Prognostic impact of polymorphisms in the MYBL2 interacting genes in breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-10-26

AUTHORS

Hong Shi, Melanie Bevier, Robert Johansson, Kerstin Enquist-Olsson, Roger Henriksson, Kari Hemminki, Per Lenner, Asta Försti

ABSTRACT

MYBL2 is a transcription factor, which regulates the expression of genes involved in cancer progression. In this study, we investigated whether putative functional variants in genes regulating MYBL2 (E2F1, E2F3 and E2F4) or in genes, which are regulated by MYBL2 (BCL2, BIRC5, COL1A1, COL1A2, COL5A2, ERBB2, CLU, LIN9 and TOP2A) affect breast cancer (BC) susceptibility and clinical outcome. Twenty-eight SNPs were genotyped in a population-based series of 782 Swedish BC cases and 1,559 matched controls. BC-specific survival analysis of BIRC5 suggested that carriers of the minor allele of rs8073069 and rs1042489 have a worse survival compared with the major homozygotes (HR 2.46, 95% CI 1.39–4.36 and HR 1.81, 95% CI 1.01–3.25, respectively). The poor survival was observed especially in women with aggressive tumours. Multivariate analysis supported the role of rs8073069 as an independent prognostic marker. For BCL2, minor allele carriers of rs1564483 were more likely to have hormone receptor-positive tumours than the major homozygotes. Another SNP in BCL2, rs4987852, was associated with tumour stages II–IV and histologic grade 3. In CLU, the minor allele carriers of rs9331888 were more likely to have tumours with regional lymph node metastasis and stages II–IV than the major homozygotes. In conclusion, our study suggests a role of genetic variation in BIRC5, BCL2 and CLU as progression and prognostic markers for BC, supporting previous studies based on the expression of the genes. More... »

PAGES

1039-1047

References to SciGraph publications

  • 2003-11. Cell cycle regulation by the B-Myb transcription factor in CELLULAR AND MOLECULAR LIFE SCIENCES
  • 2007-02-06. Survivin is an independent predictor of short-term survival in poor prognostic breast cancer patients in BRITISH JOURNAL OF CANCER
  • 2008-02-24. Surveying germline genomic landscape of breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2009-03-02. A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells in ONCOGENE
  • 2005-01-12. Common ERBB2 polymorphisms and risk of breast cancer in a white British population: a case–control study in BREAST CANCER RESEARCH
  • 2010-01-25. The transcription factor GATA-1 is overexpressed in breast carcinomas and contributes to survivin upregulation via a promoter polymorphism in ONCOGENE
  • 2011-01-24. Gene signatures of breast cancer progression and metastasis in BREAST CANCER RESEARCH
  • 2007-06-28. Is breast cancer prognosis inherited? in BREAST CANCER RESEARCH
  • 2006-11-28. Comprehensive analysis of the ATM, CHEK2 and ERBB2genes in relation to breast tumour characteristics and survival: a population-based case-control and follow-up study in BREAST CANCER RESEARCH
  • 2010-07-27. BCL2 in breast cancer: a favourable prognostic marker across molecular subtypes and independent of adjuvant therapy received in BRITISH JOURNAL OF CANCER
  • 2011-06-01. Single nucleotide polymorphisms in the 20q13 amplicon genes in relation to breast cancer risk and clinical outcome in BREAST CANCER RESEARCH AND TREATMENT
  • 2007-08-03. Survival in breast cancer is familial in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-03-14. Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 1999-02-11. B-MYB transactivates its own promoter through SP1-binding sites in ONCOGENE
  • 2010-03-22. Effects of clusterin over-expression on metastatic progression and therapy in breast cancer in BMC CANCER
  • 2007-03-22. An overview of prognostic factors for long-term survivors of breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 1990-11. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death in NATURE
  • 2009-11. Emerging roles of E2Fs in cancer: an exit from cell cycle control in NATURE REVIEWS CANCER
  • 2002-05. Prospective study of IGF-I, IGF-binding proteins, and breast cancer risk, in Northern and Southern Sweden in CANCER CAUSES & CONTROL
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-011-1826-2

    DOI

    http://dx.doi.org/10.1007/s10549-011-1826-2

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1021824986

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/22037783


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    362 grid-institutes:grid.7497.d schema:alternateName Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    363 schema:name Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120, Heidelberg, Germany
    364 rdf:type schema:Organization
     




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