A multi-center pragmatic, randomized, feasibility trial comparing standard of care schedules of filgrastim administration for primary febrile neutropenia prophylaxis in ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2018-04

AUTHORS

Mohammed F. K. Ibrahim, John Hilton, Sasha Mazzarello, Dean Fergusson, Brian Hutton, Andrew Robinson, Nadia Califaretti, Tina Hsu, Stan Gertler, Mihaela Mates, Carol Stober, Lisa Vandermeer, Ranjeeta Mallick, Mark Clemons

ABSTRACT

INTRODUCTION: The most effective duration of filgrastim as primary febrile neutropenia (FN) prophylaxis in early breast cancer (EBC) patients is unknown. Despite significant differences in cost and toxicity, no prospective trial has been performed to optimize practice. We assessed the feasibility of using a novel pragmatic trial model to compare the most commonly used schedules of filgrastim. METHODS: Early breast cancer patients receiving chemotherapy were randomized to 5, 7, or 10 days of filgrastim as primary FN prophylaxis. The trial methodology integrated broad eligibility criteria, simply defined endpoints, an integrated consent model incorporating oral consent, and web-based randomization in the clinic. Feasibility was reflected through a combination of primary endpoints including patient and physician engagement (if > 50% of appropriate patients approached agree to participate, and if > 50% of physicians approached patients for the study). Secondary endpoints included the first occurrence rates of FN, treatment-related hospital admission, or chemotherapy dose reductions/delays/discontinuation. RESULTS: From May 2015 to August 2016, 142/149 (95.3%) patients approached agreed to participate and were randomized. Seventeen of 24 (70.8%) medical oncologists approached and randomized patients. The 142 patients received a total of 495 cycles of chemotherapy. Aggregate incidences of a first event by patient were FN (8/142, 5.6%), treatment-related hospitalization (6/142, 4.2%), chemotherapy discontinuation (7/142, 4.9%), chemotherapy delays (5/142, 3.5%), and chemotherapy dose reduction (18/142, 12.7%). Overall, 31.7% (45/142) of patients and 9.0% (45/495) of chemotherapy cycles were associated with one of these first events. CONCLUSION: This study met its feasibility endpoints. This novel pragmatic trial approach offers a means of comparing standard of care treatments in a practical and cost-effective manner. The trial will now be expanded to compare rates of FN between the three filgrastim schedules. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02428114. More... »

PAGES

371-379

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-017-4604-y

DOI

http://dx.doi.org/10.1007/s10549-017-4604-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1099700092

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29214415


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy-Induced Febrile Neutropenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cost-Benefit Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Administration Schedule", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Feasibility Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Filgrastim", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hematologic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Incidence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ontario", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Practice Guidelines as Topic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Standard of Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Young Adult", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Ottawa", 
          "id": "https://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ibrahim", 
        "givenName": "Mohammed F. K.", 
        "id": "sg:person.012754470322.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012754470322.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada", 
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hilton", 
        "givenName": "John", 
        "id": "sg:person.01011642231.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011642231.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzarello", 
        "givenName": "Sasha", 
        "id": "sg:person.0737376756.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada", 
            "Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fergusson", 
        "givenName": "Dean", 
        "id": "sg:person.01152765352.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152765352.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada", 
            "Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutton", 
        "givenName": "Brian", 
        "id": "sg:person.01235465321.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235465321.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Care South East", 
          "id": "https://www.grid.ac/institutes/grid.477028.e", 
          "name": [
            "Cancer Centre of Southeastern Ontario, Kingston, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Robinson", 
        "givenName": "Andrew", 
        "id": "sg:person.014571461331.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014571461331.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Grand River Regional Cancer Centre, Kitchener, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Califaretti", 
        "givenName": "Nadia", 
        "id": "sg:person.01022250610.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022250610.11"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ottawa", 
          "id": "https://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hsu", 
        "givenName": "Tina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Ottawa", 
          "id": "https://www.grid.ac/institutes/grid.28046.38", 
          "name": [
            "Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gertler", 
        "givenName": "Stan", 
        "id": "sg:person.01230721252.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230721252.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cancer Care South East", 
          "id": "https://www.grid.ac/institutes/grid.477028.e", 
          "name": [
            "Cancer Centre of Southeastern Ontario, Kingston, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mates", 
        "givenName": "Mihaela", 
        "id": "sg:person.01201550771.63", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201550771.63"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Stober", 
        "givenName": "Carol", 
        "id": "sg:person.012546702415.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012546702415.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandermeer", 
        "givenName": "Lisa", 
        "id": "sg:person.0761055556.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mallick", 
        "givenName": "Ranjeeta", 
        "id": "sg:person.0657754474.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657754474.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada", 
            "Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clemons", 
        "givenName": "Mark", 
        "id": "sg:person.01216107435.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.10.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006780383"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-011-1375-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017473885", 
          "https://doi.org/10.1007/s00520-011-1375-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2015.62.3488", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021783900"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm438", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024333619"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jop.2016.013474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029512117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.0508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032930162"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2010.10.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034049872"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034733668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq196", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034733668"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd007913.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036547737"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3747/co.v18i3.751", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037734300"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.2014.4164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037858442"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3747/co.20.1306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038319021"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3747/co.v17i2.498", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039793562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.i5239", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043964837"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1472-6963-14-189", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050821717", 
          "https://doi.org/10.1186/1472-6963-14-189"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmhle1312508", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051027676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052859374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdq195", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052859374"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2013.0148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078801616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.6004/jnccn.2013.0148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1078801616"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2018-04", 
    "datePublishedReg": "2018-04-01", 
    "description": "INTRODUCTION: The most effective duration of filgrastim as primary febrile neutropenia (FN) prophylaxis in early breast cancer (EBC) patients is unknown. Despite significant differences in cost and toxicity, no prospective trial has been performed to optimize practice. We assessed the feasibility of using a novel pragmatic trial model to compare the most commonly used schedules of filgrastim.\nMETHODS: Early breast cancer patients receiving chemotherapy were randomized to 5, 7, or 10\u00a0days of filgrastim as primary FN prophylaxis. The trial methodology integrated broad eligibility criteria, simply defined endpoints, an integrated consent model incorporating oral consent, and web-based randomization in the clinic. Feasibility was reflected through a combination of primary endpoints including patient and physician engagement (if\u00a0>\u00a050% of appropriate patients approached agree to participate, and if\u00a0>\u00a050% of physicians approached patients for the study). Secondary endpoints included the first occurrence rates of FN, treatment-related hospital admission, or chemotherapy dose reductions/delays/discontinuation.\nRESULTS: From May 2015 to August 2016, 142/149 (95.3%) patients approached agreed to participate and were randomized. Seventeen of 24 (70.8%) medical oncologists approached and randomized patients. The 142 patients received a total of 495 cycles of chemotherapy. Aggregate incidences of a first event by patient were FN (8/142, 5.6%), treatment-related hospitalization (6/142, 4.2%), chemotherapy discontinuation (7/142, 4.9%), chemotherapy delays (5/142, 3.5%), and chemotherapy dose reduction (18/142, 12.7%). Overall, 31.7% (45/142) of patients and 9.0% (45/495) of chemotherapy cycles were associated with one of these first events.\nCONCLUSION: This study met its feasibility endpoints. This novel pragmatic trial approach offers a means of comparing standard of care treatments in a practical and cost-effective manner. The trial will now be expanded to compare rates of FN between the three filgrastim schedules.\nTRIAL REGISTRATION: ClinicalTrials.gov: NCT02428114.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-017-4604-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "168"
      }
    ], 
    "name": "A multi-center pragmatic, randomized, feasibility trial comparing standard of care schedules of filgrastim administration for primary febrile neutropenia prophylaxis in early-stage breast cancer", 
    "pagination": "371-379", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a7421fa98a3644b682831eb311feccbb825ac98fcf837ace2d26a01652fbf77a"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "29214415"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-017-4604-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1099700092"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-017-4604-y", 
      "https://app.dimensions.ai/details/publication/pub.1099700092"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T12:25", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000362_0000000362/records_87106_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10549-017-4604-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4604-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4604-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4604-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4604-y'


 

This table displays all metadata directly associated to this object as RDF triples.

313 TRIPLES      21 PREDICATES      69 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-017-4604-y schema:about N04ae0f38f146404497dc71a48302a262
2 N1cf45124fc2d4ea2b4f8feaad64be217
3 N2d15f699c5144cb992be7c0741fa27a0
4 N343337f1f23d4688b9c11eb7b04ca17d
5 N3defef00c09d439cacf23e79c7f638da
6 N4a2e10e6a3794d2787fd732be834dc54
7 N69c4a869fd15416cbf6c9dcfbce66248
8 N6add8c26f87b491fa996d848e12a38d3
9 N739c1ab50dac40fcb62e6e5d0b669ac6
10 N7fbfc0ef880d43e0ad94fa1a6883d968
11 N7fc97d285bfe4c4aa7e1b43f47091a66
12 N80b442ce1dfa43cbb99d421b041ad039
13 N8f60c97f13e44621b995d0947783caba
14 N97b4643742524176bb43d30a5f0ee2e6
15 N9e984d293447454ab1c78f7ae46de440
16 Na40a76d1fe1d44bcb1f23c7b6d3dc7c7
17 Naece9237e10445adb9ce91506e57d7c8
18 Nb82d0caf6cd54f828ae14aad83a3f40d
19 Nd98390016a3d43469b24447f4dd9fc77
20 Ne3015200068f4f3782dd54c7f5d169ea
21 Neaa5bed271534586a5521dbd2a200959
22 Nfa5b78f415b44deebf3ef36c12437f29
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N887f0719d0514366b275b2b71235dffc
26 schema:citation sg:pub.10.1007/s00520-011-1375-6
27 sg:pub.10.1186/1472-6963-14-189
28 https://doi.org/10.1001/jama.2014.4164
29 https://doi.org/10.1002/14651858.cd007913.pub2
30 https://doi.org/10.1016/j.ejca.2010.10.001
31 https://doi.org/10.1016/j.ejca.2010.10.013
32 https://doi.org/10.1056/nejmhle1312508
33 https://doi.org/10.1093/annonc/mdm438
34 https://doi.org/10.1093/annonc/mdq195
35 https://doi.org/10.1093/annonc/mdq196
36 https://doi.org/10.1136/bmj.i5239
37 https://doi.org/10.1200/jco.2009.23.0508
38 https://doi.org/10.1200/jco.2015.62.3488
39 https://doi.org/10.1200/jop.2016.013474
40 https://doi.org/10.3747/co.20.1306
41 https://doi.org/10.3747/co.v17i2.498
42 https://doi.org/10.3747/co.v18i3.751
43 https://doi.org/10.6004/jnccn.2013.0148
44 schema:datePublished 2018-04
45 schema:datePublishedReg 2018-04-01
46 schema:description INTRODUCTION: The most effective duration of filgrastim as primary febrile neutropenia (FN) prophylaxis in early breast cancer (EBC) patients is unknown. Despite significant differences in cost and toxicity, no prospective trial has been performed to optimize practice. We assessed the feasibility of using a novel pragmatic trial model to compare the most commonly used schedules of filgrastim. METHODS: Early breast cancer patients receiving chemotherapy were randomized to 5, 7, or 10 days of filgrastim as primary FN prophylaxis. The trial methodology integrated broad eligibility criteria, simply defined endpoints, an integrated consent model incorporating oral consent, and web-based randomization in the clinic. Feasibility was reflected through a combination of primary endpoints including patient and physician engagement (if > 50% of appropriate patients approached agree to participate, and if > 50% of physicians approached patients for the study). Secondary endpoints included the first occurrence rates of FN, treatment-related hospital admission, or chemotherapy dose reductions/delays/discontinuation. RESULTS: From May 2015 to August 2016, 142/149 (95.3%) patients approached agreed to participate and were randomized. Seventeen of 24 (70.8%) medical oncologists approached and randomized patients. The 142 patients received a total of 495 cycles of chemotherapy. Aggregate incidences of a first event by patient were FN (8/142, 5.6%), treatment-related hospitalization (6/142, 4.2%), chemotherapy discontinuation (7/142, 4.9%), chemotherapy delays (5/142, 3.5%), and chemotherapy dose reduction (18/142, 12.7%). Overall, 31.7% (45/142) of patients and 9.0% (45/495) of chemotherapy cycles were associated with one of these first events. CONCLUSION: This study met its feasibility endpoints. This novel pragmatic trial approach offers a means of comparing standard of care treatments in a practical and cost-effective manner. The trial will now be expanded to compare rates of FN between the three filgrastim schedules. TRIAL REGISTRATION: ClinicalTrials.gov: NCT02428114.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf Na5311f5f067d4637b2a0962031f19be4
51 Nb950b92f379549c09fb1b3883abfca11
52 sg:journal.1092777
53 schema:name A multi-center pragmatic, randomized, feasibility trial comparing standard of care schedules of filgrastim administration for primary febrile neutropenia prophylaxis in early-stage breast cancer
54 schema:pagination 371-379
55 schema:productId N0a8b594f8d664f76a73eb61d1d26db74
56 N10380d21d9164f8a99e89b777c398bf6
57 N7d246f92482e49c6be32a6984057dd6c
58 N9426e65c6704420eaee44230b0fe5f60
59 Na98c0f4007e54273909b1afbb6625125
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099700092
61 https://doi.org/10.1007/s10549-017-4604-y
62 schema:sdDatePublished 2019-04-11T12:25
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N5f370452525c48879e58437555638816
65 schema:url https://link.springer.com/10.1007%2Fs10549-017-4604-y
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N04ae0f38f146404497dc71a48302a262 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Time Factors
71 rdf:type schema:DefinedTerm
72 N0a8b594f8d664f76a73eb61d1d26db74 schema:name nlm_unique_id
73 schema:value 8111104
74 rdf:type schema:PropertyValue
75 N10380d21d9164f8a99e89b777c398bf6 schema:name pubmed_id
76 schema:value 29214415
77 rdf:type schema:PropertyValue
78 N1cf45124fc2d4ea2b4f8feaad64be217 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Standard of Care
80 rdf:type schema:DefinedTerm
81 N2d15f699c5144cb992be7c0741fa27a0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Filgrastim
83 rdf:type schema:DefinedTerm
84 N343337f1f23d4688b9c11eb7b04ca17d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Female
86 rdf:type schema:DefinedTerm
87 N3b9ff38092e34c1dbb561a690bec4d45 rdf:first sg:person.01235465321.38
88 rdf:rest N3d0679a581664052af40d4b2c96abe49
89 N3d0679a581664052af40d4b2c96abe49 rdf:first sg:person.014571461331.20
90 rdf:rest N80f1196e02e5405590e29d7f7fc5c5ed
91 N3defef00c09d439cacf23e79c7f638da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Aged, 80 and over
93 rdf:type schema:DefinedTerm
94 N48ed84a615e84c05b1e8f684eb13aea1 rdf:first sg:person.01152765352.19
95 rdf:rest N3b9ff38092e34c1dbb561a690bec4d45
96 N4a2e10e6a3794d2787fd732be834dc54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
97 schema:name Treatment Outcome
98 rdf:type schema:DefinedTerm
99 N4c8f51da753c4465bc64654ab538d477 rdf:first sg:person.0761055556.65
100 rdf:rest Nf015fd0460c9427c9c605e20ef350af5
101 N5f370452525c48879e58437555638816 schema:name Springer Nature - SN SciGraph project
102 rdf:type schema:Organization
103 N5ffc1ce131874667aeaea5f78749800f schema:name Grand River Regional Cancer Centre, Kitchener, Canada
104 rdf:type schema:Organization
105 N69c4a869fd15416cbf6c9dcfbce66248 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name Breast Neoplasms
107 rdf:type schema:DefinedTerm
108 N6add8c26f87b491fa996d848e12a38d3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Cost-Benefit Analysis
110 rdf:type schema:DefinedTerm
111 N739c1ab50dac40fcb62e6e5d0b669ac6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Drug Administration Schedule
113 rdf:type schema:DefinedTerm
114 N7714a04bbaf74462ae947179bdb158da rdf:first sg:person.0737376756.24
115 rdf:rest N48ed84a615e84c05b1e8f684eb13aea1
116 N7d246f92482e49c6be32a6984057dd6c schema:name readcube_id
117 schema:value a7421fa98a3644b682831eb311feccbb825ac98fcf837ace2d26a01652fbf77a
118 rdf:type schema:PropertyValue
119 N7fbfc0ef880d43e0ad94fa1a6883d968 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Adult
121 rdf:type schema:DefinedTerm
122 N7fc97d285bfe4c4aa7e1b43f47091a66 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Humans
124 rdf:type schema:DefinedTerm
125 N80b442ce1dfa43cbb99d421b041ad039 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Aged
127 rdf:type schema:DefinedTerm
128 N80f1196e02e5405590e29d7f7fc5c5ed rdf:first sg:person.01022250610.11
129 rdf:rest Ne416be429ec54b5e9fd5a08101a9b406
130 N887f0719d0514366b275b2b71235dffc rdf:first sg:person.012754470322.02
131 rdf:rest Nbe13c288b9044d4eb7a1f5ec485b7f11
132 N8f60c97f13e44621b995d0947783caba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Practice Guidelines as Topic
134 rdf:type schema:DefinedTerm
135 N9426e65c6704420eaee44230b0fe5f60 schema:name dimensions_id
136 schema:value pub.1099700092
137 rdf:type schema:PropertyValue
138 N97b4643742524176bb43d30a5f0ee2e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Incidence
140 rdf:type schema:DefinedTerm
141 N9e984d293447454ab1c78f7ae46de440 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
142 schema:name Middle Aged
143 rdf:type schema:DefinedTerm
144 Na40a76d1fe1d44bcb1f23c7b6d3dc7c7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Hematologic Agents
146 rdf:type schema:DefinedTerm
147 Na5311f5f067d4637b2a0962031f19be4 schema:volumeNumber 168
148 rdf:type schema:PublicationVolume
149 Na98c0f4007e54273909b1afbb6625125 schema:name doi
150 schema:value 10.1007/s10549-017-4604-y
151 rdf:type schema:PropertyValue
152 Naece9237e10445adb9ce91506e57d7c8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Young Adult
154 rdf:type schema:DefinedTerm
155 Nb82d0caf6cd54f828ae14aad83a3f40d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Ontario
157 rdf:type schema:DefinedTerm
158 Nb950b92f379549c09fb1b3883abfca11 schema:issueNumber 2
159 rdf:type schema:PublicationIssue
160 Nb9706ec9c920492fac6653a6ca128c37 rdf:first sg:person.01201550771.63
161 rdf:rest Nefb48cbf726c402397a90a29c0861d28
162 Nbd593a2618c3401fa6a7e11ce99132c8 rdf:first sg:person.01230721252.04
163 rdf:rest Nb9706ec9c920492fac6653a6ca128c37
164 Nbe13c288b9044d4eb7a1f5ec485b7f11 rdf:first sg:person.01011642231.93
165 rdf:rest N7714a04bbaf74462ae947179bdb158da
166 Nd9281bc591904b9699f109138378de8f rdf:first sg:person.01216107435.90
167 rdf:rest rdf:nil
168 Nd98390016a3d43469b24447f4dd9fc77 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Neoplasm Staging
170 rdf:type schema:DefinedTerm
171 Ne3015200068f4f3782dd54c7f5d169ea schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Feasibility Studies
173 rdf:type schema:DefinedTerm
174 Ne416be429ec54b5e9fd5a08101a9b406 rdf:first Nf10a73f8a56e46fb96e865b08771be0a
175 rdf:rest Nbd593a2618c3401fa6a7e11ce99132c8
176 Neaa5bed271534586a5521dbd2a200959 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
177 schema:name Antineoplastic Combined Chemotherapy Protocols
178 rdf:type schema:DefinedTerm
179 Nefb48cbf726c402397a90a29c0861d28 rdf:first sg:person.012546702415.53
180 rdf:rest N4c8f51da753c4465bc64654ab538d477
181 Nf015fd0460c9427c9c605e20ef350af5 rdf:first sg:person.0657754474.04
182 rdf:rest Nd9281bc591904b9699f109138378de8f
183 Nf10a73f8a56e46fb96e865b08771be0a schema:affiliation https://www.grid.ac/institutes/grid.28046.38
184 schema:familyName Hsu
185 schema:givenName Tina
186 rdf:type schema:Person
187 Nfa5b78f415b44deebf3ef36c12437f29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Chemotherapy-Induced Febrile Neutropenia
189 rdf:type schema:DefinedTerm
190 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
191 schema:name Medical and Health Sciences
192 rdf:type schema:DefinedTerm
193 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
194 schema:name Oncology and Carcinogenesis
195 rdf:type schema:DefinedTerm
196 sg:journal.1092777 schema:issn 0167-6806
197 1573-7217
198 schema:name Breast Cancer Research and Treatment
199 rdf:type schema:Periodical
200 sg:person.01011642231.93 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
201 schema:familyName Hilton
202 schema:givenName John
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011642231.93
204 rdf:type schema:Person
205 sg:person.01022250610.11 schema:affiliation N5ffc1ce131874667aeaea5f78749800f
206 schema:familyName Califaretti
207 schema:givenName Nadia
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01022250610.11
209 rdf:type schema:Person
210 sg:person.01152765352.19 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
211 schema:familyName Fergusson
212 schema:givenName Dean
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152765352.19
214 rdf:type schema:Person
215 sg:person.01201550771.63 schema:affiliation https://www.grid.ac/institutes/grid.477028.e
216 schema:familyName Mates
217 schema:givenName Mihaela
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201550771.63
219 rdf:type schema:Person
220 sg:person.01216107435.90 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
221 schema:familyName Clemons
222 schema:givenName Mark
223 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90
224 rdf:type schema:Person
225 sg:person.01230721252.04 schema:affiliation https://www.grid.ac/institutes/grid.28046.38
226 schema:familyName Gertler
227 schema:givenName Stan
228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230721252.04
229 rdf:type schema:Person
230 sg:person.01235465321.38 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
231 schema:familyName Hutton
232 schema:givenName Brian
233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235465321.38
234 rdf:type schema:Person
235 sg:person.012546702415.53 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
236 schema:familyName Stober
237 schema:givenName Carol
238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012546702415.53
239 rdf:type schema:Person
240 sg:person.012754470322.02 schema:affiliation https://www.grid.ac/institutes/grid.28046.38
241 schema:familyName Ibrahim
242 schema:givenName Mohammed F. K.
243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012754470322.02
244 rdf:type schema:Person
245 sg:person.014571461331.20 schema:affiliation https://www.grid.ac/institutes/grid.477028.e
246 schema:familyName Robinson
247 schema:givenName Andrew
248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014571461331.20
249 rdf:type schema:Person
250 sg:person.0657754474.04 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
251 schema:familyName Mallick
252 schema:givenName Ranjeeta
253 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0657754474.04
254 rdf:type schema:Person
255 sg:person.0737376756.24 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
256 schema:familyName Mazzarello
257 schema:givenName Sasha
258 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24
259 rdf:type schema:Person
260 sg:person.0761055556.65 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
261 schema:familyName Vandermeer
262 schema:givenName Lisa
263 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65
264 rdf:type schema:Person
265 sg:pub.10.1007/s00520-011-1375-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017473885
266 https://doi.org/10.1007/s00520-011-1375-6
267 rdf:type schema:CreativeWork
268 sg:pub.10.1186/1472-6963-14-189 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050821717
269 https://doi.org/10.1186/1472-6963-14-189
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1001/jama.2014.4164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037858442
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1002/14651858.cd007913.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036547737
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/j.ejca.2010.10.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006780383
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/j.ejca.2010.10.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034049872
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1056/nejmhle1312508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051027676
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1093/annonc/mdm438 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024333619
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1093/annonc/mdq195 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052859374
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1093/annonc/mdq196 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034733668
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1136/bmj.i5239 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043964837
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1200/jco.2009.23.0508 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032930162
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1200/jco.2015.62.3488 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021783900
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1200/jop.2016.013474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029512117
294 rdf:type schema:CreativeWork
295 https://doi.org/10.3747/co.20.1306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038319021
296 rdf:type schema:CreativeWork
297 https://doi.org/10.3747/co.v17i2.498 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039793562
298 rdf:type schema:CreativeWork
299 https://doi.org/10.3747/co.v18i3.751 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037734300
300 rdf:type schema:CreativeWork
301 https://doi.org/10.6004/jnccn.2013.0148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1078801616
302 rdf:type schema:CreativeWork
303 https://www.grid.ac/institutes/grid.28046.38 schema:alternateName University of Ottawa
304 schema:name Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada
305 rdf:type schema:Organization
306 https://www.grid.ac/institutes/grid.412687.e schema:alternateName Ottawa Hospital
307 schema:name Clinical Epidemiology Program, The Ottawa Hospital Research Institute, Ottawa, Canada
308 Division of Medical Oncology, Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Canada
309 Ottawa Hospital Research Institute and University of Ottawa, Ottawa, Canada
310 rdf:type schema:Organization
311 https://www.grid.ac/institutes/grid.477028.e schema:alternateName Cancer Care South East
312 schema:name Cancer Centre of Southeastern Ontario, Kingston, Canada
313 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...