ATR and MYC expressions to clinicopathological features and survival outcomes. RESULTS: In MYC over expressed tumours, high ATR or low ATM levels were associated with aggressive breast cancer features such as higher tumour grade, de-differentiation, pleomorphism, high mitotic index, high-risk Nottingham Prognostic Index, triple negative and basal-like breast cancers (all adjusted p values < 0.05). Tumours with low ATM or high ATR levels in conjunction with MYC overexpression also have worse overall breast cancer-specific survival (BCSS) (p value < 0.05). CONCLUSIONS: We conclude that ATR/ATM-directed stratification and personalisation of therapy may be feasible in MYC overexpressed breast cancer.
45 schema:genre research_article
46 schema:inLanguage en
47 schema:isAccessibleForFree false
48 schema:isPartOf sg:journal.1092777
49 schema:name Clinicopathological significance of ataxia telangiectasia-mutated (ATM) kinase and ataxia telangiectasia-mutated and Rad3-related (ATR) kinase in MYC overexpressed breast cancers
50 schema:pagination 1-11
51 schema:productId N14325821eb5e4c7c92d4ce06760e97de
52 N27dfde6780e244ac98294087c2d35a19
53 N2f1825125d854ccd9313450ad77dacad
54 N46f70841c79e45f9b210e712c52b9760
55 Naa54d065ea1c4ebc952eb277b996af96
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1112070604
57 https://doi.org/10.1007/s10549-018-05113-8
58 schema:sdDatePublished 2019-04-11T09:04
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Nb7fe978e1791437abad901a3fafa054c
61 schema:url https://link.springer.com/10.1007%2Fs10549-018-05113-8
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N087d9033d37241419a930ba511ec0b98 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
66 schema:familyName Ali
67 schema:givenName Reem
68 rdf:type schema:Person
69 N0bca6158c72d4551850b60c28ff1a1e4 schema:affiliation https://www.grid.ac/institutes/grid.240404.6
70 schema:familyName Savva
71 schema:givenName Constantinos
72 rdf:type schema:Person
73 N14325821eb5e4c7c92d4ce06760e97de schema:name readcube_id
74 schema:value c08a8aee5fd1541e65faf8ae2ac33560eb6bd686f16592146716c0c75b949040
75 rdf:type schema:PropertyValue
76 N27dfde6780e244ac98294087c2d35a19 schema:name nlm_unique_id
77 schema:value 8111104
78 rdf:type schema:PropertyValue
79 N2f1825125d854ccd9313450ad77dacad schema:name pubmed_id
80 schema:value 30746633
81 rdf:type schema:PropertyValue
82 N41cad7bff93d4515a864211fe64325b4 rdf:first N9ee1dd61235d4456a19f8c4c6f47790d
83 rdf:rest rdf:nil
84 N46f70841c79e45f9b210e712c52b9760 schema:name doi
85 schema:value 10.1007/s10549-018-05113-8
86 rdf:type schema:PropertyValue
87 N606a9901fe35498a86a73c71d271334c rdf:first N0bca6158c72d4551850b60c28ff1a1e4
88 rdf:rest Nb593db0f4a114de5b36a15c77cd46ad4
89 N66856d03f2a04f54b7f6c22ffc7df517 rdf:first N89553cff1d1946c8add3796fd94a14db
90 rdf:rest N87de556de6d042f5bc36e5eb9bfc3493
91 N87de556de6d042f5bc36e5eb9bfc3493 rdf:first N8acc553ec0974e47a25177150b896ae3
92 rdf:rest N41cad7bff93d4515a864211fe64325b4
93 N89553cff1d1946c8add3796fd94a14db schema:affiliation https://www.grid.ac/institutes/grid.4563.4
94 schema:familyName Rakha
95 schema:givenName Emad A.
96 rdf:type schema:Person
97 N89a4516ac9b7412fa6908bdf67ec6f63 schema:affiliation https://www.grid.ac/institutes/grid.240404.6
98 schema:familyName De Souza
99 schema:givenName Karen
100 rdf:type schema:Person
101 N8acc553ec0974e47a25177150b896ae3 schema:affiliation https://www.grid.ac/institutes/grid.4563.4
102 schema:familyName Green
103 schema:givenName Andrew R.
104 rdf:type schema:Person
105 N9083d7fc1c70410f9dae1af38c101fe0 rdf:first N087d9033d37241419a930ba511ec0b98
106 rdf:rest N66856d03f2a04f54b7f6c22ffc7df517
107 N9ee1dd61235d4456a19f8c4c6f47790d schema:affiliation https://www.grid.ac/institutes/grid.4563.4
108 schema:familyName Madhusudan
109 schema:givenName Srinivasan
110 rdf:type schema:Person
111 Naa54d065ea1c4ebc952eb277b996af96 schema:name dimensions_id
112 schema:value pub.1112070604
113 rdf:type schema:PropertyValue
114 Nb593db0f4a114de5b36a15c77cd46ad4 rdf:first N89a4516ac9b7412fa6908bdf67ec6f63
115 rdf:rest N9083d7fc1c70410f9dae1af38c101fe0
116 Nb7fe978e1791437abad901a3fafa054c schema:name Springer Nature - SN SciGraph project
117 rdf:type schema:Organization
118 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
119 schema:name Medical and Health Sciences
120 rdf:type schema:DefinedTerm
121 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
122 schema:name Oncology and Carcinogenesis
123 rdf:type schema:DefinedTerm
124 sg:journal.1092777 schema:issn 0167-6806
125 1573-7217
126 schema:name Breast Cancer Research and Treatment
127 rdf:type schema:Periodical
128 sg:pub.10.1038/bjc.2016.46 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037190454
129 https://doi.org/10.1038/bjc.2016.46
130 rdf:type schema:CreativeWork
131 sg:pub.10.1038/nature10983 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014607335
132 https://doi.org/10.1038/nature10983
133 rdf:type schema:CreativeWork
134 sg:pub.10.1038/nrm.2017.67 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091217755
135 https://doi.org/10.1038/nrm.2017.67
136 rdf:type schema:CreativeWork
137 sg:pub.10.1038/nrm3546 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047891925
138 https://doi.org/10.1038/nrm3546
139 rdf:type schema:CreativeWork
140 sg:pub.10.1038/onc.2013.275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034137455
141 https://doi.org/10.1038/onc.2013.275
142 rdf:type schema:CreativeWork
143 sg:pub.10.1038/s41392-018-0008-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101130554
144 https://doi.org/10.1038/s41392-018-0008-7
145 rdf:type schema:CreativeWork
146 sg:pub.10.1038/sj.onc.1209873 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041078054
147 https://doi.org/10.1038/sj.onc.1209873
148 rdf:type schema:CreativeWork
149 sg:pub.10.1054/bjoc.2000.1522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034175533
150 https://doi.org/10.1054/bjoc.2000.1522
151 rdf:type schema:CreativeWork
152 sg:pub.10.1186/1747-1028-7-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044903023
153 https://doi.org/10.1186/1747-1028-7-6
154 rdf:type schema:CreativeWork
155 sg:pub.10.1186/1756-9966-32-95 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008494380
156 https://doi.org/10.1186/1756-9966-32-95
157 rdf:type schema:CreativeWork
158 https://doi.org/10.1016/j.bbagrm.2014.03.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002432260
159 rdf:type schema:CreativeWork
160 https://doi.org/10.1016/j.cell.2012.03.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047284773
161 rdf:type schema:CreativeWork
162 https://doi.org/10.1016/j.ctrv.2013.03.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009647529
163 rdf:type schema:CreativeWork
164 https://doi.org/10.1016/j.dnarep.2017.06.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085962157
165 rdf:type schema:CreativeWork
166 https://doi.org/10.1016/j.gde.2009.11.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040524318
167 rdf:type schema:CreativeWork
168 https://doi.org/10.1016/j.jsbmb.2015.02.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035035687
169 rdf:type schema:CreativeWork
170 https://doi.org/10.1016/j.molonc.2014.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029363924
171 rdf:type schema:CreativeWork
172 https://doi.org/10.1016/j.neo.2014.09.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010194222
173 rdf:type schema:CreativeWork
174 https://doi.org/10.1016/s0092-8674(00)00188-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023269017
175 rdf:type schema:CreativeWork
176 https://doi.org/10.1073/pnas.0507367103 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038586376
177 rdf:type schema:CreativeWork
178 https://doi.org/10.1093/jnci/dji237 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023556722
179 rdf:type schema:CreativeWork
180 https://doi.org/10.1101/cshperspect.a014241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007687362
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1101/cshperspect.a014266 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012215524
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1101/cshperspect.a014357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047723058
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1101/cshperspect.a014407 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013716777
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1101/cshperspect.a014423 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038032174
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1158/0008-5472.can-10-3776 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035089351
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1158/1078-0432.ccr-10-2567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043987722
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1158/1078-0432.ccr-11-1198 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020248092
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1158/1078-0432.ccr-15-0479 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063224904
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1158/1535-7163.mct-15-0945 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053421694
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1158/1535-7163.mct-16-0378 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083395494
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1177/1947601910378691 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047096408
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1182/blood-2015-05-644872 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064122721
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1210/me.2011-1037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064328688
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1586/14737140.8.10.1689 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006893274
209 rdf:type schema:CreativeWork
210 https://doi.org/10.18632/oncotarget.9156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010462800
211 rdf:type schema:CreativeWork
212 https://doi.org/10.4103/2319-4170.125655 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035298410
213 rdf:type schema:CreativeWork
214 https://www.grid.ac/institutes/grid.240404.6 schema:alternateName Nottingham University Hospitals NHS Trust
215 schema:name Department of Oncology, Nottingham University Hospitals, NG5 1PB, Nottingham, UK
216 rdf:type schema:Organization
217 https://www.grid.ac/institutes/grid.4563.4 schema:alternateName University of Nottingham
218 schema:name Department of Oncology, Nottingham University Hospitals, NG5 1PB, Nottingham, UK
219 Department of Pathology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, School of Medicine, University of Nottingham, NG5 1PB, Nottingham, UK
220 Translational Oncology, Nottingham Breast Cancer Research Centre, Division of Cancer and Stem Cells, Academic Unit of Oncology, School of Medicine, University of Nottingham, NG51 PB, Nottingham, UK
221 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...