Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2015-07

AUTHORS

Sasha Mazzarello, Brian Hutton, Mohammed F. K. Ibrahim, Carmel Jacobs, Risa Shorr, Stephanie Smith, Terry Ng, Mark Clemons

ABSTRACT

Symptoms of urogenital atrophy are common in breast cancer survivors. Its optimal management is currently unknown. A systematic review of randomized controlled trials (RCTs) evaluating treatments for urogenital atrophy in breast cancer patients was performed. EMBASE, Ovid Medline and the Cochrane Library were searched from 1946 to November 2014. Outcomes included improvements in both vaginal symptoms (e.g., dryness, pain, dyspareunia and itching) and vaginal hormone response measured by validated scales [e.g., Vaginal Health Index (VHI) and Vaginal Maturation Index (VMI)]. Of 430 unique citations identified, 4 studies (n = 196) met inclusion criteria. Interventions included pH-balanced gel, Replens(®), lidocaine, Estring(®) and Vagifem(®). Sample sizes ranged from 7 to 98 patients. Given the heterogeneity of the studies, a narrative synthesis of results was performed. One study of 98 patients suggested that vaginal pH-balanced gel (mean VHI 5.00 ± 0.816, mean VMI 51.18 ± 3.753) was more efficient than placebo (VHI 16.98 ± 3.875, p < 0.001, VMI 47.87 ± 2.728, p < 0.001) at 12 weeks in providing vaginal symptom relief. In patients who used lidocaine, 90 % had reduced dyspareunia compared to saline in a study of 46 patients. Although increased serum estradiol occurred, both Estring(®) and Vagifem(®) were shown to improve quality of life and VMI in a study of seven patients. Treatment of urogenital atrophy remains a challenging issue and there is a paucity of RCT evidence addressing this knowledge gap. It is evident that more prospective trials are needed. More... »

PAGES

1-8

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-015-3434-z

DOI

http://dx.doi.org/10.1007/s10549-015-3434-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1002984615

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/26003182


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Atrophy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease Management", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female Urogenital Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Randomized Controlled Trials as Topic", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mazzarello", 
        "givenName": "Sasha", 
        "id": "sg:person.0737376756.24", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hutton", 
        "givenName": "Brian", 
        "id": "sg:person.01235465321.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235465321.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ibrahim", 
        "givenName": "Mohammed F. K.", 
        "id": "sg:person.012754470322.02", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012754470322.02"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jacobs", 
        "givenName": "Carmel", 
        "id": "sg:person.01036635505.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036635505.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "The Ottawa Hospital, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shorr", 
        "givenName": "Risa", 
        "id": "sg:person.01016010441.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016010441.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Smith", 
        "givenName": "Stephanie", 
        "id": "sg:person.0651052101.37", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651052101.37"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ng", 
        "givenName": "Terry", 
        "id": "sg:person.01132237041.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132237041.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ottawa Hospital", 
          "id": "https://www.grid.ac/institutes/grid.412687.e", 
          "name": [
            "Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Canada", 
            "Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Clemons", 
        "givenName": "Mark", 
        "id": "sg:person.01216107435.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1016/j.ejca.2012.07.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001308924"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.2007-0234", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004135901"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(12)61963-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006312031"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5122(95)00956-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006921450"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-3-642-45769-2_38", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014853163", 
          "https://doi.org/10.1007/978-3-642-45769-2_38"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e3182118790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020833086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e3182118790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020833086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e3182118790", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020833086"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13697137.2012.756466", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021288676"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.maturitas.2011.09.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022379007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)15493-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026400310"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji071", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030054143"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/14651858.cd001500.pub2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031034848"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0000000000000203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031629013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0000000000000203", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031629013"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006263818115", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032185952", 
          "https://doi.org/10.1023/a:1006263818115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ajog.2010.08.035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033350385"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e31816c5541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033603119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e31816c5541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033603119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.d5928", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041893471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-005-0847-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041959587", 
          "https://doi.org/10.1007/s00520-005-0847-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-005-0847-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041959587", 
          "https://doi.org/10.1007/s00520-005-0847-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00520-005-0847-y", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041959587", 
          "https://doi.org/10.1007/s00520-005-0847-y"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.clon.2012.06.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043854024"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(08)70341-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048840099"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2009.n.020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052388473"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13697137.2010.522875", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052625955"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/jcem.87.1.8141", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064324808"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1997.15.3.969", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083057210"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2015-07", 
    "datePublishedReg": "2015-07-01", 
    "description": "Symptoms of urogenital atrophy are common in breast cancer survivors. Its optimal management is currently unknown. A systematic review of randomized controlled trials (RCTs) evaluating treatments for urogenital atrophy in breast cancer patients was performed. EMBASE, Ovid Medline and the Cochrane Library were searched from 1946 to November 2014. Outcomes included improvements in both vaginal symptoms (e.g., dryness, pain, dyspareunia and itching) and vaginal hormone response measured by validated scales [e.g., Vaginal Health Index (VHI) and Vaginal Maturation Index (VMI)]. Of 430 unique citations identified, 4 studies (n = 196) met inclusion criteria. Interventions included pH-balanced gel, Replens(\u00ae), lidocaine, Estring(\u00ae) and Vagifem(\u00ae). Sample sizes ranged from 7 to 98 patients. Given the heterogeneity of the studies, a narrative synthesis of results was performed. One study of 98 patients suggested that vaginal pH-balanced gel (mean VHI 5.00 \u00b1 0.816, mean VMI 51.18 \u00b1 3.753) was more efficient than placebo (VHI 16.98 \u00b1 3.875, p < 0.001, VMI 47.87 \u00b1 2.728, p < 0.001) at 12 weeks in providing vaginal symptom relief. In patients who used lidocaine, 90 % had reduced dyspareunia compared to saline in a study of 46 patients. Although increased serum estradiol occurred, both Estring(\u00ae) and Vagifem(\u00ae) were shown to improve quality of life and VMI in a study of seven patients. Treatment of urogenital atrophy remains a challenging issue and there is a paucity of RCT evidence addressing this knowledge gap. It is evident that more prospective trials are needed.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-015-3434-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "152"
      }
    ], 
    "name": "Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials", 
    "pagination": "1-8", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "0e368d6bf9a23c9f779b528f12f9499550d3ebe24dbfff15c9666893dc889299"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "26003182"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-015-3434-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1002984615"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-015-3434-z", 
      "https://app.dimensions.ai/details/publication/pub.1002984615"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T23:23", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8693_00000510.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10549-015-3434-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3434-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3434-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3434-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-015-3434-z'


 

This table displays all metadata directly associated to this object as RDF triples.

227 TRIPLES      21 PREDICATES      59 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-015-3434-z schema:about N1fa915bdd1a44c9598beff8e8b6b4910
2 N216bc8a9a38c4dfd8518ee483c2728f2
3 N25bf4de78ae74d7c8a7a44567587a14d
4 N5b40c28b7b7b4ef09b607002512939fe
5 N7a7b79891b324393a9b8027bb5e4a51c
6 Nc1931a92c1694ee0aa4ff7a12932fe4f
7 Nf8b02ed45fd94fb6a7ede1517bb1b29f
8 anzsrc-for:11
9 anzsrc-for:1103
10 schema:author N7151eb7bfabf4d04985da731ac2de3d4
11 schema:citation sg:pub.10.1007/978-3-642-45769-2_38
12 sg:pub.10.1007/s00520-005-0847-y
13 sg:pub.10.1023/a:1006263818115
14 https://doi.org/10.1002/14651858.cd001500.pub2
15 https://doi.org/10.1016/0378-5122(95)00956-6
16 https://doi.org/10.1016/j.ajog.2010.08.035
17 https://doi.org/10.1016/j.clon.2012.06.009
18 https://doi.org/10.1016/j.ejca.2012.07.003
19 https://doi.org/10.1016/j.maturitas.2011.09.003
20 https://doi.org/10.1016/s0140-6736(04)15493-7
21 https://doi.org/10.1016/s0140-6736(12)61963-1
22 https://doi.org/10.1016/s1470-2045(08)70341-3
23 https://doi.org/10.1093/jnci/dji071
24 https://doi.org/10.1097/aog.0000000000000203
25 https://doi.org/10.1097/aog.0b013e3182118790
26 https://doi.org/10.1097/gme.0b013e31816c5541
27 https://doi.org/10.1136/bmj.d5928
28 https://doi.org/10.1200/jco.1997.15.3.969
29 https://doi.org/10.1210/jcem.87.1.8141
30 https://doi.org/10.1634/theoncologist.2007-0234
31 https://doi.org/10.3109/13697137.2010.522875
32 https://doi.org/10.3109/13697137.2012.756466
33 https://doi.org/10.3816/cbc.2009.n.020
34 schema:datePublished 2015-07
35 schema:datePublishedReg 2015-07-01
36 schema:description Symptoms of urogenital atrophy are common in breast cancer survivors. Its optimal management is currently unknown. A systematic review of randomized controlled trials (RCTs) evaluating treatments for urogenital atrophy in breast cancer patients was performed. EMBASE, Ovid Medline and the Cochrane Library were searched from 1946 to November 2014. Outcomes included improvements in both vaginal symptoms (e.g., dryness, pain, dyspareunia and itching) and vaginal hormone response measured by validated scales [e.g., Vaginal Health Index (VHI) and Vaginal Maturation Index (VMI)]. Of 430 unique citations identified, 4 studies (n = 196) met inclusion criteria. Interventions included pH-balanced gel, Replens(®), lidocaine, Estring(®) and Vagifem(®). Sample sizes ranged from 7 to 98 patients. Given the heterogeneity of the studies, a narrative synthesis of results was performed. One study of 98 patients suggested that vaginal pH-balanced gel (mean VHI 5.00 ± 0.816, mean VMI 51.18 ± 3.753) was more efficient than placebo (VHI 16.98 ± 3.875, p < 0.001, VMI 47.87 ± 2.728, p < 0.001) at 12 weeks in providing vaginal symptom relief. In patients who used lidocaine, 90 % had reduced dyspareunia compared to saline in a study of 46 patients. Although increased serum estradiol occurred, both Estring(®) and Vagifem(®) were shown to improve quality of life and VMI in a study of seven patients. Treatment of urogenital atrophy remains a challenging issue and there is a paucity of RCT evidence addressing this knowledge gap. It is evident that more prospective trials are needed.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N7020382d619440bb8410a42d5a3cb563
41 N702542eb6db34e73a0bfb69648716370
42 sg:journal.1092777
43 schema:name Management of urogenital atrophy in breast cancer patients: a systematic review of available evidence from randomized trials
44 schema:pagination 1-8
45 schema:productId N006ff89e1e07462da3a4181e9d6fb4bf
46 N0aaee89f1d9f4ae7b9e24fdffd510fb2
47 N0df2f12d18f044a7ac8199b40ef93e26
48 N18eca886c1f4481abcf19db6fd966a5f
49 N2b595b97db864a6191c31eef819d9e54
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002984615
51 https://doi.org/10.1007/s10549-015-3434-z
52 schema:sdDatePublished 2019-04-10T23:23
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher N3dbf937cbec248c987592cc1df37151d
55 schema:url http://link.springer.com/10.1007%2Fs10549-015-3434-z
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N006ff89e1e07462da3a4181e9d6fb4bf schema:name dimensions_id
60 schema:value pub.1002984615
61 rdf:type schema:PropertyValue
62 N0aaee89f1d9f4ae7b9e24fdffd510fb2 schema:name readcube_id
63 schema:value 0e368d6bf9a23c9f779b528f12f9499550d3ebe24dbfff15c9666893dc889299
64 rdf:type schema:PropertyValue
65 N0df2f12d18f044a7ac8199b40ef93e26 schema:name pubmed_id
66 schema:value 26003182
67 rdf:type schema:PropertyValue
68 N18eca886c1f4481abcf19db6fd966a5f schema:name doi
69 schema:value 10.1007/s10549-015-3434-z
70 rdf:type schema:PropertyValue
71 N1fa915bdd1a44c9598beff8e8b6b4910 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Randomized Controlled Trials as Topic
73 rdf:type schema:DefinedTerm
74 N216bc8a9a38c4dfd8518ee483c2728f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
75 schema:name Atrophy
76 rdf:type schema:DefinedTerm
77 N25bf4de78ae74d7c8a7a44567587a14d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Female
79 rdf:type schema:DefinedTerm
80 N2b595b97db864a6191c31eef819d9e54 schema:name nlm_unique_id
81 schema:value 8111104
82 rdf:type schema:PropertyValue
83 N3dbf937cbec248c987592cc1df37151d schema:name Springer Nature - SN SciGraph project
84 rdf:type schema:Organization
85 N3f400731b82f433ab9ce2d213d72fbac rdf:first sg:person.01216107435.90
86 rdf:rest rdf:nil
87 N53bd544d9b954cc09dd6b3c83936a764 rdf:first sg:person.01235465321.38
88 rdf:rest Ndefb31aed3c143409d86b59d2338c337
89 N5b40c28b7b7b4ef09b607002512939fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Disease Management
91 rdf:type schema:DefinedTerm
92 N5bad6bb7a79a406d952c53cae41ee478 rdf:first sg:person.01132237041.41
93 rdf:rest N3f400731b82f433ab9ce2d213d72fbac
94 N6190128e1c93480fa061f7591f04b9e5 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada
95 rdf:type schema:Organization
96 N7020382d619440bb8410a42d5a3cb563 schema:volumeNumber 152
97 rdf:type schema:PublicationVolume
98 N702542eb6db34e73a0bfb69648716370 schema:issueNumber 1
99 rdf:type schema:PublicationIssue
100 N7151eb7bfabf4d04985da731ac2de3d4 rdf:first sg:person.0737376756.24
101 rdf:rest N53bd544d9b954cc09dd6b3c83936a764
102 N7a7b79891b324393a9b8027bb5e4a51c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Breast Neoplasms
104 rdf:type schema:DefinedTerm
105 N83cffb447e1f4a9da4bfe651ce320f2b rdf:first sg:person.01016010441.99
106 rdf:rest N8bf987b0b7d64016a09a5958e598e71d
107 N8bf987b0b7d64016a09a5958e598e71d rdf:first sg:person.0651052101.37
108 rdf:rest N5bad6bb7a79a406d952c53cae41ee478
109 N9cbbe680515e46d08443850a75842177 rdf:first sg:person.01036635505.66
110 rdf:rest N83cffb447e1f4a9da4bfe651ce320f2b
111 Nb4f093b6c66d4330bddce97cf9365927 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada
112 rdf:type schema:Organization
113 Nc1931a92c1694ee0aa4ff7a12932fe4f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Female Urogenital Diseases
115 rdf:type schema:DefinedTerm
116 Ncb3a6a0a8d6c43b9847ae50ea3a92a65 schema:name Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada
117 rdf:type schema:Organization
118 Ndefb31aed3c143409d86b59d2338c337 rdf:first sg:person.012754470322.02
119 rdf:rest N9cbbe680515e46d08443850a75842177
120 Nf8b02ed45fd94fb6a7ede1517bb1b29f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Humans
122 rdf:type schema:DefinedTerm
123 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
124 schema:name Medical and Health Sciences
125 rdf:type schema:DefinedTerm
126 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
127 schema:name Clinical Sciences
128 rdf:type schema:DefinedTerm
129 sg:journal.1092777 schema:issn 0167-6806
130 1573-7217
131 schema:name Breast Cancer Research and Treatment
132 rdf:type schema:Periodical
133 sg:person.01016010441.99 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
134 schema:familyName Shorr
135 schema:givenName Risa
136 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01016010441.99
137 rdf:type schema:Person
138 sg:person.01036635505.66 schema:affiliation Ncb3a6a0a8d6c43b9847ae50ea3a92a65
139 schema:familyName Jacobs
140 schema:givenName Carmel
141 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036635505.66
142 rdf:type schema:Person
143 sg:person.01132237041.41 schema:affiliation Nb4f093b6c66d4330bddce97cf9365927
144 schema:familyName Ng
145 schema:givenName Terry
146 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01132237041.41
147 rdf:type schema:Person
148 sg:person.01216107435.90 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
149 schema:familyName Clemons
150 schema:givenName Mark
151 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01216107435.90
152 rdf:type schema:Person
153 sg:person.01235465321.38 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
154 schema:familyName Hutton
155 schema:givenName Brian
156 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235465321.38
157 rdf:type schema:Person
158 sg:person.012754470322.02 schema:affiliation N6190128e1c93480fa061f7591f04b9e5
159 schema:familyName Ibrahim
160 schema:givenName Mohammed F. K.
161 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012754470322.02
162 rdf:type schema:Person
163 sg:person.0651052101.37 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
164 schema:familyName Smith
165 schema:givenName Stephanie
166 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0651052101.37
167 rdf:type schema:Person
168 sg:person.0737376756.24 schema:affiliation https://www.grid.ac/institutes/grid.412687.e
169 schema:familyName Mazzarello
170 schema:givenName Sasha
171 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0737376756.24
172 rdf:type schema:Person
173 sg:pub.10.1007/978-3-642-45769-2_38 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014853163
174 https://doi.org/10.1007/978-3-642-45769-2_38
175 rdf:type schema:CreativeWork
176 sg:pub.10.1007/s00520-005-0847-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1041959587
177 https://doi.org/10.1007/s00520-005-0847-y
178 rdf:type schema:CreativeWork
179 sg:pub.10.1023/a:1006263818115 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032185952
180 https://doi.org/10.1023/a:1006263818115
181 rdf:type schema:CreativeWork
182 https://doi.org/10.1002/14651858.cd001500.pub2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031034848
183 rdf:type schema:CreativeWork
184 https://doi.org/10.1016/0378-5122(95)00956-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006921450
185 rdf:type schema:CreativeWork
186 https://doi.org/10.1016/j.ajog.2010.08.035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033350385
187 rdf:type schema:CreativeWork
188 https://doi.org/10.1016/j.clon.2012.06.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043854024
189 rdf:type schema:CreativeWork
190 https://doi.org/10.1016/j.ejca.2012.07.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001308924
191 rdf:type schema:CreativeWork
192 https://doi.org/10.1016/j.maturitas.2011.09.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022379007
193 rdf:type schema:CreativeWork
194 https://doi.org/10.1016/s0140-6736(04)15493-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026400310
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1016/s0140-6736(12)61963-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006312031
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/s1470-2045(08)70341-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048840099
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1093/jnci/dji071 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030054143
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1097/aog.0000000000000203 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031629013
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1097/aog.0b013e3182118790 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020833086
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1097/gme.0b013e31816c5541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033603119
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1136/bmj.d5928 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041893471
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1200/jco.1997.15.3.969 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083057210
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1210/jcem.87.1.8141 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064324808
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1634/theoncologist.2007-0234 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004135901
215 rdf:type schema:CreativeWork
216 https://doi.org/10.3109/13697137.2010.522875 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052625955
217 rdf:type schema:CreativeWork
218 https://doi.org/10.3109/13697137.2012.756466 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021288676
219 rdf:type schema:CreativeWork
220 https://doi.org/10.3816/cbc.2009.n.020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052388473
221 rdf:type schema:CreativeWork
222 https://www.grid.ac/institutes/grid.412687.e schema:alternateName Ottawa Hospital
223 schema:name Cancer Therapeutics Program, Ottawa Hospital Research Institute, Ottawa, Canada
224 Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Canada
225 Division of Medical Oncology and Department of Medicine, The Ottawa Hospital Cancer Centre, University of Ottawa, 501 Smyth Road, Box 912, K1H 8L6, Ottawa, ON, Canada
226 The Ottawa Hospital, Ottawa, Canada
227 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...