Pooled analysis of diarrhea events in patients with cancer treated with lapatinib View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2008-11

AUTHORS

John P. Crown, Harold A. Burris, Fran Boyle, Suzanne Jones, Maria Koehler, Beth O. Newstat, Roma Parikh, Cristina Oliva, Alaknanda Preston, Julie Byrne, Steve Chan

ABSTRACT

PURPOSE: To characterize diarrhea events in patients with cancer treated with lapatinib as monotherapy or in combination with capecitabine or taxanes. PATIENTS AND METHODS: Eleven clinical trials (phase I, II, or III) in patients with metastatic cancer were analyzed. Lapatinib was administered at doses ranging from 1,000 to 1,500 mg/day as monotherapy (n = 926) or in combination with capecitabine (n = 198) or taxanes (n = 687). Diarrhea events were characterized based on severity, time to onset, duration, required interventions, and clinical outcomes. RESULTS: In the pooled analysis of nine studies, diarrhea occurred in 55% of lapatinib-treated patients and 24% of patients not receiving lapatinib. All grade diarrhea occurred in 51% of patients treated with lapatinib monotherapy and 65% treated with lapatinib plus capecitabine. In a separate analysis, 48% of patients treated with lapatinib plus a taxane experienced diarrhea. Overall, most diarrhea events were grade 1/2. Grade 3 events occurred in <10% of patients and grade 4 events were rare ( More... »

PAGES

317-325

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-007-9860-9

DOI

http://dx.doi.org/10.1007/s10549-007-9860-9

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1029527984

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/18204897


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