Clinical predictors of long-term survival in HER2-positive metastatic breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2016-02

AUTHORS

Pooja Murthy, Kelley M. Kidwell, Anne F. Schott, Sofia D. Merajver, Jennifer J. Griggs, Jeffrey D. Smerage, Catherine H. Van Poznak, Max S. Wicha, Daniel F. Hayes, N. Lynn Henry

ABSTRACT

Prior to availability of anti-HER2 therapies, HER2-positive metastatic breast cancer (MBC) was associated with a poor prognosis. Prospective randomized trials have demonstrated survival benefit from anti-HER2 treatments. Anecdotal observations have suggested that a small but meaningful fraction of patients with HER2-positive MBC may be "exceptional responders" with long survival. We hypothesized that demographic and/or clinicopathologic characteristics can be identified to distinguish short-term from long-term survivors. A retrospective, single-institution review of 168 patients with HER2-positive MBC who received treatment with anti-HER2 therapy in the metastatic setting was performed. Cox proportional hazards analysis was used to assess factors associated with long-term survival. Median overall survival from the time of breast cancer recurrence was 3.9 years (95 % CI 3.4-5.2). From the time of diagnosis of MBC, 56 (33 %) survived for 5 or more years and 12 (7 %) survived more than 10 years. Of the 66 patients diagnosed with central nervous system metastases, 9 (14 %) survived more than 5 years following that diagnosis. Younger age at diagnosis, lower stage, hormone receptor positive status, and only having one organ involved at diagnosis were associated with longer survival. Four patients discontinued anti-HER2 therapy and are without evidence of progression of disease after a median 7.4 years (0.2-12.0) since stopping therapy. In a cohort of patients with HER2-positive MBC treated primarily with trastuzumab and lapatinib, 7 % of patients were "exceptional responders." Combining these clinical factors with molecular determinants of prolonged survival may provide insights for individualizing treatment selection. More... »

PAGES

589-595

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-016-3705-3

DOI

http://dx.doi.org/10.1007/s10549-016-3705-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005851446

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26875184


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Brain Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Metastasis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quinazolines", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptor, ErbB-2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Trastuzumab", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murthy", 
        "givenName": "Pooja", 
        "id": "sg:person.01346233417.23", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346233417.23"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, SPH II M2525, 48109-2029, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kidwell", 
        "givenName": "Kelley M.", 
        "id": "sg:person.01020741650.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020741650.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Schott", 
        "givenName": "Anne F.", 
        "id": "sg:person.01234442277.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234442277.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Merajver", 
        "givenName": "Sofia D.", 
        "id": "sg:person.0725527540.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725527540.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Griggs", 
        "givenName": "Jennifer J.", 
        "id": "sg:person.0624650765.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624650765.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smerage", 
        "givenName": "Jeffrey D.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Van Poznak", 
        "givenName": "Catherine H.", 
        "id": "sg:person.01170147467.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170147467.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wicha", 
        "givenName": "Max S.", 
        "id": "sg:person.0753375704.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753375704.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hayes", 
        "givenName": "Daniel F.", 
        "id": "sg:person.013712224532.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712224532.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Michigan\u2013Ann Arbor", 
          "id": "https://www.grid.ac/institutes/grid.214458.e", 
          "name": [
            "Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Henry", 
        "givenName": "N. Lynn", 
        "id": "sg:person.01042733643.27", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/bjc.2014.174", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007246393", 
          "https://doi.org/10.1038/bjc.2014.174"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.18.9159", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008720167"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.breast.2012.12.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011970543"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1113216", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013126608"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.2025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013179310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.breast.2015.09.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014640146"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052306", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014794593"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02782192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023645859", 
          "https://doi.org/10.1007/bf02782192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02782192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023645859", 
          "https://doi.org/10.1007/bf02782192"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-2962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024696626"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2013.50.9984", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028197158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp353", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029577729"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm200103153441101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031768583"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.8481", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032444268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0627-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034406962", 
          "https://doi.org/10.1007/s10549-009-0627-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0627-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034406962", 
          "https://doi.org/10.1007/s10549-009-0627-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-009-0627-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034406962", 
          "https://doi.org/10.1007/s10549-009-0627-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052122", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035589584"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1413513", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043562849"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.9844", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048089129"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.3798106", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062621480"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1999.17.9.2639", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074549894"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-02", 
    "datePublishedReg": "2016-02-01", 
    "description": "Prior to availability of anti-HER2 therapies, HER2-positive metastatic breast cancer (MBC) was associated with a poor prognosis. Prospective randomized trials have demonstrated survival benefit from anti-HER2 treatments. Anecdotal observations have suggested that a small but meaningful fraction of patients with HER2-positive MBC may be \"exceptional responders\" with long survival. We hypothesized that demographic and/or clinicopathologic characteristics can be identified to distinguish short-term from long-term survivors. A retrospective, single-institution review of 168 patients with HER2-positive MBC who received treatment with anti-HER2 therapy in the metastatic setting was performed. Cox proportional hazards analysis was used to assess factors associated with long-term survival. Median overall survival from the time of breast cancer recurrence was 3.9\u00a0years (95\u00a0% CI 3.4-5.2). From the time of diagnosis of MBC, 56 (33\u00a0%) survived for 5 or more years and 12 (7\u00a0%) survived more than 10\u00a0years. Of the 66 patients diagnosed with central nervous system metastases, 9 (14\u00a0%) survived more than 5\u00a0years following that diagnosis. Younger age at diagnosis, lower stage, hormone receptor positive status, and only having one organ involved at diagnosis were associated with longer survival. Four patients discontinued anti-HER2 therapy and are without evidence of progression of disease after a median 7.4\u00a0years (0.2-12.0) since stopping therapy. In a cohort of patients with HER2-positive MBC treated primarily with trastuzumab and lapatinib, 7\u00a0% of patients were \"exceptional responders.\" Combining these clinical factors with molecular determinants of prolonged survival may provide insights for individualizing treatment selection. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-016-3705-3", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4897906", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438854", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "155"
      }
    ], 
    "name": "Clinical predictors of long-term survival in HER2-positive metastatic breast cancer", 
    "pagination": "589-595", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "1be0989a4795d603e847d154a955a524bb0ab0d44d0e1ed0be3b84f6a94aeaa3"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26875184"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-016-3705-3"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1005851446"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-016-3705-3", 
      "https://app.dimensions.ai/details/publication/pub.1005851446"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T22:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8690_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10549-016-3705-3"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3705-3'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3705-3'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3705-3'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-016-3705-3'


 

This table displays all metadata directly associated to this object as RDF triples.

264 TRIPLES      21 PREDICATES      65 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-016-3705-3 schema:about N1214c69540dc437b88d04c91df849939
2 N20a1325661214ac89bf117ac67765bb0
3 N401acaf0757c4910adbe2eb6c8798021
4 N4db5eeeda6f44ccb8a419212fc4dce15
5 N770dcf4600424cf4a1a245cb87da3e29
6 N790ebb4fbd2347619bbaf997acac0c15
7 N7d2dda9486ec45eda3a89c079a3a7619
8 N85345fa84222478a8076649e8d8b465e
9 Na43ea00837db40dd9cffa17626dcadca
10 Nb408888a6426463b81a4ce32962362e9
11 Nb7be150ed90049548249628684376a8e
12 Ndd47a3e0aee241cfac338c41aaaaf1f9
13 Ne2b125e8ba224cd5a9efbab060539eb7
14 Ne3f0cb2bd54a4470927985bcbb0d2dd4
15 Ne5edb9ab4e28445fba000583a86ba031
16 Nf73de26886a04353a64f4b5f0b80e2c0
17 Nf984947ae66b41829e765983b9f3ebc1
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Nd19e0a9dde344db9b307c558db5adf3c
21 schema:citation sg:pub.10.1007/bf02782192
22 sg:pub.10.1007/s10549-009-0627-3
23 sg:pub.10.1038/bjc.2014.174
24 https://doi.org/10.1016/j.breast.2012.12.006
25 https://doi.org/10.1016/j.breast.2015.09.008
26 https://doi.org/10.1056/nejm200103153441101
27 https://doi.org/10.1056/nejmoa052122
28 https://doi.org/10.1056/nejmoa052306
29 https://doi.org/10.1056/nejmoa1113216
30 https://doi.org/10.1056/nejmoa1413513
31 https://doi.org/10.1093/annonc/mdp353
32 https://doi.org/10.1126/science.3798106
33 https://doi.org/10.1158/1078-0432.ccr-10-2962
34 https://doi.org/10.1200/jco.1999.17.9.2639
35 https://doi.org/10.1200/jco.2008.18.9159
36 https://doi.org/10.1200/jco.2008.19.8481
37 https://doi.org/10.1200/jco.2008.19.9844
38 https://doi.org/10.1200/jco.2009.23.2025
39 https://doi.org/10.1200/jco.2013.50.9984
40 schema:datePublished 2016-02
41 schema:datePublishedReg 2016-02-01
42 schema:description Prior to availability of anti-HER2 therapies, HER2-positive metastatic breast cancer (MBC) was associated with a poor prognosis. Prospective randomized trials have demonstrated survival benefit from anti-HER2 treatments. Anecdotal observations have suggested that a small but meaningful fraction of patients with HER2-positive MBC may be "exceptional responders" with long survival. We hypothesized that demographic and/or clinicopathologic characteristics can be identified to distinguish short-term from long-term survivors. A retrospective, single-institution review of 168 patients with HER2-positive MBC who received treatment with anti-HER2 therapy in the metastatic setting was performed. Cox proportional hazards analysis was used to assess factors associated with long-term survival. Median overall survival from the time of breast cancer recurrence was 3.9 years (95 % CI 3.4-5.2). From the time of diagnosis of MBC, 56 (33 %) survived for 5 or more years and 12 (7 %) survived more than 10 years. Of the 66 patients diagnosed with central nervous system metastases, 9 (14 %) survived more than 5 years following that diagnosis. Younger age at diagnosis, lower stage, hormone receptor positive status, and only having one organ involved at diagnosis were associated with longer survival. Four patients discontinued anti-HER2 therapy and are without evidence of progression of disease after a median 7.4 years (0.2-12.0) since stopping therapy. In a cohort of patients with HER2-positive MBC treated primarily with trastuzumab and lapatinib, 7 % of patients were "exceptional responders." Combining these clinical factors with molecular determinants of prolonged survival may provide insights for individualizing treatment selection.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree true
46 schema:isPartOf N174710cd8fdc424bb5068822aa36add6
47 N1b9a3dc5997c4f91ad720e18c651b2ec
48 sg:journal.1092777
49 schema:name Clinical predictors of long-term survival in HER2-positive metastatic breast cancer
50 schema:pagination 589-595
51 schema:productId N2de19c05e4714705995a604d6799acd0
52 N2de9965ebc1648d8861759c472522b9f
53 N65a49fad1ff041a5832a6ae5bc9ac92a
54 N8ffce69c997b47b8a6a790c81471f128
55 Na351f5c3019944ad9e2d39eeafe4384f
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005851446
57 https://doi.org/10.1007/s10549-016-3705-3
58 schema:sdDatePublished 2019-04-10T22:31
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher Nd22f8c9eeb374c57bac352248ebcc22a
61 schema:url http://link.springer.com/10.1007%2Fs10549-016-3705-3
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N1214c69540dc437b88d04c91df849939 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Breast Neoplasms
67 rdf:type schema:DefinedTerm
68 N174710cd8fdc424bb5068822aa36add6 schema:volumeNumber 155
69 rdf:type schema:PublicationVolume
70 N1b9a3dc5997c4f91ad720e18c651b2ec schema:issueNumber 3
71 rdf:type schema:PublicationIssue
72 N20a1325661214ac89bf117ac67765bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Female
74 rdf:type schema:DefinedTerm
75 N2de19c05e4714705995a604d6799acd0 schema:name dimensions_id
76 schema:value pub.1005851446
77 rdf:type schema:PropertyValue
78 N2de9965ebc1648d8861759c472522b9f schema:name readcube_id
79 schema:value 1be0989a4795d603e847d154a955a524bb0ab0d44d0e1ed0be3b84f6a94aeaa3
80 rdf:type schema:PropertyValue
81 N3751c4ebc2b24a0f89b093fb136c0527 rdf:first sg:person.0624650765.48
82 rdf:rest Ne6272c20901c474db9b6077ef0128791
83 N401acaf0757c4910adbe2eb6c8798021 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Proportional Hazards Models
85 rdf:type schema:DefinedTerm
86 N4db5eeeda6f44ccb8a419212fc4dce15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Neoplasm Recurrence, Local
88 rdf:type schema:DefinedTerm
89 N507a0f8c54e04b89818eedb2739732f4 rdf:first sg:person.01170147467.31
90 rdf:rest Ndeb044f0e8e54bdab12121edf0d2de39
91 N5ef04af903c6457f8baeed02a871ce76 rdf:first sg:person.0725527540.93
92 rdf:rest N3751c4ebc2b24a0f89b093fb136c0527
93 N65a49fad1ff041a5832a6ae5bc9ac92a schema:name pubmed_id
94 schema:value 26875184
95 rdf:type schema:PropertyValue
96 N704eaa6ddc2a4a0f82097057a91b8c9f rdf:first sg:person.01020741650.38
97 rdf:rest Nb598d0ebd6dc483282bbf9d3f419d385
98 N770dcf4600424cf4a1a245cb87da3e29 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Antineoplastic Combined Chemotherapy Protocols
100 rdf:type schema:DefinedTerm
101 N790ebb4fbd2347619bbaf997acac0c15 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Adult
103 rdf:type schema:DefinedTerm
104 N7d2dda9486ec45eda3a89c079a3a7619 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Trastuzumab
106 rdf:type schema:DefinedTerm
107 N82fab2b5f9e54e2a9d1572b657bb67d4 rdf:first sg:person.013712224532.50
108 rdf:rest Nd6e522ad8f404e7688926222378481f5
109 N85345fa84222478a8076649e8d8b465e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Aged, 80 and over
111 rdf:type schema:DefinedTerm
112 N8ffce69c997b47b8a6a790c81471f128 schema:name nlm_unique_id
113 schema:value 8111104
114 rdf:type schema:PropertyValue
115 N9d623f54cc6b411690eb6e1ae6eafff1 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
116 schema:familyName Smerage
117 schema:givenName Jeffrey D.
118 rdf:type schema:Person
119 Na351f5c3019944ad9e2d39eeafe4384f schema:name doi
120 schema:value 10.1007/s10549-016-3705-3
121 rdf:type schema:PropertyValue
122 Na43ea00837db40dd9cffa17626dcadca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Middle Aged
124 rdf:type schema:DefinedTerm
125 Nb408888a6426463b81a4ce32962362e9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Prognosis
127 rdf:type schema:DefinedTerm
128 Nb598d0ebd6dc483282bbf9d3f419d385 rdf:first sg:person.01234442277.45
129 rdf:rest N5ef04af903c6457f8baeed02a871ce76
130 Nb7be150ed90049548249628684376a8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
131 schema:name Neoplasm Metastasis
132 rdf:type schema:DefinedTerm
133 Nd19e0a9dde344db9b307c558db5adf3c rdf:first sg:person.01346233417.23
134 rdf:rest N704eaa6ddc2a4a0f82097057a91b8c9f
135 Nd22f8c9eeb374c57bac352248ebcc22a schema:name Springer Nature - SN SciGraph project
136 rdf:type schema:Organization
137 Nd6e522ad8f404e7688926222378481f5 rdf:first sg:person.01042733643.27
138 rdf:rest rdf:nil
139 Ndd47a3e0aee241cfac338c41aaaaf1f9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
140 schema:name Disease-Free Survival
141 rdf:type schema:DefinedTerm
142 Ndeb044f0e8e54bdab12121edf0d2de39 rdf:first sg:person.0753375704.58
143 rdf:rest N82fab2b5f9e54e2a9d1572b657bb67d4
144 Ne2b125e8ba224cd5a9efbab060539eb7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
145 schema:name Humans
146 rdf:type schema:DefinedTerm
147 Ne3f0cb2bd54a4470927985bcbb0d2dd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Quinazolines
149 rdf:type schema:DefinedTerm
150 Ne5edb9ab4e28445fba000583a86ba031 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Brain Neoplasms
152 rdf:type schema:DefinedTerm
153 Ne6272c20901c474db9b6077ef0128791 rdf:first N9d623f54cc6b411690eb6e1ae6eafff1
154 rdf:rest N507a0f8c54e04b89818eedb2739732f4
155 Nf73de26886a04353a64f4b5f0b80e2c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
156 schema:name Receptor, ErbB-2
157 rdf:type schema:DefinedTerm
158 Nf984947ae66b41829e765983b9f3ebc1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
159 schema:name Aged
160 rdf:type schema:DefinedTerm
161 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
162 schema:name Medical and Health Sciences
163 rdf:type schema:DefinedTerm
164 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
165 schema:name Oncology and Carcinogenesis
166 rdf:type schema:DefinedTerm
167 sg:grant.2438854 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-016-3705-3
168 rdf:type schema:MonetaryGrant
169 sg:grant.4897906 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-016-3705-3
170 rdf:type schema:MonetaryGrant
171 sg:journal.1092777 schema:issn 0167-6806
172 1573-7217
173 schema:name Breast Cancer Research and Treatment
174 rdf:type schema:Periodical
175 sg:person.01020741650.38 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
176 schema:familyName Kidwell
177 schema:givenName Kelley M.
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020741650.38
179 rdf:type schema:Person
180 sg:person.01042733643.27 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
181 schema:familyName Henry
182 schema:givenName N. Lynn
183 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01042733643.27
184 rdf:type schema:Person
185 sg:person.01170147467.31 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
186 schema:familyName Van Poznak
187 schema:givenName Catherine H.
188 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01170147467.31
189 rdf:type schema:Person
190 sg:person.01234442277.45 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
191 schema:familyName Schott
192 schema:givenName Anne F.
193 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01234442277.45
194 rdf:type schema:Person
195 sg:person.01346233417.23 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
196 schema:familyName Murthy
197 schema:givenName Pooja
198 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346233417.23
199 rdf:type schema:Person
200 sg:person.013712224532.50 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
201 schema:familyName Hayes
202 schema:givenName Daniel F.
203 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013712224532.50
204 rdf:type schema:Person
205 sg:person.0624650765.48 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
206 schema:familyName Griggs
207 schema:givenName Jennifer J.
208 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0624650765.48
209 rdf:type schema:Person
210 sg:person.0725527540.93 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
211 schema:familyName Merajver
212 schema:givenName Sofia D.
213 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0725527540.93
214 rdf:type schema:Person
215 sg:person.0753375704.58 schema:affiliation https://www.grid.ac/institutes/grid.214458.e
216 schema:familyName Wicha
217 schema:givenName Max S.
218 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0753375704.58
219 rdf:type schema:Person
220 sg:pub.10.1007/bf02782192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023645859
221 https://doi.org/10.1007/bf02782192
222 rdf:type schema:CreativeWork
223 sg:pub.10.1007/s10549-009-0627-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034406962
224 https://doi.org/10.1007/s10549-009-0627-3
225 rdf:type schema:CreativeWork
226 sg:pub.10.1038/bjc.2014.174 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007246393
227 https://doi.org/10.1038/bjc.2014.174
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1016/j.breast.2012.12.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011970543
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1016/j.breast.2015.09.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014640146
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1056/nejm200103153441101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031768583
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1056/nejmoa052122 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035589584
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1056/nejmoa052306 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014794593
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1056/nejmoa1113216 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013126608
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1056/nejmoa1413513 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043562849
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1093/annonc/mdp353 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029577729
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1126/science.3798106 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062621480
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1158/1078-0432.ccr-10-2962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024696626
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1200/jco.1999.17.9.2639 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074549894
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1200/jco.2008.18.9159 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008720167
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1200/jco.2008.19.8481 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032444268
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1200/jco.2008.19.9844 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048089129
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1200/jco.2009.23.2025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013179310
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1200/jco.2013.50.9984 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028197158
260 rdf:type schema:CreativeWork
261 https://www.grid.ac/institutes/grid.214458.e schema:alternateName University of Michigan–Ann Arbor
262 schema:name Biostatistics, University of Michigan School of Public Health, 1415 Washington Heights, SPH II M2525, 48109-2029, Ann Arbor, MI, USA
263 Internal Medicine/Hematology/Oncology, University of Michigan Medical School, 1500 East Medical Center Dr, Med Inn Bldg C450, 48109-5843, Ann Arbor, MI, USA
264 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...