Pathological complete response rates following different neoadjuvant chemotherapy regimens for operable breast cancer according to ER status, in two parallel, ... View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2012-04

AUTHORS

Milvia Zambetti, Mauro Mansutti, Patricia Gomez, Ana Lluch, Christian Dittrich, Claudio Zamagni, Eva Ciruelos, Lorenzo Pavesi, Vladimir Semiglazov, Elena De Benedictis, Fernando Gaion, Mario Bari, Paolo Morandi, Pinuccia Valagussa, Gianni Luca

ABSTRACT

Sequential doxorubicin/paclitaxel (AT) followed by CMF treatment was shown to be an active neoadjuvant chemotherapy regimen in the first European Cooperative Trial in Operable Breast Cancer (ECTO I trial). The aim of the current study (ECTO II) is to assess the complete pathological response (pCR) rate following three different anthracycline and taxane-containing neoadjuvant chemotherapy regimens, with or without capecitabine (X). Patients with operable, invasive breast cancer > 2.0 cm in diameter, were randomized to AT→CMF, AT→CMX or AC→TX regimens in two parallel, randomized, open-label, phase II trials (within a single study) in patients with estrogen receptor negative (ER-) and estrogen receptor positive (ER+) diseases, respectively. Exemestane was delivered concomitantly with neoadjuvant chemotherapy in ER+ tumors. Achievement of pCR was more common in ER- than ER+ women (45.3 vs. 10.4%). Capecitabine was only associated with a higher frequency of pCR in ER+ patients receiving AT→CMX. Overall response rates (ORR) ranged from 88 to 97%, and this translated into high rates of breast-conserving surgery (67% of ER- patients and 72% of ER+ patients). All three regimens were well tolerated. Febrile neutropenia and gastrointestinal effects were the most common grade ≥ 3 adverse events. As expected, the ECTO II study showed higher pCR rates in patients with ER- disease. Substituting capecitabine for fluorouracil (± methotrexate) in anthracycline/taxane-containing regimens appeared to be beneficial only in ER+ tumors. Translational studies investigating interactions between therapeutic agents and tumor biology are warranted to refine patient selection and improve the results of neoadjuvant chemotherapy. More... »

PAGES

843-851

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-011-1660-6

DOI

http://dx.doi.org/10.1007/s10549-011-1660-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1030428342

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21750964


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Androstadienes", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Antineoplastic Combined Chemotherapy Protocols", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Capecitabine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cyclophosphamide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Deoxycytidine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Doxorubicin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorouracil", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Leukopenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Methotrexate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoadjuvant Therapy", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm Invasiveness", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neoplasm, Residual", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Neutropenia", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Paclitaxel", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Receptors, Estrogen", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy", 
            "Fondazione Centro San Raffaele del Monte Tabor, Via Olgettina, 60, 20132, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zambetti", 
        "givenName": "Milvia", 
        "id": "sg:person.0724013156.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724013156.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ospedale Universitario Santa Maria della Misericordia, Udine, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mansutti", 
        "givenName": "Mauro", 
        "id": "sg:person.01275164360.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275164360.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitari Vall d'Hebron", 
          "id": "https://www.grid.ac/institutes/grid.411083.f", 
          "name": [
            "Hospital General Vall d\u2019Hebron, Barcelona, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gomez", 
        "givenName": "Patricia", 
        "id": "sg:person.0754424111.72", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754424111.72"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Cl\u00ednico Universitario de Valencia", 
          "id": "https://www.grid.ac/institutes/grid.411308.f", 
          "name": [
            "Hospital Cl\u00ednico Universitario de Valencia, Valencia, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lluch", 
        "givenName": "Ana", 
        "id": "sg:person.01274311013.83", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274311013.83"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Kaiser-Franz-Josef-Spital", 
          "id": "https://www.grid.ac/institutes/grid.414836.c", 
          "name": [
            "LBI-ACR & ACR-ITR VIEnna, Kaiser Franz Josef-Spital, Vienna, Austria"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Dittrich", 
        "givenName": "Christian", 
        "id": "sg:person.01032470343.99", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032470343.99"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Policlinico S.Orsola-Malpighi", 
          "id": "https://www.grid.ac/institutes/grid.412311.4", 
          "name": [
            "Ospedale Policlinico S.Orsola Malpighi, Bologna, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zamagni", 
        "givenName": "Claudio", 
        "id": "sg:person.01325122371.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325122371.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hospital Universitario 12 De Octubre", 
          "id": "https://www.grid.ac/institutes/grid.144756.5", 
          "name": [
            "Hospital Universitario 12 de Octubre, Madrid, Spain"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ciruelos", 
        "givenName": "Eva", 
        "id": "sg:person.01102566244.31", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102566244.31"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondazione Salvatore Maugeri", 
          "id": "https://www.grid.ac/institutes/grid.418378.1", 
          "name": [
            "Fondazione Salvatore Maugeri, Pavia, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pavesi", 
        "givenName": "Lorenzo", 
        "id": "sg:person.01202644560.81", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202644560.81"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Institute of Oncology NN Petrov", 
          "id": "https://www.grid.ac/institutes/grid.465337.0", 
          "name": [
            "NN Petrov Research Institute of Oncology, St. Petersburg, Russian Federation"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Semiglazov", 
        "givenName": "Vladimir", 
        "id": "sg:person.01103717633.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103717633.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Istituto Nazionale dei Tumori", 
          "id": "https://www.grid.ac/institutes/grid.417893.0", 
          "name": [
            "Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "De Benedictis", 
        "givenName": "Elena", 
        "id": "sg:person.01020606657.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020606657.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Ospedale Civile di Camposampiero, Camposampiero, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gaion", 
        "givenName": "Fernando", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Presidio Ospedaliero di Noale, Noale, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Bari", 
        "givenName": "Mario", 
        "id": "sg:person.01157345246.93", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157345246.93"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Ospedale San Bortolo", 
          "id": "https://www.grid.ac/institutes/grid.416303.3", 
          "name": [
            "Ospedale S. Bortolo, Vicenza, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Morandi", 
        "givenName": "Paolo", 
        "id": "sg:person.01316767370.64", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316767370.64"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Fondazione Michelangelo", 
          "id": "https://www.grid.ac/institutes/grid.476276.6", 
          "name": [
            "Fondazione Michelangelo, Milan, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Valagussa", 
        "givenName": "Pinuccia", 
        "id": "sg:person.0715002305.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715002305.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "San Raffaele Hospital", 
          "id": "https://www.grid.ac/institutes/grid.18887.3e", 
          "name": [
            "Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy", 
            "Fondazione Centro San Raffaele del Monte Tabor, Via Olgettina, 60, 20132, Milano, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luca", 
        "givenName": "Gianni", 
        "id": "sg:person.0602632027.96", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602632027.96"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1200/jco.2005.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000047665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000047665"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2006.n.044", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001054119"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1345", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003769138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-05-0539", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004000710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9701-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005466694", 
          "https://doi.org/10.1007/s10549-007-9701-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9701-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005466694", 
          "https://doi.org/10.1007/s10549-007-9701-x"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(11)70122-x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007541846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr2227", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008698022", 
          "https://doi.org/10.1186/bcr2227"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2004.12.128", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008924497"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3816/cbc.2003.s.011", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009197858"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4741.2010.00935.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009987835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1524-4741.2010.00935.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009987835"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.8451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010492454"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.07.032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014791751"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.23.8303", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018720284"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.22789", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018815156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.04.1665", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019068116"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.078", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019539487"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023309553", 
          "https://doi.org/10.1038/sj.bjc.6601784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601784", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023309553", 
          "https://doi.org/10.1038/sj.bjc.6601784"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-06-1109", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025893789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-010-0939-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026380530", 
          "https://doi.org/10.1007/s10549-010-0939-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdh016", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030684198"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(04)17666-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031625479"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.10.956", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032672610"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdm201", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032729393"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(09)70307-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035627502"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(09)61964-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038345999"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djn085", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040857992"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0960-0760(03)00370-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041775418"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/dji021", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042544349"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/annonc/mdp322", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042592360"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.05.3694", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042823680"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.02.6914", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045440787"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2008.19.2567", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046979357"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa052258", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047902372"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050542710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.24876", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050542710"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1023/a:1013128213451", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056306132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2003.12.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064203987"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1080114926", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.1.93", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083201621"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.1998.16.8.2672", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1083305985"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2012-04", 
    "datePublishedReg": "2012-04-01", 
    "description": "Sequential doxorubicin/paclitaxel (AT) followed by CMF treatment was shown to be an active neoadjuvant chemotherapy regimen in the first European Cooperative Trial in Operable Breast Cancer (ECTO I trial). The aim of the current study (ECTO II) is to assess the complete pathological response (pCR) rate following three different anthracycline and taxane-containing neoadjuvant chemotherapy regimens, with or without capecitabine (X). Patients with operable, invasive breast cancer > 2.0 cm in diameter, were randomized to AT\u2192CMF, AT\u2192CMX or AC\u2192TX regimens in two parallel, randomized, open-label, phase II trials (within a single study) in patients with estrogen receptor negative (ER-) and estrogen receptor positive (ER+) diseases, respectively. Exemestane was delivered concomitantly with neoadjuvant chemotherapy in ER+ tumors. Achievement of pCR was more common in ER- than ER+ women (45.3 vs. 10.4%). Capecitabine was only associated with a higher frequency of pCR in ER+ patients receiving AT\u2192CMX. Overall response rates (ORR) ranged from 88 to 97%, and this translated into high rates of breast-conserving surgery (67% of ER- patients and 72% of ER+ patients). All three regimens were well tolerated. Febrile neutropenia and gastrointestinal effects were the most common grade \u2265 3 adverse events. As expected, the ECTO II study showed higher pCR rates in patients with ER- disease. Substituting capecitabine for fluorouracil (\u00b1 methotrexate) in anthracycline/taxane-containing regimens appeared to be beneficial only in ER+ tumors. Translational studies investigating interactions between therapeutic agents and tumor biology are warranted to refine patient selection and improve the results of neoadjuvant chemotherapy.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-011-1660-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "132"
      }
    ], 
    "name": "Pathological complete response rates following different neoadjuvant chemotherapy regimens for operable breast cancer according to ER status, in two parallel, randomized phase II trials with an adaptive study design (ECTO II)", 
    "pagination": "843-851", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "90f541ef15c520926e484e7ed07a61a201d5fe5e3702b05197554b34f8d73242"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "21750964"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-011-1660-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1030428342"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-011-1660-6", 
      "https://app.dimensions.ai/details/publication/pub.1030428342"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T20:39", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8684_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10549-011-1660-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1660-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1660-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1660-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-011-1660-6'


 

This table displays all metadata directly associated to this object as RDF triples.

411 TRIPLES      21 PREDICATES      90 URIs      43 LITERALS      31 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-011-1660-6 schema:about N01bdd32e6f6342abbee07065edd6369a
2 N05faed3ca48f44da8423c13f9be6bdcc
3 N09f4765d369d4aa0b5612c4277a61a5d
4 N0d277020b2ac481fa5a3f5888edbe086
5 N142882c0865b4b5e8f04d16d245dc103
6 N16368edaaf5d4db3a1e79eb955c4e787
7 N1d18fca288f64fe4bd2108212aaaa478
8 N21d41f701e41498e812e82a376975199
9 N235446d50bcc4238bd6fcdcc8c320409
10 N2a2f44def34544f1893efb07727f6f2e
11 N37885cce9917406d98f23783edb583bc
12 N6a00716a16a64f6ab6e272a6c331901a
13 N8e819b295e4644b69599b13dfd8cae9a
14 N9793400ab7394876a2cade69fbe4df65
15 N99a266ead0db409aaea8e1097ecf6556
16 N9d110a101f9f4fbab5eb1d5bf35adcf8
17 Na9a54ff9d3194905b136ab7b8c2884ce
18 Ncbe0bb106aa746088e82d44c444f8878
19 Nd6ff8740e85a41a3abae91305924304a
20 Ndb958c4b1aed4c5ca523c2ba84b06a99
21 Ne2e67bc111e744168e37524edc192751
22 Neb60415d9871443e82c4f5a24cab98c6
23 anzsrc-for:11
24 anzsrc-for:1112
25 schema:author N11ae840faedd49ceb068d70e290fe737
26 schema:citation sg:pub.10.1007/s10549-007-9701-x
27 sg:pub.10.1007/s10549-010-0939-3
28 sg:pub.10.1038/sj.bjc.6601784
29 sg:pub.10.1186/bcr2227
30 https://app.dimensions.ai/details/publication/pub.1080114926
31 https://doi.org/10.1002/cncr.22789
32 https://doi.org/10.1002/cncr.24876
33 https://doi.org/10.1016/s0140-6736(04)17666-6
34 https://doi.org/10.1016/s0140-6736(09)61964-4
35 https://doi.org/10.1016/s0960-0760(03)00370-4
36 https://doi.org/10.1016/s1470-2045(09)70307-9
37 https://doi.org/10.1016/s1470-2045(11)70122-x
38 https://doi.org/10.1023/a:1013128213451
39 https://doi.org/10.1056/nejmoa052258
40 https://doi.org/10.1093/annonc/mdh016
41 https://doi.org/10.1093/annonc/mdm201
42 https://doi.org/10.1093/annonc/mdp322
43 https://doi.org/10.1093/jnci/dji021
44 https://doi.org/10.1093/jnci/djn085
45 https://doi.org/10.1111/j.1524-4741.2010.00935.x
46 https://doi.org/10.1158/1078-0432.ccr-05-0539
47 https://doi.org/10.1158/1078-0432.ccr-06-1109
48 https://doi.org/10.1158/1078-0432.ccr-06-1345
49 https://doi.org/10.1200/jco.1998.16.1.93
50 https://doi.org/10.1200/jco.1998.16.8.2672
51 https://doi.org/10.1200/jco.2003.12.005
52 https://doi.org/10.1200/jco.2004.12.128
53 https://doi.org/10.1200/jco.2005.02.6914
54 https://doi.org/10.1200/jco.2005.04.005
55 https://doi.org/10.1200/jco.2005.04.1665
56 https://doi.org/10.1200/jco.2005.05.078
57 https://doi.org/10.1200/jco.2005.05.3694
58 https://doi.org/10.1200/jco.2005.07.032
59 https://doi.org/10.1200/jco.2005.10.956
60 https://doi.org/10.1200/jco.2008.19.2567
61 https://doi.org/10.1200/jco.2009.23.8303
62 https://doi.org/10.1200/jco.2009.23.8451
63 https://doi.org/10.3816/cbc.2003.s.011
64 https://doi.org/10.3816/cbc.2006.n.044
65 schema:datePublished 2012-04
66 schema:datePublishedReg 2012-04-01
67 schema:description Sequential doxorubicin/paclitaxel (AT) followed by CMF treatment was shown to be an active neoadjuvant chemotherapy regimen in the first European Cooperative Trial in Operable Breast Cancer (ECTO I trial). The aim of the current study (ECTO II) is to assess the complete pathological response (pCR) rate following three different anthracycline and taxane-containing neoadjuvant chemotherapy regimens, with or without capecitabine (X). Patients with operable, invasive breast cancer > 2.0 cm in diameter, were randomized to AT→CMF, AT→CMX or AC→TX regimens in two parallel, randomized, open-label, phase II trials (within a single study) in patients with estrogen receptor negative (ER-) and estrogen receptor positive (ER+) diseases, respectively. Exemestane was delivered concomitantly with neoadjuvant chemotherapy in ER+ tumors. Achievement of pCR was more common in ER- than ER+ women (45.3 vs. 10.4%). Capecitabine was only associated with a higher frequency of pCR in ER+ patients receiving AT→CMX. Overall response rates (ORR) ranged from 88 to 97%, and this translated into high rates of breast-conserving surgery (67% of ER- patients and 72% of ER+ patients). All three regimens were well tolerated. Febrile neutropenia and gastrointestinal effects were the most common grade ≥ 3 adverse events. As expected, the ECTO II study showed higher pCR rates in patients with ER- disease. Substituting capecitabine for fluorouracil (± methotrexate) in anthracycline/taxane-containing regimens appeared to be beneficial only in ER+ tumors. Translational studies investigating interactions between therapeutic agents and tumor biology are warranted to refine patient selection and improve the results of neoadjuvant chemotherapy.
68 schema:genre research_article
69 schema:inLanguage en
70 schema:isAccessibleForFree false
71 schema:isPartOf N41d44578151a42b6a26242de224444cd
72 N808ccf23c5df4a60ba43e81b0ed62364
73 sg:journal.1092777
74 schema:name Pathological complete response rates following different neoadjuvant chemotherapy regimens for operable breast cancer according to ER status, in two parallel, randomized phase II trials with an adaptive study design (ECTO II)
75 schema:pagination 843-851
76 schema:productId N1e0b963db16d4031b985310c147a8563
77 N74a9799521ff4b5cbd85fbee86a0aebe
78 Nb5660ebbe012410e842bc3ae032e74bb
79 Nc12c3ae96aab4f28a5bc151e915f910c
80 Nefab1a301e694850a7bd7b752fb69727
81 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030428342
82 https://doi.org/10.1007/s10549-011-1660-6
83 schema:sdDatePublished 2019-04-10T20:39
84 schema:sdLicense https://scigraph.springernature.com/explorer/license/
85 schema:sdPublisher N5ca2cb3639d741acb2d70a5098a65d4d
86 schema:url http://link.springer.com/10.1007/s10549-011-1660-6
87 sgo:license sg:explorer/license/
88 sgo:sdDataset articles
89 rdf:type schema:ScholarlyArticle
90 N01bdd32e6f6342abbee07065edd6369a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
91 schema:name Leukopenia
92 rdf:type schema:DefinedTerm
93 N0461a755fe2f42d3be760a38194f6e20 rdf:first sg:person.01316767370.64
94 rdf:rest N635300be1984419db9245e82de7a82e2
95 N05faed3ca48f44da8423c13f9be6bdcc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Neoplasm Invasiveness
97 rdf:type schema:DefinedTerm
98 N09f4765d369d4aa0b5612c4277a61a5d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Paclitaxel
100 rdf:type schema:DefinedTerm
101 N0d277020b2ac481fa5a3f5888edbe086 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Humans
103 rdf:type schema:DefinedTerm
104 N0db06d6ade9c4dec83a2975eb45de335 rdf:first sg:person.01325122371.71
105 rdf:rest N6550cb4c5d874a2b85a8505e35fa601d
106 N11ae840faedd49ceb068d70e290fe737 rdf:first sg:person.0724013156.01
107 rdf:rest N43d99bc4c29a48029a9b10ee6188f75f
108 N142882c0865b4b5e8f04d16d245dc103 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Adult
110 rdf:type schema:DefinedTerm
111 N16368edaaf5d4db3a1e79eb955c4e787 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Doxorubicin
113 rdf:type schema:DefinedTerm
114 N1d18fca288f64fe4bd2108212aaaa478 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
115 schema:name Aged
116 rdf:type schema:DefinedTerm
117 N1e0b963db16d4031b985310c147a8563 schema:name doi
118 schema:value 10.1007/s10549-011-1660-6
119 rdf:type schema:PropertyValue
120 N21d41f701e41498e812e82a376975199 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Neoplasm, Residual
122 rdf:type schema:DefinedTerm
123 N235446d50bcc4238bd6fcdcc8c320409 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Antineoplastic Combined Chemotherapy Protocols
125 rdf:type schema:DefinedTerm
126 N267dcd8a214443f68ce7158aa5a953fa rdf:first sg:person.01274311013.83
127 rdf:rest Nd0d423a0ab624ba799eaa340d77bffb5
128 N2a2f44def34544f1893efb07727f6f2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Female
130 rdf:type schema:DefinedTerm
131 N2c5ef54f67d341bcb820709e56210dfc rdf:first sg:person.01157345246.93
132 rdf:rest N0461a755fe2f42d3be760a38194f6e20
133 N37885cce9917406d98f23783edb583bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Breast Neoplasms
135 rdf:type schema:DefinedTerm
136 N3d8caf299b7d430987bec9bd8fda0916 rdf:first sg:person.0754424111.72
137 rdf:rest N267dcd8a214443f68ce7158aa5a953fa
138 N41d44578151a42b6a26242de224444cd schema:volumeNumber 132
139 rdf:type schema:PublicationVolume
140 N426af8104cf446498a521c9d59c0dc17 rdf:first sg:person.01103717633.38
141 rdf:rest Nde53deaefb194879b52776138dfc9175
142 N43d99bc4c29a48029a9b10ee6188f75f rdf:first sg:person.01275164360.81
143 rdf:rest N3d8caf299b7d430987bec9bd8fda0916
144 N5ca2cb3639d741acb2d70a5098a65d4d schema:name Springer Nature - SN SciGraph project
145 rdf:type schema:Organization
146 N635300be1984419db9245e82de7a82e2 rdf:first sg:person.0715002305.49
147 rdf:rest Nd6765d20cb924541b06d1ea6cd87c6f2
148 N6550cb4c5d874a2b85a8505e35fa601d rdf:first sg:person.01102566244.31
149 rdf:rest N94f3a2009045400eba58c41cccabfd6e
150 N69a3b6da6eff4e18953512b009b05797 schema:affiliation N9a1647671c8a4ac2940be0552a17de4a
151 schema:familyName Gaion
152 schema:givenName Fernando
153 rdf:type schema:Person
154 N6a00716a16a64f6ab6e272a6c331901a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Middle Aged
156 rdf:type schema:DefinedTerm
157 N74a9799521ff4b5cbd85fbee86a0aebe schema:name pubmed_id
158 schema:value 21750964
159 rdf:type schema:PropertyValue
160 N808ccf23c5df4a60ba43e81b0ed62364 schema:issueNumber 3
161 rdf:type schema:PublicationIssue
162 N84aea693f2c748e3b05a563ed7f18c6a schema:name Presidio Ospedaliero di Noale, Noale, Italy
163 rdf:type schema:Organization
164 N89208845ba93482598a5dafdb3a304c0 rdf:first N69a3b6da6eff4e18953512b009b05797
165 rdf:rest N2c5ef54f67d341bcb820709e56210dfc
166 N8e819b295e4644b69599b13dfd8cae9a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
167 schema:name Neoadjuvant Therapy
168 rdf:type schema:DefinedTerm
169 N94f3a2009045400eba58c41cccabfd6e rdf:first sg:person.01202644560.81
170 rdf:rest N426af8104cf446498a521c9d59c0dc17
171 N9793400ab7394876a2cade69fbe4df65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
172 schema:name Receptors, Estrogen
173 rdf:type schema:DefinedTerm
174 N99a266ead0db409aaea8e1097ecf6556 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
175 schema:name Cyclophosphamide
176 rdf:type schema:DefinedTerm
177 N9a1647671c8a4ac2940be0552a17de4a schema:name Ospedale Civile di Camposampiero, Camposampiero, Italy
178 rdf:type schema:Organization
179 N9d110a101f9f4fbab5eb1d5bf35adcf8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
180 schema:name Deoxycytidine
181 rdf:type schema:DefinedTerm
182 Na9a54ff9d3194905b136ab7b8c2884ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
183 schema:name Capecitabine
184 rdf:type schema:DefinedTerm
185 Nb5660ebbe012410e842bc3ae032e74bb schema:name nlm_unique_id
186 schema:value 8111104
187 rdf:type schema:PropertyValue
188 Nc014d3f08b4940599878bffa527f48a1 schema:name Ospedale Universitario Santa Maria della Misericordia, Udine, Italy
189 rdf:type schema:Organization
190 Nc12c3ae96aab4f28a5bc151e915f910c schema:name dimensions_id
191 schema:value pub.1030428342
192 rdf:type schema:PropertyValue
193 Ncbe0bb106aa746088e82d44c444f8878 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
194 schema:name Treatment Outcome
195 rdf:type schema:DefinedTerm
196 Nd0d423a0ab624ba799eaa340d77bffb5 rdf:first sg:person.01032470343.99
197 rdf:rest N0db06d6ade9c4dec83a2975eb45de335
198 Nd6765d20cb924541b06d1ea6cd87c6f2 rdf:first sg:person.0602632027.96
199 rdf:rest rdf:nil
200 Nd6ff8740e85a41a3abae91305924304a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
201 schema:name Fluorouracil
202 rdf:type schema:DefinedTerm
203 Ndb958c4b1aed4c5ca523c2ba84b06a99 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
204 schema:name Androstadienes
205 rdf:type schema:DefinedTerm
206 Nde53deaefb194879b52776138dfc9175 rdf:first sg:person.01020606657.30
207 rdf:rest N89208845ba93482598a5dafdb3a304c0
208 Ne2e67bc111e744168e37524edc192751 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
209 schema:name Neutropenia
210 rdf:type schema:DefinedTerm
211 Neb60415d9871443e82c4f5a24cab98c6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
212 schema:name Methotrexate
213 rdf:type schema:DefinedTerm
214 Nefab1a301e694850a7bd7b752fb69727 schema:name readcube_id
215 schema:value 90f541ef15c520926e484e7ed07a61a201d5fe5e3702b05197554b34f8d73242
216 rdf:type schema:PropertyValue
217 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
218 schema:name Medical and Health Sciences
219 rdf:type schema:DefinedTerm
220 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
221 schema:name Oncology and Carcinogenesis
222 rdf:type schema:DefinedTerm
223 sg:journal.1092777 schema:issn 0167-6806
224 1573-7217
225 schema:name Breast Cancer Research and Treatment
226 rdf:type schema:Periodical
227 sg:person.01020606657.30 schema:affiliation https://www.grid.ac/institutes/grid.417893.0
228 schema:familyName De Benedictis
229 schema:givenName Elena
230 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01020606657.30
231 rdf:type schema:Person
232 sg:person.01032470343.99 schema:affiliation https://www.grid.ac/institutes/grid.414836.c
233 schema:familyName Dittrich
234 schema:givenName Christian
235 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01032470343.99
236 rdf:type schema:Person
237 sg:person.01102566244.31 schema:affiliation https://www.grid.ac/institutes/grid.144756.5
238 schema:familyName Ciruelos
239 schema:givenName Eva
240 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01102566244.31
241 rdf:type schema:Person
242 sg:person.01103717633.38 schema:affiliation https://www.grid.ac/institutes/grid.465337.0
243 schema:familyName Semiglazov
244 schema:givenName Vladimir
245 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01103717633.38
246 rdf:type schema:Person
247 sg:person.01157345246.93 schema:affiliation N84aea693f2c748e3b05a563ed7f18c6a
248 schema:familyName Bari
249 schema:givenName Mario
250 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01157345246.93
251 rdf:type schema:Person
252 sg:person.01202644560.81 schema:affiliation https://www.grid.ac/institutes/grid.418378.1
253 schema:familyName Pavesi
254 schema:givenName Lorenzo
255 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01202644560.81
256 rdf:type schema:Person
257 sg:person.01274311013.83 schema:affiliation https://www.grid.ac/institutes/grid.411308.f
258 schema:familyName Lluch
259 schema:givenName Ana
260 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01274311013.83
261 rdf:type schema:Person
262 sg:person.01275164360.81 schema:affiliation Nc014d3f08b4940599878bffa527f48a1
263 schema:familyName Mansutti
264 schema:givenName Mauro
265 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01275164360.81
266 rdf:type schema:Person
267 sg:person.01316767370.64 schema:affiliation https://www.grid.ac/institutes/grid.416303.3
268 schema:familyName Morandi
269 schema:givenName Paolo
270 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01316767370.64
271 rdf:type schema:Person
272 sg:person.01325122371.71 schema:affiliation https://www.grid.ac/institutes/grid.412311.4
273 schema:familyName Zamagni
274 schema:givenName Claudio
275 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01325122371.71
276 rdf:type schema:Person
277 sg:person.0602632027.96 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
278 schema:familyName Luca
279 schema:givenName Gianni
280 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0602632027.96
281 rdf:type schema:Person
282 sg:person.0715002305.49 schema:affiliation https://www.grid.ac/institutes/grid.476276.6
283 schema:familyName Valagussa
284 schema:givenName Pinuccia
285 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0715002305.49
286 rdf:type schema:Person
287 sg:person.0724013156.01 schema:affiliation https://www.grid.ac/institutes/grid.18887.3e
288 schema:familyName Zambetti
289 schema:givenName Milvia
290 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0724013156.01
291 rdf:type schema:Person
292 sg:person.0754424111.72 schema:affiliation https://www.grid.ac/institutes/grid.411083.f
293 schema:familyName Gomez
294 schema:givenName Patricia
295 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0754424111.72
296 rdf:type schema:Person
297 sg:pub.10.1007/s10549-007-9701-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1005466694
298 https://doi.org/10.1007/s10549-007-9701-x
299 rdf:type schema:CreativeWork
300 sg:pub.10.1007/s10549-010-0939-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026380530
301 https://doi.org/10.1007/s10549-010-0939-3
302 rdf:type schema:CreativeWork
303 sg:pub.10.1038/sj.bjc.6601784 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023309553
304 https://doi.org/10.1038/sj.bjc.6601784
305 rdf:type schema:CreativeWork
306 sg:pub.10.1186/bcr2227 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008698022
307 https://doi.org/10.1186/bcr2227
308 rdf:type schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1080114926 schema:CreativeWork
310 https://doi.org/10.1002/cncr.22789 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018815156
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/cncr.24876 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050542710
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/s0140-6736(04)17666-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031625479
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/s0140-6736(09)61964-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038345999
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s0960-0760(03)00370-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041775418
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1016/s1470-2045(09)70307-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035627502
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1016/s1470-2045(11)70122-x schema:sameAs https://app.dimensions.ai/details/publication/pub.1007541846
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1023/a:1013128213451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1056306132
325 rdf:type schema:CreativeWork
326 https://doi.org/10.1056/nejmoa052258 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047902372
327 rdf:type schema:CreativeWork
328 https://doi.org/10.1093/annonc/mdh016 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030684198
329 rdf:type schema:CreativeWork
330 https://doi.org/10.1093/annonc/mdm201 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032729393
331 rdf:type schema:CreativeWork
332 https://doi.org/10.1093/annonc/mdp322 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042592360
333 rdf:type schema:CreativeWork
334 https://doi.org/10.1093/jnci/dji021 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042544349
335 rdf:type schema:CreativeWork
336 https://doi.org/10.1093/jnci/djn085 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040857992
337 rdf:type schema:CreativeWork
338 https://doi.org/10.1111/j.1524-4741.2010.00935.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1009987835
339 rdf:type schema:CreativeWork
340 https://doi.org/10.1158/1078-0432.ccr-05-0539 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004000710
341 rdf:type schema:CreativeWork
342 https://doi.org/10.1158/1078-0432.ccr-06-1109 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025893789
343 rdf:type schema:CreativeWork
344 https://doi.org/10.1158/1078-0432.ccr-06-1345 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003769138
345 rdf:type schema:CreativeWork
346 https://doi.org/10.1200/jco.1998.16.1.93 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083201621
347 rdf:type schema:CreativeWork
348 https://doi.org/10.1200/jco.1998.16.8.2672 schema:sameAs https://app.dimensions.ai/details/publication/pub.1083305985
349 rdf:type schema:CreativeWork
350 https://doi.org/10.1200/jco.2003.12.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064203987
351 rdf:type schema:CreativeWork
352 https://doi.org/10.1200/jco.2004.12.128 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008924497
353 rdf:type schema:CreativeWork
354 https://doi.org/10.1200/jco.2005.02.6914 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045440787
355 rdf:type schema:CreativeWork
356 https://doi.org/10.1200/jco.2005.04.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000047665
357 rdf:type schema:CreativeWork
358 https://doi.org/10.1200/jco.2005.04.1665 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019068116
359 rdf:type schema:CreativeWork
360 https://doi.org/10.1200/jco.2005.05.078 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019539487
361 rdf:type schema:CreativeWork
362 https://doi.org/10.1200/jco.2005.05.3694 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042823680
363 rdf:type schema:CreativeWork
364 https://doi.org/10.1200/jco.2005.07.032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014791751
365 rdf:type schema:CreativeWork
366 https://doi.org/10.1200/jco.2005.10.956 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032672610
367 rdf:type schema:CreativeWork
368 https://doi.org/10.1200/jco.2008.19.2567 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046979357
369 rdf:type schema:CreativeWork
370 https://doi.org/10.1200/jco.2009.23.8303 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018720284
371 rdf:type schema:CreativeWork
372 https://doi.org/10.1200/jco.2009.23.8451 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010492454
373 rdf:type schema:CreativeWork
374 https://doi.org/10.3816/cbc.2003.s.011 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009197858
375 rdf:type schema:CreativeWork
376 https://doi.org/10.3816/cbc.2006.n.044 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001054119
377 rdf:type schema:CreativeWork
378 https://www.grid.ac/institutes/grid.144756.5 schema:alternateName Hospital Universitario 12 De Octubre
379 schema:name Hospital Universitario 12 de Octubre, Madrid, Spain
380 rdf:type schema:Organization
381 https://www.grid.ac/institutes/grid.18887.3e schema:alternateName San Raffaele Hospital
382 schema:name Fondazione Centro San Raffaele del Monte Tabor, Via Olgettina, 60, 20132, Milano, Italy
383 Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
384 rdf:type schema:Organization
385 https://www.grid.ac/institutes/grid.411083.f schema:alternateName Hospital Universitari Vall d'Hebron
386 schema:name Hospital General Vall d’Hebron, Barcelona, Spain
387 rdf:type schema:Organization
388 https://www.grid.ac/institutes/grid.411308.f schema:alternateName Hospital Clínico Universitario de Valencia
389 schema:name Hospital Clínico Universitario de Valencia, Valencia, Spain
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.412311.4 schema:alternateName Policlinico S.Orsola-Malpighi
392 schema:name Ospedale Policlinico S.Orsola Malpighi, Bologna, Italy
393 rdf:type schema:Organization
394 https://www.grid.ac/institutes/grid.414836.c schema:alternateName Kaiser-Franz-Josef-Spital
395 schema:name LBI-ACR & ACR-ITR VIEnna, Kaiser Franz Josef-Spital, Vienna, Austria
396 rdf:type schema:Organization
397 https://www.grid.ac/institutes/grid.416303.3 schema:alternateName Ospedale San Bortolo
398 schema:name Ospedale S. Bortolo, Vicenza, Italy
399 rdf:type schema:Organization
400 https://www.grid.ac/institutes/grid.417893.0 schema:alternateName Istituto Nazionale dei Tumori
401 schema:name Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy
402 rdf:type schema:Organization
403 https://www.grid.ac/institutes/grid.418378.1 schema:alternateName Fondazione Salvatore Maugeri
404 schema:name Fondazione Salvatore Maugeri, Pavia, Italy
405 rdf:type schema:Organization
406 https://www.grid.ac/institutes/grid.465337.0 schema:alternateName Institute of Oncology NN Petrov
407 schema:name NN Petrov Research Institute of Oncology, St. Petersburg, Russian Federation
408 rdf:type schema:Organization
409 https://www.grid.ac/institutes/grid.476276.6 schema:alternateName Fondazione Michelangelo
410 schema:name Fondazione Michelangelo, Milan, Italy
411 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...