Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer ... View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11-30

AUTHORS

Daniele Campa, Rainer Claus, Lucie Dostal, Angelika Stein, Jenny Chang-Claude, Karina Meidtner, Heiner Boeing, Anja Olsen, Anne Tjønneland, Kim Overvad, Laudina Rodríguez, Catalina Bonet, Maria-José Sánchez, Pilar Amiano, José María Huerta, Aurelio Barricarte, Kay-Tee Khaw, Nicholas Wareham, Ruth C. Travis, Naomi E. Allen, Antonia Trichopoulou, Christina Bamia, Vassiliki Benetou, Domenico Palli, Claudia Agnoli, Salvatore Panico, Rosario Tumino, Carlotta Sacerdote, Henk van Kranen, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Carla H. van Gils, Per Lenner, Malin Sund, Eiliv Lund, Inger Torhild Gram, Sabina Rinaldi, Veronique Chajes, Isabelle Romieu, Pierre Engel, Marie Christine Boutron-Ruault, Françoise Clavel-Chapelon, Afshan Siddiq, Elio Riboli, Federico Canzian, Rudolf Kaaks

ABSTRACT

AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecular mechanisms are thought to play a key role in breast carcinogenesis. We investigated the genetic variability of four genes encoding AMPK (PRKAA1, PRKAA2, PRKAB1 and PRKAB2). Using a tagging approach and selecting SNPs we covered all the common genetic variation of these genes. We tested association of tagging SNPs in our four candidate genes with breast cancer (BC) risk in a study of 1340 BC cases and 2536 controls nested into the European Prospective Investigation into Cancer and Nutrition (EPIC). Given the relevance of AMPK on fatty acid synthesis and the importance of body fatness as a BC risk factor, we tested association of SNPs and body-mass index as well. We observed no statistically significant association between the SNPs in the PRKAs genes and BC risk and BMI after correction for multiple testing. More... »

PAGES

761-767

Journal

TITLE

Breast Cancer Research and Treatment

ISSUE

3

VOLUME

127

Author Affiliations

  • Department of Cancer Epidemiology, German Cancer Research Center, Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
  • Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Germany
  • Institute of Cancer Epidemiology, The Danish Cancer Society, Copenhagen, Denmark
  • Department of Epidemiology, School of Public Health, Aarhus University, Aarhus, Denmark
  • Public Health and Participation Directorate, Health and Health Care Services Council, Oveido, Asturias, Spain
  • Department of Epidemiology, Catalan Institute of Oncology, Barcelona, Spain
  • Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Madrid, Spain
  • Public Health Division of Gipuzkoa, Instituto Investigación BioDonostia, IISBioDonostia, San Sebastian, Gipuzkoa, Spain
  • Department of Epidemiology, Murcia Regional Health Authority, Murcia, Spain
  • Navarre Public Health Institute, Pamplona, Spain
  • University of Cambridge School of Clinical Medicine, Cambridge, UK
  • MRC Epidemiology Unit, Cambridge, UK
  • Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, UK
  • WHO Collaborating Center for Food and Nutrition Policies, Department of Hygiene, Epidemiology and Medical Statistics, University of Athens Medical School, Athens, Greece
  • Molecular and Nutritional Epidemiology Unit, Cancer Research and Prevention Institute—ISPO, Florence, Italy
  • Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy
  • Department of Clinical and Experimental Medicine, Federico II University, Naples, Italy
  • Cancer registry and Histopathology Unit, “Civile-M.P.Arezzo” Hospital, ASP 7, Ragusa, Italy
  • Human Genetic Foundation (HuGeF), Turin, Italy
  • Centre for Nutrition and Health (CVG), National Institute for Public Health and the Environment, Bilthoven, Netherlands
  • Julius Center, University Medical Center, Utrecht, The Netherlands
  • Department of Public Health and Clinical Medicine, Umeå University, Umeå, Sweden
  • Department of Surgery, Umeå University, Umeå, Sweden
  • Institute of Community Medicine University of Tromsø, Tromsø, Norway
  • International Agency for Research on Cancer, Lyon, France
  • INSERM UMR 1018, Team 9: Nutrition, Hormones et Santé des femmes, Centre de Recherche en Epidémiologie et Santé des Populations, Hôpital Paul Brousse, Villejuif, France
  • Imperial College, London, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-010-1269-1

    DOI

    http://dx.doi.org/10.1007/s10549-010-1269-1

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1045092782

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21116708


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