Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2017-07

AUTHORS

Kunal C. Kadakia, Kelley M. Kidwell, Nicholas J. Seewald, Claire F. Snyder, Anna Maria Storniolo, Julie L. Otte, David A. Flockhart, Daniel F. Hayes, Vered Stearns, N. Lynn Henry

ABSTRACT

PURPOSE: Aromatase inhibitors (AI), which decrease circulating estradiol concentrations in post-menopausal women, are associated with toxicities that limit adherence. Approximately one-third of patients will tolerate a different AI after not tolerating the first. We report the effect of crossover from exemestane to letrozole or vice versa on patient-reported outcomes (PROs) and whether the success of crossover is due to lack of estrogen suppression. METHODS: Post-menopausal women enrolled on a prospective trial initiating AI therapy for early-stage breast cancer were randomized to exemestane or letrozole. Those that discontinued for intolerance were offered protocol-directed crossover to the other AI after a washout period. Changes in PROs, including pain [Visual Analog Scale (VAS)] and functional status [Health Assessment Questionnaire (HAQ)], were compared after 3 months on the first versus the second AI. Estradiol and drug concentrations were measured. RESULTS: Eighty-three patients participated in the crossover protocol, of whom 91.3% reported improvement in symptoms prior to starting the second AI. Functional status worsened less after 3 months with the second AI (HAQ mean change AI #1: 0.2 [SD 0.41] vs. AI #2: -0.05 [SD 0.36]; p = 0.001); change in pain scores was similar between the first and second AI (VAS mean change AI #1: 0.8 [SD 2.7] vs. AI #2: -0.2 [SD 2.8]; p = 0.19). No statistical differences in estradiol or drug concentrations were found between those that continued or discontinued AI after crossover. CONCLUSIONS: Although all AIs act via the same mechanism, a subset of patients intolerant to one AI report improved PROs with a different one. The mechanism of this tolerance remains unknown, but does not appear to be due to non-adherence to, or insufficient estrogen suppression by, the second AI. More... »

PAGES

411-419

References to SciGraph publications

  • 2011-11. Plasma Letrozole Concentrations in Postmenopausal Women With Breast Cancer Are Associated With CYP2A6 Genetic Variants, Body Mass Index, and Age in CLINICAL PHARMACOLOGY & THERAPEUTICS
  • 2010-02. Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study in BREAST CANCER RESEARCH AND TREATMENT
  • 2017-12. Polymorphisms in drug-metabolizing enzymes and steady-state exemestane concentration in postmenopausal patients with breast cancer in THE PHARMACOGENOMICS JOURNAL
  • 2003-11. Aromatase inhibitors for breast cancer: lessons from the laboratory in NATURE REVIEWS CANCER
  • 2013-10. Aromatase inhibitor-induced modulation of breast density: clinical and genetic effects in BRITISH JOURNAL OF CANCER
  • 2017-02. Effects of exemestane and letrozole therapy on plasma concentrations of estrogens in a randomized trial of postmenopausal women with breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2007-05. Health Utilities Using the EQ-5D in Studies of Cancer in PHARMACOECONOMICS
  • 2013-04. Genetic associations with toxicity-related discontinuation of aromatase inhibitor therapy for breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2005-12. Patients’ preferences for adjuvant endocrine therapy in early breast cancer: what makes it worthwhile? in BRITISH JOURNAL OF CANCER
  • 2013-04. Cohort study of adherence to adjuvant endocrine therapy, breast cancer recurrence and mortality in BRITISH JOURNAL OF CANCER
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-017-4260-2

    DOI

    http://dx.doi.org/10.1007/s10549-017-4260-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1085079186

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/28451964


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Adult", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aged, 80 and over", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Androstadienes", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Aromatase Inhibitors", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Chemotherapy, Adjuvant", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Cross-Over Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Estradiol", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Letrozole", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Middle Aged", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Nitriles", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Patient Reported Outcome Measures", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Prospective Studies", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Random Allocation", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Treatment Outcome", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Triazoles", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Michigan Medicine", 
              "id": "https://www.grid.ac/institutes/grid.412590.b", 
              "name": [
                "University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kadakia", 
            "givenName": "Kunal C.", 
            "id": "sg:person.01215071475.03", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215071475.03"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Kidwell", 
            "givenName": "Kelley M.", 
            "id": "sg:person.01020741650.38", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020741650.38"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Michigan\u2013Ann Arbor", 
              "id": "https://www.grid.ac/institutes/grid.214458.e", 
              "name": [
                "Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Seewald", 
            "givenName": "Nicholas J.", 
            "id": "sg:person.01102721711.82", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102721711.82"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Snyder", 
            "givenName": "Claire F.", 
            "id": "sg:person.01052333023.09", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052333023.09"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Storniolo", 
            "givenName": "Anna Maria", 
            "id": "sg:person.01011023657.40", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011023657.40"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "School of Nursing, Indiana University, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Otte", 
            "givenName": "Julie L.", 
            "id": "sg:person.0714404434.72", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714404434.72"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Indiana University \u2013 Purdue University Indianapolis", 
              "id": "https://www.grid.ac/institutes/grid.257413.6", 
              "name": [
                "Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Flockhart", 
            "givenName": "David A.", 
            "id": "sg:person.0604202123.54", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604202123.54"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Michigan Medicine", 
              "id": "https://www.grid.ac/institutes/grid.412590.b", 
              "name": [
                "Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Hayes", 
            "givenName": "Daniel F.", 
            "id": "sg:person.013712224532.50", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712224532.50"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Johns Hopkins University", 
              "id": "https://www.grid.ac/institutes/grid.21107.35", 
              "name": [
                "Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Stearns", 
            "givenName": "Vered", 
            "id": "sg:person.01145244423.36", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145244423.36"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "University of Utah", 
              "id": "https://www.grid.ac/institutes/grid.223827.e", 
              "name": [
                "Division of Oncology, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Dr. #3362, 84112, Salt Lake City, UT, USA"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Henry", 
            "givenName": "N. Lynn", 
            "id": "sg:person.01042733643.27", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1007/s10549-016-4077-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000945453", 
              "https://doi.org/10.1007/s10549-016-4077-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-016-4077-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000945453", 
              "https://doi.org/10.1007/s10549-016-4077-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001887379", 
              "https://doi.org/10.1038/nrc1211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1211", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001887379", 
              "https://doi.org/10.1038/nrc1211"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2007.10.7573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1002273845"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.jpain.2009.06.007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1004310454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-013-2504-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005807815", 
              "https://doi.org/10.1007/s10549-013-2504-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2016.67.1487", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1010471013"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.587", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011472925", 
              "https://doi.org/10.1038/bjc.2013.587"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.genhosppsych.2013.08.010", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1012653174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2015.65.9573", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1014039579"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1634/theoncologist.2015-0349", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015705674"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/tpj.2016.60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1018215744", 
              "https://doi.org/10.1038/tpj.2016.60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019779211", 
              "https://doi.org/10.1038/sj.bjc.6602874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/sj.bjc.6602874", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019779211", 
              "https://doi.org/10.1038/sj.bjc.6602874"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1016/j.steroids.2007.05.003", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1019982252"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.2011.38.0261", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1026786975"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.2165/00019053-200725050-00002", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1029250985", 
              "https://doi.org/10.2165/00019053-200725050-00002"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1080/016128498248917", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1038019109"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/bjc.2013.116", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1042514922", 
              "https://doi.org/10.1038/bjc.2013.116"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/clpt.2011.174", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049545512", 
              "https://doi.org/10.1038/clpt.2011.174"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0692-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053729540", 
              "https://doi.org/10.1007/s10549-009-0692-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-009-0692-7", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1053729540", 
              "https://doi.org/10.1007/s10549-009-0692-7"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1093/jnci/87.18.1372", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1059819483"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1158/0008-5472.sabcs-09-805", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1063217711"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1075211058", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://app.dimensions.ai/details/publication/pub.1077031272", 
            "type": "CreativeWork"
          }, 
          {
            "id": "https://doi.org/10.1200/jco.1998.16.2.515", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1083213032"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2017-07", 
        "datePublishedReg": "2017-07-01", 
        "description": "PURPOSE: Aromatase inhibitors (AI), which decrease circulating estradiol concentrations in post-menopausal women, are associated with toxicities that limit adherence. Approximately one-third of patients will tolerate a different AI after not tolerating the first. We report the effect of crossover from exemestane to letrozole or vice versa on patient-reported outcomes (PROs) and whether the success of crossover is due to lack of estrogen suppression.\nMETHODS: Post-menopausal women enrolled on a prospective trial initiating AI therapy for early-stage breast cancer were randomized to exemestane or letrozole. Those that discontinued for intolerance were offered protocol-directed crossover to the other AI after a washout period. Changes in PROs, including pain [Visual Analog Scale (VAS)] and functional status [Health Assessment Questionnaire (HAQ)], were compared after 3\u00a0months on the first versus the second AI. Estradiol and drug concentrations were measured.\nRESULTS: Eighty-three patients participated in the crossover protocol, of whom 91.3% reported improvement in symptoms prior to starting the second AI. Functional status worsened less after 3\u00a0months with the second AI (HAQ mean change AI #1: 0.2 [SD 0.41] vs. AI #2: -0.05 [SD 0.36]; p\u00a0=\u00a00.001); change in pain scores was similar between the first and second AI (VAS mean change AI #1: 0.8 [SD 2.7] vs. AI #2: -0.2 [SD 2.8]; p\u00a0=\u00a00.19). No statistical differences in estradiol or drug concentrations were found between those that continued or discontinued AI after crossover.\nCONCLUSIONS: Although all AIs act via the same mechanism, a subset of patients intolerant to one AI report improved PROs with a different one. The mechanism of this tolerance remains unknown, but does not appear to be due to non-adherence to, or insufficient estrogen suppression by, the second AI.", 
        "genre": "research_article", 
        "id": "sg:pub.10.1007/s10549-017-4260-2", 
        "inLanguage": [
          "en"
        ], 
        "isAccessibleForFree": false, 
        "isFundedItemOf": [
          {
            "id": "sg:grant.7745683", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2683954", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2690863", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2424015", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2682755", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2423963", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.3536131", 
            "type": "MonetaryGrant"
          }, 
          {
            "id": "sg:grant.2423971", 
            "type": "MonetaryGrant"
          }
        ], 
        "isPartOf": [
          {
            "id": "sg:journal.1092777", 
            "issn": [
              "0167-6806", 
              "1573-7217"
            ], 
            "name": "Breast Cancer Research and Treatment", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "164"
          }
        ], 
        "name": "Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors", 
        "pagination": "411-419", 
        "productId": [
          {
            "name": "readcube_id", 
            "type": "PropertyValue", 
            "value": [
              "cd75e3e9df70898641cdcd45b1b520ebfc7377f651ee10370c86c2d55497badb"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "28451964"
            ]
          }, 
          {
            "name": "nlm_unique_id", 
            "type": "PropertyValue", 
            "value": [
              "8111104"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10549-017-4260-2"
            ]
          }, 
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1085079186"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10549-017-4260-2", 
          "https://app.dimensions.ai/details/publication/pub.1085079186"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2019-04-11T10:30", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000349_0000000349/records_113644_00000004.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://link.springer.com/10.1007%2Fs10549-017-4260-2"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4260-2'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4260-2'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4260-2'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-017-4260-2'


     

    This table displays all metadata directly associated to this object as RDF triples.

    321 TRIPLES      21 PREDICATES      72 URIs      40 LITERALS      28 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10549-017-4260-2 schema:about N293ff2ee255645cf99a7a211857438a2
    2 N31a1aa17edb84a2b819c674c4c748cdc
    3 N33087588da6c405eb20418219b675ae0
    4 N337d3ea755614a4eae18a733091d2424
    5 N4941f2fd51df451db89584bc4122c497
    6 N59d7306b02d94c2b8085c69cee9cfa04
    7 N67c8de0f616045628a69680e11428140
    8 N84de332f1c674c68bbd9ba5d1e866b1c
    9 N88d612044f4342b9873269b0c3b30fa6
    10 N8bac3d73ccdb423fb9ce4e0a9a7ff9ca
    11 N8c6d46d3b4e346d598b98cfa9eed2c4f
    12 N9be2e8bfced6472286aa3ea93f88398f
    13 Nc2aa08e17f0b44d499683c61a74711be
    14 Nd3a0cf3cd90a43dab1a16faea43d3d3b
    15 Nd5c64b28dec047a2b6ffbe0d3d87479a
    16 Ne0b8c17067e947a7b49cd1760372c63f
    17 Nedc37f42a4b34f15aa5c2556bdc75ec7
    18 Nf9774c02413845d894b7d2ab5a026f8d
    19 Nfb8f1f098ae34d6a8097586ceb623976
    20 anzsrc-for:11
    21 anzsrc-for:1112
    22 schema:author N65a54132c76948ef9388e69da82fedd4
    23 schema:citation sg:pub.10.1007/s10549-009-0692-7
    24 sg:pub.10.1007/s10549-013-2504-3
    25 sg:pub.10.1007/s10549-016-4077-4
    26 sg:pub.10.1038/bjc.2013.116
    27 sg:pub.10.1038/bjc.2013.587
    28 sg:pub.10.1038/clpt.2011.174
    29 sg:pub.10.1038/nrc1211
    30 sg:pub.10.1038/sj.bjc.6602874
    31 sg:pub.10.1038/tpj.2016.60
    32 sg:pub.10.2165/00019053-200725050-00002
    33 https://app.dimensions.ai/details/publication/pub.1075211058
    34 https://app.dimensions.ai/details/publication/pub.1077031272
    35 https://doi.org/10.1016/j.genhosppsych.2013.08.010
    36 https://doi.org/10.1016/j.jpain.2009.06.007
    37 https://doi.org/10.1016/j.steroids.2007.05.003
    38 https://doi.org/10.1080/016128498248917
    39 https://doi.org/10.1093/jnci/87.18.1372
    40 https://doi.org/10.1158/0008-5472.sabcs-09-805
    41 https://doi.org/10.1200/jco.1998.16.2.515
    42 https://doi.org/10.1200/jco.2007.10.7573
    43 https://doi.org/10.1200/jco.2011.38.0261
    44 https://doi.org/10.1200/jco.2015.65.9573
    45 https://doi.org/10.1200/jco.2016.67.1487
    46 https://doi.org/10.1634/theoncologist.2015-0349
    47 schema:datePublished 2017-07
    48 schema:datePublishedReg 2017-07-01
    49 schema:description PURPOSE: Aromatase inhibitors (AI), which decrease circulating estradiol concentrations in post-menopausal women, are associated with toxicities that limit adherence. Approximately one-third of patients will tolerate a different AI after not tolerating the first. We report the effect of crossover from exemestane to letrozole or vice versa on patient-reported outcomes (PROs) and whether the success of crossover is due to lack of estrogen suppression. METHODS: Post-menopausal women enrolled on a prospective trial initiating AI therapy for early-stage breast cancer were randomized to exemestane or letrozole. Those that discontinued for intolerance were offered protocol-directed crossover to the other AI after a washout period. Changes in PROs, including pain [Visual Analog Scale (VAS)] and functional status [Health Assessment Questionnaire (HAQ)], were compared after 3 months on the first versus the second AI. Estradiol and drug concentrations were measured. RESULTS: Eighty-three patients participated in the crossover protocol, of whom 91.3% reported improvement in symptoms prior to starting the second AI. Functional status worsened less after 3 months with the second AI (HAQ mean change AI #1: 0.2 [SD 0.41] vs. AI #2: -0.05 [SD 0.36]; p = 0.001); change in pain scores was similar between the first and second AI (VAS mean change AI #1: 0.8 [SD 2.7] vs. AI #2: -0.2 [SD 2.8]; p = 0.19). No statistical differences in estradiol or drug concentrations were found between those that continued or discontinued AI after crossover. CONCLUSIONS: Although all AIs act via the same mechanism, a subset of patients intolerant to one AI report improved PROs with a different one. The mechanism of this tolerance remains unknown, but does not appear to be due to non-adherence to, or insufficient estrogen suppression by, the second AI.
    50 schema:genre research_article
    51 schema:inLanguage en
    52 schema:isAccessibleForFree false
    53 schema:isPartOf Nc8280035c9c245638f831f064b6ea115
    54 Nd2ea5919d02d4a04b4d128d1c6556c6b
    55 sg:journal.1092777
    56 schema:name Prospective assessment of patient-reported outcomes and estradiol and drug concentrations in patients experiencing toxicity from adjuvant aromatase inhibitors
    57 schema:pagination 411-419
    58 schema:productId N4167ae4666a7434b998ee880f5226047
    59 N6dbfbf32544c4a1a8af675b9835c1047
    60 N7dc5742ea0f941ada3849a3ed8da54a8
    61 N8d3d491d230b44b9826a697caab58ee3
    62 Nec61e778833b4b6a972f18b8f15650e6
    63 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085079186
    64 https://doi.org/10.1007/s10549-017-4260-2
    65 schema:sdDatePublished 2019-04-11T10:30
    66 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    67 schema:sdPublisher N50e28ae2291a4aa2898c6e74a93b13ec
    68 schema:url https://link.springer.com/10.1007%2Fs10549-017-4260-2
    69 sgo:license sg:explorer/license/
    70 sgo:sdDataset articles
    71 rdf:type schema:ScholarlyArticle
    72 N293ff2ee255645cf99a7a211857438a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    73 schema:name Triazoles
    74 rdf:type schema:DefinedTerm
    75 N2ff5285ccd7c4d41b2d4bb15fc55fc18 rdf:first sg:person.01052333023.09
    76 rdf:rest N6c8bbeb0f45540bda4c84ea1bfc19b0a
    77 N31a1aa17edb84a2b819c674c4c748cdc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    78 schema:name Middle Aged
    79 rdf:type schema:DefinedTerm
    80 N33087588da6c405eb20418219b675ae0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    81 schema:name Cross-Over Studies
    82 rdf:type schema:DefinedTerm
    83 N337d3ea755614a4eae18a733091d2424 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    84 schema:name Humans
    85 rdf:type schema:DefinedTerm
    86 N4167ae4666a7434b998ee880f5226047 schema:name dimensions_id
    87 schema:value pub.1085079186
    88 rdf:type schema:PropertyValue
    89 N4941f2fd51df451db89584bc4122c497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    90 schema:name Prospective Studies
    91 rdf:type schema:DefinedTerm
    92 N50e28ae2291a4aa2898c6e74a93b13ec schema:name Springer Nature - SN SciGraph project
    93 rdf:type schema:Organization
    94 N5493fd90267d4cda9591fddda5bb11f5 rdf:first sg:person.01042733643.27
    95 rdf:rest rdf:nil
    96 N578ab3bcc5a54191b5986657326a0f50 rdf:first sg:person.013712224532.50
    97 rdf:rest Na6a0a2e74b9c43ad9b54a919bfb28bba
    98 N59d7306b02d94c2b8085c69cee9cfa04 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    99 schema:name Androstadienes
    100 rdf:type schema:DefinedTerm
    101 N65a54132c76948ef9388e69da82fedd4 rdf:first sg:person.01215071475.03
    102 rdf:rest Nccac7414a48a4172abba095907e2fdc0
    103 N67c8de0f616045628a69680e11428140 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    104 schema:name Aromatase Inhibitors
    105 rdf:type schema:DefinedTerm
    106 N6c8bbeb0f45540bda4c84ea1bfc19b0a rdf:first sg:person.01011023657.40
    107 rdf:rest Nabf66aecdc974566bd5588b788406033
    108 N6dbfbf32544c4a1a8af675b9835c1047 schema:name doi
    109 schema:value 10.1007/s10549-017-4260-2
    110 rdf:type schema:PropertyValue
    111 N7dc5742ea0f941ada3849a3ed8da54a8 schema:name readcube_id
    112 schema:value cd75e3e9df70898641cdcd45b1b520ebfc7377f651ee10370c86c2d55497badb
    113 rdf:type schema:PropertyValue
    114 N84de332f1c674c68bbd9ba5d1e866b1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    115 schema:name Letrozole
    116 rdf:type schema:DefinedTerm
    117 N88d612044f4342b9873269b0c3b30fa6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    118 schema:name Aged, 80 and over
    119 rdf:type schema:DefinedTerm
    120 N8bac3d73ccdb423fb9ce4e0a9a7ff9ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    121 schema:name Chemotherapy, Adjuvant
    122 rdf:type schema:DefinedTerm
    123 N8c6d46d3b4e346d598b98cfa9eed2c4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    124 schema:name Estradiol
    125 rdf:type schema:DefinedTerm
    126 N8d3d491d230b44b9826a697caab58ee3 schema:name nlm_unique_id
    127 schema:value 8111104
    128 rdf:type schema:PropertyValue
    129 N9be2e8bfced6472286aa3ea93f88398f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    130 schema:name Patient Reported Outcome Measures
    131 rdf:type schema:DefinedTerm
    132 Na6a0a2e74b9c43ad9b54a919bfb28bba rdf:first sg:person.01145244423.36
    133 rdf:rest N5493fd90267d4cda9591fddda5bb11f5
    134 Nabf66aecdc974566bd5588b788406033 rdf:first sg:person.0714404434.72
    135 rdf:rest Nea2b25f0f6674c9fbadd7050cd7b767e
    136 Nc2aa08e17f0b44d499683c61a74711be schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    137 schema:name Treatment Outcome
    138 rdf:type schema:DefinedTerm
    139 Nc8280035c9c245638f831f064b6ea115 schema:issueNumber 2
    140 rdf:type schema:PublicationIssue
    141 Nccac7414a48a4172abba095907e2fdc0 rdf:first sg:person.01020741650.38
    142 rdf:rest Nf542b7d1bb154ecba702b076601973e0
    143 Nd2ea5919d02d4a04b4d128d1c6556c6b schema:volumeNumber 164
    144 rdf:type schema:PublicationVolume
    145 Nd3a0cf3cd90a43dab1a16faea43d3d3b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    146 schema:name Adult
    147 rdf:type schema:DefinedTerm
    148 Nd5c64b28dec047a2b6ffbe0d3d87479a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    149 schema:name Random Allocation
    150 rdf:type schema:DefinedTerm
    151 Ne0b8c17067e947a7b49cd1760372c63f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    152 schema:name Breast Neoplasms
    153 rdf:type schema:DefinedTerm
    154 Nea2b25f0f6674c9fbadd7050cd7b767e rdf:first sg:person.0604202123.54
    155 rdf:rest N578ab3bcc5a54191b5986657326a0f50
    156 Nec61e778833b4b6a972f18b8f15650e6 schema:name pubmed_id
    157 schema:value 28451964
    158 rdf:type schema:PropertyValue
    159 Nedc37f42a4b34f15aa5c2556bdc75ec7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    160 schema:name Nitriles
    161 rdf:type schema:DefinedTerm
    162 Nf542b7d1bb154ecba702b076601973e0 rdf:first sg:person.01102721711.82
    163 rdf:rest N2ff5285ccd7c4d41b2d4bb15fc55fc18
    164 Nf9774c02413845d894b7d2ab5a026f8d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    165 schema:name Aged
    166 rdf:type schema:DefinedTerm
    167 Nfb8f1f098ae34d6a8097586ceb623976 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    168 schema:name Female
    169 rdf:type schema:DefinedTerm
    170 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    171 schema:name Medical and Health Sciences
    172 rdf:type schema:DefinedTerm
    173 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    174 schema:name Oncology and Carcinogenesis
    175 rdf:type schema:DefinedTerm
    176 sg:grant.2423963 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    177 rdf:type schema:MonetaryGrant
    178 sg:grant.2423971 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    179 rdf:type schema:MonetaryGrant
    180 sg:grant.2424015 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    181 rdf:type schema:MonetaryGrant
    182 sg:grant.2682755 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    183 rdf:type schema:MonetaryGrant
    184 sg:grant.2683954 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    185 rdf:type schema:MonetaryGrant
    186 sg:grant.2690863 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    187 rdf:type schema:MonetaryGrant
    188 sg:grant.3536131 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    189 rdf:type schema:MonetaryGrant
    190 sg:grant.7745683 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-017-4260-2
    191 rdf:type schema:MonetaryGrant
    192 sg:journal.1092777 schema:issn 0167-6806
    193 1573-7217
    194 schema:name Breast Cancer Research and Treatment
    195 rdf:type schema:Periodical
    196 sg:person.01011023657.40 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    197 schema:familyName Storniolo
    198 schema:givenName Anna Maria
    199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01011023657.40
    200 rdf:type schema:Person
    201 sg:person.01020741650.38 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    202 schema:familyName Kidwell
    203 schema:givenName Kelley M.
    204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020741650.38
    205 rdf:type schema:Person
    206 sg:person.01042733643.27 schema:affiliation https://www.grid.ac/institutes/grid.223827.e
    207 schema:familyName Henry
    208 schema:givenName N. Lynn
    209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27
    210 rdf:type schema:Person
    211 sg:person.01052333023.09 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    212 schema:familyName Snyder
    213 schema:givenName Claire F.
    214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052333023.09
    215 rdf:type schema:Person
    216 sg:person.01102721711.82 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
    217 schema:familyName Seewald
    218 schema:givenName Nicholas J.
    219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102721711.82
    220 rdf:type schema:Person
    221 sg:person.01145244423.36 schema:affiliation https://www.grid.ac/institutes/grid.21107.35
    222 schema:familyName Stearns
    223 schema:givenName Vered
    224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01145244423.36
    225 rdf:type schema:Person
    226 sg:person.01215071475.03 schema:affiliation https://www.grid.ac/institutes/grid.412590.b
    227 schema:familyName Kadakia
    228 schema:givenName Kunal C.
    229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215071475.03
    230 rdf:type schema:Person
    231 sg:person.013712224532.50 schema:affiliation https://www.grid.ac/institutes/grid.412590.b
    232 schema:familyName Hayes
    233 schema:givenName Daniel F.
    234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712224532.50
    235 rdf:type schema:Person
    236 sg:person.0604202123.54 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    237 schema:familyName Flockhart
    238 schema:givenName David A.
    239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604202123.54
    240 rdf:type schema:Person
    241 sg:person.0714404434.72 schema:affiliation https://www.grid.ac/institutes/grid.257413.6
    242 schema:familyName Otte
    243 schema:givenName Julie L.
    244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0714404434.72
    245 rdf:type schema:Person
    246 sg:pub.10.1007/s10549-009-0692-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053729540
    247 https://doi.org/10.1007/s10549-009-0692-7
    248 rdf:type schema:CreativeWork
    249 sg:pub.10.1007/s10549-013-2504-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005807815
    250 https://doi.org/10.1007/s10549-013-2504-3
    251 rdf:type schema:CreativeWork
    252 sg:pub.10.1007/s10549-016-4077-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000945453
    253 https://doi.org/10.1007/s10549-016-4077-4
    254 rdf:type schema:CreativeWork
    255 sg:pub.10.1038/bjc.2013.116 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042514922
    256 https://doi.org/10.1038/bjc.2013.116
    257 rdf:type schema:CreativeWork
    258 sg:pub.10.1038/bjc.2013.587 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011472925
    259 https://doi.org/10.1038/bjc.2013.587
    260 rdf:type schema:CreativeWork
    261 sg:pub.10.1038/clpt.2011.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049545512
    262 https://doi.org/10.1038/clpt.2011.174
    263 rdf:type schema:CreativeWork
    264 sg:pub.10.1038/nrc1211 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001887379
    265 https://doi.org/10.1038/nrc1211
    266 rdf:type schema:CreativeWork
    267 sg:pub.10.1038/sj.bjc.6602874 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019779211
    268 https://doi.org/10.1038/sj.bjc.6602874
    269 rdf:type schema:CreativeWork
    270 sg:pub.10.1038/tpj.2016.60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018215744
    271 https://doi.org/10.1038/tpj.2016.60
    272 rdf:type schema:CreativeWork
    273 sg:pub.10.2165/00019053-200725050-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029250985
    274 https://doi.org/10.2165/00019053-200725050-00002
    275 rdf:type schema:CreativeWork
    276 https://app.dimensions.ai/details/publication/pub.1075211058 schema:CreativeWork
    277 https://app.dimensions.ai/details/publication/pub.1077031272 schema:CreativeWork
    278 https://doi.org/10.1016/j.genhosppsych.2013.08.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012653174
    279 rdf:type schema:CreativeWork
    280 https://doi.org/10.1016/j.jpain.2009.06.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004310454
    281 rdf:type schema:CreativeWork
    282 https://doi.org/10.1016/j.steroids.2007.05.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019982252
    283 rdf:type schema:CreativeWork
    284 https://doi.org/10.1080/016128498248917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038019109
    285 rdf:type schema:CreativeWork
    286 https://doi.org/10.1093/jnci/87.18.1372 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059819483
    287 rdf:type schema:CreativeWork
    288 https://doi.org/10.1158/0008-5472.sabcs-09-805 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063217711
    289 rdf:type schema:CreativeWork
    290 https://doi.org/10.1200/jco.1998.16.2.515 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083213032
    291 rdf:type schema:CreativeWork
    292 https://doi.org/10.1200/jco.2007.10.7573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002273845
    293 rdf:type schema:CreativeWork
    294 https://doi.org/10.1200/jco.2011.38.0261 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026786975
    295 rdf:type schema:CreativeWork
    296 https://doi.org/10.1200/jco.2015.65.9573 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014039579
    297 rdf:type schema:CreativeWork
    298 https://doi.org/10.1200/jco.2016.67.1487 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010471013
    299 rdf:type schema:CreativeWork
    300 https://doi.org/10.1634/theoncologist.2015-0349 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015705674
    301 rdf:type schema:CreativeWork
    302 https://www.grid.ac/institutes/grid.21107.35 schema:alternateName Johns Hopkins University
    303 schema:name Breast Cancer Program, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, MD, USA
    304 Division of General Internal Medicine, Johns Hopkins School of Medicine, Baltimore, MD, USA
    305 rdf:type schema:Organization
    306 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
    307 schema:name Department of Biostatistics, University of Michigan School of Public Health, Ann Arbor, MI, USA
    308 Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA
    309 rdf:type schema:Organization
    310 https://www.grid.ac/institutes/grid.223827.e schema:alternateName University of Utah
    311 schema:name Division of Oncology, Huntsman Cancer Institute, University of Utah, 2000 Circle of Hope Dr. #3362, 84112, Salt Lake City, UT, USA
    312 rdf:type schema:Organization
    313 https://www.grid.ac/institutes/grid.257413.6 schema:alternateName Indiana University – Purdue University Indianapolis
    314 schema:name Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, IN, USA
    315 Melvin and Bren Simon Cancer Center, Indiana University School of Medicine, Indianapolis, IN, USA
    316 School of Nursing, Indiana University, Indianapolis, IN, USA
    317 rdf:type schema:Organization
    318 https://www.grid.ac/institutes/grid.412590.b schema:alternateName Michigan Medicine
    319 schema:name Breast Oncology Program, University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    320 University of Michigan Comprehensive Cancer Center, Ann Arbor, MI, USA
    321 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...