TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2009-01

AUTHORS

Monzur Rahman, Sean R. Davis, Janet G. Pumphrey, Jing Bao, Marion M. Nau, Paul S. Meltzer, Stanley Lipkowitz

ABSTRACT

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis in some but not all breast cancer cell lines. Breast cancers can be divided into those which express the estrogen (ER) and progesterone (PR) receptors, those with HER-2 amplification, and those without expression of ER, PR, or HER-2 amplification (referred to as basal or triple-negative breast cancer). We tested a panel of 20 breast cancer cell lines representing the different types of breast cancer to evaluate if the molecular phenotype of the breast cancer cells determined their response to TRAIL. The most striking finding was that eight of eleven triple-negative cell lines are sensitive to TRAIL-mediated apoptosis. The eight TRAIL-sensitive triple-negative cell lines have a mesenchymal phenotype while the three TRAIL-resistant triple-negative cell lines have an epithelial phenotype. Two of five cell lines with HER-2 amplification were sensitive to TRAIL and none of the five ER positive cell lines were sensitive. RNAi-mediated knockdown of TRAIL receptor expression demonstrated that TRAIL Receptor 2 (TRAIL-R2) mediates the effects of TRAIL, even when both TRAIL-R1 and TRAIL-R2 are expressed. Finally, inhibition of EGFR, expressed in both TRAIL-sensitive and TRAIL-resistant triple-negative breast cancer cell lines, using a small molecule tyrosine kinase inhibitor (AG1478), enhanced TRAIL-induced apoptosis in TRAIL-sensitive cell lines but did not convert resistant cells into TRAIL-sensitive cells. Together, these findings suggest that a subset of triple-negative breast cancer, those with mesenchymal features, may be the most likely to benefit from TRAIL targeted therapy. These findings could form the basis to select breast cancer patients for clinical trials of TRAIL-R2 ligands. More... »

PAGES

217-230

References to SciGraph publications

  • 2007-11. Dasatinib, an orally active small molecule inhibitor of both the src and abl kinases, selectively inhibits growth of basal-type/“triple-negative” breast cancer cell lines growing in vitro in BREAST CANCER RESEARCH AND TREATMENT
  • 2006-04. Gene expression profiling of breast cell lines identifies potential new basal markers in ONCOGENE
  • 1999-12. SUM-159PT cells: a novel estrogen independent human breast cancer model system in BREAST CANCER RESEARCH AND TREATMENT
  • 2005. limma: Linear Models for Microarray Data in BIOINFORMATICS AND COMPUTATIONAL BIOLOGY SOLUTIONS USING R AND BIOCONDUCTOR
  • 2002-11. Cytogenetic Alterations and Cytokeratin Expression Patterns in Breast Cancer: Integrating a New Model of Breast Differentiation into Cytogenetic Pathways of Breast Carcinogenesis in LABORATORY INVESTIGATION
  • 2002-06. Targeting death and decoy receptors of the tumour-necrosis factor superfamily in NATURE REVIEWS CANCER
  • 2004-09. Bioconductor: open software development for computational biology and bioinformatics in GENOME BIOLOGY
  • 2007-09-02. Death-receptor O-glycosylation controls tumor-cell sensitivity to the proapoptotic ligand Apo2L/TRAIL in NATURE MEDICINE
  • 2003. Identification of Genes Associated with the Invasive Status of Human Mammary Carcinoma Cell Lines by Transcriptional Profiling in TUMOR BIOLOGY
  • 2006-02. Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma in MODERN PATHOLOGY
  • 1996-01. Human breast cancer cell lines as models of growth regulation and disease progression in JOURNAL OF MAMMARY GLAND BIOLOGY AND NEOPLASIA
  • 1999-02. Tumoricidal activity of tumor necrosis factor–related apoptosis–inducing ligand in vivo in NATURE MEDICINE
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10549-008-9924-5

    DOI

    http://dx.doi.org/10.1007/s10549-008-9924-5

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1004175549

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/18266105


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