Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-10

AUTHORS

N. Lynn Henry, James M. Rae, Lang Li, Faouzi Azzouz, Todd C. Skaar, Zereunesay Desta, Matthew J. Sikora, Santosh Philips, Anne T. Nguyen, Anna Maria Storniolo, Daniel F. Hayes, David A. Flockhart, Vered Stearns, Consortium on Breast Cancer Pharmacogenomics Investigators

ABSTRACT

Women with reduced CYP2D6 activity have low endoxifen concentrations and likely worse long term benefits from tamoxifen. We investigated the association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. We collected hot flash frequency and severity data over 12 months from 297 women initiating tamoxifen. We performed CYP2D6 genotyping using the AmpliChip CYP450 test and correlated inherited genetic polymorphisms in CYP2D6 and tamoxifen-induced hot flashes. Intermediate metabolizers had greater mean hot flash scores after 4 months of tamoxifen therapy (44.3) compared to poor metabolizers (20.6, P = 0.038) or extensive metabolizers (26.9, P = 0.011). At 4 months, we observed a trend toward fewer severe hot flashes in poor metabolizers compared to intermediate plus extensive metabolizers (P = 0.062). CYP2D6 activity may be a modest predictive factor for tamoxifen-induced hot flashes. The presence or absence of hot flashes should not be used to determine tamoxifen's efficacy. More... »

PAGES

571-575

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-009-0309-1

DOI

http://dx.doi.org/10.1007/s10549-009-0309-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1016753749

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19153830


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curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-009-0309-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-009-0309-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-009-0309-1'


 

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