Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-08

AUTHORS

P. Pujol, D. Stoppa Lyonnet, T. Frebourg, J. Blin, M. C. Picot, C. Lasset, C. Dugast, P. Berthet, B. Bressac de Paillerets, H. Sobol, S. Grandjouan, F. Soubrier, B. Buecher, R. Guimbaud, R. Lidereau, P. Jonveaux, C. Houdayer, S. Giraud, S. Olschwang, E. Nogue, V. Galibert, C. Bara, F. Nowak, D. Khayat, C. Nogues

ABSTRACT

Based on nationwide data from the French national cancer institute (INCa), we analyzed the evolution of cancer genetics consultations and testing over time, and the uptake of targeted tests in relatives of families with BRCA1/2 or MMR genes mutation. Genetic testing and consultations for familial high-risk individuals are exclusively funded and monitored by the INCa in France. All nationwide cancer genetics centers reported annually standardized parameters of activity from 2003 to 2011. The analysis included a total of 240,134 consultations and 134,652 genetic tests enabling to identify 32,494 mutation carriers. Referral for hereditary breast and ovarian cancer (HBOC) or colorectal cancer predisposition syndromes represented 59 % (141,639) and 23.2 % (55,698) consultations, respectively. From 2003 to 2011, we found a dramatic and steady increase of tests performed for BRCA1/2 (from 2,095 to 7,393 tests/year, P < 0.0001) but not for MMR genes (from 1,144 to 1,635/year, P = NS). The overall percentage of deleterious mutations identified in the probands tested was 13.8 and 20.9 % in HBOC and Lynch syndromes, respectively. Pooled analysis for BRCA1/2 and Lynch syndrome tests showed an inverse relationship between the percentage of mutation detected and the absolute number of tests performed over the time (overall Cochran-Armitage test for trend: P < 0.001). In families with BRCA1/2 or MMR identified mutations, there was an average number of 2.94 and 3.28 relatives performing targeted tests, respectively. This nationwide study shows a lack of referral and genetic testing in Lynch as compared to HBOC syndromes. Only a third of relatives of a proband with a predisposing mutation performed a targeted test. Enhanced information about benefit of genetic testing should be given to clinicians and patients for Lynch syndrome and relatives of a proband carrying an identified predisposing mutation. More... »

PAGES

135-144

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-013-2669-9

DOI

http://dx.doi.org/10.1007/s10549-013-2669-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1036166099

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23974829


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adaptor Proteins, Signal Transducing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cancer Care Facilities", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colorectal Neoplasms, Hereditary Nonpolyposis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mismatch Repair", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA-Binding Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Family Health", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "France", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Carrier Screening", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Counseling", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Testing", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Laboratories", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MutL Protein Homolog 1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "MutS Homolog 2 Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplastic Syndromes, Hereditary", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Ovarian Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Referral and Consultation", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University Hospital of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.157868.5", 
          "name": [
            "Centre Hospitalier Universitaire de Montpellier, Montpellier, France", 
            "INSERM 896, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pujol", 
        "givenName": "P.", 
        "id": "sg:person.01173341502.91", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173341502.91"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Institut Curie, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lyonnet", 
        "givenName": "D. Stoppa", 
        "id": "sg:person.01317742302.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317742302.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Charles-Nicolle", 
          "id": "https://www.grid.ac/institutes/grid.417615.0", 
          "name": [
            "Service d\u2019Oncog\u00e9n\u00e9tique, Centre Hospitalier Universitaire de Rouen, Rouen, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Frebourg", 
        "givenName": "T.", 
        "id": "sg:person.01352525620.40", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352525620.40"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re des Affaires sociales et de la Sant\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.418199.c", 
          "name": [
            "Institut National du Cancer, Boulogne-Billancourt, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Blin", 
        "givenName": "J.", 
        "id": "sg:person.01074452375.16", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074452375.16"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.157868.5", 
          "name": [
            "Centre Hospitalier Universitaire de Montpellier, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Picot", 
        "givenName": "M. C.", 
        "id": "sg:person.0604267733.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604267733.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre L\u00e9on B\u00e9rard", 
          "id": "https://www.grid.ac/institutes/grid.418116.b", 
          "name": [
            "Centre L\u00e9on B\u00e9rard, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lasset", 
        "givenName": "C.", 
        "id": "sg:person.01235147631.62", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235147631.62"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Eug\u00e8ne Marquis", 
          "id": "https://www.grid.ac/institutes/grid.417988.b", 
          "name": [
            "Centre Eug\u00e8ne Marquis, Rennes, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dugast", 
        "givenName": "C.", 
        "id": "sg:person.0600451421.85", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600451421.85"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "UniCancer Group", 
          "id": "https://www.grid.ac/institutes/grid.418189.d", 
          "name": [
            "Centre Fran\u00e7ois Baclesse, Caen, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Berthet", 
        "givenName": "P.", 
        "id": "sg:person.01032654762.41", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032654762.41"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Gustave Roussy", 
          "id": "https://www.grid.ac/institutes/grid.14925.3b", 
          "name": [
            "Institut Gustave Roussy, Villejuif, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "de Paillerets", 
        "givenName": "B. Bressac", 
        "id": "sg:person.0627053763.13", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627053763.13"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Paoli-Calmettes", 
          "id": "https://www.grid.ac/institutes/grid.418443.e", 
          "name": [
            "Institut Paoli Calmettes, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sobol", 
        "givenName": "H.", 
        "id": "sg:person.0730711015.53", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730711015.53"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Cochin", 
          "id": "https://www.grid.ac/institutes/grid.411784.f", 
          "name": [
            "H\u00f4pital Cochin, AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grandjouan", 
        "givenName": "S.", 
        "id": "sg:person.01370642043.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370642043.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "H\u00f4pital Piti\u00e9 Salp\u00e9tri\u00e8re, AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Soubrier", 
        "givenName": "F.", 
        "id": "sg:person.01031010714.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031010714.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital Europ\u00e9en Georges-Pompidou", 
          "id": "https://www.grid.ac/institutes/grid.414093.b", 
          "name": [
            "Institut Curie, Paris, France", 
            "H\u00f4pital Europ\u00e9en Georges Pompidou, AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Buecher", 
        "givenName": "B.", 
        "id": "sg:person.01317547512.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317547512.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institut Claudius Regaud", 
          "id": "https://www.grid.ac/institutes/grid.417829.1", 
          "name": [
            "Institut Claudius R\u00e9gaud, Toulouse, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Guimbaud", 
        "givenName": "R.", 
        "id": "sg:person.0750667273.97", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750667273.97"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Institut Curie, Saint-Cloud, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lidereau", 
        "givenName": "R.", 
        "id": "sg:person.01144241361.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144241361.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Centre Hospitalier Universitaire de Nancy", 
          "id": "https://www.grid.ac/institutes/grid.410527.5", 
          "name": [
            "Centre Hospitalier Universitaire de Nancy, Nancy, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jonveaux", 
        "givenName": "P.", 
        "id": "sg:person.01201435025.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201435025.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Institut Curie, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Houdayer", 
        "givenName": "C.", 
        "id": "sg:person.0670312346.56", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670312346.56"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital \u00c9douard-Herriot", 
          "id": "https://www.grid.ac/institutes/grid.412180.e", 
          "name": [
            "H\u00f4pital Edouard Herriot, Lyon, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giraud", 
        "givenName": "S.", 
        "id": "sg:person.01365561357.22", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365561357.22"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "H\u00f4pital de la Timone", 
          "id": "https://www.grid.ac/institutes/grid.411266.6", 
          "name": [
            "H\u00f4pital La Timone, AP-HM, Marseille, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Olschwang", 
        "givenName": "S.", 
        "id": "sg:person.0713446061.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713446061.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.157868.5", 
          "name": [
            "Centre Hospitalier Universitaire de Montpellier, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nogue", 
        "givenName": "E.", 
        "id": "sg:person.0703633223.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703633223.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Montpellier", 
          "id": "https://www.grid.ac/institutes/grid.157868.5", 
          "name": [
            "Centre Hospitalier Universitaire de Montpellier, Montpellier, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Galibert", 
        "givenName": "V.", 
        "id": "sg:person.0721612775.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721612775.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re des Affaires sociales et de la Sant\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.418199.c", 
          "name": [
            "Institut National du Cancer, Boulogne-Billancourt, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bara", 
        "givenName": "C.", 
        "id": "sg:person.0767726175.68", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767726175.68"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Minist\u00e8re des Affaires sociales et de la Sant\u00e9", 
          "id": "https://www.grid.ac/institutes/grid.418199.c", 
          "name": [
            "Institut National du Cancer, Boulogne-Billancourt, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nowak", 
        "givenName": "F.", 
        "id": "sg:person.01213511575.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213511575.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Piti\u00e9-Salp\u00eatri\u00e8re Hospital", 
          "id": "https://www.grid.ac/institutes/grid.411439.a", 
          "name": [
            "Institut National du Cancer, Boulogne-Billancourt, France", 
            "H\u00f4pital Piti\u00e9 Salp\u00e9tri\u00e8re, AP-HP, Paris, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Khayat", 
        "givenName": "D.", 
        "id": "sg:person.0701560574.65", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701560574.65"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute Curie", 
          "id": "https://www.grid.ac/institutes/grid.418596.7", 
          "name": [
            "Institut Curie, Saint-Cloud, France"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nogues", 
        "givenName": "C.", 
        "id": "sg:person.01326716022.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326716022.60"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1097/01.gim.0000086477.00766.c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002316523", 
          "https://doi.org/10.1097/01.gim.0000086477.00766.c9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/01.gim.0000086477.00766.c9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002316523", 
          "https://doi.org/10.1097/01.gim.0000086477.00766.c9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002331489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/375033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002331489"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0399-8320(05)82159-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003454177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2011.01788.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003638836"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gco.0b013e32801195da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003663344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gco.0b013e32801195da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003663344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gco.0b013e32801195da", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003663344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.amepre.2010.09.027", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004337173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cgh.2010.03.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004869786"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.04.188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004923574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2008.01146.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005250492"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006256853", 
          "https://doi.org/10.1038/ng.586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng.586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006256853", 
          "https://doi.org/10.1038/ng.586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10689-006-9114-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011560997", 
          "https://doi.org/10.1007/s10689-006-9114-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-10-0325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011824912"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-05-0002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012223449"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.7784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014351293"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e3181da08d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015069224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/aog.0b013e3181da08d7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015069224"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.296.12.1507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019575764"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1318.2009.01898.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023165311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1463-1318.2009.01898.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023165311"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2010.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023388209", 
          "https://doi.org/10.1038/nrclinonc.2010.166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrclinonc.2010.166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023388209", 
          "https://doi.org/10.1038/nrclinonc.2010.166"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/aje/kwf139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029342239"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032400871"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0043994", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034264999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmcp071286", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034851725"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10269-011-2074-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038224294", 
          "https://doi.org/10.1007/s10269-011-2074-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26166", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039772235"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604830", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040036207", 
          "https://doi.org/10.1038/sj.bjc.6604830"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2009.01230.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043586216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1399-0004.2009.01230.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043586216"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/gim.0b013e3181d38f2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043662043", 
          "https://doi.org/10.1097/gim.0b013e3181d38f2f"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1097/gim.0b013e3181d38f2f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043662043", 
          "https://doi.org/10.1097/gim.0b013e3181d38f2f"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.295.12.1379", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045252160"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(05)70394-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047012056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10897-012-9531-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049696807", 
          "https://doi.org/10.1007/s10897-012-9531-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ajmg.a.32643", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049789995"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.01.7541", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051429338"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.1997.03550150046034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052044615"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrc2054", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052051499", 
          "https://doi.org/10.1038/nrc2054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3001616", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070163897"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2307/3001775", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070164004"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2000.18.11.2193", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1074645666"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076846307", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076863923", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1684/bdc.2009.0943", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077956436"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1078354258", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082815803", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-08", 
    "datePublishedReg": "2013-08-01", 
    "description": "Based on nationwide data from the French national cancer institute (INCa), we analyzed the evolution of cancer genetics consultations and testing over time, and the uptake of targeted tests in relatives of families with BRCA1/2 or MMR genes mutation. Genetic testing and consultations for familial high-risk individuals are exclusively funded and monitored by the INCa in France. All nationwide cancer genetics centers reported annually standardized parameters of activity from 2003 to 2011. The analysis included a total of 240,134 consultations and 134,652 genetic tests enabling to identify 32,494 mutation carriers. Referral for hereditary breast and ovarian cancer (HBOC) or colorectal cancer predisposition syndromes represented 59 % (141,639) and 23.2 % (55,698) consultations, respectively. From 2003 to 2011, we found a dramatic and steady increase of tests performed for BRCA1/2 (from 2,095 to 7,393 tests/year, P < 0.0001) but not for MMR genes (from 1,144 to 1,635/year, P = NS). The overall percentage of deleterious mutations identified in the probands tested was 13.8 and 20.9 % in HBOC and Lynch syndromes, respectively. Pooled analysis for BRCA1/2 and Lynch syndrome tests showed an inverse relationship between the percentage of mutation detected and the absolute number of tests performed over the time (overall Cochran-Armitage test for trend: P < 0.001). In families with BRCA1/2 or MMR identified mutations, there was an average number of 2.94 and 3.28 relatives performing targeted tests, respectively. This nationwide study shows a lack of referral and genetic testing in Lynch as compared to HBOC syndromes. Only a third of relatives of a proband with a predisposing mutation performed a targeted test. Enhanced information about benefit of genetic testing should be given to clinicians and patients for Lynch syndrome and relatives of a proband carrying an identified predisposing mutation.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-013-2669-9", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "141"
      }
    ], 
    "name": "Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests", 
    "pagination": "135-144", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ac481b2a37328118cbf64f60f99e6eda92b93a57e625b1523db519f785a9bdce"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23974829"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-013-2669-9"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1036166099"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-013-2669-9", 
      "https://app.dimensions.ai/details/publication/pub.1036166099"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T15:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8664_00000514.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10549-013-2669-9"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2669-9'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2669-9'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2669-9'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2669-9'


 

This table displays all metadata directly associated to this object as RDF triples.

517 TRIPLES      21 PREDICATES      96 URIs      46 LITERALS      34 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-013-2669-9 schema:about N0ce861e63bef42dd896e21c2ce399cdb
2 N0d506a0c332246f29e012113a34b843f
3 N1a52038f818b4f32a6b2fdcddd64eddf
4 N2125edac440a441f8d5c657fa6a6b9cd
5 N31ed60e906a24b99978145ac7423d7b3
6 N39b5ee4ec4c642e3abbafc0daa325de6
7 N43fcfdb083a54b35bd2ed5e58c6df8fd
8 N53ba75a5fe74436db4cde4cccf97b6bd
9 N596f61fbd331445e89df3cfaa57a1ed0
10 N5cb50d4add32413d8a557dac8e0b53c1
11 N67a6369affc2470f9c7f82348a668207
12 N6ebd4155211b4ee28e8b8c78efd55737
13 N70c95866e4334e7bb83794a4ded8ff82
14 N7875511a0dc849038b8fb4423fbb41a6
15 N87ba8a7cd9f845218a19d6a75e8276c5
16 N87ed9048bf304ca6b170e22ad0b984b1
17 N9802dc01ba0249178f5232ec95f4b466
18 N99c953cc547a4d84876dd6356c9bca18
19 Na4ef58a6209b42abb28237a6985492df
20 Na63063988bd141089014ece47771d2b7
21 Na8eabc3b57d748beb5a8a1ad5094b081
22 Naa4046fb01e54f10a1383081b9820100
23 Nad9074661f614852af90cb01183a4022
24 Nb3a2ee236a5b4643be81549a858014b2
25 Nd390f3f25ecb42b189bbd48c292f80fb
26 anzsrc-for:11
27 anzsrc-for:1112
28 schema:author Ncf6be0804af94749a6303084f203f33c
29 schema:citation sg:pub.10.1007/s10269-011-2074-4
30 sg:pub.10.1007/s10689-006-9114-8
31 sg:pub.10.1007/s10897-012-9531-9
32 sg:pub.10.1038/ng.586
33 sg:pub.10.1038/nrc2054
34 sg:pub.10.1038/nrclinonc.2010.166
35 sg:pub.10.1038/sj.bjc.6604830
36 sg:pub.10.1097/01.gim.0000086477.00766.c9
37 sg:pub.10.1097/gim.0b013e3181d38f2f
38 https://app.dimensions.ai/details/publication/pub.1076846307
39 https://app.dimensions.ai/details/publication/pub.1076863923
40 https://app.dimensions.ai/details/publication/pub.1078354258
41 https://app.dimensions.ai/details/publication/pub.1082815803
42 https://doi.org/10.1001/jama.1997.03550150046034
43 https://doi.org/10.1001/jama.295.12.1379
44 https://doi.org/10.1001/jama.296.12.1507
45 https://doi.org/10.1002/ajmg.a.32643
46 https://doi.org/10.1002/cncr.24200
47 https://doi.org/10.1002/cncr.26166
48 https://doi.org/10.1016/j.amepre.2010.09.027
49 https://doi.org/10.1016/j.cgh.2010.03.010
50 https://doi.org/10.1016/s0140-6736(05)70394-9
51 https://doi.org/10.1016/s0399-8320(05)82159-1
52 https://doi.org/10.1056/nejmcp071286
53 https://doi.org/10.1086/375033
54 https://doi.org/10.1093/aje/kwf139
55 https://doi.org/10.1097/aog.0b013e3181da08d7
56 https://doi.org/10.1097/gco.0b013e32801195da
57 https://doi.org/10.1111/j.1399-0004.2008.01146.x
58 https://doi.org/10.1111/j.1399-0004.2009.01230.x
59 https://doi.org/10.1111/j.1399-0004.2011.01788.x
60 https://doi.org/10.1111/j.1463-1318.2009.01898.x
61 https://doi.org/10.1158/1055-9965.epi-05-0002
62 https://doi.org/10.1158/1055-9965.epi-10-0325
63 https://doi.org/10.1200/jco.2000.18.11.2193
64 https://doi.org/10.1200/jco.2004.04.188
65 https://doi.org/10.1200/jco.2005.01.7541
66 https://doi.org/10.1200/jco.2009.23.7784
67 https://doi.org/10.1371/journal.pone.0043994
68 https://doi.org/10.1684/bdc.2009.0943
69 https://doi.org/10.2307/3001616
70 https://doi.org/10.2307/3001775
71 schema:datePublished 2013-08
72 schema:datePublishedReg 2013-08-01
73 schema:description Based on nationwide data from the French national cancer institute (INCa), we analyzed the evolution of cancer genetics consultations and testing over time, and the uptake of targeted tests in relatives of families with BRCA1/2 or MMR genes mutation. Genetic testing and consultations for familial high-risk individuals are exclusively funded and monitored by the INCa in France. All nationwide cancer genetics centers reported annually standardized parameters of activity from 2003 to 2011. The analysis included a total of 240,134 consultations and 134,652 genetic tests enabling to identify 32,494 mutation carriers. Referral for hereditary breast and ovarian cancer (HBOC) or colorectal cancer predisposition syndromes represented 59 % (141,639) and 23.2 % (55,698) consultations, respectively. From 2003 to 2011, we found a dramatic and steady increase of tests performed for BRCA1/2 (from 2,095 to 7,393 tests/year, P < 0.0001) but not for MMR genes (from 1,144 to 1,635/year, P = NS). The overall percentage of deleterious mutations identified in the probands tested was 13.8 and 20.9 % in HBOC and Lynch syndromes, respectively. Pooled analysis for BRCA1/2 and Lynch syndrome tests showed an inverse relationship between the percentage of mutation detected and the absolute number of tests performed over the time (overall Cochran-Armitage test for trend: P < 0.001). In families with BRCA1/2 or MMR identified mutations, there was an average number of 2.94 and 3.28 relatives performing targeted tests, respectively. This nationwide study shows a lack of referral and genetic testing in Lynch as compared to HBOC syndromes. Only a third of relatives of a proband with a predisposing mutation performed a targeted test. Enhanced information about benefit of genetic testing should be given to clinicians and patients for Lynch syndrome and relatives of a proband carrying an identified predisposing mutation.
74 schema:genre research_article
75 schema:inLanguage en
76 schema:isAccessibleForFree false
77 schema:isPartOf N0808bee5a4c44e05959d5a3eaeb096dd
78 N2d06566be691472084ff2c1ee5e08595
79 sg:journal.1092777
80 schema:name Lack of referral for genetic counseling and testing in BRCA1/2 and Lynch syndromes: a nationwide study based on 240,134 consultations and 134,652 genetic tests
81 schema:pagination 135-144
82 schema:productId N253c804352ee48258628167a416b7469
83 N39accfb60d7f471fb13db3cbc8535445
84 N447aa9c983c14faaa9558761471aafd8
85 Nc40f921567c346ee9b4b2b25bb235f81
86 Nc551b9ac845a48a8870ba337bf9e7449
87 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036166099
88 https://doi.org/10.1007/s10549-013-2669-9
89 schema:sdDatePublished 2019-04-10T15:52
90 schema:sdLicense https://scigraph.springernature.com/explorer/license/
91 schema:sdPublisher Na0f9b59326334a49aea75aa6cbb1b1a8
92 schema:url http://link.springer.com/10.1007%2Fs10549-013-2669-9
93 sgo:license sg:explorer/license/
94 sgo:sdDataset articles
95 rdf:type schema:ScholarlyArticle
96 N0808bee5a4c44e05959d5a3eaeb096dd schema:volumeNumber 141
97 rdf:type schema:PublicationVolume
98 N0ce861e63bef42dd896e21c2ce399cdb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Neoplastic Syndromes, Hereditary
100 rdf:type schema:DefinedTerm
101 N0d506a0c332246f29e012113a34b843f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Cancer Care Facilities
103 rdf:type schema:DefinedTerm
104 N199dc5d7abeb4228b3168d89d21506ae rdf:first sg:person.01031010714.57
105 rdf:rest Nc6a1a89a1edf42a1b54b4eec5848b0f8
106 N1a52038f818b4f32a6b2fdcddd64eddf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
107 schema:name Colorectal Neoplasms, Hereditary Nonpolyposis
108 rdf:type schema:DefinedTerm
109 N1bcd6f0bead24ddaa447adf0f7ae651f rdf:first sg:person.0670312346.56
110 rdf:rest N80c9bd28886546ad9b9f10deae1b0e4e
111 N1f0f5645baac43dbaae3af6bff656ea2 rdf:first sg:person.0701560574.65
112 rdf:rest N8057d12174cc4cf0b20e53d0e5880ff8
113 N2125edac440a441f8d5c657fa6a6b9cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Family Health
115 rdf:type schema:DefinedTerm
116 N2247ba76ea1d4ad592556df79ecbcff2 rdf:first sg:person.0703633223.07
117 rdf:rest N3400b0a26e7542888cf9aca0b2c1b5a3
118 N253c804352ee48258628167a416b7469 schema:name dimensions_id
119 schema:value pub.1036166099
120 rdf:type schema:PropertyValue
121 N2d06566be691472084ff2c1ee5e08595 schema:issueNumber 1
122 rdf:type schema:PublicationIssue
123 N31ed60e906a24b99978145ac7423d7b3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Mutation
125 rdf:type schema:DefinedTerm
126 N3400b0a26e7542888cf9aca0b2c1b5a3 rdf:first sg:person.0721612775.93
127 rdf:rest N6a6dfb74d2b740f7b5ed94a76775e89d
128 N38c1d695acd34cf380dd3c797fe3bd66 rdf:first sg:person.01213511575.30
129 rdf:rest N1f0f5645baac43dbaae3af6bff656ea2
130 N39accfb60d7f471fb13db3cbc8535445 schema:name nlm_unique_id
131 schema:value 8111104
132 rdf:type schema:PropertyValue
133 N39b5ee4ec4c642e3abbafc0daa325de6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Genes, BRCA1
135 rdf:type schema:DefinedTerm
136 N3fc0415212124e818d97c27a8165fa64 rdf:first sg:person.01032654762.41
137 rdf:rest N94c4a1c02fb745528dcdd77529b822e3
138 N40558aa71b794b5e85a40f603975076d rdf:first sg:person.01370642043.05
139 rdf:rest N199dc5d7abeb4228b3168d89d21506ae
140 N43fcfdb083a54b35bd2ed5e58c6df8fd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Genetic Counseling
142 rdf:type schema:DefinedTerm
143 N447aa9c983c14faaa9558761471aafd8 schema:name readcube_id
144 schema:value ac481b2a37328118cbf64f60f99e6eda92b93a57e625b1523db519f785a9bdce
145 rdf:type schema:PropertyValue
146 N53ba75a5fe74436db4cde4cccf97b6bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Laboratories
148 rdf:type schema:DefinedTerm
149 N596f61fbd331445e89df3cfaa57a1ed0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
150 schema:name Nuclear Proteins
151 rdf:type schema:DefinedTerm
152 N5b825d55a26c49e9a14448d3ec11694d rdf:first sg:person.0750667273.97
153 rdf:rest Nabb0c9474cbc4292b8c471172202eeba
154 N5cb50d4add32413d8a557dac8e0b53c1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name DNA Mutational Analysis
156 rdf:type schema:DefinedTerm
157 N67a6369affc2470f9c7f82348a668207 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Female
159 rdf:type schema:DefinedTerm
160 N6a6dfb74d2b740f7b5ed94a76775e89d rdf:first sg:person.0767726175.68
161 rdf:rest N38c1d695acd34cf380dd3c797fe3bd66
162 N6ebd4155211b4ee28e8b8c78efd55737 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
163 schema:name MutL Protein Homolog 1
164 rdf:type schema:DefinedTerm
165 N70c95866e4334e7bb83794a4ded8ff82 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Ovarian Neoplasms
167 rdf:type schema:DefinedTerm
168 N7875511a0dc849038b8fb4423fbb41a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Genes, BRCA2
170 rdf:type schema:DefinedTerm
171 N7bf8ff60ef484f56857023de5d43993c rdf:first sg:person.01201435025.87
172 rdf:rest N1bcd6f0bead24ddaa447adf0f7ae651f
173 N8057d12174cc4cf0b20e53d0e5880ff8 rdf:first sg:person.01326716022.60
174 rdf:rest rdf:nil
175 N807d8c6878934dfe89ec92a96076ab1c rdf:first sg:person.01074452375.16
176 rdf:rest Na4575a00091a40c8a5f46669db81d6fd
177 N80c9bd28886546ad9b9f10deae1b0e4e rdf:first sg:person.01365561357.22
178 rdf:rest N8d70c815e5c44cfe85d6e09a3f7ec0c2
179 N87ba8a7cd9f845218a19d6a75e8276c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name DNA-Binding Proteins
181 rdf:type schema:DefinedTerm
182 N87ed9048bf304ca6b170e22ad0b984b1 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name DNA Mismatch Repair
184 rdf:type schema:DefinedTerm
185 N8d70c815e5c44cfe85d6e09a3f7ec0c2 rdf:first sg:person.0713446061.52
186 rdf:rest N2247ba76ea1d4ad592556df79ecbcff2
187 N917bb70456ad418a8f3c60335fca95a0 rdf:first sg:person.01317742302.15
188 rdf:rest Ncc697f7fc5ed4c6383ce80f2ca43fd7a
189 N94c4a1c02fb745528dcdd77529b822e3 rdf:first sg:person.0627053763.13
190 rdf:rest Nc6015446ac084b7cb224c155e6272175
191 N9802dc01ba0249178f5232ec95f4b466 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
192 schema:name Genetic Carrier Screening
193 rdf:type schema:DefinedTerm
194 N99c953cc547a4d84876dd6356c9bca18 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Genetic Testing
196 rdf:type schema:DefinedTerm
197 Na0f9b59326334a49aea75aa6cbb1b1a8 schema:name Springer Nature - SN SciGraph project
198 rdf:type schema:Organization
199 Na4575a00091a40c8a5f46669db81d6fd rdf:first sg:person.0604267733.93
200 rdf:rest Nfdde28f1890045b5ad5ba195775ecb7b
201 Na4ef58a6209b42abb28237a6985492df schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Male
203 rdf:type schema:DefinedTerm
204 Na63063988bd141089014ece47771d2b7 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
205 schema:name France
206 rdf:type schema:DefinedTerm
207 Na8eabc3b57d748beb5a8a1ad5094b081 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Referral and Consultation
209 rdf:type schema:DefinedTerm
210 Naa4046fb01e54f10a1383081b9820100 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name MutS Homolog 2 Protein
212 rdf:type schema:DefinedTerm
213 Nabb0c9474cbc4292b8c471172202eeba rdf:first sg:person.01144241361.34
214 rdf:rest N7bf8ff60ef484f56857023de5d43993c
215 Nad9074661f614852af90cb01183a4022 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
216 schema:name Adaptor Proteins, Signal Transducing
217 rdf:type schema:DefinedTerm
218 Nb3a2ee236a5b4643be81549a858014b2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
219 schema:name Humans
220 rdf:type schema:DefinedTerm
221 Nc40f921567c346ee9b4b2b25bb235f81 schema:name doi
222 schema:value 10.1007/s10549-013-2669-9
223 rdf:type schema:PropertyValue
224 Nc5070d051def418dbb9bbe7b7c80f859 rdf:first sg:person.0600451421.85
225 rdf:rest N3fc0415212124e818d97c27a8165fa64
226 Nc551b9ac845a48a8870ba337bf9e7449 schema:name pubmed_id
227 schema:value 23974829
228 rdf:type schema:PropertyValue
229 Nc6015446ac084b7cb224c155e6272175 rdf:first sg:person.0730711015.53
230 rdf:rest N40558aa71b794b5e85a40f603975076d
231 Nc6a1a89a1edf42a1b54b4eec5848b0f8 rdf:first sg:person.01317547512.52
232 rdf:rest N5b825d55a26c49e9a14448d3ec11694d
233 Ncc697f7fc5ed4c6383ce80f2ca43fd7a rdf:first sg:person.01352525620.40
234 rdf:rest N807d8c6878934dfe89ec92a96076ab1c
235 Ncf6be0804af94749a6303084f203f33c rdf:first sg:person.01173341502.91
236 rdf:rest N917bb70456ad418a8f3c60335fca95a0
237 Nd390f3f25ecb42b189bbd48c292f80fb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
238 schema:name Breast Neoplasms
239 rdf:type schema:DefinedTerm
240 Nfdde28f1890045b5ad5ba195775ecb7b rdf:first sg:person.01235147631.62
241 rdf:rest Nc5070d051def418dbb9bbe7b7c80f859
242 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
243 schema:name Medical and Health Sciences
244 rdf:type schema:DefinedTerm
245 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
246 schema:name Oncology and Carcinogenesis
247 rdf:type schema:DefinedTerm
248 sg:journal.1092777 schema:issn 0167-6806
249 1573-7217
250 schema:name Breast Cancer Research and Treatment
251 rdf:type schema:Periodical
252 sg:person.01031010714.57 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
253 schema:familyName Soubrier
254 schema:givenName F.
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01031010714.57
256 rdf:type schema:Person
257 sg:person.01032654762.41 schema:affiliation https://www.grid.ac/institutes/grid.418189.d
258 schema:familyName Berthet
259 schema:givenName P.
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032654762.41
261 rdf:type schema:Person
262 sg:person.01074452375.16 schema:affiliation https://www.grid.ac/institutes/grid.418199.c
263 schema:familyName Blin
264 schema:givenName J.
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01074452375.16
266 rdf:type schema:Person
267 sg:person.01144241361.34 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
268 schema:familyName Lidereau
269 schema:givenName R.
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144241361.34
271 rdf:type schema:Person
272 sg:person.01173341502.91 schema:affiliation https://www.grid.ac/institutes/grid.157868.5
273 schema:familyName Pujol
274 schema:givenName P.
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01173341502.91
276 rdf:type schema:Person
277 sg:person.01201435025.87 schema:affiliation https://www.grid.ac/institutes/grid.410527.5
278 schema:familyName Jonveaux
279 schema:givenName P.
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01201435025.87
281 rdf:type schema:Person
282 sg:person.01213511575.30 schema:affiliation https://www.grid.ac/institutes/grid.418199.c
283 schema:familyName Nowak
284 schema:givenName F.
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01213511575.30
286 rdf:type schema:Person
287 sg:person.01235147631.62 schema:affiliation https://www.grid.ac/institutes/grid.418116.b
288 schema:familyName Lasset
289 schema:givenName C.
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01235147631.62
291 rdf:type schema:Person
292 sg:person.01317547512.52 schema:affiliation https://www.grid.ac/institutes/grid.414093.b
293 schema:familyName Buecher
294 schema:givenName B.
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317547512.52
296 rdf:type schema:Person
297 sg:person.01317742302.15 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
298 schema:familyName Lyonnet
299 schema:givenName D. Stoppa
300 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01317742302.15
301 rdf:type schema:Person
302 sg:person.01326716022.60 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
303 schema:familyName Nogues
304 schema:givenName C.
305 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01326716022.60
306 rdf:type schema:Person
307 sg:person.01352525620.40 schema:affiliation https://www.grid.ac/institutes/grid.417615.0
308 schema:familyName Frebourg
309 schema:givenName T.
310 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352525620.40
311 rdf:type schema:Person
312 sg:person.01365561357.22 schema:affiliation https://www.grid.ac/institutes/grid.412180.e
313 schema:familyName Giraud
314 schema:givenName S.
315 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01365561357.22
316 rdf:type schema:Person
317 sg:person.01370642043.05 schema:affiliation https://www.grid.ac/institutes/grid.411784.f
318 schema:familyName Grandjouan
319 schema:givenName S.
320 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370642043.05
321 rdf:type schema:Person
322 sg:person.0600451421.85 schema:affiliation https://www.grid.ac/institutes/grid.417988.b
323 schema:familyName Dugast
324 schema:givenName C.
325 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0600451421.85
326 rdf:type schema:Person
327 sg:person.0604267733.93 schema:affiliation https://www.grid.ac/institutes/grid.157868.5
328 schema:familyName Picot
329 schema:givenName M. C.
330 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604267733.93
331 rdf:type schema:Person
332 sg:person.0627053763.13 schema:affiliation https://www.grid.ac/institutes/grid.14925.3b
333 schema:familyName de Paillerets
334 schema:givenName B. Bressac
335 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0627053763.13
336 rdf:type schema:Person
337 sg:person.0670312346.56 schema:affiliation https://www.grid.ac/institutes/grid.418596.7
338 schema:familyName Houdayer
339 schema:givenName C.
340 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670312346.56
341 rdf:type schema:Person
342 sg:person.0701560574.65 schema:affiliation https://www.grid.ac/institutes/grid.411439.a
343 schema:familyName Khayat
344 schema:givenName D.
345 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0701560574.65
346 rdf:type schema:Person
347 sg:person.0703633223.07 schema:affiliation https://www.grid.ac/institutes/grid.157868.5
348 schema:familyName Nogue
349 schema:givenName E.
350 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0703633223.07
351 rdf:type schema:Person
352 sg:person.0713446061.52 schema:affiliation https://www.grid.ac/institutes/grid.411266.6
353 schema:familyName Olschwang
354 schema:givenName S.
355 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0713446061.52
356 rdf:type schema:Person
357 sg:person.0721612775.93 schema:affiliation https://www.grid.ac/institutes/grid.157868.5
358 schema:familyName Galibert
359 schema:givenName V.
360 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721612775.93
361 rdf:type schema:Person
362 sg:person.0730711015.53 schema:affiliation https://www.grid.ac/institutes/grid.418443.e
363 schema:familyName Sobol
364 schema:givenName H.
365 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0730711015.53
366 rdf:type schema:Person
367 sg:person.0750667273.97 schema:affiliation https://www.grid.ac/institutes/grid.417829.1
368 schema:familyName Guimbaud
369 schema:givenName R.
370 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0750667273.97
371 rdf:type schema:Person
372 sg:person.0767726175.68 schema:affiliation https://www.grid.ac/institutes/grid.418199.c
373 schema:familyName Bara
374 schema:givenName C.
375 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767726175.68
376 rdf:type schema:Person
377 sg:pub.10.1007/s10269-011-2074-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038224294
378 https://doi.org/10.1007/s10269-011-2074-4
379 rdf:type schema:CreativeWork
380 sg:pub.10.1007/s10689-006-9114-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011560997
381 https://doi.org/10.1007/s10689-006-9114-8
382 rdf:type schema:CreativeWork
383 sg:pub.10.1007/s10897-012-9531-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049696807
384 https://doi.org/10.1007/s10897-012-9531-9
385 rdf:type schema:CreativeWork
386 sg:pub.10.1038/ng.586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006256853
387 https://doi.org/10.1038/ng.586
388 rdf:type schema:CreativeWork
389 sg:pub.10.1038/nrc2054 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052051499
390 https://doi.org/10.1038/nrc2054
391 rdf:type schema:CreativeWork
392 sg:pub.10.1038/nrclinonc.2010.166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023388209
393 https://doi.org/10.1038/nrclinonc.2010.166
394 rdf:type schema:CreativeWork
395 sg:pub.10.1038/sj.bjc.6604830 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040036207
396 https://doi.org/10.1038/sj.bjc.6604830
397 rdf:type schema:CreativeWork
398 sg:pub.10.1097/01.gim.0000086477.00766.c9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002316523
399 https://doi.org/10.1097/01.gim.0000086477.00766.c9
400 rdf:type schema:CreativeWork
401 sg:pub.10.1097/gim.0b013e3181d38f2f schema:sameAs https://app.dimensions.ai/details/publication/pub.1043662043
402 https://doi.org/10.1097/gim.0b013e3181d38f2f
403 rdf:type schema:CreativeWork
404 https://app.dimensions.ai/details/publication/pub.1076846307 schema:CreativeWork
405 https://app.dimensions.ai/details/publication/pub.1076863923 schema:CreativeWork
406 https://app.dimensions.ai/details/publication/pub.1078354258 schema:CreativeWork
407 https://app.dimensions.ai/details/publication/pub.1082815803 schema:CreativeWork
408 https://doi.org/10.1001/jama.1997.03550150046034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052044615
409 rdf:type schema:CreativeWork
410 https://doi.org/10.1001/jama.295.12.1379 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045252160
411 rdf:type schema:CreativeWork
412 https://doi.org/10.1001/jama.296.12.1507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019575764
413 rdf:type schema:CreativeWork
414 https://doi.org/10.1002/ajmg.a.32643 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049789995
415 rdf:type schema:CreativeWork
416 https://doi.org/10.1002/cncr.24200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032400871
417 rdf:type schema:CreativeWork
418 https://doi.org/10.1002/cncr.26166 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039772235
419 rdf:type schema:CreativeWork
420 https://doi.org/10.1016/j.amepre.2010.09.027 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004337173
421 rdf:type schema:CreativeWork
422 https://doi.org/10.1016/j.cgh.2010.03.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004869786
423 rdf:type schema:CreativeWork
424 https://doi.org/10.1016/s0140-6736(05)70394-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047012056
425 rdf:type schema:CreativeWork
426 https://doi.org/10.1016/s0399-8320(05)82159-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003454177
427 rdf:type schema:CreativeWork
428 https://doi.org/10.1056/nejmcp071286 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034851725
429 rdf:type schema:CreativeWork
430 https://doi.org/10.1086/375033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002331489
431 rdf:type schema:CreativeWork
432 https://doi.org/10.1093/aje/kwf139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029342239
433 rdf:type schema:CreativeWork
434 https://doi.org/10.1097/aog.0b013e3181da08d7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015069224
435 rdf:type schema:CreativeWork
436 https://doi.org/10.1097/gco.0b013e32801195da schema:sameAs https://app.dimensions.ai/details/publication/pub.1003663344
437 rdf:type schema:CreativeWork
438 https://doi.org/10.1111/j.1399-0004.2008.01146.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005250492
439 rdf:type schema:CreativeWork
440 https://doi.org/10.1111/j.1399-0004.2009.01230.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1043586216
441 rdf:type schema:CreativeWork
442 https://doi.org/10.1111/j.1399-0004.2011.01788.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1003638836
443 rdf:type schema:CreativeWork
444 https://doi.org/10.1111/j.1463-1318.2009.01898.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1023165311
445 rdf:type schema:CreativeWork
446 https://doi.org/10.1158/1055-9965.epi-05-0002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012223449
447 rdf:type schema:CreativeWork
448 https://doi.org/10.1158/1055-9965.epi-10-0325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011824912
449 rdf:type schema:CreativeWork
450 https://doi.org/10.1200/jco.2000.18.11.2193 schema:sameAs https://app.dimensions.ai/details/publication/pub.1074645666
451 rdf:type schema:CreativeWork
452 https://doi.org/10.1200/jco.2004.04.188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004923574
453 rdf:type schema:CreativeWork
454 https://doi.org/10.1200/jco.2005.01.7541 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051429338
455 rdf:type schema:CreativeWork
456 https://doi.org/10.1200/jco.2009.23.7784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014351293
457 rdf:type schema:CreativeWork
458 https://doi.org/10.1371/journal.pone.0043994 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034264999
459 rdf:type schema:CreativeWork
460 https://doi.org/10.1684/bdc.2009.0943 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077956436
461 rdf:type schema:CreativeWork
462 https://doi.org/10.2307/3001616 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070163897
463 rdf:type schema:CreativeWork
464 https://doi.org/10.2307/3001775 schema:sameAs https://app.dimensions.ai/details/publication/pub.1070164004
465 rdf:type schema:CreativeWork
466 https://www.grid.ac/institutes/grid.14925.3b schema:alternateName Institut Gustave Roussy
467 schema:name Institut Gustave Roussy, Villejuif, France
468 rdf:type schema:Organization
469 https://www.grid.ac/institutes/grid.157868.5 schema:alternateName University Hospital of Montpellier
470 schema:name Centre Hospitalier Universitaire de Montpellier, Montpellier, France
471 INSERM 896, Montpellier, France
472 rdf:type schema:Organization
473 https://www.grid.ac/institutes/grid.410527.5 schema:alternateName Centre Hospitalier Universitaire de Nancy
474 schema:name Centre Hospitalier Universitaire de Nancy, Nancy, France
475 rdf:type schema:Organization
476 https://www.grid.ac/institutes/grid.411266.6 schema:alternateName Hôpital de la Timone
477 schema:name Hôpital La Timone, AP-HM, Marseille, France
478 rdf:type schema:Organization
479 https://www.grid.ac/institutes/grid.411439.a schema:alternateName Pitié-Salpêtrière Hospital
480 schema:name Hôpital Pitié Salpétrière, AP-HP, Paris, France
481 Institut National du Cancer, Boulogne-Billancourt, France
482 rdf:type schema:Organization
483 https://www.grid.ac/institutes/grid.411784.f schema:alternateName Hôpital Cochin
484 schema:name Hôpital Cochin, AP-HP, Paris, France
485 rdf:type schema:Organization
486 https://www.grid.ac/institutes/grid.412180.e schema:alternateName Hôpital Édouard-Herriot
487 schema:name Hôpital Edouard Herriot, Lyon, France
488 rdf:type schema:Organization
489 https://www.grid.ac/institutes/grid.414093.b schema:alternateName Hôpital Européen Georges-Pompidou
490 schema:name Hôpital Européen Georges Pompidou, AP-HP, Paris, France
491 Institut Curie, Paris, France
492 rdf:type schema:Organization
493 https://www.grid.ac/institutes/grid.417615.0 schema:alternateName Hôpital Charles-Nicolle
494 schema:name Service d’Oncogénétique, Centre Hospitalier Universitaire de Rouen, Rouen, France
495 rdf:type schema:Organization
496 https://www.grid.ac/institutes/grid.417829.1 schema:alternateName Institut Claudius Regaud
497 schema:name Institut Claudius Régaud, Toulouse, France
498 rdf:type schema:Organization
499 https://www.grid.ac/institutes/grid.417988.b schema:alternateName Centre Eugène Marquis
500 schema:name Centre Eugène Marquis, Rennes, France
501 rdf:type schema:Organization
502 https://www.grid.ac/institutes/grid.418116.b schema:alternateName Centre Léon Bérard
503 schema:name Centre Léon Bérard, Lyon, France
504 rdf:type schema:Organization
505 https://www.grid.ac/institutes/grid.418189.d schema:alternateName UniCancer Group
506 schema:name Centre François Baclesse, Caen, France
507 rdf:type schema:Organization
508 https://www.grid.ac/institutes/grid.418199.c schema:alternateName Ministère des Affaires sociales et de la Santé
509 schema:name Institut National du Cancer, Boulogne-Billancourt, France
510 rdf:type schema:Organization
511 https://www.grid.ac/institutes/grid.418443.e schema:alternateName Institute Paoli-Calmettes
512 schema:name Institut Paoli Calmettes, Marseille, France
513 rdf:type schema:Organization
514 https://www.grid.ac/institutes/grid.418596.7 schema:alternateName Institute Curie
515 schema:name Institut Curie, Paris, France
516 Institut Curie, Saint-Cloud, France
517 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...