IGF-I during primiparous pregnancy and maternal risk of breast cancer View Full Text


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Article Info

DATE

2009-09-02

AUTHORS

Tianhui Chen, Annekatrin Lukanova, Kjell Grankvist, Anne Zeleniuch-Jacquotte, Marianne Wulff, Robert Johansson, Helena Schock, Per Lenner, Goran Hallmans, Goran Wadell, Paolo Toniolo, Eva Lundin

ABSTRACT

Previously, we reported that insulin-like growth factor (IGF)-I during early pregnancy is positively associated with maternal risk of breast cancer. To further explore this association, we designed a new study limited to women who donated a blood sample during their first pregnancy ending with childbirth. A case–control study was nested within the Northern Sweden Maternity Cohort in which repository since 1975, serum specimens remaining after early pregnancy screening for infectious diseases had been preserved. Study subjects were selected among women who donated a blood sample during the full-term pregnancy that led to the birth of their first child. Two hundred and forty-four women with invasive breast cancer were eligible. Two controls, matching the index case for age and date at blood donation were selected (n = 453). IGF-I was measured in serum samples on an Immulite 2000 analyzer. Conditional logistic regression was used to estimate odds ratios and 95% confidence intervals. A significant positive association of breast cancer with IGF-I was observed, with OR of 1.73 (95% CI: 1.14–2.63) for the top tertile, P < 0.009. Subgroup analyses did not indicate statistical heterogeneity of the association by ages at sampling and diagnosis or by lag time to cancer diagnosis, although somewhat stronger associations with risk were observed in women ≤age 25 at index pregnancy and for cases diagnosed within 15 years of blood donation. The results of the study add further evidence for an adverse effect of elevated IGF-I concentrations during early reproductive life on risk of breast cancer. More... »

PAGES

169-175

References to SciGraph publications

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  • 1998-01. Role of Hormones in Mammary Cancer Initiation and Progression in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2002-02-26. Differential effects of reproductive factors on the risk of pre- and postmenopausal breast cancer. Results from a large cohort of French women in BRITISH JOURNAL OF CANCER
  • 2002-05. Dual effect of first full term pregnancy on breast cancer risk: empirical evidence and postulated underlying biology in CANCER CAUSES & CONTROL
  • 2004-02. Radiation and breast cancer: a review of current evidence in BREAST CANCER RESEARCH
  • 2002-05. Transient increase in breast cancer risk after giving birth: postpartum period with the highest risk (Sweden) in CANCER CAUSES & CONTROL
  • 1998-02. Endocrine effects of IGF-I on normal and transformed breast epithelial cells: potential relevance to strategies for breast cancer treatment and prevention in BREAST CANCER RESEARCH AND TREATMENT
  • 2008-11-20. IGF Ligand and Receptor Regulation of Mammary Development in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2008-11-11. The Impact of Transgenic IGF-IR Overexpression on Mammary Development and Tumorigenesis in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 2006-04. Pregnancy-associated breast cancer and metastasis in NATURE REVIEWS CANCER
  • 2007-01-19. Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients in BREAST CANCER RESEARCH
  • 1996. Smoothing by Local Regression: Principles and Methods in STATISTICAL THEORY AND COMPUTATIONAL ASPECTS OF SMOOTHING
  • 1996. Rejoinder in STATISTICAL THEORY AND COMPUTATIONAL ASPECTS OF SMOOTHING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-009-0519-6

    DOI

    http://dx.doi.org/10.1007/s10549-009-0519-6

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1039582903

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19728079


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