The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-04

AUTHORS

A-Yong Cao, Juan Huang, Zhen Hu, Wen-Feng Li, Zhong-Liang Ma, Li-Li Tang, Bin Zhang, Feng-Xi Su, Jie Zhou, Gen-Hong Di, Kun-Wei Shen, Jiong Wu, Jin-Song Lu, Jian-Min Luo, Wen-Tao Yuan, Zhen-Zhou Shen, Wei Huang, Zhi-Ming Shao

ABSTRACT

PALB2 has been recently identified as breast cancer susceptibility gene in western populations. To investigate the contribution of PALB2 mutations to Chinese non-BRCA1/BRCA2 hereditary breast cancer, we screened all coding exons and intron-exon boundaries of PALB2 in 360 Chinese women with early-onset breast cancer or affected relatives from five breast disease clinical centers in China by utilizing PCR-DHPLC and DNA sequencing analysis. Some genetic variants identified in the cases were then studied in 864 normal controls with no personal or family history of breast cancer. Two protein-truncating PALB2 mutations, 751C>T and 1050_1051delAAinsTCT, were identified in three separate families, and 751C>T was a recurrent mutation. Neither of them, however, were present in the controls (P=0.025). All the truncating mutations occurred in exon 4 of PALB2, and there were still three unclassified variants were detected in the same fragment. We found that exon 4 accounted for 44.1% (15/34) of the person-times carrying with any variant in our study. PALB2 mutations were responsible for approximately 1% of Chinese women with early-onset breast cancer and affected relatives. Our results suggested that a detection of exon 4 before the assay of the whole PALB2 gene might be a cost-effective approach to the screening of Chinese population. More... »

PAGES

457-462

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-008-0036-z

DOI

http://dx.doi.org/10.1007/s10549-008-0036-z

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1039948839

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18446436


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age of Onset", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "China", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Family Health", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fanconi Anemia Complementation Group N Protein", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA1", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genes, BRCA2", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Germ-Line Mutation", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Nuclear Proteins", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prevalence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Tumor Suppressor Proteins", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Cao", 
        "givenName": "A-Yong", 
        "id": "sg:person.01052321024.19", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052321024.19"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Breast, Xiangya Hospital, Central South University, Changsha, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Juan", 
        "id": "sg:person.01120434224.77", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120434224.77"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hu", 
        "givenName": "Zhen", 
        "id": "sg:person.01002300615.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002300615.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Wen-Feng", 
        "id": "sg:person.0742055567.92", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742055567.92"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Affiliated Hospital of Qingdao University", 
          "id": "https://www.grid.ac/institutes/grid.412521.1", 
          "name": [
            "Department of Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ma", 
        "givenName": "Zhong-Liang", 
        "id": "sg:person.01164544566.50", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164544566.50"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Department of Breast, Xiangya Hospital, Central South University, Changsha, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Tang", 
        "givenName": "Li-Li", 
        "id": "sg:person.01351111224.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351111224.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Liaoning Cancer Hospital & Institute", 
          "id": "https://www.grid.ac/institutes/grid.459742.9", 
          "name": [
            "Department of Breast Disease, Liaoning Cancer Hospital & Institute, Shenyang, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Bin", 
        "id": "sg:person.0631470267.70", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631470267.70"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sun Yat-sen University", 
          "id": "https://www.grid.ac/institutes/grid.12981.33", 
          "name": [
            "Department of Breast Surgery, Second Affiliated Hospital of Zhongshan University, Guangzhou, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Su", 
        "givenName": "Feng-Xi", 
        "id": "sg:person.01277242514.35", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277242514.35"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Sun Yat-sen University", 
          "id": "https://www.grid.ac/institutes/grid.12981.33", 
          "name": [
            "Department of Breast Surgery, Second Affiliated Hospital of Zhongshan University, Guangzhou, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhou", 
        "givenName": "Jie", 
        "id": "sg:person.0755421067.05", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755421067.05"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Di", 
        "givenName": "Gen-Hong", 
        "id": "sg:person.0635331367.30", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635331367.30"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Kun-Wei", 
        "id": "sg:person.01371142665.34", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371142665.34"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wu", 
        "givenName": "Jiong", 
        "id": "sg:person.07476074554.74", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07476074554.74"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lu", 
        "givenName": "Jin-Song", 
        "id": "sg:person.013374217714.38", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013374217714.38"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Luo", 
        "givenName": "Jian-Min", 
        "id": "sg:person.0740506444.57", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740506444.57"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese National Human Genome Center at Shanghai", 
          "id": "https://www.grid.ac/institutes/grid.464306.3", 
          "name": [
            "Chinese National Human Genome Center at Shanghai, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Yuan", 
        "givenName": "Wen-Tao", 
        "id": "sg:person.0577223627.75", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577223627.75"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Zhen-Zhou", 
        "id": "sg:person.01027700627.00", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027700627.00"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Chinese National Human Genome Center at Shanghai", 
          "id": "https://www.grid.ac/institutes/grid.464306.3", 
          "name": [
            "Chinese National Human Genome Center at Shanghai, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Huang", 
        "givenName": "Wei", 
        "id": "sg:person.07746326077.04", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746326077.04"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Shanghai Medical College of Fudan University", 
          "id": "https://www.grid.ac/institutes/grid.11841.3d", 
          "name": [
            "Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong\u2019an Road, 200032, Shanghai, People\u2019s Republic of China"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shao", 
        "givenName": "Zhi-Ming", 
        "id": "sg:person.011433144317.11", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011433144317.11"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1073/pnas.0701724104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005396371"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005614815", 
          "https://doi.org/10.1038/ng1942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1942", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005614815", 
          "https://doi.org/10.1038/ng1942"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molcel.2006.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1007379344"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.9156", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013132682"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-006-0105-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015541824", 
          "https://doi.org/10.1007/s00432-006-0105-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-006-0105-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015541824", 
          "https://doi.org/10.1007/s00432-006-0105-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00432-006-0105-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015541824", 
          "https://doi.org/10.1007/s00432-006-0105-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022261638", 
          "https://doi.org/10.1038/ng1959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1959", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022261638", 
          "https://doi.org/10.1038/ng1959"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nature05609", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022412135", 
          "https://doi.org/10.1038/nature05609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390100500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029610764", 
          "https://doi.org/10.1007/s004390100500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s004390100500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029610764", 
          "https://doi.org/10.1007/s004390100500"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/humu.1130", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030480134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030963670", 
          "https://doi.org/10.1038/ng1947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030963670", 
          "https://doi.org/10.1038/ng1947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1470-2045(07)70025-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1033725441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ccr.2007.01.010", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034415774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.ejhg.5201860", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1034454581", 
          "https://doi.org/10.1038/sj.ejhg.5201860"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr1828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038191449", 
          "https://doi.org/10.1186/bcr1828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/bcr1828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038191449", 
          "https://doi.org/10.1186/bcr1828"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020220147113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049352850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00313020220147113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049352850"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/djj500", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050444229"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9708-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051784852", 
          "https://doi.org/10.1007/s10549-007-9708-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10549-007-9708-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051784852", 
          "https://doi.org/10.1007/s10549-007-9708-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074721673", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074721674", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2009-04", 
    "datePublishedReg": "2009-04-01", 
    "description": "PALB2 has been recently identified as breast cancer susceptibility gene in western populations. To investigate the contribution of PALB2 mutations to Chinese non-BRCA1/BRCA2 hereditary breast cancer, we screened all coding exons and intron-exon boundaries of PALB2 in 360 Chinese women with early-onset breast cancer or affected relatives from five breast disease clinical centers in China by utilizing PCR-DHPLC and DNA sequencing analysis. Some genetic variants identified in the cases were then studied in 864 normal controls with no personal or family history of breast cancer. Two protein-truncating PALB2 mutations, 751C>T and 1050_1051delAAinsTCT, were identified in three separate families, and 751C>T was a recurrent mutation. Neither of them, however, were present in the controls (P=0.025). All the truncating mutations occurred in exon 4 of PALB2, and there were still three unclassified variants were detected in the same fragment. We found that exon 4 accounted for 44.1% (15/34) of the person-times carrying with any variant in our study. PALB2 mutations were responsible for approximately 1% of Chinese women with early-onset breast cancer and affected relatives. Our results suggested that a detection of exon 4 before the assay of the whole PALB2 gene might be a cost-effective approach to the screening of Chinese population.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-008-0036-z", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4984081", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.4947022", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "114"
      }
    ], 
    "name": "The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives", 
    "pagination": "457-462", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "be4cbdcd8e40f94b1f461d72981177f5ee418ece88b423e7e551e527d435cfdd"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "18446436"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-008-0036-z"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1039948839"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-008-0036-z", 
      "https://app.dimensions.ai/details/publication/pub.1039948839"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T14:34", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13106_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10549-008-0036-z"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0036-z'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0036-z'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0036-z'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-008-0036-z'


 

This table displays all metadata directly associated to this object as RDF triples.

340 TRIPLES      21 PREDICATES      65 URIs      38 LITERALS      26 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-008-0036-z schema:about N0650799c27934955b4aa5284317ea1a3
2 N28e747a40bb64f34bcaead951e889992
3 N3846bbe61bb6424588bb6adaf7af2326
4 N396e3f5fef704488be95612e2540a40e
5 N3a9bb287f867464bb66799a7da9d6e4d
6 N44ccef5a70754a62bef1c74b3287f8da
7 N4c31f6133c404c959e265b3e635ff173
8 N565665a70c274631a5baef50087be6d9
9 N59d087b842694f50beac3b767768fd1c
10 N7dccdb04ce68415d830dd4dac272858c
11 Nb4741370f81844978946469fd381512f
12 Nb60fe85777364224a9fa69f094cb9d78
13 Nd44071ea398546eea599d067ed730b54
14 Ndedb16aea4c149dd9f5fc88388d01a59
15 Ne63338def10143d7b661b92ce661bb6f
16 Nef5db5b5c46f4f04af52ec4fe7ba2db3
17 Nfa6f79c685a64bb184eb3b08528e02ac
18 anzsrc-for:11
19 anzsrc-for:1112
20 schema:author Nfd91981498fd41bcbc9c2069c89cb68e
21 schema:citation sg:pub.10.1007/s00432-006-0105-9
22 sg:pub.10.1007/s004390100500
23 sg:pub.10.1007/s10549-007-9708-3
24 sg:pub.10.1038/nature05609
25 sg:pub.10.1038/ng1942
26 sg:pub.10.1038/ng1947
27 sg:pub.10.1038/ng1959
28 sg:pub.10.1038/sj.ejhg.5201860
29 sg:pub.10.1186/bcr1828
30 https://app.dimensions.ai/details/publication/pub.1074721673
31 https://app.dimensions.ai/details/publication/pub.1074721674
32 https://doi.org/10.1002/humu.1130
33 https://doi.org/10.1002/humu.9156
34 https://doi.org/10.1016/j.ccr.2007.01.010
35 https://doi.org/10.1016/j.molcel.2006.05.022
36 https://doi.org/10.1016/s1470-2045(07)70025-6
37 https://doi.org/10.1073/pnas.0701724104
38 https://doi.org/10.1080/00313020220147113
39 https://doi.org/10.1093/jnci/djj500
40 schema:datePublished 2009-04
41 schema:datePublishedReg 2009-04-01
42 schema:description PALB2 has been recently identified as breast cancer susceptibility gene in western populations. To investigate the contribution of PALB2 mutations to Chinese non-BRCA1/BRCA2 hereditary breast cancer, we screened all coding exons and intron-exon boundaries of PALB2 in 360 Chinese women with early-onset breast cancer or affected relatives from five breast disease clinical centers in China by utilizing PCR-DHPLC and DNA sequencing analysis. Some genetic variants identified in the cases were then studied in 864 normal controls with no personal or family history of breast cancer. Two protein-truncating PALB2 mutations, 751C>T and 1050_1051delAAinsTCT, were identified in three separate families, and 751C>T was a recurrent mutation. Neither of them, however, were present in the controls (P=0.025). All the truncating mutations occurred in exon 4 of PALB2, and there were still three unclassified variants were detected in the same fragment. We found that exon 4 accounted for 44.1% (15/34) of the person-times carrying with any variant in our study. PALB2 mutations were responsible for approximately 1% of Chinese women with early-onset breast cancer and affected relatives. Our results suggested that a detection of exon 4 before the assay of the whole PALB2 gene might be a cost-effective approach to the screening of Chinese population.
43 schema:genre research_article
44 schema:inLanguage en
45 schema:isAccessibleForFree false
46 schema:isPartOf N4695627904fa4450a0f10553d7fe515f
47 N70e52ca4744843cf9d664d381dfd335a
48 sg:journal.1092777
49 schema:name The prevalence of PALB2 germline mutations in BRCA1/BRCA2 negative Chinese women with early onset breast cancer or affected relatives
50 schema:pagination 457-462
51 schema:productId N2cd3dd733c2d4a499b5afcb52bfe0fc2
52 Na45d481ec0d641aaa62ebcbc0c1b2880
53 Ncee61fa5b3124922a0f21b8b84aa69da
54 Nf9d4ff243644487dbe626db52cfb4a5e
55 Nfe1a6f388d0f414bbcade57487d6878e
56 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039948839
57 https://doi.org/10.1007/s10549-008-0036-z
58 schema:sdDatePublished 2019-04-11T14:34
59 schema:sdLicense https://scigraph.springernature.com/explorer/license/
60 schema:sdPublisher N68268099940a4b5ab5e2ece30947137e
61 schema:url http://link.springer.com/10.1007/s10549-008-0036-z
62 sgo:license sg:explorer/license/
63 sgo:sdDataset articles
64 rdf:type schema:ScholarlyArticle
65 N0650799c27934955b4aa5284317ea1a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
66 schema:name Germ-Line Mutation
67 rdf:type schema:DefinedTerm
68 N13fa7d2028684895bdcf63a3d498600b rdf:first sg:person.01164544566.50
69 rdf:rest N8b3fabc618d04a7a84ba0832d1c5b2d8
70 N256aafcbf39c45eca4cf069ae0ac5bdd rdf:first sg:person.0742055567.92
71 rdf:rest N13fa7d2028684895bdcf63a3d498600b
72 N28e747a40bb64f34bcaead951e889992 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Genes, BRCA1
74 rdf:type schema:DefinedTerm
75 N2cd3dd733c2d4a499b5afcb52bfe0fc2 schema:name nlm_unique_id
76 schema:value 8111104
77 rdf:type schema:PropertyValue
78 N3846bbe61bb6424588bb6adaf7af2326 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
79 schema:name Humans
80 rdf:type schema:DefinedTerm
81 N396e3f5fef704488be95612e2540a40e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
82 schema:name Breast Neoplasms
83 rdf:type schema:DefinedTerm
84 N3a9bb287f867464bb66799a7da9d6e4d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
85 schema:name Fanconi Anemia Complementation Group N Protein
86 rdf:type schema:DefinedTerm
87 N41e4037ed18b4d469815b0f68128b970 rdf:first sg:person.0631470267.70
88 rdf:rest Ne82975d515d0485e9db4823c9759ef80
89 N44ccef5a70754a62bef1c74b3287f8da schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
90 schema:name Aged, 80 and over
91 rdf:type schema:DefinedTerm
92 N4695627904fa4450a0f10553d7fe515f schema:volumeNumber 114
93 rdf:type schema:PublicationVolume
94 N4c31f6133c404c959e265b3e635ff173 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name China
96 rdf:type schema:DefinedTerm
97 N508c48c957734cd985b1a04f9f064f28 rdf:first sg:person.0635331367.30
98 rdf:rest N86357f7bec0f4012aae40ee35a936b34
99 N565665a70c274631a5baef50087be6d9 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
100 schema:name Female
101 rdf:type schema:DefinedTerm
102 N59d087b842694f50beac3b767768fd1c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
103 schema:name Age of Onset
104 rdf:type schema:DefinedTerm
105 N633daa4f33ce4aa09f5242326bf76ad0 rdf:first sg:person.0740506444.57
106 rdf:rest N7f6fd2ac284645108b230f025976ab57
107 N68268099940a4b5ab5e2ece30947137e schema:name Springer Nature - SN SciGraph project
108 rdf:type schema:Organization
109 N70e52ca4744843cf9d664d381dfd335a schema:issueNumber 3
110 rdf:type schema:PublicationIssue
111 N7dccdb04ce68415d830dd4dac272858c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
112 schema:name Genes, BRCA2
113 rdf:type schema:DefinedTerm
114 N7f6fd2ac284645108b230f025976ab57 rdf:first sg:person.0577223627.75
115 rdf:rest Nf4a8d07a21ff49d291052c476da8c71f
116 N86357f7bec0f4012aae40ee35a936b34 rdf:first sg:person.01371142665.34
117 rdf:rest Ne795dfcaee1d4f0ea361ec7e6bd82cc9
118 N8b3fabc618d04a7a84ba0832d1c5b2d8 rdf:first sg:person.01351111224.30
119 rdf:rest N41e4037ed18b4d469815b0f68128b970
120 N8e95824b67764d2290029246de39e784 rdf:first sg:person.013374217714.38
121 rdf:rest N633daa4f33ce4aa09f5242326bf76ad0
122 Na45d481ec0d641aaa62ebcbc0c1b2880 schema:name dimensions_id
123 schema:value pub.1039948839
124 rdf:type schema:PropertyValue
125 Nb4741370f81844978946469fd381512f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Aged
127 rdf:type schema:DefinedTerm
128 Nb60fe85777364224a9fa69f094cb9d78 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
129 schema:name Nuclear Proteins
130 rdf:type schema:DefinedTerm
131 Nbbce175befd44ba9a14fe66a8fbb0658 schema:name Department of Breast, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
132 rdf:type schema:Organization
133 Nbd4bd75b4a634b72aa4f1b90235e1a4b rdf:first sg:person.0755421067.05
134 rdf:rest N508c48c957734cd985b1a04f9f064f28
135 Nbf446f5543ac4c34848180312a0210a2 rdf:first sg:person.01002300615.92
136 rdf:rest N256aafcbf39c45eca4cf069ae0ac5bdd
137 Ncee61fa5b3124922a0f21b8b84aa69da schema:name pubmed_id
138 schema:value 18446436
139 rdf:type schema:PropertyValue
140 Nd44071ea398546eea599d067ed730b54 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
141 schema:name Family Health
142 rdf:type schema:DefinedTerm
143 Nd8d61f06d04847debab53a471e322443 rdf:first sg:person.01120434224.77
144 rdf:rest Nbf446f5543ac4c34848180312a0210a2
145 Nd9cf588561164bc1894ebb8da1517d88 rdf:first sg:person.011433144317.11
146 rdf:rest rdf:nil
147 Ndedb16aea4c149dd9f5fc88388d01a59 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Middle Aged
149 rdf:type schema:DefinedTerm
150 Ne5b4704d6ff8443baf07a32ba2f65221 schema:name Department of Breast, Xiangya Hospital, Central South University, Changsha, People’s Republic of China
151 rdf:type schema:Organization
152 Ne63338def10143d7b661b92ce661bb6f schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
153 schema:name Prevalence
154 rdf:type schema:DefinedTerm
155 Ne795dfcaee1d4f0ea361ec7e6bd82cc9 rdf:first sg:person.07476074554.74
156 rdf:rest N8e95824b67764d2290029246de39e784
157 Ne82975d515d0485e9db4823c9759ef80 rdf:first sg:person.01277242514.35
158 rdf:rest Nbd4bd75b4a634b72aa4f1b90235e1a4b
159 Nef5db5b5c46f4f04af52ec4fe7ba2db3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
160 schema:name Adult
161 rdf:type schema:DefinedTerm
162 Nf266ca672f3a446fb511ed85a252fa22 rdf:first sg:person.07746326077.04
163 rdf:rest Nd9cf588561164bc1894ebb8da1517d88
164 Nf4a8d07a21ff49d291052c476da8c71f rdf:first sg:person.01027700627.00
165 rdf:rest Nf266ca672f3a446fb511ed85a252fa22
166 Nf9d4ff243644487dbe626db52cfb4a5e schema:name doi
167 schema:value 10.1007/s10549-008-0036-z
168 rdf:type schema:PropertyValue
169 Nfa6f79c685a64bb184eb3b08528e02ac schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
170 schema:name Tumor Suppressor Proteins
171 rdf:type schema:DefinedTerm
172 Nfd91981498fd41bcbc9c2069c89cb68e rdf:first sg:person.01052321024.19
173 rdf:rest Nd8d61f06d04847debab53a471e322443
174 Nfe1a6f388d0f414bbcade57487d6878e schema:name readcube_id
175 schema:value be4cbdcd8e40f94b1f461d72981177f5ee418ece88b423e7e551e527d435cfdd
176 rdf:type schema:PropertyValue
177 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
178 schema:name Medical and Health Sciences
179 rdf:type schema:DefinedTerm
180 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
181 schema:name Oncology and Carcinogenesis
182 rdf:type schema:DefinedTerm
183 sg:grant.4947022 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-008-0036-z
184 rdf:type schema:MonetaryGrant
185 sg:grant.4984081 http://pending.schema.org/fundedItem sg:pub.10.1007/s10549-008-0036-z
186 rdf:type schema:MonetaryGrant
187 sg:journal.1092777 schema:issn 0167-6806
188 1573-7217
189 schema:name Breast Cancer Research and Treatment
190 rdf:type schema:Periodical
191 sg:person.01002300615.92 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
192 schema:familyName Hu
193 schema:givenName Zhen
194 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01002300615.92
195 rdf:type schema:Person
196 sg:person.01027700627.00 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
197 schema:familyName Shen
198 schema:givenName Zhen-Zhou
199 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01027700627.00
200 rdf:type schema:Person
201 sg:person.01052321024.19 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
202 schema:familyName Cao
203 schema:givenName A-Yong
204 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01052321024.19
205 rdf:type schema:Person
206 sg:person.01120434224.77 schema:affiliation Nbbce175befd44ba9a14fe66a8fbb0658
207 schema:familyName Huang
208 schema:givenName Juan
209 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01120434224.77
210 rdf:type schema:Person
211 sg:person.011433144317.11 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
212 schema:familyName Shao
213 schema:givenName Zhi-Ming
214 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.011433144317.11
215 rdf:type schema:Person
216 sg:person.01164544566.50 schema:affiliation https://www.grid.ac/institutes/grid.412521.1
217 schema:familyName Ma
218 schema:givenName Zhong-Liang
219 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01164544566.50
220 rdf:type schema:Person
221 sg:person.01277242514.35 schema:affiliation https://www.grid.ac/institutes/grid.12981.33
222 schema:familyName Su
223 schema:givenName Feng-Xi
224 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277242514.35
225 rdf:type schema:Person
226 sg:person.013374217714.38 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
227 schema:familyName Lu
228 schema:givenName Jin-Song
229 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.013374217714.38
230 rdf:type schema:Person
231 sg:person.01351111224.30 schema:affiliation Ne5b4704d6ff8443baf07a32ba2f65221
232 schema:familyName Tang
233 schema:givenName Li-Li
234 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01351111224.30
235 rdf:type schema:Person
236 sg:person.01371142665.34 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
237 schema:familyName Shen
238 schema:givenName Kun-Wei
239 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371142665.34
240 rdf:type schema:Person
241 sg:person.0577223627.75 schema:affiliation https://www.grid.ac/institutes/grid.464306.3
242 schema:familyName Yuan
243 schema:givenName Wen-Tao
244 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0577223627.75
245 rdf:type schema:Person
246 sg:person.0631470267.70 schema:affiliation https://www.grid.ac/institutes/grid.459742.9
247 schema:familyName Zhang
248 schema:givenName Bin
249 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0631470267.70
250 rdf:type schema:Person
251 sg:person.0635331367.30 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
252 schema:familyName Di
253 schema:givenName Gen-Hong
254 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0635331367.30
255 rdf:type schema:Person
256 sg:person.0740506444.57 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
257 schema:familyName Luo
258 schema:givenName Jian-Min
259 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0740506444.57
260 rdf:type schema:Person
261 sg:person.0742055567.92 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
262 schema:familyName Li
263 schema:givenName Wen-Feng
264 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0742055567.92
265 rdf:type schema:Person
266 sg:person.07476074554.74 schema:affiliation https://www.grid.ac/institutes/grid.11841.3d
267 schema:familyName Wu
268 schema:givenName Jiong
269 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07476074554.74
270 rdf:type schema:Person
271 sg:person.0755421067.05 schema:affiliation https://www.grid.ac/institutes/grid.12981.33
272 schema:familyName Zhou
273 schema:givenName Jie
274 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0755421067.05
275 rdf:type schema:Person
276 sg:person.07746326077.04 schema:affiliation https://www.grid.ac/institutes/grid.464306.3
277 schema:familyName Huang
278 schema:givenName Wei
279 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07746326077.04
280 rdf:type schema:Person
281 sg:pub.10.1007/s00432-006-0105-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015541824
282 https://doi.org/10.1007/s00432-006-0105-9
283 rdf:type schema:CreativeWork
284 sg:pub.10.1007/s004390100500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029610764
285 https://doi.org/10.1007/s004390100500
286 rdf:type schema:CreativeWork
287 sg:pub.10.1007/s10549-007-9708-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051784852
288 https://doi.org/10.1007/s10549-007-9708-3
289 rdf:type schema:CreativeWork
290 sg:pub.10.1038/nature05609 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022412135
291 https://doi.org/10.1038/nature05609
292 rdf:type schema:CreativeWork
293 sg:pub.10.1038/ng1942 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005614815
294 https://doi.org/10.1038/ng1942
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/ng1947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030963670
297 https://doi.org/10.1038/ng1947
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/ng1959 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022261638
300 https://doi.org/10.1038/ng1959
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/sj.ejhg.5201860 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034454581
303 https://doi.org/10.1038/sj.ejhg.5201860
304 rdf:type schema:CreativeWork
305 sg:pub.10.1186/bcr1828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038191449
306 https://doi.org/10.1186/bcr1828
307 rdf:type schema:CreativeWork
308 https://app.dimensions.ai/details/publication/pub.1074721673 schema:CreativeWork
309 https://app.dimensions.ai/details/publication/pub.1074721674 schema:CreativeWork
310 https://doi.org/10.1002/humu.1130 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030480134
311 rdf:type schema:CreativeWork
312 https://doi.org/10.1002/humu.9156 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013132682
313 rdf:type schema:CreativeWork
314 https://doi.org/10.1016/j.ccr.2007.01.010 schema:sameAs https://app.dimensions.ai/details/publication/pub.1034415774
315 rdf:type schema:CreativeWork
316 https://doi.org/10.1016/j.molcel.2006.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1007379344
317 rdf:type schema:CreativeWork
318 https://doi.org/10.1016/s1470-2045(07)70025-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1033725441
319 rdf:type schema:CreativeWork
320 https://doi.org/10.1073/pnas.0701724104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005396371
321 rdf:type schema:CreativeWork
322 https://doi.org/10.1080/00313020220147113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049352850
323 rdf:type schema:CreativeWork
324 https://doi.org/10.1093/jnci/djj500 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050444229
325 rdf:type schema:CreativeWork
326 https://www.grid.ac/institutes/grid.11841.3d schema:alternateName Shanghai Medical College of Fudan University
327 schema:name Breast Cancer Institute, Cancer Hospital/Cancer Institute, Department of Oncology, Shanghai Medical College, Fudan University, 270 Dong’an Road, 200032, Shanghai, People’s Republic of China
328 rdf:type schema:Organization
329 https://www.grid.ac/institutes/grid.12981.33 schema:alternateName Sun Yat-sen University
330 schema:name Department of Breast Surgery, Second Affiliated Hospital of Zhongshan University, Guangzhou, People’s Republic of China
331 rdf:type schema:Organization
332 https://www.grid.ac/institutes/grid.412521.1 schema:alternateName Affiliated Hospital of Qingdao University
333 schema:name Department of Surgery, The Affiliated Hospital of Qingdao University Medical College, Qingdao, People’s Republic of China
334 rdf:type schema:Organization
335 https://www.grid.ac/institutes/grid.459742.9 schema:alternateName Liaoning Cancer Hospital & Institute
336 schema:name Department of Breast Disease, Liaoning Cancer Hospital & Institute, Shenyang, People’s Republic of China
337 rdf:type schema:Organization
338 https://www.grid.ac/institutes/grid.464306.3 schema:alternateName Chinese National Human Genome Center at Shanghai
339 schema:name Chinese National Human Genome Center at Shanghai, Shanghai, People’s Republic of China
340 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...