Relationship between oestrogen receptor status and proliferation in predicting response and long-term outcome to neoadjuvant chemotherapy for breast cancer View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-01

AUTHORS

Robin L. Jones, Janine Salter, Roger A’Hern, Ash Nerurkar, Marina Parton, Jorge S. Reis-Filho, Ian E. Smith, Mitchell Dowsett

ABSTRACT

Oestrogen receptor (ER) negative breast cancers are more likely to achieve a pathological complete response (pCR) to neoadjuvant chemotherapy compared to those with ER positive tumours. ER positive tumours exhibit low proliferation and ER negative cancers high proliferation. The aim of this study was to determine to what extent the better response of ER negative cancers correlates with proliferation rate. A retrospective analysis of a prospectively maintained database identified 175 neoadjuvant chemotherapy patients with tissue available for Ki67 analysis. On univariate analysis, pre-therapy Ki67 (P = 0.04), ER status (P = 0.002), HER2 status (P = 0.004) and grade (P = 0.0009) were associated with a pCR. In a multivariate model, HER2 was the only significant predictor of pCR. No significant relationship between pre-therapy Ki67 and relapse-free and overall survival was demonstrated. Ki67 is not an independent predictor of clinical CR or pCR. Aspects of ER status beyond its inverse relationship with proliferation may contribute to its predictive value for pCR. More... »

PAGES

315

References to SciGraph publications

  • 2007-05. Ki-67 as prognostic marker in early breast cancer: a meta-analysis of published studies involving 12 155 patients in BRITISH JOURNAL OF CANCER
  • 1998-02. Prognostic role of clinical, pathological and biological characteristics in patients with locally advanced breast cancer in BRITISH JOURNAL OF CANCER
  • 2003-09. Early changes in apoptosis and proliferation following primary chemotherapy for breast cancer in BRITISH JOURNAL OF CANCER
  • 2007-12. Topoisomerase II alpha amplification may predict benefit from adjuvant anthracyclines in HER2 positive early breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • 2003-03. Expression of Cell Cycle Regulatory Proteins in Breast Carcinomas Before and After Preoperative Chemotherapy in BREAST CANCER RESEARCH AND TREATMENT
  • 2003-02. Breast cancer response to neoadjuvant chemotherapy: predictive markers and relation with outcome in BRITISH JOURNAL OF CANCER
  • 2004-12. Oestrogen receptor status, pathological complete response and prognosis in patients receiving neoadjuvant chemotherapy for early breast cancer in BRITISH JOURNAL OF CANCER
  • 2008-04. Evaluation of ER and Ki-67 proliferation index as prognostic factors for survival following neoadjuvant chemotherapy with doxorubicin/docetaxel for locally advanced breast cancer in CANCER CHEMOTHERAPY AND PHARMACOLOGY
  • 2006-02. Pathological complete response and residual DCIS following neoadjuvant chemotherapy for breast carcinoma in BRITISH JOURNAL OF CANCER
  • 2009-07. The prognostic significance of Ki67 before and after neoadjuvant chemotherapy in breast cancer in BREAST CANCER RESEARCH AND TREATMENT
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-009-0329-x

    DOI

    http://dx.doi.org/10.1007/s10549-009-0329-x

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1003747864

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/19247830


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