Polyamines metabolism and breast cancer: state of the art and perspectives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-10-08

AUTHORS

Manuela Cervelli, Stefano Pietropaoli, Fabrizio Signore, Roberto Amendola, Paolo Mariottini

ABSTRACT

Breast cancer (BC) is a common disease that generally occurs in women over the age of 50, and the risk is especially high for women over 60 years of age. One of the major BC therapeutic problems is that tumors initially responsive to chemotherapeutic approaches can progress to more aggressive forms poorly responsive to therapies. Polyamines (PAs) are small polycationic alkylamines, naturally occurring and essential for normal cell growth and development in eukaryotes. The intracellular concentration of PA is maintained within strongly controlled contents, while a dysregulation occurs in BC cells. Polyamines facilitate the interactions of transcription factors, such as estrogen receptors with their specific response element, and are involved in the proliferation of ER-negative and highly invasive BC tumor cells. Since PA metabolism has a critical role in cell death and proliferation, it represents a potential target for intervention in BC. The goal of this study was to perform a literature search reviewing the association between PA metabolism and BC, and the current evidence supporting the BC treatment targeting PA metabolism. We here describe in vitro and in vivo models, as well as the clinical trials that have been utilized to unveil the relationship between PA metabolism and BC. Polyamine pathway is still an important target for the development of BC chemotherapy via enzyme inhibitors. Furthermore, a recent promising strategy in breast anticancer therapy is to exploit the self-regulatory nature of PA metabolism using PA analogs to affect PA homeostasis. Nowadays, antineoplastic compounds targeting the PA pathway with novel mechanisms are of great interest and high social impact for BC chemotherapy. More... »

PAGES

233-248

References to SciGraph publications

  • 2013-09-03. Spermine metabolism and radiation-derived reactive oxygen species for future therapeutic implications in cancer: an additive or adaptive response in AMINO ACIDS
  • 2013-12-21. Increased breast cancer cell toxicity by palladination of the polyamine analogue N1,N11-bis(ethyl)norspermine in AMINO ACIDS
  • 2004-10. Polyamines and cancer: old molecules, new understanding in NATURE REVIEWS CANCER
  • 1986-09. A phase II study of α-difluoromethylornithine (DFMO) for the treatment of metastatic melanoma in INVESTIGATIONAL NEW DRUGS
  • 2008-02-27. In vitro and in vivo effects of the conformationally restricted polyamine analogue CGC-11047 on small cell and non-small cell lung cancer cells in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2013-11-05. Purvalanol A is a strong apoptotic inducer via activating polyamine catabolic pathway in MCF-7 estrogen receptor positive breast cancer cells in MOLECULAR BIOLOGY REPORTS
  • 2013-06. Structure–Function Relationships in the Evolutionary Framework of Spermine Oxidase in JOURNAL OF MOLECULAR EVOLUTION
  • 2012-09-14. Role of ornithine decarboxylase in regulation of estrogen receptor alpha expression and growth in human breast cancer cells in BREAST CANCER RESEARCH AND TREATMENT
  • 2011-01-13. Current Status of the Polyamine Research Field in POLYAMINES
  • 2010-09-14. Probing mammalian spermine oxidase enzyme–substrate complex through molecular modeling, site-directed mutagenesis and biochemical characterization in AMINO ACIDS
  • 1988-07. Role of polyamines in the growth of hormone-responsive experimental breast cancerin vivo in BREAST CANCER RESEARCH AND TREATMENT
  • 2002-03. Influence of polyamines on in vitro and in vivo features of aggressive and metastatic behavior by human breast cancer cells in CLINICAL & EXPERIMENTAL METASTASIS
  • 2011-08-02. Spermine oxidase: ten years after in AMINO ACIDS
  • 2001-05. Immunohistochemical detection of ornithine-decarboxylase in primary and metastatic human breast cancer specimens in BREAST CANCER RESEARCH AND TREATMENT
  • 2012-06-20. Molecular evolution of the polyamine oxidase gene family in Metazoa in BMC EVOLUTIONARY BIOLOGY
  • 1994-01. Estradiol control of ornithine decarboxylase mRNA, enzyme activity, and polyamine levels in MCF-7 breast cancer cells: therapeutic implications in BREAST CANCER RESEARCH AND TREATMENT
  • 2011-08-12. Choosing the right cell line for breast cancer research in BREAST CANCER RESEARCH
  • 2013-08-10. Inflammation, carcinogenesis and neurodegeneration studies in transgenic animal models for polyamine research in AMINO ACIDS
  • 1996-10. Structure-activity relations of s-adenosylmethionine decarboxylase inhibitors on the growth of MCF-7 breast cancer cells in BREAST CANCER RESEARCH AND TREATMENT
  • 1997-09. Unusual central nervous system toxicity in a phase I study of N1N11diethylnorspermine in patients with advanced malignancy in INVESTIGATIONAL NEW DRUGS
  • 2002-04. Biochemical effects and growth inhibition in MCF-7 cells caused by novel sulphonamido oxa-polyamine derivatives in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2010-10-14. Spermine oxidase (SMO) activity in breast tumor tissues and biochemical analysis of the anticancer spermine analogues BENSpm and CPENSpm in BMC CANCER
  • 1991-05. Polyamine involvement in the secretion and action of TGF-α in hormone sensitive human breast cancer cells in culture in BREAST CANCER RESEARCH AND TREATMENT
  • 2001-02. Phase I Study of N1-N11-Diethylnorspermine (DENSPM) Administered TID for 6 Days in Patients with Advanced Malignancies in INVESTIGATIONAL NEW DRUGS
  • 2001-02. Polyamines in cell growth and cell death: molecular mechanisms and therapeutic applications in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-05. Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases in NATURE REVIEWS DRUG DISCOVERY
  • 2007-02-27. Effects of polyamine depletion by α-difluoromethylornithine on in vitro and in vivo biological properties of 4T1 murine mammary cancer cells in BREAST CANCER RESEARCH AND TREATMENT
  • 1994-03. Phase I study of combined alpha Interferon, alpha difluoromethylornithine (DFMO), and doxorubicin in advanced malignancy in INVESTIGATIONAL NEW DRUGS
  • 1995-04. Polyamine profiles and growth properties of ornithine decarboxylase overexpressing MCF-7 breast cancer cells in culture in BREAST CANCER RESEARCH AND TREATMENT
  • 1995-01. Growth and biochemical effects of unsymmetrically substituted polyamine analogues in human lung tumor cells 1 in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1988. Regulation of Polyamine Biosynthetic Activity by Spermidine and Spermine Analogs — A Novel Antiproliferative Strategy in PROGRESS IN POLYAMINE RESEARCH
  • 2011-07-30. Polyamine analogs modulate gene expression by inhibiting lysine-specific demethylase 1 (LSD1) and altering chromatin structure in human breast cancer cells in AMINO ACIDS
  • 2009-08-30. The role of the polyamine catabolic enzymes SSAT and SMO in the synergistic effects of standard chemotherapeutic agents with a polyamine analogue in human breast cancer cell lines in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 1991-01. Selectivity of polyamine involvement in hormone action on normal and neoplastic target tissues of the rat in BREAST CANCER RESEARCH AND TREATMENT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-014-3156-7

    DOI

    http://dx.doi.org/10.1007/s10549-014-3156-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019170611

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/25292420


    Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
    Incoming Citations Browse incoming citations for this publication using opencitations.net

    JSON-LD is the canonical representation for SciGraph data.

    TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

    [
      {
        "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
        "about": [
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Medical and Health Sciences", 
            "type": "DefinedTerm"
          }, 
          {
            "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
            "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
            "name": "Oncology and Carcinogenesis", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Animals", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Antineoplastic Agents", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Biogenic Polyamines", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Breast Neoplasms", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Female", 
            "type": "DefinedTerm"
          }, 
          {
            "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
            "name": "Humans", 
            "type": "DefinedTerm"
          }
        ], 
        "author": [
          {
            "affiliation": {
              "alternateName": "Department of Sciences, University \u201cRoma Tre\u201d, Viale G. Marconi 446, 00146, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8509.4", 
              "name": [
                "Department of Sciences, University \u201cRoma Tre\u201d, Viale G. Marconi 446, 00146, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Cervelli", 
            "givenName": "Manuela", 
            "id": "sg:person.01115316666.31", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115316666.31"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Sciences, University \u201cRoma Tre\u201d, Viale G. Marconi 446, 00146, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8509.4", 
              "name": [
                "Department of Sciences, University \u201cRoma Tre\u201d, Viale G. Marconi 446, 00146, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Pietropaoli", 
            "givenName": "Stefano", 
            "id": "sg:person.01127072652.75", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127072652.75"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Obstetrics and Gynaecology, San Camillo Hospital, 00149, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.416308.8", 
              "name": [
                "Department of Obstetrics and Gynaecology, San Camillo Hospital, 00149, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Signore", 
            "givenName": "Fabrizio", 
            "id": "sg:person.0723534345.10", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723534345.10"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "UT BIORAD RAB, ENEA, 00123, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.5196.b", 
              "name": [
                "UT BIORAD RAB, ENEA, 00123, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Amendola", 
            "givenName": "Roberto", 
            "id": "sg:person.01211407014.33", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211407014.33"
            ], 
            "type": "Person"
          }, 
          {
            "affiliation": {
              "alternateName": "Department of Sciences, University \u201cRoma Tre\u201d, Viale G. Marconi 446, 00146, Rome, Italy", 
              "id": "http://www.grid.ac/institutes/grid.8509.4", 
              "name": [
                "Department of Sciences, University \u201cRoma Tre\u201d, Viale G. Marconi 446, 00146, Rome, Italy"
              ], 
              "type": "Organization"
            }, 
            "familyName": "Mariottini", 
            "givenName": "Paolo", 
            "id": "sg:person.01231545266.41", 
            "sameAs": [
              "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231545266.41"
            ], 
            "type": "Person"
          }
        ], 
        "citation": [
          {
            "id": "sg:pub.10.1023/a:1006448516938", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011013365", 
              "https://doi.org/10.1023/a:1006448516938"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00666490", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024234522", 
              "https://doi.org/10.1007/bf00666490"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/bcr2889", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1033565721", 
              "https://doi.org/10.1186/bcr2889"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s11033-013-2847-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1022718043", 
              "https://doi.org/10.1007/s11033-013-2847-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-012-2235-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1017732737", 
              "https://doi.org/10.1007/s10549-012-2235-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01806368", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000216807", 
              "https://doi.org/10.1007/bf01806368"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00179593", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024099426", 
              "https://doi.org/10.1007/bf00179593"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1010697218986", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028084261", 
              "https://doi.org/10.1023/a:1010697218986"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01807281", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1036291018", 
              "https://doi.org/10.1007/bf01807281"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00239-013-9570-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024468454", 
              "https://doi.org/10.1007/s00239-013-9570-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00873231", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1032921959", 
              "https://doi.org/10.1007/bf00873231"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-008-0706-x", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1040384030", 
              "https://doi.org/10.1007/s00280-008-0706-x"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-61779-034-8_1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001004301", 
              "https://doi.org/10.1007/978-1-61779-034-8_1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01980970", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1043194992", 
              "https://doi.org/10.1007/bf01980970"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00685735", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1005809362", 
              "https://doi.org/10.1007/bf00685735"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf01806157", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1050805271", 
              "https://doi.org/10.1007/bf01806157"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/978-1-4684-5637-0_60", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1028502741", 
              "https://doi.org/10.1007/978-1-4684-5637-0_60"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00018-002-8460-4", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1047577622", 
              "https://doi.org/10.1007/s00018-002-8460-4"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2407-10-555", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1001773895", 
              "https://doi.org/10.1186/1471-2407-10-555"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-013-1572-3", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1009437610", 
              "https://doi.org/10.1007/s00726-013-1572-3"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrc1454", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1015480726", 
              "https://doi.org/10.1038/nrc1454"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1005827231849", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1000026162", 
              "https://doi.org/10.1023/a:1005827231849"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s10549-007-9533-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1020248333", 
              "https://doi.org/10.1007/s10549-007-9533-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/bf00665680", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035508417", 
              "https://doi.org/10.1007/bf00665680"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1038/nrd2243", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024966872", 
              "https://doi.org/10.1038/nrd2243"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-011-1014-z", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1045735246", 
              "https://doi.org/10.1007/s00726-011-1014-z"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-013-1621-y", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1023366361", 
              "https://doi.org/10.1007/s00726-013-1621-y"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-010-0735-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1024378998", 
              "https://doi.org/10.1007/s00726-010-0735-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00280-009-1112-8", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1035964935", 
              "https://doi.org/10.1007/s00280-009-1112-8"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1186/1471-2148-12-90", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1049387934", 
              "https://doi.org/10.1186/1471-2148-12-90"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-011-1004-1", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1011501803", 
              "https://doi.org/10.1007/s00726-011-1004-1"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1023/a:1014536909007", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1003756876", 
              "https://doi.org/10.1023/a:1014536909007"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/s00726-013-1579-9", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1039086906", 
              "https://doi.org/10.1007/s00726-013-1579-9"
            ], 
            "type": "CreativeWork"
          }, 
          {
            "id": "sg:pub.10.1007/pl00000852", 
            "sameAs": [
              "https://app.dimensions.ai/details/publication/pub.1041046925", 
              "https://doi.org/10.1007/pl00000852"
            ], 
            "type": "CreativeWork"
          }
        ], 
        "datePublished": "2014-10-08", 
        "datePublishedReg": "2014-10-08", 
        "description": "Abstract\nBreast cancer (BC) is a common disease that generally occurs in women over the age of 50, and the risk is especially high for women over 60\u00a0years of age. One of the major BC therapeutic problems is that tumors initially responsive to chemotherapeutic approaches can progress to more aggressive forms poorly responsive to therapies. Polyamines (PAs) are small polycationic alkylamines, naturally occurring and essential for normal cell growth and development in eukaryotes. The intracellular concentration of PA is maintained within strongly controlled contents, while a dysregulation occurs in BC cells. Polyamines facilitate the interactions of transcription factors, such as estrogen receptors with their specific response element, and are involved in the proliferation of ER-negative and highly invasive BC tumor cells. Since PA metabolism has a critical role in cell death and proliferation, it represents a potential target for intervention in BC. The goal of this study was to perform a literature search reviewing the association between PA metabolism and BC, and the current evidence supporting the BC treatment targeting PA metabolism. We here describe in vitro and in vivo models, as well as the clinical trials that have been utilized to unveil the relationship between PA metabolism and BC. Polyamine pathway is still an important target for the development of BC chemotherapy via enzyme inhibitors. Furthermore, a recent promising strategy in breast anticancer therapy is to exploit the self-regulatory nature of PA metabolism using PA analogs to affect PA homeostasis. Nowadays, antineoplastic compounds targeting the PA pathway with novel mechanisms are of great interest and high social impact for BC chemotherapy.", 
        "genre": "article", 
        "id": "sg:pub.10.1007/s10549-014-3156-7", 
        "inLanguage": "en", 
        "isAccessibleForFree": false, 
        "isPartOf": [
          {
            "id": "sg:journal.1092777", 
            "issn": [
              "0167-6806", 
              "1573-7217"
            ], 
            "name": "Breast Cancer Research and Treatment", 
            "publisher": "Springer Nature", 
            "type": "Periodical"
          }, 
          {
            "issueNumber": "2", 
            "type": "PublicationIssue"
          }, 
          {
            "type": "PublicationVolume", 
            "volumeNumber": "148"
          }
        ], 
        "keywords": [
          "breast cancer", 
          "BC chemotherapy", 
          "years of age", 
          "proliferation of ER", 
          "therapeutic problems", 
          "clinical trials", 
          "estrogen receptor", 
          "aggressive form", 
          "enzyme inhibitors", 
          "BC cells", 
          "current evidence", 
          "chemotherapeutic approaches", 
          "vivo model", 
          "literature search", 
          "tumor cells", 
          "common disease", 
          "BC treatment", 
          "anticancer therapy", 
          "PA metabolism", 
          "potential target", 
          "chemotherapy", 
          "therapy", 
          "cancer", 
          "polyamine metabolism", 
          "important target", 
          "metabolism", 
          "polyamine pathway", 
          "antineoplastic compounds", 
          "recent promising strategies", 
          "intracellular concentration", 
          "women", 
          "cell death", 
          "age", 
          "novel mechanism", 
          "specific response elements", 
          "cell growth", 
          "promising strategy", 
          "proliferation", 
          "critical role", 
          "response element", 
          "cells", 
          "tumors", 
          "normal cell growth", 
          "disease", 
          "PA analogues", 
          "pathway", 
          "trials", 
          "transcription factors", 
          "receptors", 
          "death", 
          "dysregulation", 
          "high social impact", 
          "polycationic alkylamines", 
          "intervention", 
          "risk", 
          "treatment", 
          "target", 
          "vitro", 
          "polyamines", 
          "homeostasis", 
          "association", 
          "inhibitors", 
          "years", 
          "evidence", 
          "factors", 
          "development", 
          "PA homeostasis", 
          "study", 
          "ER", 
          "role", 
          "PA pathway", 
          "concentration", 
          "mechanism", 
          "search", 
          "analogues", 
          "relationship", 
          "strategies", 
          "impact", 
          "great interest", 
          "growth", 
          "goal", 
          "social impact", 
          "compounds", 
          "form", 
          "interaction", 
          "interest", 
          "model", 
          "content", 
          "approach", 
          "perspective", 
          "state", 
          "nature", 
          "problem", 
          "self-regulatory nature", 
          "elements", 
          "art", 
          "alkylamines", 
          "eukaryotes", 
          "major BC therapeutic problems", 
          "BC therapeutic problems", 
          "small polycationic alkylamines", 
          "invasive BC tumor cells", 
          "BC tumor cells", 
          "breast anticancer therapy"
        ], 
        "name": "Polyamines metabolism and breast cancer: state of the art and perspectives", 
        "pagination": "233-248", 
        "productId": [
          {
            "name": "dimensions_id", 
            "type": "PropertyValue", 
            "value": [
              "pub.1019170611"
            ]
          }, 
          {
            "name": "doi", 
            "type": "PropertyValue", 
            "value": [
              "10.1007/s10549-014-3156-7"
            ]
          }, 
          {
            "name": "pubmed_id", 
            "type": "PropertyValue", 
            "value": [
              "25292420"
            ]
          }
        ], 
        "sameAs": [
          "https://doi.org/10.1007/s10549-014-3156-7", 
          "https://app.dimensions.ai/details/publication/pub.1019170611"
        ], 
        "sdDataset": "articles", 
        "sdDatePublished": "2021-11-01T18:23", 
        "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
        "sdPublisher": {
          "name": "Springer Nature - SN SciGraph project", 
          "type": "Organization"
        }, 
        "sdSource": "s3://com-springernature-scigraph/baseset/20211101/entities/gbq_results/article/article_639.jsonl", 
        "type": "ScholarlyArticle", 
        "url": "https://doi.org/10.1007/s10549-014-3156-7"
      }
    ]
     

    Download the RDF metadata as:  json-ld nt turtle xml License info

    HOW TO GET THIS DATA PROGRAMMATICALLY:

    JSON-LD is a popular format for linked data which is fully compatible with JSON.

    curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-014-3156-7'

    N-Triples is a line-based linked data format ideal for batch operations.

    curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-014-3156-7'

    Turtle is a human-readable linked data format.

    curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-014-3156-7'

    RDF/XML is a standard XML format for linked data.

    curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-014-3156-7'


     

    This table displays all metadata directly associated to this object as RDF triples.

    360 TRIPLES      22 PREDICATES      170 URIs      128 LITERALS      13 BLANK NODES

    Subject Predicate Object
    1 sg:pub.10.1007/s10549-014-3156-7 schema:about N306971ef00e749799c84daf2c18b2fdd
    2 N3685735c2b82442695c46e1ae8bd689e
    3 N5b3c9943d9ca4022834bc36bb76e0d9d
    4 Nc0e9010b0abb4a3eb79af8ed391633f7
    5 Nd759a0c929b9466abb8dbffc24cd6123
    6 Neae534cb9edb4234a4483fb329b3611e
    7 anzsrc-for:11
    8 anzsrc-for:1112
    9 schema:author N3effab9ecf2345f88ae660b41023c83c
    10 schema:citation sg:pub.10.1007/978-1-4684-5637-0_60
    11 sg:pub.10.1007/978-1-61779-034-8_1
    12 sg:pub.10.1007/bf00179593
    13 sg:pub.10.1007/bf00665680
    14 sg:pub.10.1007/bf00666490
    15 sg:pub.10.1007/bf00685735
    16 sg:pub.10.1007/bf00873231
    17 sg:pub.10.1007/bf01806157
    18 sg:pub.10.1007/bf01806368
    19 sg:pub.10.1007/bf01807281
    20 sg:pub.10.1007/bf01980970
    21 sg:pub.10.1007/pl00000852
    22 sg:pub.10.1007/s00018-002-8460-4
    23 sg:pub.10.1007/s00239-013-9570-3
    24 sg:pub.10.1007/s00280-008-0706-x
    25 sg:pub.10.1007/s00280-009-1112-8
    26 sg:pub.10.1007/s00726-010-0735-8
    27 sg:pub.10.1007/s00726-011-1004-1
    28 sg:pub.10.1007/s00726-011-1014-z
    29 sg:pub.10.1007/s00726-013-1572-3
    30 sg:pub.10.1007/s00726-013-1579-9
    31 sg:pub.10.1007/s00726-013-1621-y
    32 sg:pub.10.1007/s10549-007-9533-8
    33 sg:pub.10.1007/s10549-012-2235-x
    34 sg:pub.10.1007/s11033-013-2847-1
    35 sg:pub.10.1023/a:1005827231849
    36 sg:pub.10.1023/a:1006448516938
    37 sg:pub.10.1023/a:1010697218986
    38 sg:pub.10.1023/a:1014536909007
    39 sg:pub.10.1038/nrc1454
    40 sg:pub.10.1038/nrd2243
    41 sg:pub.10.1186/1471-2148-12-90
    42 sg:pub.10.1186/1471-2407-10-555
    43 sg:pub.10.1186/bcr2889
    44 schema:datePublished 2014-10-08
    45 schema:datePublishedReg 2014-10-08
    46 schema:description Abstract Breast cancer (BC) is a common disease that generally occurs in women over the age of 50, and the risk is especially high for women over 60 years of age. One of the major BC therapeutic problems is that tumors initially responsive to chemotherapeutic approaches can progress to more aggressive forms poorly responsive to therapies. Polyamines (PAs) are small polycationic alkylamines, naturally occurring and essential for normal cell growth and development in eukaryotes. The intracellular concentration of PA is maintained within strongly controlled contents, while a dysregulation occurs in BC cells. Polyamines facilitate the interactions of transcription factors, such as estrogen receptors with their specific response element, and are involved in the proliferation of ER-negative and highly invasive BC tumor cells. Since PA metabolism has a critical role in cell death and proliferation, it represents a potential target for intervention in BC. The goal of this study was to perform a literature search reviewing the association between PA metabolism and BC, and the current evidence supporting the BC treatment targeting PA metabolism. We here describe in vitro and in vivo models, as well as the clinical trials that have been utilized to unveil the relationship between PA metabolism and BC. Polyamine pathway is still an important target for the development of BC chemotherapy via enzyme inhibitors. Furthermore, a recent promising strategy in breast anticancer therapy is to exploit the self-regulatory nature of PA metabolism using PA analogs to affect PA homeostasis. Nowadays, antineoplastic compounds targeting the PA pathway with novel mechanisms are of great interest and high social impact for BC chemotherapy.
    47 schema:genre article
    48 schema:inLanguage en
    49 schema:isAccessibleForFree false
    50 schema:isPartOf N51efce2adc58470b9b669573345d9440
    51 Nc2d100d8a52e4b75a06f46a4fd66efb8
    52 sg:journal.1092777
    53 schema:keywords BC cells
    54 BC chemotherapy
    55 BC therapeutic problems
    56 BC treatment
    57 BC tumor cells
    58 ER
    59 PA analogues
    60 PA homeostasis
    61 PA metabolism
    62 PA pathway
    63 age
    64 aggressive form
    65 alkylamines
    66 analogues
    67 anticancer therapy
    68 antineoplastic compounds
    69 approach
    70 art
    71 association
    72 breast anticancer therapy
    73 breast cancer
    74 cancer
    75 cell death
    76 cell growth
    77 cells
    78 chemotherapeutic approaches
    79 chemotherapy
    80 clinical trials
    81 common disease
    82 compounds
    83 concentration
    84 content
    85 critical role
    86 current evidence
    87 death
    88 development
    89 disease
    90 dysregulation
    91 elements
    92 enzyme inhibitors
    93 estrogen receptor
    94 eukaryotes
    95 evidence
    96 factors
    97 form
    98 goal
    99 great interest
    100 growth
    101 high social impact
    102 homeostasis
    103 impact
    104 important target
    105 inhibitors
    106 interaction
    107 interest
    108 intervention
    109 intracellular concentration
    110 invasive BC tumor cells
    111 literature search
    112 major BC therapeutic problems
    113 mechanism
    114 metabolism
    115 model
    116 nature
    117 normal cell growth
    118 novel mechanism
    119 pathway
    120 perspective
    121 polyamine metabolism
    122 polyamine pathway
    123 polyamines
    124 polycationic alkylamines
    125 potential target
    126 problem
    127 proliferation
    128 proliferation of ER
    129 promising strategy
    130 recent promising strategies
    131 receptors
    132 relationship
    133 response element
    134 risk
    135 role
    136 search
    137 self-regulatory nature
    138 small polycationic alkylamines
    139 social impact
    140 specific response elements
    141 state
    142 strategies
    143 study
    144 target
    145 therapeutic problems
    146 therapy
    147 transcription factors
    148 treatment
    149 trials
    150 tumor cells
    151 tumors
    152 vitro
    153 vivo model
    154 women
    155 years
    156 years of age
    157 schema:name Polyamines metabolism and breast cancer: state of the art and perspectives
    158 schema:pagination 233-248
    159 schema:productId N11bae30528314bc7909b7a372e30a35c
    160 N69a5b29fe49a48d3b5dc0180092ca768
    161 N9fdd65cf65824bd38185c3d169bbb124
    162 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019170611
    163 https://doi.org/10.1007/s10549-014-3156-7
    164 schema:sdDatePublished 2021-11-01T18:23
    165 schema:sdLicense https://scigraph.springernature.com/explorer/license/
    166 schema:sdPublisher N2bb7eb97b8784a7591dcf2f023cc8919
    167 schema:url https://doi.org/10.1007/s10549-014-3156-7
    168 sgo:license sg:explorer/license/
    169 sgo:sdDataset articles
    170 rdf:type schema:ScholarlyArticle
    171 N11bae30528314bc7909b7a372e30a35c schema:name dimensions_id
    172 schema:value pub.1019170611
    173 rdf:type schema:PropertyValue
    174 N1ce5a4a816be46ddbe4fd3ae5b29a461 rdf:first sg:person.01211407014.33
    175 rdf:rest N7afdd7de1bee4641b5a5947b6300cfa1
    176 N2bb7eb97b8784a7591dcf2f023cc8919 schema:name Springer Nature - SN SciGraph project
    177 rdf:type schema:Organization
    178 N306971ef00e749799c84daf2c18b2fdd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    179 schema:name Animals
    180 rdf:type schema:DefinedTerm
    181 N3685735c2b82442695c46e1ae8bd689e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    182 schema:name Female
    183 rdf:type schema:DefinedTerm
    184 N3effab9ecf2345f88ae660b41023c83c rdf:first sg:person.01115316666.31
    185 rdf:rest Nf699df193e1e4b1cbb39905a9ad7941d
    186 N405b0d19df194f81b2d12fbbe5f72ea5 rdf:first sg:person.0723534345.10
    187 rdf:rest N1ce5a4a816be46ddbe4fd3ae5b29a461
    188 N51efce2adc58470b9b669573345d9440 schema:volumeNumber 148
    189 rdf:type schema:PublicationVolume
    190 N5b3c9943d9ca4022834bc36bb76e0d9d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    191 schema:name Antineoplastic Agents
    192 rdf:type schema:DefinedTerm
    193 N69a5b29fe49a48d3b5dc0180092ca768 schema:name doi
    194 schema:value 10.1007/s10549-014-3156-7
    195 rdf:type schema:PropertyValue
    196 N7afdd7de1bee4641b5a5947b6300cfa1 rdf:first sg:person.01231545266.41
    197 rdf:rest rdf:nil
    198 N9fdd65cf65824bd38185c3d169bbb124 schema:name pubmed_id
    199 schema:value 25292420
    200 rdf:type schema:PropertyValue
    201 Nc0e9010b0abb4a3eb79af8ed391633f7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    202 schema:name Humans
    203 rdf:type schema:DefinedTerm
    204 Nc2d100d8a52e4b75a06f46a4fd66efb8 schema:issueNumber 2
    205 rdf:type schema:PublicationIssue
    206 Nd759a0c929b9466abb8dbffc24cd6123 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    207 schema:name Biogenic Polyamines
    208 rdf:type schema:DefinedTerm
    209 Neae534cb9edb4234a4483fb329b3611e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
    210 schema:name Breast Neoplasms
    211 rdf:type schema:DefinedTerm
    212 Nf699df193e1e4b1cbb39905a9ad7941d rdf:first sg:person.01127072652.75
    213 rdf:rest N405b0d19df194f81b2d12fbbe5f72ea5
    214 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
    215 schema:name Medical and Health Sciences
    216 rdf:type schema:DefinedTerm
    217 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
    218 schema:name Oncology and Carcinogenesis
    219 rdf:type schema:DefinedTerm
    220 sg:journal.1092777 schema:issn 0167-6806
    221 1573-7217
    222 schema:name Breast Cancer Research and Treatment
    223 schema:publisher Springer Nature
    224 rdf:type schema:Periodical
    225 sg:person.01115316666.31 schema:affiliation grid-institutes:grid.8509.4
    226 schema:familyName Cervelli
    227 schema:givenName Manuela
    228 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115316666.31
    229 rdf:type schema:Person
    230 sg:person.01127072652.75 schema:affiliation grid-institutes:grid.8509.4
    231 schema:familyName Pietropaoli
    232 schema:givenName Stefano
    233 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01127072652.75
    234 rdf:type schema:Person
    235 sg:person.01211407014.33 schema:affiliation grid-institutes:grid.5196.b
    236 schema:familyName Amendola
    237 schema:givenName Roberto
    238 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211407014.33
    239 rdf:type schema:Person
    240 sg:person.01231545266.41 schema:affiliation grid-institutes:grid.8509.4
    241 schema:familyName Mariottini
    242 schema:givenName Paolo
    243 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01231545266.41
    244 rdf:type schema:Person
    245 sg:person.0723534345.10 schema:affiliation grid-institutes:grid.416308.8
    246 schema:familyName Signore
    247 schema:givenName Fabrizio
    248 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0723534345.10
    249 rdf:type schema:Person
    250 sg:pub.10.1007/978-1-4684-5637-0_60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028502741
    251 https://doi.org/10.1007/978-1-4684-5637-0_60
    252 rdf:type schema:CreativeWork
    253 sg:pub.10.1007/978-1-61779-034-8_1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001004301
    254 https://doi.org/10.1007/978-1-61779-034-8_1
    255 rdf:type schema:CreativeWork
    256 sg:pub.10.1007/bf00179593 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024099426
    257 https://doi.org/10.1007/bf00179593
    258 rdf:type schema:CreativeWork
    259 sg:pub.10.1007/bf00665680 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035508417
    260 https://doi.org/10.1007/bf00665680
    261 rdf:type schema:CreativeWork
    262 sg:pub.10.1007/bf00666490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024234522
    263 https://doi.org/10.1007/bf00666490
    264 rdf:type schema:CreativeWork
    265 sg:pub.10.1007/bf00685735 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005809362
    266 https://doi.org/10.1007/bf00685735
    267 rdf:type schema:CreativeWork
    268 sg:pub.10.1007/bf00873231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032921959
    269 https://doi.org/10.1007/bf00873231
    270 rdf:type schema:CreativeWork
    271 sg:pub.10.1007/bf01806157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050805271
    272 https://doi.org/10.1007/bf01806157
    273 rdf:type schema:CreativeWork
    274 sg:pub.10.1007/bf01806368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000216807
    275 https://doi.org/10.1007/bf01806368
    276 rdf:type schema:CreativeWork
    277 sg:pub.10.1007/bf01807281 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036291018
    278 https://doi.org/10.1007/bf01807281
    279 rdf:type schema:CreativeWork
    280 sg:pub.10.1007/bf01980970 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043194992
    281 https://doi.org/10.1007/bf01980970
    282 rdf:type schema:CreativeWork
    283 sg:pub.10.1007/pl00000852 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041046925
    284 https://doi.org/10.1007/pl00000852
    285 rdf:type schema:CreativeWork
    286 sg:pub.10.1007/s00018-002-8460-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047577622
    287 https://doi.org/10.1007/s00018-002-8460-4
    288 rdf:type schema:CreativeWork
    289 sg:pub.10.1007/s00239-013-9570-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024468454
    290 https://doi.org/10.1007/s00239-013-9570-3
    291 rdf:type schema:CreativeWork
    292 sg:pub.10.1007/s00280-008-0706-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040384030
    293 https://doi.org/10.1007/s00280-008-0706-x
    294 rdf:type schema:CreativeWork
    295 sg:pub.10.1007/s00280-009-1112-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035964935
    296 https://doi.org/10.1007/s00280-009-1112-8
    297 rdf:type schema:CreativeWork
    298 sg:pub.10.1007/s00726-010-0735-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024378998
    299 https://doi.org/10.1007/s00726-010-0735-8
    300 rdf:type schema:CreativeWork
    301 sg:pub.10.1007/s00726-011-1004-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011501803
    302 https://doi.org/10.1007/s00726-011-1004-1
    303 rdf:type schema:CreativeWork
    304 sg:pub.10.1007/s00726-011-1014-z schema:sameAs https://app.dimensions.ai/details/publication/pub.1045735246
    305 https://doi.org/10.1007/s00726-011-1014-z
    306 rdf:type schema:CreativeWork
    307 sg:pub.10.1007/s00726-013-1572-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009437610
    308 https://doi.org/10.1007/s00726-013-1572-3
    309 rdf:type schema:CreativeWork
    310 sg:pub.10.1007/s00726-013-1579-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039086906
    311 https://doi.org/10.1007/s00726-013-1579-9
    312 rdf:type schema:CreativeWork
    313 sg:pub.10.1007/s00726-013-1621-y schema:sameAs https://app.dimensions.ai/details/publication/pub.1023366361
    314 https://doi.org/10.1007/s00726-013-1621-y
    315 rdf:type schema:CreativeWork
    316 sg:pub.10.1007/s10549-007-9533-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020248333
    317 https://doi.org/10.1007/s10549-007-9533-8
    318 rdf:type schema:CreativeWork
    319 sg:pub.10.1007/s10549-012-2235-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1017732737
    320 https://doi.org/10.1007/s10549-012-2235-x
    321 rdf:type schema:CreativeWork
    322 sg:pub.10.1007/s11033-013-2847-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022718043
    323 https://doi.org/10.1007/s11033-013-2847-1
    324 rdf:type schema:CreativeWork
    325 sg:pub.10.1023/a:1005827231849 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000026162
    326 https://doi.org/10.1023/a:1005827231849
    327 rdf:type schema:CreativeWork
    328 sg:pub.10.1023/a:1006448516938 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011013365
    329 https://doi.org/10.1023/a:1006448516938
    330 rdf:type schema:CreativeWork
    331 sg:pub.10.1023/a:1010697218986 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028084261
    332 https://doi.org/10.1023/a:1010697218986
    333 rdf:type schema:CreativeWork
    334 sg:pub.10.1023/a:1014536909007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003756876
    335 https://doi.org/10.1023/a:1014536909007
    336 rdf:type schema:CreativeWork
    337 sg:pub.10.1038/nrc1454 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015480726
    338 https://doi.org/10.1038/nrc1454
    339 rdf:type schema:CreativeWork
    340 sg:pub.10.1038/nrd2243 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024966872
    341 https://doi.org/10.1038/nrd2243
    342 rdf:type schema:CreativeWork
    343 sg:pub.10.1186/1471-2148-12-90 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049387934
    344 https://doi.org/10.1186/1471-2148-12-90
    345 rdf:type schema:CreativeWork
    346 sg:pub.10.1186/1471-2407-10-555 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001773895
    347 https://doi.org/10.1186/1471-2407-10-555
    348 rdf:type schema:CreativeWork
    349 sg:pub.10.1186/bcr2889 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033565721
    350 https://doi.org/10.1186/bcr2889
    351 rdf:type schema:CreativeWork
    352 grid-institutes:grid.416308.8 schema:alternateName Department of Obstetrics and Gynaecology, San Camillo Hospital, 00149, Rome, Italy
    353 schema:name Department of Obstetrics and Gynaecology, San Camillo Hospital, 00149, Rome, Italy
    354 rdf:type schema:Organization
    355 grid-institutes:grid.5196.b schema:alternateName UT BIORAD RAB, ENEA, 00123, Rome, Italy
    356 schema:name UT BIORAD RAB, ENEA, 00123, Rome, Italy
    357 rdf:type schema:Organization
    358 grid-institutes:grid.8509.4 schema:alternateName Department of Sciences, University “Roma Tre”, Viale G. Marconi 446, 00146, Rome, Italy
    359 schema:name Department of Sciences, University “Roma Tre”, Viale G. Marconi 446, 00146, Rome, Italy
    360 rdf:type schema:Organization
     




    Preview window. Press ESC to close (or click here)


    ...