Breast cancer risk after diagnosis by screening mammography of nonproliferative or proliferative benign breast disease: a study from a population-based ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2014-12-13

AUTHORS

Xavier Castells, Laia Domingo, Josep María Corominas, Isabel Torá-Rocamora, María Jesús Quintana, Marisa Baré, Carmen Vidal, Carmen Natal, Mar Sánchez, Francina Saladié, Joana Ferrer, Mar Vernet, Sonia Servitja, Ana Rodríguez-Arana, Marta Roman, Josep Alfons Espinàs, María Sala

ABSTRACT

Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies. More... »

PAGES

237-244

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-014-3208-z

DOI

http://dx.doi.org/10.1007/s10549-014-3208-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1004242153

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25503778


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20 schema:description Benign breast disease increases the risk of breast cancer. This association has scarcely been evaluated in the context of breast cancer screening programs although it is a prevalent finding in mammography screening. We assessed the association of distinct categories of benign breast disease and subsequent risk of breast cancer, as well as the influence of a family history of breast cancer. A retrospective cohort study was conducted in 545,171 women aged 50-69 years biennially screened for breast cancer in Spain. The median of follow-up was 6.1 years. The age-adjusted rate ratio (RR) of breast cancer for women with benign breast disease, histologically classified into nonproliferative and proliferative disease with and without atypia, compared with women without benign breast disease was estimated by Poisson regression analysis. A stratified analysis by family history of breast cancer was performed in a subsample. All tests were two-sided. The age-adjusted RR of breast cancer after diagnosis of benign breast disease was 2.51 (95 % CI: 2.14-2.93) compared with women without benign breast disease. The risk was higher in women with proliferative disease with atypia (RR = 4.56, 95 % CI: 2.06-10.07) followed by those with proliferative disease without atypia (RR = 3.58; 95 % CI = 2.61-4.91). Women with nonproliferative disease and without a family history of breast cancer remained also at increased risk of cancer (OR = 2.23, 95 % CI: 1.86-2.68). An increased risk of breast cancer was observed among screening participants with proliferative or nonproliferative benign breast disease, regardless of a family history of breast cancer. This information may be useful to explore risk-based screening strategies.
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27 schema:keywords Poisson regression analysis
28 Spain
29 age-adjusted rate ratio
30 analysis
31 association
32 atypia
33 benign breast disease
34 breast cancer
35 breast cancer risk
36 breast cancer screening programme
37 breast disease
38 cancer
39 cancer risk
40 cancer screening programs
41 categories
42 cohort study
43 context
44 diagnosis
45 disease
46 distinct categories
47 family history
48 findings
49 history
50 influence
51 information
52 mammography
53 mammography screening
54 median
55 nonproliferative benign breast disease
56 nonproliferative disease
57 participants
58 population-based screening programs
59 prevalent finding
60 program
61 proliferative benign breast disease
62 proliferative diseases
63 rate ratio
64 ratio
65 regression analysis
66 retrospective cohort study
67 risk
68 risk of cancer
69 risk-based screening strategies
70 screening
71 screening program
72 screening strategy
73 strategies
74 stratified analysis
75 study
76 subsample
77 subsequent risk
78 test
79 women
80 years
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