Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2010-09

AUTHORS

Kristy A. Brown, Nicole I. Hunger, Maria Docanto, Evan R. Simpson

ABSTRACT

AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inhibit aromatase expression, hence estrogen production, within the breast. The anti-diabetic drug metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells. Results demonstrate that metformin significantly decreases the forskolin/phorbol ester (FSK/PMA)-induced expression of aromatase at concentrations of 10 and 50 muM. Consistent with the hypothesized actions of metformin to increase AMPK activity, treatment with 50 muM metformin results in a significant increase in phosphorylation of AMPK at Thr172. Interestingly, metformin also causes a significant increase in LKB1 protein expression and promoter activity, thereby providing for the first time an additional mechanism by which metformin activates AMPK. Furthermore, metformin inhibits the nuclear translocation of CRTC2, a CREB-coactivator known to increase aromatase expression which is also a direct downstream target of AMPK. Overall, these results suggest that metformin would reduce the local production of estrogens within the breast thereby providing a new key therapeutic tool that could be used in the neoadjuvant and adjuvant settings and conceivably also as a preventative measure in obese women. More... »

PAGES

591-596

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-010-0834-y

DOI

http://dx.doi.org/10.1007/s10549-010-0834-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1049611731

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/20300828


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "AMP-Activated Protein Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Active Transport, Cell Nucleus", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adipose Tissue", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Animals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aromatase Inhibitors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Binding Sites", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "COS Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cercopithecus aethiops", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Colforsin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Dose-Response Relationship, Drug", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Enzyme Activation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Metformin", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Phosphorylation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Promoter Regions, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Protein-Serine-Threonine Kinases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Stromal Cells", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tetradecanoylphorbol Acetate", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Threonine", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transcription Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Transfection", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Prince Henry\u2019s Institute of Medical Research, P.O. Box 5152, 3168, Clayton, VIC, Australia", 
            "Department of Physiology, Monash University, 3168, Clayton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Brown", 
        "givenName": "Kristy A.", 
        "id": "sg:person.01100276501.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100276501.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hudson Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452824.d", 
          "name": [
            "Prince Henry\u2019s Institute of Medical Research, P.O. Box 5152, 3168, Clayton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hunger", 
        "givenName": "Nicole I.", 
        "id": "sg:person.01352526625.49", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352526625.49"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Hudson Institute of Medical Research", 
          "id": "https://www.grid.ac/institutes/grid.452824.d", 
          "name": [
            "Prince Henry\u2019s Institute of Medical Research, P.O. Box 5152, 3168, Clayton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Docanto", 
        "givenName": "Maria", 
        "id": "sg:person.0641647077.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641647077.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Monash University", 
          "id": "https://www.grid.ac/institutes/grid.1002.3", 
          "name": [
            "Prince Henry\u2019s Institute of Medical Research, P.O. Box 5152, 3168, Clayton, VIC, Australia", 
            "Department of Biochemistry and Molecular Biology, Monash University, 3168, Clayton, VIC, Australia"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Simpson", 
        "givenName": "Evan R.", 
        "id": "sg:person.01371245572.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371245572.08"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1096/fj.05-5710fje", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000458471"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-09-0108", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007047299"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1136/bmj.38415.708634.f7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022994993"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2009.22.1630", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027818369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1055-9965.epi-08-0871", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029318706"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029571611", 
          "https://doi.org/10.1038/nature03967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature03967", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029571611", 
          "https://doi.org/10.1038/nature03967"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1006/bbrc.1994.1163", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030312500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1139/y06-005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037387122"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1677/erc-06-0068", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039278789"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci13505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043705336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci13505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043705336"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.270.22.13561", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045433011"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2003.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045933221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2003.08.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045933221"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6604913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051508888", 
          "https://doi.org/10.1038/sj.bjc.6604913"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.275.1.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052895019"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/er.2004-0020", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064285822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1082466798", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2010-09", 
    "datePublishedReg": "2010-09-01", 
    "description": "AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inhibit aromatase expression, hence estrogen production, within the breast. The anti-diabetic drug metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells. Results demonstrate that metformin significantly decreases the forskolin/phorbol ester (FSK/PMA)-induced expression of aromatase at concentrations of 10 and 50 muM. Consistent with the hypothesized actions of metformin to increase AMPK activity, treatment with 50 muM metformin results in a significant increase in phosphorylation of AMPK at Thr172. Interestingly, metformin also causes a significant increase in LKB1 protein expression and promoter activity, thereby providing for the first time an additional mechanism by which metformin activates AMPK. Furthermore, metformin inhibits the nuclear translocation of CRTC2, a CREB-coactivator known to increase aromatase expression which is also a direct downstream target of AMPK. Overall, these results suggest that metformin would reduce the local production of estrogens within the breast thereby providing a new key therapeutic tool that could be used in the neoadjuvant and adjuvant settings and conceivably also as a preventative measure in obese women.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-010-0834-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.6729285", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6714500", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "123"
      }
    ], 
    "name": "Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase", 
    "pagination": "591-596", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "ec561bb252fee24c77d0952ff4e38e37381c9539c393d95bc60f5d441e7a6eea"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "20300828"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-010-0834-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1049611731"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-010-0834-y", 
      "https://app.dimensions.ai/details/publication/pub.1049611731"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T10:20", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000348_0000000348/records_54334_00000000.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10549-010-0834-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-010-0834-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-010-0834-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-010-0834-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-010-0834-y'


 

This table displays all metadata directly associated to this object as RDF triples.

244 TRIPLES      21 PREDICATES      69 URIs      45 LITERALS      33 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-010-0834-y schema:about N054c34542a66470480146f1a74dfb590
2 N2b6cfd3f24914f19b8bbdc7c80d79e32
3 N2dfd0117d09e4bc895cce2f76875a9c0
4 N37f8bc78cab141cbbae9e56d997d918b
5 N4348e0d3213744c1ae5f0f6691d204ce
6 N4476aaea782a4ad8a9bfa91fdedfdba4
7 N485d8f8c13ef4d9b8cf688c4efcadb46
8 N516917c9edc1494abacc5fbfc5aa3f5f
9 N591c493a069b45a78beb1d2a67992261
10 N5c8f1178f2524809ace6c20d8908f834
11 N608f5b2fead94f7da30af9188a581386
12 N64ec63b9c35a41bd93a613f306ff630a
13 N6fd4442c480f486d87e8922ba8d8efbb
14 N7cd78a86ce654f359ee1ee163b06c1da
15 N83f5f6abb4fc419f8b959428ec45268b
16 N8fe8fb770e9d43a796ac6d99ecb54747
17 N956b66bdbcee4e7987daddaf9e1fdb5f
18 Na0957fc2252f46e79d40121273f991e2
19 Nb268daade6b4474c960be9494eb5a5c5
20 Nb4e8e43be58c481fa33fa672210d3fe8
21 Nc1b66fb2e0c34f068e58101b5e8adbd4
22 Nd57c58906791474f8e1f021ec62b9623
23 Neab9fac3a4f44cb2adb79d5d961ead3a
24 Nfb43270ab01e47789c425c7c23b1e7a2
25 anzsrc-for:06
26 anzsrc-for:0601
27 schema:author Nf978782db52046e3bf9717759882edf1
28 schema:citation sg:pub.10.1038/nature03967
29 sg:pub.10.1038/sj.bjc.6604913
30 https://app.dimensions.ai/details/publication/pub.1082466798
31 https://doi.org/10.1006/bbrc.1994.1163
32 https://doi.org/10.1016/j.molcel.2003.08.013
33 https://doi.org/10.1074/jbc.270.22.13561
34 https://doi.org/10.1074/jbc.275.1.223
35 https://doi.org/10.1096/fj.05-5710fje
36 https://doi.org/10.1136/bmj.38415.708634.f7
37 https://doi.org/10.1139/y06-005
38 https://doi.org/10.1158/0008-5472.can-09-0108
39 https://doi.org/10.1158/1055-9965.epi-08-0871
40 https://doi.org/10.1172/jci13505
41 https://doi.org/10.1200/jco.2009.22.1630
42 https://doi.org/10.1210/er.2004-0020
43 https://doi.org/10.1677/erc-06-0068
44 schema:datePublished 2010-09
45 schema:datePublishedReg 2010-09-01
46 schema:description AMP-activated protein kinase (AMPK) is recognized as a master regulator of energy homeostasis. In concert with the AMPK-kinase LKB1, it has been shown to provide a molecular link between obesity and postmenopausal breast cancer via its actions to inhibit aromatase expression, hence estrogen production, within the breast. The anti-diabetic drug metformin is known to increase the activity of AMPK and was therefore hypothesized to inhibit aromatase expression in primary human breast adipose stromal cells. Results demonstrate that metformin significantly decreases the forskolin/phorbol ester (FSK/PMA)-induced expression of aromatase at concentrations of 10 and 50 muM. Consistent with the hypothesized actions of metformin to increase AMPK activity, treatment with 50 muM metformin results in a significant increase in phosphorylation of AMPK at Thr172. Interestingly, metformin also causes a significant increase in LKB1 protein expression and promoter activity, thereby providing for the first time an additional mechanism by which metformin activates AMPK. Furthermore, metformin inhibits the nuclear translocation of CRTC2, a CREB-coactivator known to increase aromatase expression which is also a direct downstream target of AMPK. Overall, these results suggest that metformin would reduce the local production of estrogens within the breast thereby providing a new key therapeutic tool that could be used in the neoadjuvant and adjuvant settings and conceivably also as a preventative measure in obese women.
47 schema:genre research_article
48 schema:inLanguage en
49 schema:isAccessibleForFree false
50 schema:isPartOf Na2fc7c63a41e43d892543a1a481f0a51
51 Ne62433720b184dad8913088946773d0b
52 sg:journal.1092777
53 schema:name Metformin inhibits aromatase expression in human breast adipose stromal cells via stimulation of AMP-activated protein kinase
54 schema:pagination 591-596
55 schema:productId N178ce1f4ab724b32b2f19e5500e14c20
56 N1c18c82f38dc46c092977faf267f8d58
57 N9ce74fa6088d47a5a8c097786213cc43
58 Nafc1611ab1444327acaead8de3eaf8b2
59 Nfded7d0a79064b33b1d042402dfa5fb0
60 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049611731
61 https://doi.org/10.1007/s10549-010-0834-y
62 schema:sdDatePublished 2019-04-11T10:20
63 schema:sdLicense https://scigraph.springernature.com/explorer/license/
64 schema:sdPublisher N327c41af78154e72acba7eb364924794
65 schema:url http://link.springer.com/10.1007/s10549-010-0834-y
66 sgo:license sg:explorer/license/
67 sgo:sdDataset articles
68 rdf:type schema:ScholarlyArticle
69 N054c34542a66470480146f1a74dfb590 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
70 schema:name Stromal Cells
71 rdf:type schema:DefinedTerm
72 N178ce1f4ab724b32b2f19e5500e14c20 schema:name pubmed_id
73 schema:value 20300828
74 rdf:type schema:PropertyValue
75 N1c18c82f38dc46c092977faf267f8d58 schema:name readcube_id
76 schema:value ec561bb252fee24c77d0952ff4e38e37381c9539c393d95bc60f5d441e7a6eea
77 rdf:type schema:PropertyValue
78 N2b6cfd3f24914f19b8bbdc7c80d79e32 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name AMP-Activated Protein Kinases
80 rdf:type schema:DefinedTerm
81 N2dfd0117d09e4bc895cce2f76875a9c0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Binding Sites
83 rdf:type schema:DefinedTerm
84 N327c41af78154e72acba7eb364924794 schema:name Springer Nature - SN SciGraph project
85 rdf:type schema:Organization
86 N37f8bc78cab141cbbae9e56d997d918b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
87 schema:name Transcription Factors
88 rdf:type schema:DefinedTerm
89 N4348e0d3213744c1ae5f0f6691d204ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Phosphorylation
91 rdf:type schema:DefinedTerm
92 N4476aaea782a4ad8a9bfa91fdedfdba4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
93 schema:name Animals
94 rdf:type schema:DefinedTerm
95 N485d8f8c13ef4d9b8cf688c4efcadb46 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
96 schema:name Cercopithecus aethiops
97 rdf:type schema:DefinedTerm
98 N516917c9edc1494abacc5fbfc5aa3f5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
99 schema:name Enzyme Activation
100 rdf:type schema:DefinedTerm
101 N591c493a069b45a78beb1d2a67992261 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
102 schema:name Aromatase
103 rdf:type schema:DefinedTerm
104 N5c8f1178f2524809ace6c20d8908f834 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Tetradecanoylphorbol Acetate
106 rdf:type schema:DefinedTerm
107 N608f5b2fead94f7da30af9188a581386 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
108 schema:name Adipose Tissue
109 rdf:type schema:DefinedTerm
110 N64ec63b9c35a41bd93a613f306ff630a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
111 schema:name Threonine
112 rdf:type schema:DefinedTerm
113 N655b37e1e0334c53aa00f1bf21b4e4ce rdf:first sg:person.0641647077.30
114 rdf:rest N73c351e636f24c2e8d166044b2ca7394
115 N6fd4442c480f486d87e8922ba8d8efbb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Active Transport, Cell Nucleus
117 rdf:type schema:DefinedTerm
118 N73c351e636f24c2e8d166044b2ca7394 rdf:first sg:person.01371245572.08
119 rdf:rest rdf:nil
120 N7cd78a86ce654f359ee1ee163b06c1da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Transfection
122 rdf:type schema:DefinedTerm
123 N83f5f6abb4fc419f8b959428ec45268b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
124 schema:name Humans
125 rdf:type schema:DefinedTerm
126 N8fe8fb770e9d43a796ac6d99ecb54747 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
127 schema:name Female
128 rdf:type schema:DefinedTerm
129 N956b66bdbcee4e7987daddaf9e1fdb5f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Colforsin
131 rdf:type schema:DefinedTerm
132 N9ce74fa6088d47a5a8c097786213cc43 schema:name doi
133 schema:value 10.1007/s10549-010-0834-y
134 rdf:type schema:PropertyValue
135 Na0957fc2252f46e79d40121273f991e2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
136 schema:name Promoter Regions, Genetic
137 rdf:type schema:DefinedTerm
138 Na2fc7c63a41e43d892543a1a481f0a51 schema:issueNumber 2
139 rdf:type schema:PublicationIssue
140 Nafc1611ab1444327acaead8de3eaf8b2 schema:name dimensions_id
141 schema:value pub.1049611731
142 rdf:type schema:PropertyValue
143 Nb268daade6b4474c960be9494eb5a5c5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name COS Cells
145 rdf:type schema:DefinedTerm
146 Nb4e8e43be58c481fa33fa672210d3fe8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Breast
148 rdf:type schema:DefinedTerm
149 Nb714f64c27bb41058197d4c93e6d4b70 rdf:first sg:person.01352526625.49
150 rdf:rest N655b37e1e0334c53aa00f1bf21b4e4ce
151 Nc1b66fb2e0c34f068e58101b5e8adbd4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
152 schema:name Aromatase Inhibitors
153 rdf:type schema:DefinedTerm
154 Nd57c58906791474f8e1f021ec62b9623 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
155 schema:name Metformin
156 rdf:type schema:DefinedTerm
157 Ne62433720b184dad8913088946773d0b schema:volumeNumber 123
158 rdf:type schema:PublicationVolume
159 Neab9fac3a4f44cb2adb79d5d961ead3a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Dose-Response Relationship, Drug
161 rdf:type schema:DefinedTerm
162 Nf978782db52046e3bf9717759882edf1 rdf:first sg:person.01100276501.82
163 rdf:rest Nb714f64c27bb41058197d4c93e6d4b70
164 Nfb43270ab01e47789c425c7c23b1e7a2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
165 schema:name Protein-Serine-Threonine Kinases
166 rdf:type schema:DefinedTerm
167 Nfded7d0a79064b33b1d042402dfa5fb0 schema:name nlm_unique_id
168 schema:value 8111104
169 rdf:type schema:PropertyValue
170 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
171 schema:name Biological Sciences
172 rdf:type schema:DefinedTerm
173 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
174 schema:name Biochemistry and Cell Biology
175 rdf:type schema:DefinedTerm
176 sg:grant.6714500 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-010-0834-y
177 rdf:type schema:MonetaryGrant
178 sg:grant.6729285 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-010-0834-y
179 rdf:type schema:MonetaryGrant
180 sg:journal.1092777 schema:issn 0167-6806
181 1573-7217
182 schema:name Breast Cancer Research and Treatment
183 rdf:type schema:Periodical
184 sg:person.01100276501.82 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
185 schema:familyName Brown
186 schema:givenName Kristy A.
187 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01100276501.82
188 rdf:type schema:Person
189 sg:person.01352526625.49 schema:affiliation https://www.grid.ac/institutes/grid.452824.d
190 schema:familyName Hunger
191 schema:givenName Nicole I.
192 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01352526625.49
193 rdf:type schema:Person
194 sg:person.01371245572.08 schema:affiliation https://www.grid.ac/institutes/grid.1002.3
195 schema:familyName Simpson
196 schema:givenName Evan R.
197 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371245572.08
198 rdf:type schema:Person
199 sg:person.0641647077.30 schema:affiliation https://www.grid.ac/institutes/grid.452824.d
200 schema:familyName Docanto
201 schema:givenName Maria
202 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0641647077.30
203 rdf:type schema:Person
204 sg:pub.10.1038/nature03967 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029571611
205 https://doi.org/10.1038/nature03967
206 rdf:type schema:CreativeWork
207 sg:pub.10.1038/sj.bjc.6604913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051508888
208 https://doi.org/10.1038/sj.bjc.6604913
209 rdf:type schema:CreativeWork
210 https://app.dimensions.ai/details/publication/pub.1082466798 schema:CreativeWork
211 https://doi.org/10.1006/bbrc.1994.1163 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030312500
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.molcel.2003.08.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045933221
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1074/jbc.270.22.13561 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045433011
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1074/jbc.275.1.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052895019
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1096/fj.05-5710fje schema:sameAs https://app.dimensions.ai/details/publication/pub.1000458471
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1136/bmj.38415.708634.f7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022994993
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1139/y06-005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037387122
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1158/0008-5472.can-09-0108 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007047299
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1158/1055-9965.epi-08-0871 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029318706
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1172/jci13505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043705336
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1200/jco.2009.22.1630 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027818369
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1210/er.2004-0020 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064285822
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1677/erc-06-0068 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039278789
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.1002.3 schema:alternateName Monash University
238 schema:name Department of Biochemistry and Molecular Biology, Monash University, 3168, Clayton, VIC, Australia
239 Department of Physiology, Monash University, 3168, Clayton, VIC, Australia
240 Prince Henry’s Institute of Medical Research, P.O. Box 5152, 3168, Clayton, VIC, Australia
241 rdf:type schema:Organization
242 https://www.grid.ac/institutes/grid.452824.d schema:alternateName Hudson Institute of Medical Research
243 schema:name Prince Henry’s Institute of Medical Research, P.O. Box 5152, 3168, Clayton, VIC, Australia
244 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...