Ontology type: schema:ScholarlyArticle
2012-01
AUTHORSFlorence Godey, Jean Leveque, Patrick Tas, Gwenola Gandon, Philippe Poree, Habiba Mesbah, Vincent Lavoue, Véronique Quillien, Cécile Bendavid Athias
ABSTRACTOne-step nucleic acid amplification (OSNA, Sysmex, Kobe, Japan) offers an excellent opportunity for accurate exhaustive sentinel lymph node (SLN) examination in breast cancer patients. Calibrated with conventional postoperative histology, this molecular technique yields comparable results intraoperatively, expressed as micrometastasis, macrometastasis or no metastasis depending on the CK19 mRNA copy number amplified in SLN lysates. We applied OSNA to detect metastasis in 810 SLNs from 367 patients with early stage breast cancer. We compared the rate of OSNA-positive SLNs in patients with invasive breast cancer (< 2 cm) versus the rate observed in a historical cohort using conventional histological examination of SLNs. No significant difference was observed, the OSNA assay was positive in 24.4% of patients, compared with positive histology in 24.8% in the historical cohort if including patients with isolated tumour cell (ITC) and in 23.4% excluding them. Opportunities for optimised patient management using OSNA are discussed: intraoperative detection of OSNA-positive SLNs enables axillary lymph node dissection (ALND) during the same procedure; standard OSNA techniques enable the establishment of homogeneous groups based on examination of whole SLNs for valid comparisons between different centres. More... »
PAGES509-516
http://scigraph.springernature.com/pub.10.1007/s10549-011-1808-4
DOIhttp://dx.doi.org/10.1007/s10549-011-1808-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1023005389
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/21993859
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cohort Studies",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymph Nodes",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lymphatic Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Invasiveness",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Staging",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Nucleic Acid Amplification Techniques",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prognosis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Sentinel Lymph Node Biopsy",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Biology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Godey",
"givenName": "Florence",
"id": "sg:person.01251751107.45",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01251751107.45"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Surgical Oncology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France",
"Departement of Gynecology, CHU Anne de Bretagne, 16 Bd de Bulgarie, BP 90 347, 35 203, Rennes Cedex 2, France"
],
"type": "Organization"
},
"familyName": "Leveque",
"givenName": "Jean",
"id": "sg:person.01206012023.14",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01206012023.14"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Surgical Oncology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Tas",
"givenName": "Patrick",
"id": "sg:person.01335350344.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01335350344.07"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Biology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Gandon",
"givenName": "Gwenola",
"id": "sg:person.01162425016.32",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01162425016.32"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Surgical Oncology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Poree",
"givenName": "Philippe",
"id": "sg:person.0744253057.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0744253057.58"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Surgical Oncology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Mesbah",
"givenName": "Habiba",
"id": "sg:person.0757022007.25",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0757022007.25"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Departement of Gynecology, CHU Anne de Bretagne, 16 Bd de Bulgarie, BP 90 347, 35 203, Rennes Cedex 2, France"
],
"type": "Organization"
},
"familyName": "Lavoue",
"givenName": "Vincent",
"id": "sg:person.01370764031.08",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01370764031.08"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Biology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Quillien",
"givenName": "V\u00e9ronique",
"id": "sg:person.01144715173.81",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01144715173.81"
],
"type": "Person"
},
{
"affiliation": {
"name": [
"Regional Mastology Center, Departement of Surgical Oncology, Eug\u00e8ne Marquis Comprehensive Cancer Center, Avenue de la Bataille Flandres Dunkerques, CS 44 229, 35 042, Rennes Cedex, France"
],
"type": "Organization"
},
"familyName": "Athias",
"givenName": "C\u00e9cile Bendavid",
"id": "sg:person.01141363607.71",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01141363607.71"
],
"type": "Person"
}
],
"citation": [
{
"id": "https://doi.org/10.1093/nar/28.12.e63",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000546561"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-010-1097-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001771521",
"https://doi.org/10.1245/s10434-010-1097-x"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1245/s10434-010-1097-x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1001771521",
"https://doi.org/10.1245/s10434-010-1097-x"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2009.24.5001",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1007138317"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-06-2512",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008016259"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jcp.2009.072942",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011401755"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-08-1881",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011417267"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1365-2559.2008.02998.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015991330"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1001/jama.2011.90",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1025928426"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1365-2559.2002.01387.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027263502"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ciresp.2011.04.013",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028708104"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-005-9025-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029413874",
"https://doi.org/10.1007/s10549-005-9025-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s10549-005-9025-7",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029413874",
"https://doi.org/10.1007/s10549-005-9025-7"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-008-0703-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030143236",
"https://doi.org/10.1007/s00428-008-0703-9"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00428-008-0703-9",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030143236",
"https://doi.org/10.1007/s00428-008-0703-9"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000150255.30665.52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030945670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/01.sla.0000150255.30665.52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030945670"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1136/jcp.2011.089862",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1035552603"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.03.3225",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1041085361"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.breast.2010.08.004",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1044001942"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.10539",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045776508"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1008108",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047423753"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.23451",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049609321"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/bjs.7347",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1051277242"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/modpathol.2010.36",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052898508",
"https://doi.org/10.1038/modpathol.2010.36"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1097/sla.0b013e3181f08f32",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1078206533"
],
"type": "CreativeWork"
}
],
"datePublished": "2012-01",
"datePublishedReg": "2012-01-01",
"description": "One-step nucleic acid amplification (OSNA, Sysmex, Kobe, Japan) offers an excellent opportunity for accurate exhaustive sentinel lymph node (SLN) examination in breast cancer patients. Calibrated with conventional postoperative histology, this molecular technique yields comparable results intraoperatively, expressed as micrometastasis, macrometastasis or no metastasis depending on the CK19 mRNA copy number amplified in SLN lysates. We applied OSNA to detect metastasis in 810 SLNs from 367 patients with early stage breast cancer. We compared the rate of OSNA-positive SLNs in patients with invasive breast cancer (< 2 cm) versus the rate observed in a historical cohort using conventional histological examination of SLNs. No significant difference was observed, the OSNA assay was positive in 24.4% of patients, compared with positive histology in 24.8% in the historical cohort if including patients with isolated tumour cell (ITC) and in 23.4% excluding them. Opportunities for optimised patient management using OSNA are discussed: intraoperative detection of OSNA-positive SLNs enables axillary lymph node dissection (ALND) during the same procedure; standard OSNA techniques enable the establishment of homogeneous groups based on examination of whole SLNs for valid comparisons between different centres.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10549-011-1808-4",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1092777",
"issn": [
"0167-6806",
"1573-7217"
],
"name": "Breast Cancer Research and Treatment",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "131"
}
],
"name": "Sentinel lymph node analysis in breast cancer: contribution of one-step nucleic acid amplification (OSNA)",
"pagination": "509-516",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"6d9a768adbfd4b20596edb23f5f27c3a35341ea84ed6796e2f8a89abfa735fdb"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"21993859"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8111104"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10549-011-1808-4"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1023005389"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10549-011-1808-4",
"https://app.dimensions.ai/details/publication/pub.1023005389"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-10T19:57",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8681_00000512.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007%2Fs10549-011-1808-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1808-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1808-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1808-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1808-4'
This table displays all metadata directly associated to this object as RDF triples.
267 TRIPLES
21 PREDICATES
65 URIs
35 LITERALS
23 BLANK NODES