Prognostic value of single nucleotide polymorphisms of candidate genes associated with inflammation in early stage breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-04

AUTHORS

James L. Murray, Patricia Thompson, Suk Young Yoo, Kim-Anh Do, Mala Pande, Renke Zhou, Yanhong Liu, Aysegul A. Sahin, Melissa L. Bondy, Abenaa M. Brewster

ABSTRACT

To examine the role of germline genetic variations in inflammatory pathways as modifiers of time to recurrence (TTR) in patients with early stage breast cancer (BC), DNA from 997 early stage BC patients was genotyped for 53 tagging single nucleotide polymorphisms (SNPs) in 12 genes involved in inflammation. SNPs were analyzed separately for Caucasians versus African-Americans and Hispanics. Cox proportional hazards models were used to evaluate the association between SNPs in the inflammatory genes and TTR, adjusted for clinical and pathologic covariates. In univariable analyses of Caucasian women, the homozygous genotype of 12 SNPs, including 6 NFKB1 SNPs, 4 IL4 SNPs, and 2 IL13 SNPs, were significantly associated with a decrease in TTR compared with the heterozygous and/or corresponding homozygous genotype (P < 0.05). The significant NFKB1 and IL4 SNPs were in an area of high linkage disequilibrium (D' > 0.8). After adjusting for stage, age, and treatment, carriage of the homozygous genotypes for NFKB1 rs230532 and IL13rs1800925 were independently associated with a shorter TTR (P = 0.001 and P = 0.034, respectively). In African-American and Hispanic patients, expression of NFKB1 rs3774932, TNFrs1799964, and IL4rs3024543 SNPs were associated with a shorter TTR in univariable model. Only NFKB1 rs3774932 (P = 0.02) and IL4Rrs3024543 (P = 0.03) had independent prognostic value in the multivariable model These data support the existence of host genetic susceptibility as a component in recurrence risk mediated by pro-inflammatory and immune factors, and suggest the potential for drugs which modify immune responses and inflammatory genes to improve prognosis in early stage BC. More... »

PAGES

917-924

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-013-2445-x

DOI

http://dx.doi.org/10.1007/s10549-013-2445-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1025815723

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23529385


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "African Americans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cohort Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "European Continental Ancestry Group", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Hispanic Americans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Homozygote", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Inflammatory Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-13", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-4", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Interleukin-4 Receptor alpha Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Linkage Disequilibrium", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Multivariate Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "NF-kappa B p50 Subunit", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Recurrence, Local", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Murray", 
        "givenName": "James L.", 
        "id": "sg:person.01013114134.60", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013114134.60"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Arizona", 
          "id": "https://www.grid.ac/institutes/grid.134563.6", 
          "name": [
            "The Arizona Cancer Center, Tucson, AZ, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Thompson", 
        "givenName": "Patricia", 
        "id": "sg:person.013276037727.20", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013276037727.20"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yoo", 
        "givenName": "Suk Young", 
        "id": "sg:person.0637337713.39", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637337713.39"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Do", 
        "givenName": "Kim-Anh", 
        "id": "sg:person.0652735603.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652735603.66"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pande", 
        "givenName": "Mala", 
        "id": "sg:person.0715617254.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715617254.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Baylor College of Medicine, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Renke", 
        "id": "sg:person.01312107023.03", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312107023.03"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "Baylor College of Medicine, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Yanhong", 
        "id": "sg:person.016232454004.29", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016232454004.29"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sahin", 
        "givenName": "Aysegul A.", 
        "id": "sg:person.015041554177.45", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015041554177.45"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Baylor College of Medicine", 
          "id": "https://www.grid.ac/institutes/grid.39382.33", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA", 
            "Baylor College of Medicine, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bondy", 
        "givenName": "Melissa L.", 
        "id": "sg:person.01003156731.73", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003156731.73"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "The University of Texas MD Anderson Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.240145.6", 
          "name": [
            "The University of Texas MD Anderson Cancer Center, Houston, TX, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brewster", 
        "givenName": "Abenaa M.", 
        "id": "sg:person.016133406417.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016133406417.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1371/journal.pbio.0020007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000858813"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr1746", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002958592", 
          "https://doi.org/10.1186/bcr1746"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mcn.2002.129977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005383183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1067/mcn.2002.129977", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005383183"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh232", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005886268"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000016272", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006319716"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/bth457", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008081196"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/mcb.17.7.3629", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008331890"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2009.02.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008981610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/bioinformatics/btg148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009500779"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009731986", 
          "https://doi.org/10.1038/bjc.1988.36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1988.36", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009731986", 
          "https://doi.org/10.1038/bjc.1988.36"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000055404", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010804332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e3181d32e74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012212391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e3181d32e74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012212391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/cji.0b013e3181d32e74", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012212391"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2370.2004.00462.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012746907"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(02)00703-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012930185"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/theoncologist.9-6-606", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014032406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp110", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014993498"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20061120", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015754140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-009-0707-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018479009", 
          "https://doi.org/10.1007/s00432-009-0707-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-009-0707-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018479009", 
          "https://doi.org/10.1007/s00432-009-0707-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-009-0707-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018479009", 
          "https://doi.org/10.1007/s00432-009-0707-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.2910560603", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018685012"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0215(19980925)78:1<16::aid-ijc4>3.0.co;2-#", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019871731"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3322/caac.20006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022825825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature07205", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024729982", 
          "https://doi.org/10.1038/nature07205"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/me.2011-1302", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026397513"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2010.03.014", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028329115"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0403621101", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033133429"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1022166517963", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033352588", 
          "https://doi.org/10.1023/a:1022166517963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/35021093", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033846543", 
          "https://doi.org/10.1038/35021093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.191367098", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034333528"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2105-9-14", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034538282", 
          "https://doi.org/10.1186/1471-2105-9-14"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036472976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn233", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1036472976"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/08820130902910567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038340486"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(20010215)91:4<672::aid-cncr1050>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038387977"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1159/000073201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044127435"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19891101)64:9<1914::aid-cncr2820640926>3.0.co;2-g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046597529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046632828", 
          "https://doi.org/10.1038/sj.gene.6363881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.gene.6363881", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046632828", 
          "https://doi.org/10.1038/sj.gene.6363881"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cyto.2003.10.004", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047488424"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.27.2419", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048301596"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1084/jem.20080108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048680574"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049602167", 
          "https://doi.org/10.1038/sj.onc.1203238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1203238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049602167", 
          "https://doi.org/10.1038/sj.onc.1203238"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2753", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051752983", 
          "https://doi.org/10.1186/bcr2753"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/gb-2007-8-8-r157", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052735338", 
          "https://doi.org/10.1186/gb-2007-8-8-r157"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.10.6815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052823256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2007.10.6815", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052823256"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1471-2407-6-188", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053345239", 
          "https://doi.org/10.1186/1471-2407-6-188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1099962", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062449802"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076806728", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1076995648", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-04", 
    "datePublishedReg": "2013-04-01", 
    "description": "To examine the role of germline genetic variations in inflammatory pathways as modifiers of time to recurrence (TTR) in patients with early stage breast cancer (BC), DNA from 997 early stage BC patients was genotyped for 53 tagging single nucleotide polymorphisms (SNPs) in 12 genes involved in inflammation. SNPs were analyzed separately for Caucasians versus African-Americans and Hispanics. Cox proportional hazards models were used to evaluate the association between SNPs in the inflammatory genes and TTR, adjusted for clinical and pathologic covariates. In univariable analyses of Caucasian women, the homozygous genotype of 12 SNPs, including 6 NFKB1 SNPs, 4 IL4 SNPs, and 2 IL13 SNPs, were significantly associated with a decrease in TTR compared with the heterozygous and/or corresponding homozygous genotype (P < 0.05). The significant NFKB1 and IL4 SNPs were in an area of high linkage disequilibrium (D' > 0.8). After adjusting for stage, age, and treatment, carriage of the homozygous genotypes for NFKB1 rs230532 and IL13rs1800925 were independently associated with a shorter TTR (P = 0.001 and P = 0.034, respectively). In African-American and Hispanic patients, expression of NFKB1 rs3774932, TNFrs1799964, and IL4rs3024543 SNPs were associated with a shorter TTR in univariable model. Only NFKB1 rs3774932 (P = 0.02) and IL4Rrs3024543 (P = 0.03) had independent prognostic value in the multivariable model These data support the existence of host genetic susceptibility as a component in recurrence risk mediated by pro-inflammatory and immune factors, and suggest the potential for drugs which modify immune responses and inflammatory genes to improve prognosis in early stage BC.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-013-2445-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2408814", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2569220", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2438826", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.2475326", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "138"
      }
    ], 
    "name": "Prognostic value of single nucleotide polymorphisms of candidate genes associated with inflammation in early stage breast cancer", 
    "pagination": "917-924", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7afdcec2940021412891b19781f27bacde3705391d19e7a70a3f8ad0f1fcff77"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23529385"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-013-2445-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1025815723"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-013-2445-x", 
      "https://app.dimensions.ai/details/publication/pub.1025815723"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T19:57", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000513.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10549-013-2445-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2445-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2445-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2445-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-013-2445-x'


 

This table displays all metadata directly associated to this object as RDF triples.

383 TRIPLES      21 PREDICATES      97 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-013-2445-x schema:about N0142c91613834e07b49ab337a0c2a5d4
2 N070d7420b1dd4ddeb9aa6265c7058887
3 N0dddb3eec803412984007042df811bae
4 N1c12b8fa47ea40189bc26cec3f9b39ba
5 N3bea379d5adb44fbb6a2060d702d83c3
6 N3c1c56d1cc6e400b900bb2000ed8d847
7 N43abc674bfbb488d83f531b6706ad396
8 N4704f6cd752e40b18042356128a4c224
9 N4b9c8210b17149a7bb84a7af4dc6740f
10 N7fc6b853126b4342809fba010bbb047f
11 N89bfd0eb9b0a46d2a65297a37dace904
12 N8a84c2d038de419ab855666ed96ee184
13 N8d63a93631d74fe49e8d8e9e68dcdfd5
14 Na3bd52ae0e984cce8f181a29f085cb2a
15 Nae8ed1348fd048349837c83d007f0232
16 Nbf3f1988d1e24148af81e4bebfd25770
17 Nc8bd674be1ff4d73b6b3e598fc91236e
18 Nd1f43a34337542688a37a3c92b347f1d
19 Nd34537871ac3425aa72b564851f3d7fe
20 Nd3e7331de23f42f98b324f416895c1cd
21 Nd6a340ffeae54a14a407b8cf15a6f5a6
22 Nfd65d45e1a40428c9e23a8eb3b1c88b4
23 anzsrc-for:11
24 anzsrc-for:1107
25 schema:author N94f8860978db4e568ccbfac4ef1504da
26 schema:citation sg:pub.10.1007/s00432-009-0707-0
27 sg:pub.10.1023/a:1022166517963
28 sg:pub.10.1038/35021093
29 sg:pub.10.1038/bjc.1988.36
30 sg:pub.10.1038/nature07205
31 sg:pub.10.1038/sj.gene.6363881
32 sg:pub.10.1038/sj.onc.1203238
33 sg:pub.10.1186/1471-2105-9-14
34 sg:pub.10.1186/1471-2407-6-188
35 sg:pub.10.1186/bcr1746
36 sg:pub.10.1186/bcr2753
37 sg:pub.10.1186/gb-2007-8-8-r157
38 https://app.dimensions.ai/details/publication/pub.1076806728
39 https://app.dimensions.ai/details/publication/pub.1076995648
40 https://doi.org/10.1002/(sici)1097-0215(19980925)78:1<16::aid-ijc4>3.0.co;2-#
41 https://doi.org/10.1002/1097-0142(19891101)64:9<1914::aid-cncr2820640926>3.0.co;2-g
42 https://doi.org/10.1002/1097-0142(20010215)91:4<672::aid-cncr1050>3.0.co;2-j
43 https://doi.org/10.1002/ijc.2910560603
44 https://doi.org/10.1016/j.cyto.2003.10.004
45 https://doi.org/10.1016/j.cyto.2009.02.003
46 https://doi.org/10.1016/j.cyto.2010.03.014
47 https://doi.org/10.1016/s0092-8674(02)00703-1
48 https://doi.org/10.1067/mcn.2002.129977
49 https://doi.org/10.1073/pnas.0403621101
50 https://doi.org/10.1073/pnas.191367098
51 https://doi.org/10.1080/08820130902910567
52 https://doi.org/10.1084/jem.20061120
53 https://doi.org/10.1084/jem.20080108
54 https://doi.org/10.1093/annonc/mdh232
55 https://doi.org/10.1093/annonc/mdp110
56 https://doi.org/10.1093/bioinformatics/btg148
57 https://doi.org/10.1093/bioinformatics/bth457
58 https://doi.org/10.1093/jnci/djn233
59 https://doi.org/10.1097/cji.0b013e3181d32e74
60 https://doi.org/10.1111/j.1365-2370.2004.00462.x
61 https://doi.org/10.1126/science.1099962
62 https://doi.org/10.1128/mcb.17.7.3629
63 https://doi.org/10.1159/000016272
64 https://doi.org/10.1159/000055404
65 https://doi.org/10.1159/000073201
66 https://doi.org/10.1200/jco.2007.10.6815
67 https://doi.org/10.1200/jco.2009.27.2419
68 https://doi.org/10.1210/me.2011-1302
69 https://doi.org/10.1371/journal.pbio.0020007
70 https://doi.org/10.1634/theoncologist.9-6-606
71 https://doi.org/10.3322/caac.20006
72 schema:datePublished 2013-04
73 schema:datePublishedReg 2013-04-01
74 schema:description To examine the role of germline genetic variations in inflammatory pathways as modifiers of time to recurrence (TTR) in patients with early stage breast cancer (BC), DNA from 997 early stage BC patients was genotyped for 53 tagging single nucleotide polymorphisms (SNPs) in 12 genes involved in inflammation. SNPs were analyzed separately for Caucasians versus African-Americans and Hispanics. Cox proportional hazards models were used to evaluate the association between SNPs in the inflammatory genes and TTR, adjusted for clinical and pathologic covariates. In univariable analyses of Caucasian women, the homozygous genotype of 12 SNPs, including 6 NFKB1 SNPs, 4 IL4 SNPs, and 2 IL13 SNPs, were significantly associated with a decrease in TTR compared with the heterozygous and/or corresponding homozygous genotype (P < 0.05). The significant NFKB1 and IL4 SNPs were in an area of high linkage disequilibrium (D' > 0.8). After adjusting for stage, age, and treatment, carriage of the homozygous genotypes for NFKB1 rs230532 and IL13rs1800925 were independently associated with a shorter TTR (P = 0.001 and P = 0.034, respectively). In African-American and Hispanic patients, expression of NFKB1 rs3774932, TNFrs1799964, and IL4rs3024543 SNPs were associated with a shorter TTR in univariable model. Only NFKB1 rs3774932 (P = 0.02) and IL4Rrs3024543 (P = 0.03) had independent prognostic value in the multivariable model These data support the existence of host genetic susceptibility as a component in recurrence risk mediated by pro-inflammatory and immune factors, and suggest the potential for drugs which modify immune responses and inflammatory genes to improve prognosis in early stage BC.
75 schema:genre research_article
76 schema:inLanguage en
77 schema:isAccessibleForFree true
78 schema:isPartOf N3864ede4f7174c34bb49b395b7c5910e
79 Nc0835e9688dd466c96c941142428840a
80 sg:journal.1092777
81 schema:name Prognostic value of single nucleotide polymorphisms of candidate genes associated with inflammation in early stage breast cancer
82 schema:pagination 917-924
83 schema:productId N1633bf57ab964817a5589115ab674422
84 N9d4df824beff4b2897eab8f5d6892946
85 Nb7ac2687162343f0bc7bdefb8a823186
86 Ncb5b1ab0aff94de99765ba355928543d
87 Nf7d6787f867f439486aa71562c9e7560
88 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025815723
89 https://doi.org/10.1007/s10549-013-2445-x
90 schema:sdDatePublished 2019-04-10T19:57
91 schema:sdLicense https://scigraph.springernature.com/explorer/license/
92 schema:sdPublisher Ncd2cd4b8b2724e9e95500f8335f96234
93 schema:url http://link.springer.com/10.1007%2Fs10549-013-2445-x
94 sgo:license sg:explorer/license/
95 sgo:sdDataset articles
96 rdf:type schema:ScholarlyArticle
97 N0142c91613834e07b49ab337a0c2a5d4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Multivariate Analysis
99 rdf:type schema:DefinedTerm
100 N070d7420b1dd4ddeb9aa6265c7058887 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Humans
102 rdf:type schema:DefinedTerm
103 N0dddb3eec803412984007042df811bae schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
104 schema:name Interleukin-13
105 rdf:type schema:DefinedTerm
106 N0f923754a3294ba191cab2d4271cdc4d rdf:first sg:person.01003156731.73
107 rdf:rest N8f5143b07f6546239b36a9f94d4c754f
108 N104c8fe901c04a6fa2847a5902647658 rdf:first sg:person.015041554177.45
109 rdf:rest N0f923754a3294ba191cab2d4271cdc4d
110 N1633bf57ab964817a5589115ab674422 schema:name doi
111 schema:value 10.1007/s10549-013-2445-x
112 rdf:type schema:PropertyValue
113 N1c12b8fa47ea40189bc26cec3f9b39ba schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
114 schema:name Interleukin-4
115 rdf:type schema:DefinedTerm
116 N2521655ac8b34f76987ca6aa53a77b21 rdf:first sg:person.013276037727.20
117 rdf:rest N692333cbf6e740f19eee3beeb9283de1
118 N3864ede4f7174c34bb49b395b7c5910e schema:issueNumber 3
119 rdf:type schema:PublicationIssue
120 N3bea379d5adb44fbb6a2060d702d83c3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Female
122 rdf:type schema:DefinedTerm
123 N3c1c56d1cc6e400b900bb2000ed8d847 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Cohort Studies
125 rdf:type schema:DefinedTerm
126 N43abc674bfbb488d83f531b6706ad396 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Proportional Hazards Models
128 rdf:type schema:DefinedTerm
129 N4704f6cd752e40b18042356128a4c224 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Middle Aged
131 rdf:type schema:DefinedTerm
132 N4b9c8210b17149a7bb84a7af4dc6740f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Inflammation
134 rdf:type schema:DefinedTerm
135 N692333cbf6e740f19eee3beeb9283de1 rdf:first sg:person.0637337713.39
136 rdf:rest Ned68cf6fff0947d9aa5759baecc31866
137 N7fc6b853126b4342809fba010bbb047f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Linkage Disequilibrium
139 rdf:type schema:DefinedTerm
140 N89bfd0eb9b0a46d2a65297a37dace904 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name European Continental Ancestry Group
142 rdf:type schema:DefinedTerm
143 N8a84c2d038de419ab855666ed96ee184 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Interleukin-4 Receptor alpha Subunit
145 rdf:type schema:DefinedTerm
146 N8d63a93631d74fe49e8d8e9e68dcdfd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Breast Neoplasms
148 rdf:type schema:DefinedTerm
149 N8f5143b07f6546239b36a9f94d4c754f rdf:first sg:person.016133406417.66
150 rdf:rest rdf:nil
151 N94f8860978db4e568ccbfac4ef1504da rdf:first sg:person.01013114134.60
152 rdf:rest N2521655ac8b34f76987ca6aa53a77b21
153 N9d4df824beff4b2897eab8f5d6892946 schema:name dimensions_id
154 schema:value pub.1025815723
155 rdf:type schema:PropertyValue
156 Na3bd52ae0e984cce8f181a29f085cb2a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
157 schema:name Polymorphism, Single Nucleotide
158 rdf:type schema:DefinedTerm
159 Nae8ed1348fd048349837c83d007f0232 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Genetic Predisposition to Disease
161 rdf:type schema:DefinedTerm
162 Nb7ac2687162343f0bc7bdefb8a823186 schema:name readcube_id
163 schema:value 7afdcec2940021412891b19781f27bacde3705391d19e7a70a3f8ad0f1fcff77
164 rdf:type schema:PropertyValue
165 Nbf3f1988d1e24148af81e4bebfd25770 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Homozygote
167 rdf:type schema:DefinedTerm
168 Nc0835e9688dd466c96c941142428840a schema:volumeNumber 138
169 rdf:type schema:PublicationVolume
170 Nc8bd674be1ff4d73b6b3e598fc91236e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
171 schema:name African Americans
172 rdf:type schema:DefinedTerm
173 Ncb5b1ab0aff94de99765ba355928543d schema:name nlm_unique_id
174 schema:value 8111104
175 rdf:type schema:PropertyValue
176 Ncd2cd4b8b2724e9e95500f8335f96234 schema:name Springer Nature - SN SciGraph project
177 rdf:type schema:Organization
178 Nd1f43a34337542688a37a3c92b347f1d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
179 schema:name Hispanic Americans
180 rdf:type schema:DefinedTerm
181 Nd34537871ac3425aa72b564851f3d7fe schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
182 schema:name NF-kappa B p50 Subunit
183 rdf:type schema:DefinedTerm
184 Nd3e7331de23f42f98b324f416895c1cd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
185 schema:name Prognosis
186 rdf:type schema:DefinedTerm
187 Nd6a340ffeae54a14a407b8cf15a6f5a6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
188 schema:name Inflammatory Breast Neoplasms
189 rdf:type schema:DefinedTerm
190 Nd6d74d56ee334409ba3cf1c21407d235 rdf:first sg:person.016232454004.29
191 rdf:rest N104c8fe901c04a6fa2847a5902647658
192 Ne08c0c5d82174c6ba72d2b4458a63b25 rdf:first sg:person.01312107023.03
193 rdf:rest Nd6d74d56ee334409ba3cf1c21407d235
194 Ned68cf6fff0947d9aa5759baecc31866 rdf:first sg:person.0652735603.66
195 rdf:rest Nf53712dba2b54fb5926b63d57907b257
196 Nf53712dba2b54fb5926b63d57907b257 rdf:first sg:person.0715617254.31
197 rdf:rest Ne08c0c5d82174c6ba72d2b4458a63b25
198 Nf7d6787f867f439486aa71562c9e7560 schema:name pubmed_id
199 schema:value 23529385
200 rdf:type schema:PropertyValue
201 Nfd65d45e1a40428c9e23a8eb3b1c88b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
202 schema:name Neoplasm Recurrence, Local
203 rdf:type schema:DefinedTerm
204 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
205 schema:name Medical and Health Sciences
206 rdf:type schema:DefinedTerm
207 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
208 schema:name Immunology
209 rdf:type schema:DefinedTerm
210 sg:grant.2408814 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-013-2445-x
211 rdf:type schema:MonetaryGrant
212 sg:grant.2438826 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-013-2445-x
213 rdf:type schema:MonetaryGrant
214 sg:grant.2475326 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-013-2445-x
215 rdf:type schema:MonetaryGrant
216 sg:grant.2569220 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-013-2445-x
217 rdf:type schema:MonetaryGrant
218 sg:journal.1092777 schema:issn 0167-6806
219 1573-7217
220 schema:name Breast Cancer Research and Treatment
221 rdf:type schema:Periodical
222 sg:person.01003156731.73 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
223 schema:familyName Bondy
224 schema:givenName Melissa L.
225 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01003156731.73
226 rdf:type schema:Person
227 sg:person.01013114134.60 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
228 schema:familyName Murray
229 schema:givenName James L.
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013114134.60
231 rdf:type schema:Person
232 sg:person.01312107023.03 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
233 schema:familyName Zhou
234 schema:givenName Renke
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01312107023.03
236 rdf:type schema:Person
237 sg:person.013276037727.20 schema:affiliation https://www.grid.ac/institutes/grid.134563.6
238 schema:familyName Thompson
239 schema:givenName Patricia
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013276037727.20
241 rdf:type schema:Person
242 sg:person.015041554177.45 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
243 schema:familyName Sahin
244 schema:givenName Aysegul A.
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.015041554177.45
246 rdf:type schema:Person
247 sg:person.016133406417.66 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
248 schema:familyName Brewster
249 schema:givenName Abenaa M.
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016133406417.66
251 rdf:type schema:Person
252 sg:person.016232454004.29 schema:affiliation https://www.grid.ac/institutes/grid.39382.33
253 schema:familyName Liu
254 schema:givenName Yanhong
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016232454004.29
256 rdf:type schema:Person
257 sg:person.0637337713.39 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
258 schema:familyName Yoo
259 schema:givenName Suk Young
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0637337713.39
261 rdf:type schema:Person
262 sg:person.0652735603.66 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
263 schema:familyName Do
264 schema:givenName Kim-Anh
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0652735603.66
266 rdf:type schema:Person
267 sg:person.0715617254.31 schema:affiliation https://www.grid.ac/institutes/grid.240145.6
268 schema:familyName Pande
269 schema:givenName Mala
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715617254.31
271 rdf:type schema:Person
272 sg:pub.10.1007/s00432-009-0707-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018479009
273 https://doi.org/10.1007/s00432-009-0707-0
274 rdf:type schema:CreativeWork
275 sg:pub.10.1023/a:1022166517963 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033352588
276 https://doi.org/10.1023/a:1022166517963
277 rdf:type schema:CreativeWork
278 sg:pub.10.1038/35021093 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033846543
279 https://doi.org/10.1038/35021093
280 rdf:type schema:CreativeWork
281 sg:pub.10.1038/bjc.1988.36 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009731986
282 https://doi.org/10.1038/bjc.1988.36
283 rdf:type schema:CreativeWork
284 sg:pub.10.1038/nature07205 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024729982
285 https://doi.org/10.1038/nature07205
286 rdf:type schema:CreativeWork
287 sg:pub.10.1038/sj.gene.6363881 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046632828
288 https://doi.org/10.1038/sj.gene.6363881
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/sj.onc.1203238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049602167
291 https://doi.org/10.1038/sj.onc.1203238
292 rdf:type schema:CreativeWork
293 sg:pub.10.1186/1471-2105-9-14 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034538282
294 https://doi.org/10.1186/1471-2105-9-14
295 rdf:type schema:CreativeWork
296 sg:pub.10.1186/1471-2407-6-188 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053345239
297 https://doi.org/10.1186/1471-2407-6-188
298 rdf:type schema:CreativeWork
299 sg:pub.10.1186/bcr1746 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002958592
300 https://doi.org/10.1186/bcr1746
301 rdf:type schema:CreativeWork
302 sg:pub.10.1186/bcr2753 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051752983
303 https://doi.org/10.1186/bcr2753
304 rdf:type schema:CreativeWork
305 sg:pub.10.1186/gb-2007-8-8-r157 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052735338
306 https://doi.org/10.1186/gb-2007-8-8-r157
307 rdf:type schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1076806728 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1076995648 schema:CreativeWork
310 https://doi.org/10.1002/(sici)1097-0215(19980925)78:1<16::aid-ijc4>3.0.co;2-# schema:sameAs https://app.dimensions.ai/details/publication/pub.1019871731
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/1097-0142(19891101)64:9<1914::aid-cncr2820640926>3.0.co;2-g schema:sameAs https://app.dimensions.ai/details/publication/pub.1046597529
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1002/1097-0142(20010215)91:4<672::aid-cncr1050>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1038387977
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1002/ijc.2910560603 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018685012
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/j.cyto.2003.10.004 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047488424
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/j.cyto.2009.02.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008981610
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/j.cyto.2010.03.014 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028329115
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1016/s0092-8674(02)00703-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012930185
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1067/mcn.2002.129977 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005383183
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1073/pnas.0403621101 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033133429
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1073/pnas.191367098 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034333528
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1080/08820130902910567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038340486
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1084/jem.20061120 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015754140
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1084/jem.20080108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048680574
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1093/annonc/mdh232 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005886268
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1093/annonc/mdp110 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014993498
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1093/bioinformatics/btg148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009500779
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1093/bioinformatics/bth457 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008081196
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1093/jnci/djn233 schema:sameAs https://app.dimensions.ai/details/publication/pub.1036472976
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1097/cji.0b013e3181d32e74 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012212391
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1111/j.1365-2370.2004.00462.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1012746907
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1126/science.1099962 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062449802
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1128/mcb.17.7.3629 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008331890
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1159/000016272 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006319716
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1159/000055404 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010804332
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1159/000073201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1044127435
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1200/jco.2007.10.6815 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052823256
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.2009.27.2419 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048301596
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1210/me.2011-1302 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026397513
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1371/journal.pbio.0020007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000858813
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1634/theoncologist.9-6-606 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014032406
371 rdf:type schema:CreativeWork
372 https://doi.org/10.3322/caac.20006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022825825
373 rdf:type schema:CreativeWork
374 https://www.grid.ac/institutes/grid.134563.6 schema:alternateName University of Arizona
375 schema:name The Arizona Cancer Center, Tucson, AZ, USA
376 rdf:type schema:Organization
377 https://www.grid.ac/institutes/grid.240145.6 schema:alternateName The University of Texas MD Anderson Cancer Center
378 schema:name The University of Texas MD Anderson Cancer Center, Houston, TX, USA
379 rdf:type schema:Organization
380 https://www.grid.ac/institutes/grid.39382.33 schema:alternateName Baylor College of Medicine
381 schema:name Baylor College of Medicine, Houston, TX, USA
382 The University of Texas MD Anderson Cancer Center, Houston, TX, USA
383 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...