Lymphovascular invasion after neoadjuvant chemotherapy is strongly associated with poor prognosis in breast carcinoma View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-06

AUTHORS

Anne-Sophie Hamy, Giang-Thanh Lam, Enora Laas, Lauren Darrigues, Thomas Balezeau, Julien Guerin, Alain Livartowski, Benjamin Sadacca, Jean-Yves Pierga, Anne Vincent-Salomon, Florence Coussy, Veronique Becette, Hélène Bonsang-Kitzis, Roman Rouzier, Jean-Guillaume Feron, Gabriel Benchimol, Marick Laé, Fabien Reyal

ABSTRACT

PURPOSE: Few studies evaluated the prognostic value of the presence of lymphovascular invasion (LVI) after neoadjuvant chemotherapy (NAC) for breast cancer (BC). METHODS: The association between LVI and survival was evaluated in a cohort of BC patients treated by NAC between 2002 and 2011. Five post-NAC prognostic scores (ypAJCC, RCB, CPS, CPS + EG and Neo-Bioscore) were evaluated and compared with or without the addition of LVI. RESULTS: Out of 1033 tumors, LVI was present on surgical specimens in 29.2% and absent in 70.8% of the cases. Post-NAC LVI was associated with impaired disease-free survival (DFS) (HR 2.54; 95% CI 1.96-3.31; P < 0.001), and the magnitude of this effect depended on BC subtype (Pinteraction = 0.003), (luminal BC: HR 1.83; P = 0.003; triple negative BC: HR 3.73; P < 0.001; HER2-positive BC: HR 6.21; P < 0.001). Post-NAC LVI was an independent predictor of local relapse, distant metastasis, and overall survival; and increased the accuracy of all five post-NAC prognostic scoring systems. CONCLUSIONS: Post-NAC LVI is a strong independent prognostic factor that: (i) should be systematically reported in pathology reports; (ii) should be used as stratification factor after NAC to propose inclusion in second-line trials or adjuvant treatment; (iii) should be included in post-NAC scoring systems. More... »

PAGES

295-304

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-017-4610-0

DOI

http://dx.doi.org/10.1007/s10549-017-4610-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1100679250

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29374852


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