Effect of simvastatin on the pharmacokinetics of anastrozole View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-01

AUTHORS

Ting Bao, Amanda L. Blackford, Vered Stearns

ABSTRACT

We have prospectively tested the effects of simvastatin on the pharmacokinetics of anastrozole and on estrogen concentrations in postmenopausal women with hormone receptor-positive breast cancer who were receiving adjuvant anastrozole. Following 14 days of simvastatin, we did not observe a significant change in plasma concentrations of anastrozole or hydroxyanastrozole in nine evaluable women. Likewise, we did not observe any statistically significant change in serum concentrations of either estradiol, which remained in the undetectable range, or estrone sulfate. Simvastatin and anastrozole may be safely co-administered. Pharmacokinetic results suggest that simvastatin is not likely to compromise the activity of anastrozole. More... »

PAGES

709-711

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-011-1859-6

DOI

http://dx.doi.org/10.1007/s10549-011-1859-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1006841197

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/22089963


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