A randomized, double-blind, phase II, exploratory trial evaluating the palliative benefit of either continuing pamidronate or switching to zoledronic acid ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2016-01

AUTHORS

C. Jacobs, I. Kuchuk, N. Bouganim, S. Smith, S. Mazzarello, L. Vandermeer, G. Dranitsaris, S. Dent, S. Gertler, S. Verma, X. Song, S. Simos, D. Cella, M. Clemons

ABSTRACT

Previous studies suggest switching from pamidronate to a more potent bone-targeted agent is associated with biomarker and palliative response in breast cancer patients with bone metastases. Until now, this has not been addressed in a double-blind, randomized trial. Breast cancer patients with high-risk bone metastases, despite >3 months of pamidronate, were randomized to either continue pamidronate or switch to zoledronic acid every 4 weeks for 12 weeks. Primary outcome was the proportion of patients achieving a fall in serum C-telopeptide (sCTx) at 12 weeks. Secondary outcomes included difference in mean sCTx, pain scores, quality of life, toxicity, and skeletal-related events (SREs). Seventy-three patients entered the study; median age 61 years (range 37-87). Proportion of patients achieving a fall in sCTx over the 12-week evaluation period was 26/32 (81 %) with zoledronic acid and 18/29 (62 %) with pamidronate (p = 0.095). Mean decrease in sCTx (mean difference between groups = 50 ng/L, 95 % CI 18-84; p = 0.003) was significantly greater in patients who received zoledronic acid. Quality of life, pain scores, toxicity, and frequency of new SREs were comparable between the two arms. While a switch from pamidronate to zoledronic acid resulted in reduction in mean sCTx, there were no significant differences between the arms for proportion of patients achieving a reduction in sCTx, quality of life, pain scores, toxicity or SREs. Given the lack of palliative improvement, the current data do not support a switching strategy. More... »

PAGES

77-84

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-015-3646-2

DOI

http://dx.doi.org/10.1007/s10549-015-3646-2

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1042035340

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26643085


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Density Conservation Agents", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Bone Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Combined Modality Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Diphosphonates", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Drug Substitution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Imidazoles", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Palliative Care", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Quality of Life", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacobs", 
        "givenName": "C.", 
        "id": "sg:person.01036635505.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036635505.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kuchuk", 
        "givenName": "I.", 
        "id": "sg:person.0671263556.14", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671263556.14"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bouganim", 
        "givenName": "N.", 
        "id": "sg:person.01121740556.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121740556.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada", 
            "The Ottawa Hospital Research Institute, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "S.", 
        "id": "sg:person.0651052101.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651052101.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada", 
            "The Ottawa Hospital Research Institute, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzarello", 
        "givenName": "S.", 
        "id": "sg:person.0737376756.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada", 
            "The Ottawa Hospital Research Institute, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Vandermeer", 
        "givenName": "L.", 
        "id": "sg:person.0761055556.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Statistical Consultant, 283 Danforth Ave, Suite 448, M4K 1N2, Toronto, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dranitsaris", 
        "givenName": "G.", 
        "id": "sg:person.01036510774.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036510774.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dent", 
        "givenName": "S.", 
        "id": "sg:person.01005512156.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005512156.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gertler", 
        "givenName": "S.", 
        "id": "sg:person.01230721252.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230721252.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Verma", 
        "givenName": "S.", 
        "id": "sg:person.0670243726.51", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670243726.51"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Song", 
        "givenName": "X.", 
        "id": "sg:person.0752722055.69", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752722055.69"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simos", 
        "givenName": "S.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Northwestern University", 
          "id": "https://www.grid.ac/institutes/grid.16753.36", 
          "name": [
            "Northwestern University Feinberg School of Medicine, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cella", 
        "givenName": "D.", 
        "id": "sg:person.012000260477.10", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000260477.10"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada", 
            "The Ottawa Hospital Research Institute, Ottawa, ON, Canada", 
            "Division of Medical Oncology, The Ottawa Hospital Cancer Centre, 501 Smyth Road, Box 900, K1H8L6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clemons", 
        "givenName": "M.", 
        "id": "sg:person.01216107435.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1002/cncr.11701", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006789957"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd003474.pub3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010187634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2007.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013906210"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-0981-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016809613", 
          "https://doi.org/10.1007/s10549-010-0981-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-0981-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016809613", 
          "https://doi.org/10.1007/s10549-010-0981-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-07-5234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016848993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.11892", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019888019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-009-9247-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023372650", 
          "https://doi.org/10.1007/s10585-009-9247-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10585-009-9247-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023372650", 
          "https://doi.org/10.1007/s10585-009-9247-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.10522", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024340158"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(20000301)88:5<1082::aid-cncr20>3.0.co;2-z", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024382052"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9583-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024805956", 
          "https://doi.org/10.1007/s10549-007-9583-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9583-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024805956", 
          "https://doi.org/10.1007/s10549-007-9583-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3747/co.19.1011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030497291"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033862119", 
          "https://doi.org/10.1038/sj.bjc.6601437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601437", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033862119", 
          "https://doi.org/10.1038/sj.bjc.6601437"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/jcp.2008.062505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034946250"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jpainsymman.2008.08.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036416330"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2010.32.5209", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037618245"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejm199612123352401", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037742282"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.2146", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039038702"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.07.016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044063036"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-004-0671-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046676676", 
          "https://doi.org/10.1007/s00520-004-0671-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-004-0671-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046676676", 
          "https://doi.org/10.1007/s00520-004-0671-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/spc.0000000000000084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049186850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/spc.0000000000000084", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049186850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2006.05.9212", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052619528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.06.091", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053718930"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1008238422151", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056302706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1993.11.3.570", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1082809601"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2016-01", 
    "datePublishedReg": "2016-01-01", 
    "description": "Previous studies suggest switching from pamidronate to a more potent bone-targeted agent is associated with biomarker and palliative response in breast cancer patients with bone metastases. Until now, this has not been addressed in a double-blind, randomized trial. Breast cancer patients with high-risk bone metastases, despite >3\u00a0months of pamidronate, were randomized to either continue pamidronate or switch to zoledronic acid every 4\u00a0weeks for 12\u00a0weeks. Primary outcome was the proportion of patients achieving a fall in serum C-telopeptide (sCTx) at 12\u00a0weeks. Secondary outcomes included difference in mean sCTx, pain scores, quality of life, toxicity, and skeletal-related events (SREs). Seventy-three patients entered the study; median age 61\u00a0years (range 37-87). Proportion of patients achieving a fall in sCTx over the 12-week evaluation period was 26/32 (81\u00a0%) with zoledronic acid and 18/29 (62\u00a0%) with pamidronate (p\u00a0=\u00a00.095). Mean decrease in sCTx (mean difference between groups\u00a0=\u00a050\u00a0ng/L, 95\u00a0% CI 18-84; p\u00a0=\u00a00.003) was significantly greater in patients who received zoledronic acid. Quality of life, pain scores, toxicity, and frequency of new SREs were comparable between the two arms. While a switch from pamidronate to zoledronic acid resulted in reduction in mean sCTx, there were no significant differences between the arms for proportion of patients achieving a reduction in sCTx, quality of life, pain scores, toxicity or SREs. Given the lack of palliative improvement, the current data do not support a switching strategy. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-015-3646-2", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "155"
      }
    ], 
    "name": "A randomized, double-blind, phase II, exploratory trial evaluating the palliative benefit of either continuing pamidronate or switching to zoledronic acid in patients with high-risk bone metastases from breast cancer", 
    "pagination": "77-84", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "c83c65c1031cf80033b2d4a8c42e390240d9cea0fce57d906f2e7d33c848cb65"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26643085"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-015-3646-2"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1042035340"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-015-3646-2", 
      "https://app.dimensions.ai/details/publication/pub.1042035340"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T14:10", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8660_00000515.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10549-015-3646-2"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3646-2'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3646-2'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3646-2'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3646-2'


 

This table displays all metadata directly associated to this object as RDF triples.

323 TRIPLES      21 PREDICATES      69 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-015-3646-2 schema:about N1ac144e904ad43918760bddbf4590a7e
2 N1af9edc637b9417ea88fa2bd8eb7c6ff
3 N3ac0ce4451a94779b17cf4241a976e09
4 N5502c63d1e7e461f9f455773c849bf2d
5 N5ddb22248d064d3da42da4b68b43402e
6 N7255110c77f64e45976314d53a5149ef
7 N81f2e1a0c62341909de073d4ec474026
8 N83460f937a004d94a57b93790e444e87
9 N8f19b435db8d4f6e8172169561122256
10 Nb020bb7ad62b4f2eb58efb293e9f910a
11 Nb2a627028ee64b55a59da79c404b0bcb
12 Nc102537b4c55425ea765d706e6349a57
13 Ncedf8fa63c7d49598a0e2d3490aa9259
14 Ne51f4bc3d9db48838ed59d7feacaf356
15 Nf14ec0d327c94a5e805bb38930bea263
16 Nf5e0fc80b80345a2ba18d6877c6bb767
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author Na84f3ee747f64fc1982be5dbd9f00dff
20 schema:citation sg:pub.10.1007/s00520-004-0671-9
21 sg:pub.10.1007/s10549-007-9583-y
22 sg:pub.10.1007/s10549-010-0981-1
23 sg:pub.10.1007/s10585-009-9247-x
24 sg:pub.10.1038/sj.bjc.6601437
25 https://doi.org/10.1002/(sici)1097-0142(20000301)88:5<1082::aid-cncr20>3.0.co;2-z
26 https://doi.org/10.1002/14651858.cd003474.pub3
27 https://doi.org/10.1002/cncr.10522
28 https://doi.org/10.1002/cncr.11701
29 https://doi.org/10.1002/cncr.11892
30 https://doi.org/10.1016/j.clon.2007.04.007
31 https://doi.org/10.1016/j.ejca.2012.07.016
32 https://doi.org/10.1016/j.jpainsymman.2008.08.005
33 https://doi.org/10.1023/a:1008238422151
34 https://doi.org/10.1056/nejm199612123352401
35 https://doi.org/10.1097/spc.0000000000000084
36 https://doi.org/10.1136/jcp.2008.062505
37 https://doi.org/10.1158/1078-0432.ccr-07-5234
38 https://doi.org/10.1200/jco.1993.11.3.570
39 https://doi.org/10.1200/jco.2005.06.091
40 https://doi.org/10.1200/jco.2006.05.9212
41 https://doi.org/10.1200/jco.2008.19.2146
42 https://doi.org/10.1200/jco.2010.32.5209
43 https://doi.org/10.3747/co.19.1011
44 schema:datePublished 2016-01
45 schema:datePublishedReg 2016-01-01
46 schema:description Previous studies suggest switching from pamidronate to a more potent bone-targeted agent is associated with biomarker and palliative response in breast cancer patients with bone metastases. Until now, this has not been addressed in a double-blind, randomized trial. Breast cancer patients with high-risk bone metastases, despite >3 months of pamidronate, were randomized to either continue pamidronate or switch to zoledronic acid every 4 weeks for 12 weeks. Primary outcome was the proportion of patients achieving a fall in serum C-telopeptide (sCTx) at 12 weeks. Secondary outcomes included difference in mean sCTx, pain scores, quality of life, toxicity, and skeletal-related events (SREs). Seventy-three patients entered the study; median age 61 years (range 37-87). Proportion of patients achieving a fall in sCTx over the 12-week evaluation period was 26/32 (81 %) with zoledronic acid and 18/29 (62 %) with pamidronate (p = 0.095). Mean decrease in sCTx (mean difference between groups = 50 ng/L, 95 % CI 18-84; p = 0.003) was significantly greater in patients who received zoledronic acid. Quality of life, pain scores, toxicity, and frequency of new SREs were comparable between the two arms. While a switch from pamidronate to zoledronic acid resulted in reduction in mean sCTx, there were no significant differences between the arms for proportion of patients achieving a reduction in sCTx, quality of life, pain scores, toxicity or SREs. Given the lack of palliative improvement, the current data do not support a switching strategy.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf N4fce64fc816b4bf0a985f7c51753888f
51 Nf2ee302051ec4528b2b5d08354d9fc3c
52 sg:journal.1092777
53 schema:name A randomized, double-blind, phase II, exploratory trial evaluating the palliative benefit of either continuing pamidronate or switching to zoledronic acid in patients with high-risk bone metastases from breast cancer
54 schema:pagination 77-84
55 schema:productId N6a8da40095cc430a97eda2ccba027cb8
56 N91ce97c628b74c238546e6fb425387a2
57 N99048973ff2e40169ff5fc85fe739719
58 Nab8d59136fc24fc4be0adb2412902cf3
59 Ncec942572d5d4be4b711b14babf0c9be
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042035340
61 https://doi.org/10.1007/s10549-015-3646-2
62 schema:sdDatePublished 2019-04-10T14:10
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher Nfca62b7cfb504bc2bd69fe908722db7f
65 schema:url http://link.springer.com/10.1007%2Fs10549-015-3646-2
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N016c636e41034f51a0f83a9b8ba4033e rdf:first sg:person.012000260477.10
70 rdf:rest N5e1763f659dc49a39f49bd132aa1ecf2
71 N093daafd714c4bd3b7d995cb62a6623e rdf:first sg:person.0671263556.14
72 rdf:rest Ndd7b8a226f54485b9999f43ac94ecd49
73 N1ac144e904ad43918760bddbf4590a7e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Aged
75 rdf:type schema:DefinedTerm
76 N1af9edc637b9417ea88fa2bd8eb7c6ff schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Palliative Care
78 rdf:type schema:DefinedTerm
79 N3248d063339e4a08a2d0718fa4ea94e1 rdf:first sg:person.01005512156.68
80 rdf:rest N4fb42507fd01483cb8026e1383cd9574
81 N38697b15f5884fe6a14679feddeb1f92 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
82 rdf:type schema:Organization
83 N3ac0ce4451a94779b17cf4241a976e09 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Middle Aged
85 rdf:type schema:DefinedTerm
86 N3c7491d6d82e4961aef5f6ac0604b47f rdf:first sg:person.0651052101.37
87 rdf:rest N6d77161d97734303a5d00142beba922c
88 N4fb42507fd01483cb8026e1383cd9574 rdf:first sg:person.01230721252.04
89 rdf:rest Nccb5d9db90d141baa7fa1d71c747c85a
90 N4fce64fc816b4bf0a985f7c51753888f schema:volumeNumber 155
91 rdf:type schema:PublicationVolume
92 N53ff54ff1f664fd88574d15988c92403 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
93 rdf:type schema:Organization
94 N5502c63d1e7e461f9f455773c849bf2d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Female
96 rdf:type schema:DefinedTerm
97 N5871d9d8daa84e28b22c6f9004f54518 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
98 rdf:type schema:Organization
99 N5ddb22248d064d3da42da4b68b43402e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Bone Neoplasms
101 rdf:type schema:DefinedTerm
102 N5e1763f659dc49a39f49bd132aa1ecf2 rdf:first sg:person.01216107435.90
103 rdf:rest rdf:nil
104 N6a8da40095cc430a97eda2ccba027cb8 schema:name pubmed_id
105 schema:value 26643085
106 rdf:type schema:PropertyValue
107 N6d77161d97734303a5d00142beba922c rdf:first sg:person.0737376756.24
108 rdf:rest Nd33ae7984e8a4e2ca326d5b399605e4a
109 N71efe1f9ccf548abbe386cfb58762437 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
110 rdf:type schema:Organization
111 N7255110c77f64e45976314d53a5149ef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Combined Modality Therapy
113 rdf:type schema:DefinedTerm
114 N81f2e1a0c62341909de073d4ec474026 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Breast Neoplasms
116 rdf:type schema:DefinedTerm
117 N83460f937a004d94a57b93790e444e87 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Antineoplastic Agents
119 rdf:type schema:DefinedTerm
120 N85bf6e2d692742a4abe765caee400cc4 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
121 rdf:type schema:Organization
122 N8ebca833dfc7438687586e7ecddcf342 rdf:first Nf10a77c7cb86474dba35edbddee1aa04
123 rdf:rest N016c636e41034f51a0f83a9b8ba4033e
124 N8f19b435db8d4f6e8172169561122256 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Bone Density Conservation Agents
126 rdf:type schema:DefinedTerm
127 N91ce97c628b74c238546e6fb425387a2 schema:name nlm_unique_id
128 schema:value 8111104
129 rdf:type schema:PropertyValue
130 N99048973ff2e40169ff5fc85fe739719 schema:name doi
131 schema:value 10.1007/s10549-015-3646-2
132 rdf:type schema:PropertyValue
133 Na84f3ee747f64fc1982be5dbd9f00dff rdf:first sg:person.01036635505.66
134 rdf:rest N093daafd714c4bd3b7d995cb62a6623e
135 Nab8d59136fc24fc4be0adb2412902cf3 schema:name readcube_id
136 schema:value c83c65c1031cf80033b2d4a8c42e390240d9cea0fce57d906f2e7d33c848cb65
137 rdf:type schema:PropertyValue
138 Nb020bb7ad62b4f2eb58efb293e9f910a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
139 schema:name Quality of Life
140 rdf:type schema:DefinedTerm
141 Nb0da04f016114f0a89651ef582f3849c schema:name Statistical Consultant, 283 Danforth Ave, Suite 448, M4K 1N2, Toronto, ON, Canada
142 rdf:type schema:Organization
143 Nb0e1106941784b36be72872872bab7c7 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
144 rdf:type schema:Organization
145 Nb2a627028ee64b55a59da79c404b0bcb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
146 schema:name Drug Substitution
147 rdf:type schema:DefinedTerm
148 Nbc92ddc3062847d080f3abc410d5163f schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
149 rdf:type schema:Organization
150 Nc102537b4c55425ea765d706e6349a57 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
151 schema:name Imidazoles
152 rdf:type schema:DefinedTerm
153 Nc5d95b495daf40c59c0145dd42167c63 rdf:first sg:person.01036510774.09
154 rdf:rest N3248d063339e4a08a2d0718fa4ea94e1
155 Nccb5d9db90d141baa7fa1d71c747c85a rdf:first sg:person.0670243726.51
156 rdf:rest Nf19a0456348f4e3584f0e02a886a86c7
157 Ncec942572d5d4be4b711b14babf0c9be schema:name dimensions_id
158 schema:value pub.1042035340
159 rdf:type schema:PropertyValue
160 Ncedf8fa63c7d49598a0e2d3490aa9259 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Treatment Outcome
162 rdf:type schema:DefinedTerm
163 Nd33ae7984e8a4e2ca326d5b399605e4a rdf:first sg:person.0761055556.65
164 rdf:rest Nc5d95b495daf40c59c0145dd42167c63
165 Ndd7b8a226f54485b9999f43ac94ecd49 rdf:first sg:person.01121740556.48
166 rdf:rest N3c7491d6d82e4961aef5f6ac0604b47f
167 Ne51f4bc3d9db48838ed59d7feacaf356 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
168 schema:name Diphosphonates
169 rdf:type schema:DefinedTerm
170 Nf10a77c7cb86474dba35edbddee1aa04 schema:affiliation Nb0e1106941784b36be72872872bab7c7
171 schema:familyName Simos
172 schema:givenName S.
173 rdf:type schema:Person
174 Nf14ec0d327c94a5e805bb38930bea263 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Humans
176 rdf:type schema:DefinedTerm
177 Nf19a0456348f4e3584f0e02a886a86c7 rdf:first sg:person.0752722055.69
178 rdf:rest N8ebca833dfc7438687586e7ecddcf342
179 Nf2ee302051ec4528b2b5d08354d9fc3c schema:issueNumber 1
180 rdf:type schema:PublicationIssue
181 Nf5e0fc80b80345a2ba18d6877c6bb767 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name Adult
183 rdf:type schema:DefinedTerm
184 Nfa88cd639ae44a4f85d1e0845fd632f0 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
185 rdf:type schema:Organization
186 Nfca62b7cfb504bc2bd69fe908722db7f schema:name Springer Nature - SN SciGraph project
187 rdf:type schema:Organization
188 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
189 schema:name Medical and Health Sciences
190 rdf:type schema:DefinedTerm
191 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
192 schema:name Oncology and Carcinogenesis
193 rdf:type schema:DefinedTerm
194 sg:journal.1092777 schema:issn 0167-6806
195 1573-7217
196 schema:name Breast Cancer Research and Treatment
197 rdf:type schema:Periodical
198 sg:person.01005512156.68 schema:affiliation Nbc92ddc3062847d080f3abc410d5163f
199 schema:familyName Dent
200 schema:givenName S.
201 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01005512156.68
202 rdf:type schema:Person
203 sg:person.01036510774.09 schema:affiliation Nb0da04f016114f0a89651ef582f3849c
204 schema:familyName Dranitsaris
205 schema:givenName G.
206 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036510774.09
207 rdf:type schema:Person
208 sg:person.01036635505.66 schema:affiliation Nfa88cd639ae44a4f85d1e0845fd632f0
209 schema:familyName Jacobs
210 schema:givenName C.
211 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036635505.66
212 rdf:type schema:Person
213 sg:person.01121740556.48 schema:affiliation N85bf6e2d692742a4abe765caee400cc4
214 schema:familyName Bouganim
215 schema:givenName N.
216 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01121740556.48
217 rdf:type schema:Person
218 sg:person.012000260477.10 schema:affiliation https://www.grid.ac/institutes/grid.16753.36
219 schema:familyName Cella
220 schema:givenName D.
221 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012000260477.10
222 rdf:type schema:Person
223 sg:person.01216107435.90 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
224 schema:familyName Clemons
225 schema:givenName M.
226 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90
227 rdf:type schema:Person
228 sg:person.01230721252.04 schema:affiliation N53ff54ff1f664fd88574d15988c92403
229 schema:familyName Gertler
230 schema:givenName S.
231 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230721252.04
232 rdf:type schema:Person
233 sg:person.0651052101.37 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
234 schema:familyName Smith
235 schema:givenName S.
236 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651052101.37
237 rdf:type schema:Person
238 sg:person.0670243726.51 schema:affiliation N5871d9d8daa84e28b22c6f9004f54518
239 schema:familyName Verma
240 schema:givenName S.
241 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670243726.51
242 rdf:type schema:Person
243 sg:person.0671263556.14 schema:affiliation N71efe1f9ccf548abbe386cfb58762437
244 schema:familyName Kuchuk
245 schema:givenName I.
246 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0671263556.14
247 rdf:type schema:Person
248 sg:person.0737376756.24 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
249 schema:familyName Mazzarello
250 schema:givenName S.
251 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24
252 rdf:type schema:Person
253 sg:person.0752722055.69 schema:affiliation N38697b15f5884fe6a14679feddeb1f92
254 schema:familyName Song
255 schema:givenName X.
256 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0752722055.69
257 rdf:type schema:Person
258 sg:person.0761055556.65 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
259 schema:familyName Vandermeer
260 schema:givenName L.
261 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0761055556.65
262 rdf:type schema:Person
263 sg:pub.10.1007/s00520-004-0671-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046676676
264 https://doi.org/10.1007/s00520-004-0671-9
265 rdf:type schema:CreativeWork
266 sg:pub.10.1007/s10549-007-9583-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1024805956
267 https://doi.org/10.1007/s10549-007-9583-y
268 rdf:type schema:CreativeWork
269 sg:pub.10.1007/s10549-010-0981-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016809613
270 https://doi.org/10.1007/s10549-010-0981-1
271 rdf:type schema:CreativeWork
272 sg:pub.10.1007/s10585-009-9247-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023372650
273 https://doi.org/10.1007/s10585-009-9247-x
274 rdf:type schema:CreativeWork
275 sg:pub.10.1038/sj.bjc.6601437 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033862119
276 https://doi.org/10.1038/sj.bjc.6601437
277 rdf:type schema:CreativeWork
278 https://doi.org/10.1002/(sici)1097-0142(20000301)88:5<1082::aid-cncr20>3.0.co;2-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1024382052
279 rdf:type schema:CreativeWork
280 https://doi.org/10.1002/14651858.cd003474.pub3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010187634
281 rdf:type schema:CreativeWork
282 https://doi.org/10.1002/cncr.10522 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024340158
283 rdf:type schema:CreativeWork
284 https://doi.org/10.1002/cncr.11701 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006789957
285 rdf:type schema:CreativeWork
286 https://doi.org/10.1002/cncr.11892 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019888019
287 rdf:type schema:CreativeWork
288 https://doi.org/10.1016/j.clon.2007.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013906210
289 rdf:type schema:CreativeWork
290 https://doi.org/10.1016/j.ejca.2012.07.016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044063036
291 rdf:type schema:CreativeWork
292 https://doi.org/10.1016/j.jpainsymman.2008.08.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036416330
293 rdf:type schema:CreativeWork
294 https://doi.org/10.1023/a:1008238422151 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056302706
295 rdf:type schema:CreativeWork
296 https://doi.org/10.1056/nejm199612123352401 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037742282
297 rdf:type schema:CreativeWork
298 https://doi.org/10.1097/spc.0000000000000084 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049186850
299 rdf:type schema:CreativeWork
300 https://doi.org/10.1136/jcp.2008.062505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034946250
301 rdf:type schema:CreativeWork
302 https://doi.org/10.1158/1078-0432.ccr-07-5234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016848993
303 rdf:type schema:CreativeWork
304 https://doi.org/10.1200/jco.1993.11.3.570 schema:sameAs https://app.dimensions.ai/details/publication/pub.1082809601
305 rdf:type schema:CreativeWork
306 https://doi.org/10.1200/jco.2005.06.091 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053718930
307 rdf:type schema:CreativeWork
308 https://doi.org/10.1200/jco.2006.05.9212 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052619528
309 rdf:type schema:CreativeWork
310 https://doi.org/10.1200/jco.2008.19.2146 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039038702
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1200/jco.2010.32.5209 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037618245
313 rdf:type schema:CreativeWork
314 https://doi.org/10.3747/co.19.1011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030497291
315 rdf:type schema:CreativeWork
316 https://www.grid.ac/institutes/grid.16753.36 schema:alternateName Northwestern University
317 schema:name Northwestern University Feinberg School of Medicine, Chicago, IL, USA
318 rdf:type schema:Organization
319 https://www.grid.ac/institutes/grid.412687.e schema:alternateName Ottawa Hospital
320 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital, University of Ottawa, Ottawa, ON, Canada
321 Division of Medical Oncology, The Ottawa Hospital Cancer Centre, 501 Smyth Road, Box 900, K1H8L6, Ottawa, ON, Canada
322 The Ottawa Hospital Research Institute, Ottawa, ON, Canada
323 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...