Short-term mortality in older patients treated with adjuvant chemotherapy for early-stage breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-06

AUTHORS

Aron S. Rosenstock, Xiudong Lei, Debu Tripathy, Gabriel N. Hortobagyi, Sharon H. Giordano, Mariana Chavez-MacGregor

ABSTRACT

Chemotherapy for early-stage breast cancer has lowered cancer recurrence and deaths. However, short-term mortality rates due to cancer or treatment in the general population remain largely unknown. In this study, we evaluate the short-term mortality rate and the determinants of such outcome among a cohort of older breast cancer patients treated with adjuvant chemotherapy. This is a population-based study based on the Surveillance, Epidemiology, and End Results Program (SEER)-Medicare and the Texas Cancer Registry (TCR)-Medicare databases. Patients diagnosed with early-stage breast cancer between 2003 and 2011 who were 66 years or older and were treated with adjuvant chemotherapy within 6 months of diagnosis were included. Short-term mortality was defined as death from any cause within one year of breast cancer diagnosis. Descriptive statistics and multivariable logistic regression modeling were used for the analysis. Of the 21,536 patients included, a total of 625 (2.9 %) died within one year of breast cancer diagnosis. In multivariate analysis, older age (using 66-70 as reference category; 71-75 years OR 1.31, 95 % CI 1.05-1.62; 76-80 years OR 1.73, 95 % CI 1.36-2.19; >80 years OR 3.48, 95 % CI 2.7-4.48) and higher comorbidity index (using Charlson score of 0 as a reference, those with score of 1 or >2 had higher risk OR 1.46, 95 % CI 1.19-1.8 and OR 2.98, 95 % CI 2.42-3.67, respectively) were associated with the increased risk of short-term mortality. Other factors significantly associated with the outcome were higher grade and stage, ER-negative status, poor census tract area, and mastectomy. The findings of this study revealed that, in this large cohort of older breast cancer patients treated with adjuvant chemotherapy, 2.9 % of the population died within one year of breast cancer diagnosis. Finally, it was concluded that tumor- and patient-related characteristics were associated with short-term death. Our findings add relevant information that can be used by clinicians when balancing the risk. More... »

PAGES

339-350

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-016-3815-y

DOI

http://dx.doi.org/10.1007/s10549-016-3815-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034840932

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/27146586


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chemotherapy, Adjuvant", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Logistic Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Staging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "SEER Program", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Survival Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Rosenstock", 
        "givenName": "Aron S.", 
        "id": "sg:person.01155730467.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155730467.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lei", 
        "givenName": "Xiudong", 
        "id": "sg:person.01324104373.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324104373.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tripathy", 
        "givenName": "Debu", 
        "id": "sg:person.010035615677.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010035615677.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hortobagyi", 
        "givenName": "Gabriel N.", 
        "id": "sg:person.01365732165.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giordano", 
        "givenName": "Sharon H.", 
        "id": "sg:person.0602226465.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602226465.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chavez-MacGregor", 
        "givenName": "Mariana", 
        "id": "sg:person.014461023507.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014461023507.65"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66544-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001690029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)66544-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001690029"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19990301)85:5<1104::aid-cncr14>3.0.co;2-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003084988"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0514-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006548071", 
          "https://doi.org/10.1186/s13058-015-0514-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0514-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006548071", 
          "https://doi.org/10.1186/s13058-015-0514-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s13058-015-0514-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006548071", 
          "https://doi.org/10.1186/s13058-015-0514-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0376-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009139181", 
          "https://doi.org/10.1007/s10549-009-0376-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0376-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009139181", 
          "https://doi.org/10.1007/s10549-009-0376-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0376-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009139181", 
          "https://doi.org/10.1007/s10549-009-0376-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.critrevonc.2011.04.001", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011093839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1532-5415.2010.02767.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011424887"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2144", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013572545", 
          "https://doi.org/10.1186/bcr2144"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(11)61625-5", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016340431"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199912303412706", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016990062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/94.14.1066", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017473263"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0021-9681(87)90171-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020988115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.293.9.1073", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021058036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.175", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029863798"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0895-4356(93)90103-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038314458"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199308000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038688993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00005650-199308000-00006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038688993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2012.48.1275", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039798847"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-012-2121-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039867169", 
          "https://doi.org/10.1007/s10549-012-2121-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.10.9710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051447403"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2002.08.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203071"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.02.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.7326/0003-4819-120-2-199401150-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1073698366"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1986.4.12.1748", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079949166"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-06", 
    "datePublishedReg": "2016-06-01", 
    "description": "Chemotherapy for early-stage breast cancer has lowered cancer recurrence and deaths. However, short-term mortality rates due to cancer or treatment in the general population remain largely unknown. In this study, we evaluate the short-term mortality rate and the determinants of such outcome among a cohort of older breast cancer patients treated with adjuvant chemotherapy. This is a population-based study based on the Surveillance, Epidemiology, and End Results Program (SEER)-Medicare and the Texas Cancer Registry (TCR)-Medicare databases. Patients diagnosed with early-stage breast cancer between 2003 and 2011 who were 66 years or older and were treated with adjuvant chemotherapy within 6 months of diagnosis were included. Short-term mortality was defined as death from any cause within one year of breast cancer diagnosis. Descriptive statistics and multivariable logistic regression modeling were used for the analysis. Of the 21,536 patients included, a total of 625 (2.9\u00a0%) died within one year of breast cancer diagnosis. In multivariate analysis, older age (using 66-70 as reference category; 71-75 years OR 1.31, 95\u00a0% CI 1.05-1.62; 76-80 years OR 1.73, 95\u00a0% CI 1.36-2.19; >80 years OR 3.48, 95\u00a0% CI 2.7-4.48) and higher comorbidity index (using Charlson score of 0 as a reference, those with score of 1 or >2 had higher risk OR 1.46, 95\u00a0% CI 1.19-1.8 and OR 2.98, 95\u00a0% CI 2.42-3.67, respectively) were associated with the increased risk of short-term mortality. Other factors significantly associated with the outcome were higher grade and stage, ER-negative status, poor census tract area, and mastectomy. The findings of this study revealed that, in this large cohort of older breast cancer patients treated with adjuvant chemotherapy, 2.9\u00a0% of the population died within one year of breast cancer diagnosis. Finally, it was concluded that tumor- and patient-related characteristics were associated with short-term death. Our findings add relevant information that can be used by clinicians when balancing the risk.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-016-3815-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "157"
      }
    ], 
    "name": "Short-term mortality in older patients treated with adjuvant chemotherapy for early-stage breast cancer", 
    "pagination": "339-350", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "a5f7f0c5494f73fbd864eac36d29d1efc9e32b174f84af46001d08cd10eba7db"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "27146586"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-016-3815-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1034840932"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-016-3815-y", 
      "https://app.dimensions.ai/details/publication/pub.1034840932"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:17", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000482.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10549-016-3815-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3815-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3815-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3815-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3815-y'


 

This table displays all metadata directly associated to this object as RDF triples.

224 TRIPLES      21 PREDICATES      63 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-016-3815-y schema:about N0217bea63f9c4aaf81fed0b79ea9c2f6
2 N04464f77af864678912185ad62f69476
3 N3439f2c7cad44561b5ef2abcf5fdd94d
4 N37f6c8180f1f4c2599fc8a45ee05af1d
5 N3aeb3ad83ac741adbbcd0d4f3c224c8b
6 N4d3cef396d14419ab415efa4acf89e6e
7 N80df5d879fc24caabc83af868e5373e6
8 Nc52a8ba2c2fa404fbfb4cd8a8fc52514
9 Ne4575f493300429696f55d19a56b57b1
10 Ne5cbd634d5464a4383979690550c71c3
11 Ne6bf17e6e2a24852be4384431227d68d
12 Nf36469ee5cfc4c95bc226fa1cddd8279
13 anzsrc-for:11
14 anzsrc-for:1112
15 schema:author N0ed3261a83fb40c797fd98debee3677a
16 schema:citation sg:pub.10.1007/s10549-009-0376-3
17 sg:pub.10.1007/s10549-012-2121-6
18 sg:pub.10.1186/bcr2144
19 sg:pub.10.1186/s13058-015-0514-2
20 https://doi.org/10.1001/jama.293.9.1073
21 https://doi.org/10.1002/(sici)1097-0142(19990301)85:5<1104::aid-cncr14>3.0.co;2-1
22 https://doi.org/10.1016/0021-9681(87)90171-8
23 https://doi.org/10.1016/0895-4356(93)90103-8
24 https://doi.org/10.1016/j.critrevonc.2011.04.001
25 https://doi.org/10.1016/s0140-6736(05)66544-0
26 https://doi.org/10.1016/s0140-6736(11)61625-5
27 https://doi.org/10.1056/nejm199912303412706
28 https://doi.org/10.1093/jnci/94.14.1066
29 https://doi.org/10.1097/00005650-199308000-00006
30 https://doi.org/10.1111/j.1532-5415.2010.02767.x
31 https://doi.org/10.1200/jco.1986.4.12.1748
32 https://doi.org/10.1200/jco.2002.08.056
33 https://doi.org/10.1200/jco.2003.02.046
34 https://doi.org/10.1200/jco.2005.04.175
35 https://doi.org/10.1200/jco.2007.10.9710
36 https://doi.org/10.1200/jco.2012.48.1275
37 https://doi.org/10.7326/0003-4819-120-2-199401150-00002
38 schema:datePublished 2016-06
39 schema:datePublishedReg 2016-06-01
40 schema:description Chemotherapy for early-stage breast cancer has lowered cancer recurrence and deaths. However, short-term mortality rates due to cancer or treatment in the general population remain largely unknown. In this study, we evaluate the short-term mortality rate and the determinants of such outcome among a cohort of older breast cancer patients treated with adjuvant chemotherapy. This is a population-based study based on the Surveillance, Epidemiology, and End Results Program (SEER)-Medicare and the Texas Cancer Registry (TCR)-Medicare databases. Patients diagnosed with early-stage breast cancer between 2003 and 2011 who were 66 years or older and were treated with adjuvant chemotherapy within 6 months of diagnosis were included. Short-term mortality was defined as death from any cause within one year of breast cancer diagnosis. Descriptive statistics and multivariable logistic regression modeling were used for the analysis. Of the 21,536 patients included, a total of 625 (2.9 %) died within one year of breast cancer diagnosis. In multivariate analysis, older age (using 66-70 as reference category; 71-75 years OR 1.31, 95 % CI 1.05-1.62; 76-80 years OR 1.73, 95 % CI 1.36-2.19; >80 years OR 3.48, 95 % CI 2.7-4.48) and higher comorbidity index (using Charlson score of 0 as a reference, those with score of 1 or >2 had higher risk OR 1.46, 95 % CI 1.19-1.8 and OR 2.98, 95 % CI 2.42-3.67, respectively) were associated with the increased risk of short-term mortality. Other factors significantly associated with the outcome were higher grade and stage, ER-negative status, poor census tract area, and mastectomy. The findings of this study revealed that, in this large cohort of older breast cancer patients treated with adjuvant chemotherapy, 2.9 % of the population died within one year of breast cancer diagnosis. Finally, it was concluded that tumor- and patient-related characteristics were associated with short-term death. Our findings add relevant information that can be used by clinicians when balancing the risk.
41 schema:genre research_article
42 schema:inLanguage en
43 schema:isAccessibleForFree false
44 schema:isPartOf N225d4f498c4a40b4b42d0a2f77c5abbe
45 Ne9b5e06b266a4ef0a0a4f3534062ec55
46 sg:journal.1092777
47 schema:name Short-term mortality in older patients treated with adjuvant chemotherapy for early-stage breast cancer
48 schema:pagination 339-350
49 schema:productId N36f673fff4aa40788f715cc65b86cc06
50 N4ba9c4ca4ffd4479a5798ce213cf2656
51 Nbe0d7198bbdc4d80bbeced9ccc181029
52 Ncd752975d7a34caab70bd07b5ca63074
53 Nd3a02e1a5e3d442b9537760768b3b648
54 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034840932
55 https://doi.org/10.1007/s10549-016-3815-y
56 schema:sdDatePublished 2019-04-10T23:17
57 schema:sdLicense https://scigraph.springernature.com/explorer/license/
58 schema:sdPublisher N076d066d9cd447779988c786fd159bce
59 schema:url http://link.springer.com/10.1007/s10549-016-3815-y
60 sgo:license sg:explorer/license/
61 sgo:sdDataset articles
62 rdf:type schema:ScholarlyArticle
63 N0217bea63f9c4aaf81fed0b79ea9c2f6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
64 schema:name Logistic Models
65 rdf:type schema:DefinedTerm
66 N03e9edf0b0864a0faae631f5df58d198 rdf:first sg:person.0602226465.48
67 rdf:rest N247fb47cd4464d1c98bdcead96f67d29
68 N04464f77af864678912185ad62f69476 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Chemotherapy, Adjuvant
70 rdf:type schema:DefinedTerm
71 N076d066d9cd447779988c786fd159bce schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N0ed3261a83fb40c797fd98debee3677a rdf:first sg:person.01155730467.16
74 rdf:rest Ne80d5d72227341848fa85d24e3058875
75 N225d4f498c4a40b4b42d0a2f77c5abbe schema:issueNumber 2
76 rdf:type schema:PublicationIssue
77 N247fb47cd4464d1c98bdcead96f67d29 rdf:first sg:person.014461023507.65
78 rdf:rest rdf:nil
79 N3439f2c7cad44561b5ef2abcf5fdd94d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
80 schema:name Survival Analysis
81 rdf:type schema:DefinedTerm
82 N36f673fff4aa40788f715cc65b86cc06 schema:name doi
83 schema:value 10.1007/s10549-016-3815-y
84 rdf:type schema:PropertyValue
85 N37f6c8180f1f4c2599fc8a45ee05af1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
86 schema:name SEER Program
87 rdf:type schema:DefinedTerm
88 N3aeb3ad83ac741adbbcd0d4f3c224c8b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
89 schema:name Treatment Outcome
90 rdf:type schema:DefinedTerm
91 N4ba9c4ca4ffd4479a5798ce213cf2656 schema:name readcube_id
92 schema:value a5f7f0c5494f73fbd864eac36d29d1efc9e32b174f84af46001d08cd10eba7db
93 rdf:type schema:PropertyValue
94 N4d3cef396d14419ab415efa4acf89e6e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Aged, 80 and over
96 rdf:type schema:DefinedTerm
97 N80df5d879fc24caabc83af868e5373e6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Age Distribution
99 rdf:type schema:DefinedTerm
100 Na2c95b82969949b78453557979d33f0b rdf:first sg:person.010035615677.00
101 rdf:rest Nc3fa3eb2ac89452b80c5644286f0b14c
102 Nbe0d7198bbdc4d80bbeced9ccc181029 schema:name nlm_unique_id
103 schema:value 8111104
104 rdf:type schema:PropertyValue
105 Nc3fa3eb2ac89452b80c5644286f0b14c rdf:first sg:person.01365732165.24
106 rdf:rest N03e9edf0b0864a0faae631f5df58d198
107 Nc52a8ba2c2fa404fbfb4cd8a8fc52514 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Breast Neoplasms
109 rdf:type schema:DefinedTerm
110 Ncd752975d7a34caab70bd07b5ca63074 schema:name pubmed_id
111 schema:value 27146586
112 rdf:type schema:PropertyValue
113 Nd3a02e1a5e3d442b9537760768b3b648 schema:name dimensions_id
114 schema:value pub.1034840932
115 rdf:type schema:PropertyValue
116 Ne4575f493300429696f55d19a56b57b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
117 schema:name Humans
118 rdf:type schema:DefinedTerm
119 Ne5cbd634d5464a4383979690550c71c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
120 schema:name Aged
121 rdf:type schema:DefinedTerm
122 Ne6bf17e6e2a24852be4384431227d68d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Female
124 rdf:type schema:DefinedTerm
125 Ne80d5d72227341848fa85d24e3058875 rdf:first sg:person.01324104373.10
126 rdf:rest Na2c95b82969949b78453557979d33f0b
127 Ne9b5e06b266a4ef0a0a4f3534062ec55 schema:volumeNumber 157
128 rdf:type schema:PublicationVolume
129 Nf36469ee5cfc4c95bc226fa1cddd8279 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Neoplasm Staging
131 rdf:type schema:DefinedTerm
132 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
133 schema:name Medical and Health Sciences
134 rdf:type schema:DefinedTerm
135 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
136 schema:name Oncology and Carcinogenesis
137 rdf:type schema:DefinedTerm
138 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-016-3815-y
139 rdf:type schema:MonetaryGrant
140 sg:journal.1092777 schema:issn 0167-6806
141 1573-7217
142 schema:name Breast Cancer Research and Treatment
143 rdf:type schema:Periodical
144 sg:person.010035615677.00 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
145 schema:familyName Tripathy
146 schema:givenName Debu
147 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.010035615677.00
148 rdf:type schema:Person
149 sg:person.01155730467.16 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
150 schema:familyName Rosenstock
151 schema:givenName Aron S.
152 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01155730467.16
153 rdf:type schema:Person
154 sg:person.01324104373.10 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
155 schema:familyName Lei
156 schema:givenName Xiudong
157 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324104373.10
158 rdf:type schema:Person
159 sg:person.01365732165.24 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
160 schema:familyName Hortobagyi
161 schema:givenName Gabriel N.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365732165.24
163 rdf:type schema:Person
164 sg:person.014461023507.65 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
165 schema:familyName Chavez-MacGregor
166 schema:givenName Mariana
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.014461023507.65
168 rdf:type schema:Person
169 sg:person.0602226465.48 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
170 schema:familyName Giordano
171 schema:givenName Sharon H.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602226465.48
173 rdf:type schema:Person
174 sg:pub.10.1007/s10549-009-0376-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009139181
175 https://doi.org/10.1007/s10549-009-0376-3
176 rdf:type schema:CreativeWork
177 sg:pub.10.1007/s10549-012-2121-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039867169
178 https://doi.org/10.1007/s10549-012-2121-6
179 rdf:type schema:CreativeWork
180 sg:pub.10.1186/bcr2144 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013572545
181 https://doi.org/10.1186/bcr2144
182 rdf:type schema:CreativeWork
183 sg:pub.10.1186/s13058-015-0514-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006548071
184 https://doi.org/10.1186/s13058-015-0514-2
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1001/jama.293.9.1073 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021058036
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1002/(sici)1097-0142(19990301)85:5<1104::aid-cncr14>3.0.co;2-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003084988
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/0021-9681(87)90171-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020988115
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/0895-4356(93)90103-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038314458
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/j.critrevonc.2011.04.001 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011093839
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0140-6736(05)66544-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001690029
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s0140-6736(11)61625-5 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016340431
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1056/nejm199912303412706 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016990062
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1093/jnci/94.14.1066 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017473263
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/00005650-199308000-00006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038688993
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1111/j.1532-5415.2010.02767.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1011424887
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1200/jco.1986.4.12.1748 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079949166
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1200/jco.2002.08.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203071
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1200/jco.2003.02.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203385
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1200/jco.2005.04.175 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029863798
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1200/jco.2007.10.9710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051447403
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1200/jco.2012.48.1275 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039798847
219 rdf:type schema:CreativeWork
220 https://doi.org/10.7326/0003-4819-120-2-199401150-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1073698366
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
223 schema:name The University of Texas MD Anderson Cancer Center, 1400 Pressler Street, 77030, Houston, TX, USA
224 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...