Genetic variation in genes of the fatty acid synthesis pathway and breast cancer risk View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-02-28

AUTHORS

Daniele Campa, James McKay, Olga Sinilnikova, Anika Hüsing, Ulla Vogel, Rikke Dalgaard Hansen, Kim Overvad, Petra Mariann Witt, Françoise Clavel-Chapelon, Marie-Christine Boutron-Ruault, Veronique Chajes, Sabine Rohrmann, Jenny Chang-Claude, Heiner Boeing, Eva Fisher, Antonia Trichopoulou, Dimitrios Trichopoulos, Domenico Palli, Anna Villarini, Carlotta Sacerdote, Amalia Mattiello, Rosario Tumino, Petra H. M. Peeters, Carla H. van Gils, H. Bas Bueno-de-Mesquita, Eiliv Lund, María Dolores Chirlaque, Núria Sala, Laudina Rodriguez Suarez, Aurelio Barricarte, Miren Dorronsoro, Maria-José Sánchez, Per Lenner, Göran Hallmans, Kostas Tsilidis, Sheila Bingham, Kay-Tee Khaw, Valentina Gallo, Teresa Norat, Elio Riboli, Sabina Rinaldi, Gilbert Lenoir, Sean V. Tavtigian, Federico Canzian, Rudolf Kaaks

ABSTRACT

Fatty acid synthase (FAS) is the major enzyme of lipogenesis. It catalyzes the NADPH-dependent condensation of acetyl-CoA and malonyl-CoA to produce palmitic acid. Transcription of the FAS gene is controlled synergistically by the transcription factors ChREBP (carbohydrate response element-binding protein), which is induced by glucose, and SREBP-1 (sterol response element-binding protein-1), which is stimulated by insulin through the PI3K/Akt signal transduction pathway. We investigated whether the genetic variability of the genes encoding for ChREBP, SREBP and FAS (respectively, MLXIPL, SREBF1 and FASN) is related to breast cancer risk and body-mass index (BMI) by studying 1,294 breast cancer cases and 2,452 controls from the European Prospective Investigation on Cancer (EPIC). We resequenced the FAS gene and combined information of SNPs found by resequencing and SNPs from public databases. Using a tagging approach and selecting 20 SNPs, we covered all the common genetic variation of these genes. In this study we were not able to find any statistically significant association between the SNPs in the FAS, ChREBP and SREPB-1 genes and an increased risk of breast cancer overall and by subgroups of age, menopausal status, hormone replacement therapy (HRT) use or BMI. On the other hand, we found that two SNPs in FASN were associated with BMI. More... »

PAGES

565-574

Journal

TITLE

Breast Cancer Research and Treatment

ISSUE

3

VOLUME

118

Author Affiliations

  • University of Pisa, Pisa, Italy
  • International Agency for Research on Cancer, Lyon, France
  • Hospices Civils de Lyon/Centre Léon Bérard, CNRS-Université Claude Bernard UMR5201, Lyon, France
  • Department of Cancer Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120, Heidelberg, Germany
  • National Food Institute, Technical University of Denmark, Copenhagen, Denmark
  • Danish Cancer Society, Copenhagen, Denmark
  • Aarhus University Hospital, Aalborg, Denmark
  • Insitut Gustave Roussy, Villejuif, France
  • German Institute of Human Nutrition, Potsdam-Rehbruecke, Germany
  • Department of Hygiene and Epidemiology, Medical School, University of Athens, Athens, Greece
  • Department of Epidemiology, Havard School of Public Health, Boston, MA, USA
  • Cancer Research and Prevention Institute (ISPO), Florence, Italy
  • Istituto Nazionale dei Tumori (IRCCS), Milan, Italy
  • CPO Piemonte, Torino, Italy
  • Federico II University, Naples, Italy
  • Azienda Ospedaliera “Civile M.P. Arezzo”, Ragusa, Italy
  • Julius Center, University Medical Center, Utrecht, The Netherlands
  • National Institute for Public Health and the Environment, Bilthoven, The Netherlands
  • Institute of Community Medicine University of Tromsø, Tromsø, Norway
  • Murcia Health Council, Murcia, Spain
  • Catalan Institute of Oncology, Barcelona, Spain
  • Consejería de Salud y Servicios Sanitarios Principado de Asturias, Oviedo, Spain
  • Public Health Institute of Navarra, Pamplona, Spain
  • Public Health Department of Gipuzkoa and CIBER de Epidemiología y Salud Pública (CIBERESP), San Sebastian, Spain
  • Andalusian School of Public Health and CIBERESP, Granada, Spain
  • Umeå University, Umeå, Sweden
  • University of Oxford, Oxford, UK
  • University of Cambridge, Cambridge, UK
  • Imperial College, London, UK
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-009-0347-8

    DOI

    http://dx.doi.org/10.1007/s10549-009-0347-8

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1053302483

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19252981


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