Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-09

AUTHORS

David J. Novak, Nelly Sabbaghian, Philippe Maillet, Pierre O. Chappuis, William D. Foulkes, Marc Tischkowitz

ABSTRACT

Background Around half of familial breast cancer cases are caused by germ-line mutations in genes which are critically involved in the maintenance of genome stability. Mutations in related genes functioning in DNA repair may account for currently unattributed cases. Two such genes, RAP80 and Abraxas, have recently been identified to be in a complex with BRCA1, and are required for the localization of BRCA1 to DNA damage foci. Methods RAP80 and Abraxas variants were screened for in a cohort of 95 high risk, non-BRCA1/2 breast cancer cases of varying ethnicity: those of Ashkenazi Jewish (n = 35), mixed Canadian (n = 34) and Swiss descent (n = 26). Results We have identified four missense variants, four silent SNPs, three SNPs in the UTRs and seven intronic variants in RAP80. Two of the previously reported RAP80 variants were further investigated. In Abraxas, we have identified two missense, nine intronic and two variants in the 3' UTR. Conclusions Overall, it seems unlikely that moderate to highly penetrant alleles of either RAP80 or Abraxas, confer a significantly high relative risk of breast cancer. More... »

PAGES

453-459

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-008-0134-y

DOI

http://dx.doi.org/10.1007/s10549-008-0134-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1032745748

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18695986


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carrier Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA Mutational Analysis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Jews", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Male", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Pedigree", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymerase Chain Reaction", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single Nucleotide", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Single-Stranded Conformational", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk Factors", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Departments of Oncology and Human Genetics, Program in Cancer Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Departments of Medicine and Human Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Segal Cancer Center, McGill University Sir M. B. Davis-Jewish General Hospital, 3755 Cote Ste-Catherine, H3T 1E2, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Novak", 
        "givenName": "David J.", 
        "id": "sg:person.01346317621.58", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346317621.58"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Departments of Oncology and Human Genetics, Program in Cancer Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Segal Cancer Center, McGill University Sir M. B. Davis-Jewish General Hospital, 3755 Cote Ste-Catherine, H3T 1E2, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sabbaghian", 
        "givenName": "Nelly", 
        "id": "sg:person.01215466323.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215466323.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Geneva", 
          "id": "https://www.grid.ac/institutes/grid.150338.c", 
          "name": [
            "Laboratory of Molecular Oncology, Division of Laboratory Medicine, Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, 1211, Geneva 14, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Maillet", 
        "givenName": "Philippe", 
        "id": "sg:person.0604226266.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604226266.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University Hospital of Geneva", 
          "id": "https://www.grid.ac/institutes/grid.150338.c", 
          "name": [
            "Unit of Oncogenetics and Cancer Prevention, Division of Oncology, Department of Internal Medicine; Division of Genetic Medicine, Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, 1211, Geneva 14, Switzerland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Chappuis", 
        "givenName": "Pierre O.", 
        "id": "sg:person.01244713244.07", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244713244.07"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University Health Centre", 
          "id": "https://www.grid.ac/institutes/grid.63984.30", 
          "name": [
            "Departments of Oncology and Human Genetics, Program in Cancer Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Departments of Medicine and Human Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Segal Cancer Center, McGill University Sir M. B. Davis-Jewish General Hospital, 3755 Cote Ste-Catherine, H3T 1E2, Montreal, QC, Canada", 
            "The Research Institute, McGill University Health Centre, H3G 1A4, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Foulkes", 
        "givenName": "William D.", 
        "id": "sg:person.01115252630.09", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115252630.09"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "McGill University", 
          "id": "https://www.grid.ac/institutes/grid.14709.3b", 
          "name": [
            "Departments of Oncology and Human Genetics, Program in Cancer Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Departments of Medicine and Human Genetics, McGill University, H2W 1S6, Montreal, QC, Canada", 
            "Segal Cancer Center, McGill University Sir M. B. Davis-Jewish General Hospital, 3755 Cote Ste-Catherine, H3T 1E2, Montreal, QC, Canada"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tischkowitz", 
        "givenName": "Marc", 
        "id": "sg:person.01331505626.25", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331505626.25"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nsmb1279", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002122653", 
          "https://doi.org/10.1038/nsmb1279"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nsmb1277", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003736309", 
          "https://doi.org/10.1038/nsmb1277"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/nar/gkl1112", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009971048"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139476", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010913917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.febslet.2007.08.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1011929823"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016793039", 
          "https://doi.org/10.1038/nrm1124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nrm1124", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016793039", 
          "https://doi.org/10.1038/nrm1124"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-07-0924", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017198998"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1074/jbc.m203475200", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020321367"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027313782", 
          "https://doi.org/10.1038/sj.onc.1207951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1207951", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027313782", 
          "https://doi.org/10.1038/sj.onc.1207951"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.canlet.2007.04.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032597266"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-008-0529-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033237382", 
          "https://doi.org/10.1007/s00439-008-0529-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-008-0529-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033237382", 
          "https://doi.org/10.1007/s00439-008-0529-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-008-0529-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033237382", 
          "https://doi.org/10.1007/s00439-008-0529-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-008-9933-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040160929", 
          "https://doi.org/10.1007/s10549-008-9933-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-008-9933-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040160929", 
          "https://doi.org/10.1007/s10549-008-9933-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139516", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045481140"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1139621", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049639917"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-09", 
    "datePublishedReg": "2009-09-01", 
    "description": "Background Around half of familial breast cancer cases are caused by germ-line mutations in genes which are critically involved in the maintenance of genome stability. Mutations in related genes functioning in DNA repair may account for currently unattributed cases. Two such genes, RAP80 and Abraxas, have recently been identified to be in a complex with BRCA1, and are required for the localization of BRCA1 to DNA damage foci. Methods RAP80 and Abraxas variants were screened for in a cohort of 95 high risk, non-BRCA1/2 breast cancer cases of varying ethnicity: those of Ashkenazi Jewish (n = 35), mixed Canadian (n = 34) and Swiss descent (n = 26). Results We have identified four missense variants, four silent SNPs, three SNPs in the UTRs and seven intronic variants in RAP80. Two of the previously reported RAP80 variants were further investigated. In Abraxas, we have identified two missense, nine intronic and two variants in the 3' UTR. Conclusions Overall, it seems unlikely that moderate to highly penetrant alleles of either RAP80 or Abraxas, confer a significantly high relative risk of breast cancer.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-008-0134-y", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "117"
      }
    ], 
    "name": "Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases", 
    "pagination": "453-459", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "9bff434a84736090484aa3334c96af506a96392762ad13beb0dfe2d0536bfa3c"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18695986"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-008-0134-y"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1032745748"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-008-0134-y", 
      "https://app.dimensions.ai/details/publication/pub.1032745748"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:32", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13102_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10549-008-0134-y"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0134-y'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0134-y'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0134-y'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0134-y'


 

This table displays all metadata directly associated to this object as RDF triples.

228 TRIPLES      21 PREDICATES      59 URIs      37 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-008-0134-y schema:about N01d6ba2fe9e74ac489d658551428efec
2 N1dec991d4c5c4877b54e3ffc75d066db
3 N2372361dd34e4b3d8171074f8424931c
4 N4bce7c606fb9454290b390c63d542066
5 N4cd31b3ec80d4dc9839844c51b217b0b
6 N54721cd4296249e186005369d0141db9
7 N59566de9b482455bb83e90e2a108e740
8 N7e93f7fdd87b4aac9bf4958b247e4111
9 N7f42aa8d962f4fde994c7aeb660fd47a
10 N80d5e116a79a494c8b58010fb0e5016f
11 N91469316c6bb4f10a38021da3586aa38
12 N9a638f58651e446a98f0a124293be6bc
13 Naf7126c124c74c7e9791b39d4f0adace
14 Nbed9d586b81d4546b4f24cce17627bb0
15 Ncdb28247d5ee4403a1f7cc0c84613852
16 Ne153b173257443db9f5fe86a44177327
17 anzsrc-for:11
18 anzsrc-for:1112
19 schema:author N455a93ccaa5a48f591dc78a2c17658bf
20 schema:citation sg:pub.10.1007/s00439-008-0529-1
21 sg:pub.10.1007/s10549-008-9933-4
22 sg:pub.10.1038/nrm1124
23 sg:pub.10.1038/nsmb1277
24 sg:pub.10.1038/nsmb1279
25 sg:pub.10.1038/sj.onc.1207951
26 https://doi.org/10.1016/j.canlet.2007.04.013
27 https://doi.org/10.1016/j.febslet.2007.08.012
28 https://doi.org/10.1074/jbc.m203475200
29 https://doi.org/10.1093/nar/gkl1112
30 https://doi.org/10.1126/science.1139476
31 https://doi.org/10.1126/science.1139516
32 https://doi.org/10.1126/science.1139621
33 https://doi.org/10.1158/0008-5472.can-07-0924
34 schema:datePublished 2009-09
35 schema:datePublishedReg 2009-09-01
36 schema:description Background Around half of familial breast cancer cases are caused by germ-line mutations in genes which are critically involved in the maintenance of genome stability. Mutations in related genes functioning in DNA repair may account for currently unattributed cases. Two such genes, RAP80 and Abraxas, have recently been identified to be in a complex with BRCA1, and are required for the localization of BRCA1 to DNA damage foci. Methods RAP80 and Abraxas variants were screened for in a cohort of 95 high risk, non-BRCA1/2 breast cancer cases of varying ethnicity: those of Ashkenazi Jewish (n = 35), mixed Canadian (n = 34) and Swiss descent (n = 26). Results We have identified four missense variants, four silent SNPs, three SNPs in the UTRs and seven intronic variants in RAP80. Two of the previously reported RAP80 variants were further investigated. In Abraxas, we have identified two missense, nine intronic and two variants in the 3' UTR. Conclusions Overall, it seems unlikely that moderate to highly penetrant alleles of either RAP80 or Abraxas, confer a significantly high relative risk of breast cancer.
37 schema:genre research_article
38 schema:inLanguage en
39 schema:isAccessibleForFree false
40 schema:isPartOf N58ac052e200644dd9c2e5bf6320a4bff
41 N600bc0039b85463ea0b8f34b7629fef1
42 sg:journal.1092777
43 schema:name Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases
44 schema:pagination 453-459
45 schema:productId N046fdf0a21fc4411af01a94ffb6ac8cb
46 N11441173153e41a1bb1f810399e61ad1
47 N381c534f877b45538c1baea77ce87f24
48 N67b3c54f52db43c5a70d44b12a679a36
49 N9823bfa855f54a2e966940bdc39723cf
50 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032745748
51 https://doi.org/10.1007/s10549-008-0134-y
52 schema:sdDatePublished 2019-04-11T14:32
53 schema:sdLicense https://scigraph.springernature.com/explorer/license/
54 schema:sdPublisher Ncb5eeaa561dd4715b1fa4f18d1b11bda
55 schema:url http://link.springer.com/10.1007/s10549-008-0134-y
56 sgo:license sg:explorer/license/
57 sgo:sdDataset articles
58 rdf:type schema:ScholarlyArticle
59 N01d6ba2fe9e74ac489d658551428efec schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
60 schema:name Polymorphism, Single Nucleotide
61 rdf:type schema:DefinedTerm
62 N046fdf0a21fc4411af01a94ffb6ac8cb schema:name doi
63 schema:value 10.1007/s10549-008-0134-y
64 rdf:type schema:PropertyValue
65 N11441173153e41a1bb1f810399e61ad1 schema:name dimensions_id
66 schema:value pub.1032745748
67 rdf:type schema:PropertyValue
68 N1dec991d4c5c4877b54e3ffc75d066db schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Genes, BRCA1
70 rdf:type schema:DefinedTerm
71 N2372361dd34e4b3d8171074f8424931c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
72 schema:name Carrier Proteins
73 rdf:type schema:DefinedTerm
74 N381c534f877b45538c1baea77ce87f24 schema:name pubmed_id
75 schema:value 18695986
76 rdf:type schema:PropertyValue
77 N3f7655f4252047bb8dc5be68596db444 rdf:first sg:person.01215466323.82
78 rdf:rest Naa85e885e6dc448f87f66caeb93d51e4
79 N455a93ccaa5a48f591dc78a2c17658bf rdf:first sg:person.01346317621.58
80 rdf:rest N3f7655f4252047bb8dc5be68596db444
81 N4bce7c606fb9454290b390c63d542066 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Genetic Predisposition to Disease
83 rdf:type schema:DefinedTerm
84 N4cd31b3ec80d4dc9839844c51b217b0b schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Jews
86 rdf:type schema:DefinedTerm
87 N50e99d668d7e42709a540bd8712ad56b rdf:first sg:person.01115252630.09
88 rdf:rest Nd95b9319d5894c6f81a014e1b2a28e3f
89 N54721cd4296249e186005369d0141db9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Nuclear Proteins
91 rdf:type schema:DefinedTerm
92 N58ac052e200644dd9c2e5bf6320a4bff schema:volumeNumber 117
93 rdf:type schema:PublicationVolume
94 N59566de9b482455bb83e90e2a108e740 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Polymorphism, Single-Stranded Conformational
96 rdf:type schema:DefinedTerm
97 N600bc0039b85463ea0b8f34b7629fef1 schema:issueNumber 2
98 rdf:type schema:PublicationIssue
99 N67b3c54f52db43c5a70d44b12a679a36 schema:name readcube_id
100 schema:value 9bff434a84736090484aa3334c96af506a96392762ad13beb0dfe2d0536bfa3c
101 rdf:type schema:PropertyValue
102 N7e93f7fdd87b4aac9bf4958b247e4111 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Breast Neoplasms
104 rdf:type schema:DefinedTerm
105 N7f42aa8d962f4fde994c7aeb660fd47a schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
106 schema:name DNA Mutational Analysis
107 rdf:type schema:DefinedTerm
108 N80d5e116a79a494c8b58010fb0e5016f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Humans
110 rdf:type schema:DefinedTerm
111 N91469316c6bb4f10a38021da3586aa38 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Polymerase Chain Reaction
113 rdf:type schema:DefinedTerm
114 N9823bfa855f54a2e966940bdc39723cf schema:name nlm_unique_id
115 schema:value 8111104
116 rdf:type schema:PropertyValue
117 N9a638f58651e446a98f0a124293be6bc schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Pedigree
119 rdf:type schema:DefinedTerm
120 Na80096ab3c304f329059983eed77263a rdf:first sg:person.01244713244.07
121 rdf:rest N50e99d668d7e42709a540bd8712ad56b
122 Naa85e885e6dc448f87f66caeb93d51e4 rdf:first sg:person.0604226266.18
123 rdf:rest Na80096ab3c304f329059983eed77263a
124 Naf7126c124c74c7e9791b39d4f0adace schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
125 schema:name Female
126 rdf:type schema:DefinedTerm
127 Nbed9d586b81d4546b4f24cce17627bb0 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
128 schema:name Male
129 rdf:type schema:DefinedTerm
130 Ncb5eeaa561dd4715b1fa4f18d1b11bda schema:name Springer Nature - SN SciGraph project
131 rdf:type schema:Organization
132 Ncdb28247d5ee4403a1f7cc0c84613852 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
133 schema:name Risk Factors
134 rdf:type schema:DefinedTerm
135 Nd95b9319d5894c6f81a014e1b2a28e3f rdf:first sg:person.01331505626.25
136 rdf:rest rdf:nil
137 Ne153b173257443db9f5fe86a44177327 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Genes, BRCA2
139 rdf:type schema:DefinedTerm
140 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
141 schema:name Medical and Health Sciences
142 rdf:type schema:DefinedTerm
143 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
144 schema:name Oncology and Carcinogenesis
145 rdf:type schema:DefinedTerm
146 sg:journal.1092777 schema:issn 0167-6806
147 1573-7217
148 schema:name Breast Cancer Research and Treatment
149 rdf:type schema:Periodical
150 sg:person.01115252630.09 schema:affiliation https://www.grid.ac/institutes/grid.63984.30
151 schema:familyName Foulkes
152 schema:givenName William D.
153 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01115252630.09
154 rdf:type schema:Person
155 sg:person.01215466323.82 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
156 schema:familyName Sabbaghian
157 schema:givenName Nelly
158 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215466323.82
159 rdf:type schema:Person
160 sg:person.01244713244.07 schema:affiliation https://www.grid.ac/institutes/grid.150338.c
161 schema:familyName Chappuis
162 schema:givenName Pierre O.
163 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01244713244.07
164 rdf:type schema:Person
165 sg:person.01331505626.25 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
166 schema:familyName Tischkowitz
167 schema:givenName Marc
168 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01331505626.25
169 rdf:type schema:Person
170 sg:person.01346317621.58 schema:affiliation https://www.grid.ac/institutes/grid.14709.3b
171 schema:familyName Novak
172 schema:givenName David J.
173 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01346317621.58
174 rdf:type schema:Person
175 sg:person.0604226266.18 schema:affiliation https://www.grid.ac/institutes/grid.150338.c
176 schema:familyName Maillet
177 schema:givenName Philippe
178 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0604226266.18
179 rdf:type schema:Person
180 sg:pub.10.1007/s00439-008-0529-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033237382
181 https://doi.org/10.1007/s00439-008-0529-1
182 rdf:type schema:CreativeWork
183 sg:pub.10.1007/s10549-008-9933-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040160929
184 https://doi.org/10.1007/s10549-008-9933-4
185 rdf:type schema:CreativeWork
186 sg:pub.10.1038/nrm1124 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016793039
187 https://doi.org/10.1038/nrm1124
188 rdf:type schema:CreativeWork
189 sg:pub.10.1038/nsmb1277 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003736309
190 https://doi.org/10.1038/nsmb1277
191 rdf:type schema:CreativeWork
192 sg:pub.10.1038/nsmb1279 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002122653
193 https://doi.org/10.1038/nsmb1279
194 rdf:type schema:CreativeWork
195 sg:pub.10.1038/sj.onc.1207951 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027313782
196 https://doi.org/10.1038/sj.onc.1207951
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1016/j.canlet.2007.04.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032597266
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1016/j.febslet.2007.08.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1011929823
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1074/jbc.m203475200 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020321367
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1093/nar/gkl1112 schema:sameAs https://app.dimensions.ai/details/publication/pub.1009971048
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1126/science.1139476 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010913917
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1126/science.1139516 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045481140
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1126/science.1139621 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049639917
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1158/0008-5472.can-07-0924 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017198998
213 rdf:type schema:CreativeWork
214 https://www.grid.ac/institutes/grid.14709.3b schema:alternateName McGill University
215 schema:name Departments of Medicine and Human Genetics, McGill University, H2W 1S6, Montreal, QC, Canada
216 Departments of Oncology and Human Genetics, Program in Cancer Genetics, McGill University, H2W 1S6, Montreal, QC, Canada
217 Segal Cancer Center, McGill University Sir M. B. Davis-Jewish General Hospital, 3755 Cote Ste-Catherine, H3T 1E2, Montreal, QC, Canada
218 rdf:type schema:Organization
219 https://www.grid.ac/institutes/grid.150338.c schema:alternateName University Hospital of Geneva
220 schema:name Laboratory of Molecular Oncology, Division of Laboratory Medicine, Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
221 Unit of Oncogenetics and Cancer Prevention, Division of Oncology, Department of Internal Medicine; Division of Genetic Medicine, Department of Genetic Medicine and Laboratory, University Hospitals of Geneva, 1211, Geneva 14, Switzerland
222 rdf:type schema:Organization
223 https://www.grid.ac/institutes/grid.63984.30 schema:alternateName McGill University Health Centre
224 schema:name Departments of Medicine and Human Genetics, McGill University, H2W 1S6, Montreal, QC, Canada
225 Departments of Oncology and Human Genetics, Program in Cancer Genetics, McGill University, H2W 1S6, Montreal, QC, Canada
226 Segal Cancer Center, McGill University Sir M. B. Davis-Jewish General Hospital, 3755 Cote Ste-Catherine, H3T 1E2, Montreal, QC, Canada
227 The Research Institute, McGill University Health Centre, H3G 1A4, Montreal, QC, Canada
228 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...