Influence of ABCB1 polymorphisms and docetaxel pharmacokinetics on pathological response to neoadjuvant chemotherapy in breast cancer patients View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2013-06

AUTHORS

Pierre Lévy, Joseph Gligorov, Martine Antoine, Keyvan Rezai, Eric Lévy, Frédéric Selle, Pierre Saintigny, François Lokiec, Danielle Avenin, Karine Beerblock, Jean-Pierre Lotz, Jean-François Bernaudin, Anne Fajac

ABSTRACT

We have previously reported an association between ABCB1 C3435T polymorphism and docetaxel pharmacokinetics in breast cancer patients. We therefore investigated whether these parameters could account for variations in pathological response. Five ABCB1 polymorphisms including C3435T polymorphism were analyzed in breast cancer patients receiving neoadjuvant chemotherapy with doxorubicin and docetaxel (n = 101). Pathological response was assessed using the Sataloff classification. Pharmacokinetic analysis was performed for the first course of docetaxel (n = 84). No significant association was found between ABCB1 polymorphisms or docetaxel pharmacokinetics and pathological complete response. C3435T genotype was an independent predictive factor of good response in breast (response >50 %, i.e., Sataloff T-A and T-B): OR: 4.6 (95 % CI: 1.3-16.1), p = 0.015, for TT patients versus CT and CC patients. Area under the plasma concentration-time curve (AUC) of docetaxel was the only independent predictive factor of the total absence of response in breast (Sataloff T-D): OR: 14.3, (95 % CI: 1.7-118), p = 0.015, for AUC of docetaxel <3,500 μg h/L versus ≥3,500 μg h/L. These results suggest that C3435T polymorphism and docetaxel exposure are involved in the response to neoadjuvant chemotherapy in breast cancer patients and may be useful to optimize individualized therapy. More... »

PAGES

421-428

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-013-2545-7

DOI

http://dx.doi.org/10.1007/s10549-013-2545-7

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1034412135

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23666532


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Download the RDF metadata as:  json-ld nt turtle xml License info

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