Ontology type: schema:ScholarlyArticle
2008-09
AUTHORSJanice M. Knowlden, Helen E. Jones, Denise Barrow, Julia M. W. Gee, Robert I. Nicholson, Iain R. Hutcheson
ABSTRACTClassically the insulin receptor substrate-1 (IRS-1) is an essential component of insulin-like growth factor type 1 receptor (IGF-IR) signalling, providing an interface between the receptor and key downstream signalling cascades. Here, however, we show that in tamoxifen-resistant MCF-7 (Tam-R) breast cancer cells, that are highly dependent on epidermal growth factor receptor (EGFR) for growth, IRS-1 can interact with EGFR and be preferentially phosphorylated on tyrosine (Y) 896, a Grb2 binding site. Indeed, phosphorylation of this site is greatly enhanced by exposure of these cells, and other EGFR-positive cell lines, to EGF. Importantly, while IGF-II promotes phosphorylation of IRS-1 on Y612, a PI3-K recruitment site, it has limited effect on Y896 phosphorylation in Tam-R cells. Furthermore, EGF and IGF-II co-treatment, reduces the ability of IGF-II to phosphorylate Y612, whilst maintaining Y896 phosphorylation, suggesting that the EGFR is the dominant recruiter of IRS-1 in this cell line. Significantly, challenge of Tam-R cells with the EGFR-selective tyrosine kinase inhibitor gefitinib, for 7 days, reduces IRS-1/EGFR association and IRS-1 Y896 phosphorylation, while promoting IRS-1/IGF-IR association and IRS-1 Y612 phosphorylation. Furthermore, gefitinib significantly enhances IGF-II-mediated phosphorylation of IRS-1 Y612 and AKT in Tam-R cells. Importantly, induction of this pathway by gefitinib can be abrogated by inhibition/downregulation of the IGF-IR. Our data would therefore suggest a novel association exists between the EGFR and IRS-1 in several EGFR-positive cancer cell lines. This association acts to promote phosphorylation of IRS-1 at Y896 and drive MAPK signalling whilst preventing recruitment of IRS-1 by the IGF-IR and inhibiting signalling via this receptor. Treatment with gefitinib alters the dynamics of this system, promoting IGF-IR signalling, the dominant gefitinib-resistant growth regulatory pathway in Tam-R cells, thus, potentially limiting its efficacy. More... »
PAGES79-91
http://scigraph.springernature.com/pub.10.1007/s10549-007-9763-9
DOIhttp://dx.doi.org/10.1007/s10549-007-9763-9
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1037907096
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/17902048
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biochemistry and Cell Biology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Biological Sciences",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adaptor Proteins, Signal Transducing",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antineoplastic Agents",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Blotting, Western",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Cell Line, Tumor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Drug Resistance, Neoplasm",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "ErbB Receptors",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Gefitinib",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Immunoprecipitation",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Insulin Receptor Substrate Proteins",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Lung Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Male",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Prostatic Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Quinazolines",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptor Cross-Talk",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Receptors, Somatomedin",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Signal Transduction",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF, Cardiff, UK"
],
"type": "Organization"
},
"familyName": "Knowlden",
"givenName": "Janice M.",
"id": "sg:person.01211220110.63",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01211220110.63"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF, Cardiff, UK"
],
"type": "Organization"
},
"familyName": "Jones",
"givenName": "Helen E.",
"id": "sg:person.01247003636.76",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01247003636.76"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF, Cardiff, UK"
],
"type": "Organization"
},
"familyName": "Barrow",
"givenName": "Denise",
"id": "sg:person.01277511160.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01277511160.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF, Cardiff, UK"
],
"type": "Organization"
},
"familyName": "Gee",
"givenName": "Julia M. W.",
"id": "sg:person.012457220672.07",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.012457220672.07"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF, Cardiff, UK"
],
"type": "Organization"
},
"familyName": "Nicholson",
"givenName": "Robert I.",
"id": "sg:person.0670333460.58",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0670333460.58"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cardiff University",
"id": "https://www.grid.ac/institutes/grid.5600.3",
"name": [
"Tenovus Centre for Cancer Research, Welsh School of Pharmacy, Cardiff University, Redwood Building, King Edward VII Avenue, CF10 3XF, Cardiff, UK"
],
"type": "Organization"
},
"familyName": "Hutcheson",
"givenName": "Iain R.",
"id": "sg:person.01143104710.88",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01143104710.88"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/sj.bjc.6601921",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000414058",
"https://doi.org/10.1038/sj.bjc.6601921"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6601921",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1000414058",
"https://doi.org/10.1038/sj.bjc.6601921"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1206388",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004564925",
"https://doi.org/10.1038/sj.onc.1206388"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1206388",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1004564925",
"https://doi.org/10.1038/sj.onc.1206388"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1432-1327.2001.02327.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1008167468"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.m000412200",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1009241429"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1046/j.1432-1327.2001.01831.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011629817"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/s0959-8049(01)00231-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1011723495"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1023/b:brea.0000041623.21338.47",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015249151",
"https://doi.org/10.1023/b:brea.0000041623.21338.47"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/erc.1.00799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015606139"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/erc.1.00799",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015606139"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1186/bcr1028",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1018289267",
"https://doi.org/10.1186/bcr1028"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1634/theoncologist.7-suppl_4-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1019857496"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/93.24.1852",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1022747550"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/1040-8428(94)00144-i",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027064147"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/erc.1.00992",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1028888523"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001250051387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029374185",
"https://doi.org/10.1007/s001250051387"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s001250051387",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1029374185",
"https://doi.org/10.1007/s001250051387"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033468470",
"https://doi.org/10.1038/nature04177"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033468470",
"https://doi.org/10.1038/nature04177"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nature04177",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033468470",
"https://doi.org/10.1038/nature04177"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.1099314",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033538744"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2002-220620",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1033760962"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204277",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034076763",
"https://doi.org/10.1038/sj.onc.1204277"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1204277",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034076763",
"https://doi.org/10.1038/sj.onc.1204277"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1677/erc.1.01059",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1034112291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1053/sonc.2002.31521",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037819249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20020903",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038309123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1042/bj20020903",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1038309123"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/ijc.11445",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039084964"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2005.11.890",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040419394"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/emboj/19.13.3159",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040473291"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1074/jbc.270.25.14863",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042170678"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa040938",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042907590"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/14796694.1.4.461",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043722359"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203587",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045386828",
"https://doi.org/10.1038/sj.onc.1203587"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.onc.1203587",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1045386828",
"https://doi.org/10.1038/sj.onc.1203587"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049475665",
"https://doi.org/10.1038/sj.bjc.6603237"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/sj.bjc.6603237",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1049475665",
"https://doi.org/10.1038/sj.bjc.6603237"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1093/jnci/85.16.1327",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1059818100"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-031206",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1063224756"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1200/jco.2002.10.112",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064203155"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1064245480",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/en.2005-0247",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064247375"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo.136.2.7835273",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064279945"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1210/endo.142.7.8283",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1064284476"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1517/14796694.1.2.221",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067590514"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1517/14796694.1.2.221",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1067590514"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1074976743",
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/j.1460-2075.1986.tb04528.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1079436431"
],
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083124264",
"type": "CreativeWork"
},
{
"id": "https://app.dimensions.ai/details/publication/pub.1083346988",
"type": "CreativeWork"
}
],
"datePublished": "2008-09",
"datePublishedReg": "2008-09-01",
"description": "Classically the insulin receptor substrate-1 (IRS-1) is an essential component of insulin-like growth factor type 1 receptor (IGF-IR) signalling, providing an interface between the receptor and key downstream signalling cascades. Here, however, we show that in tamoxifen-resistant MCF-7 (Tam-R) breast cancer cells, that are highly dependent on epidermal growth factor receptor (EGFR) for growth, IRS-1 can interact with EGFR and be preferentially phosphorylated on tyrosine (Y) 896, a Grb2 binding site. Indeed, phosphorylation of this site is greatly enhanced by exposure of these cells, and other EGFR-positive cell lines, to EGF. Importantly, while IGF-II promotes phosphorylation of IRS-1 on Y612, a PI3-K recruitment site, it has limited effect on Y896 phosphorylation in Tam-R cells. Furthermore, EGF and IGF-II co-treatment, reduces the ability of IGF-II to phosphorylate Y612, whilst maintaining Y896 phosphorylation, suggesting that the EGFR is the dominant recruiter of IRS-1 in this cell line. Significantly, challenge of Tam-R cells with the EGFR-selective tyrosine kinase inhibitor gefitinib, for 7 days, reduces IRS-1/EGFR association and IRS-1 Y896 phosphorylation, while promoting IRS-1/IGF-IR association and IRS-1 Y612 phosphorylation. Furthermore, gefitinib significantly enhances IGF-II-mediated phosphorylation of IRS-1 Y612 and AKT in Tam-R cells. Importantly, induction of this pathway by gefitinib can be abrogated by inhibition/downregulation of the IGF-IR. Our data would therefore suggest a novel association exists between the EGFR and IRS-1 in several EGFR-positive cancer cell lines. This association acts to promote phosphorylation of IRS-1 at Y896 and drive MAPK signalling whilst preventing recruitment of IRS-1 by the IGF-IR and inhibiting signalling via this receptor. Treatment with gefitinib alters the dynamics of this system, promoting IGF-IR signalling, the dominant gefitinib-resistant growth regulatory pathway in Tam-R cells, thus, potentially limiting its efficacy.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10549-007-9763-9",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1092777",
"issn": [
"0167-6806",
"1573-7217"
],
"name": "Breast Cancer Research and Treatment",
"type": "Periodical"
},
{
"issueNumber": "1",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "111"
}
],
"name": "Insulin receptor substrate-1 involvement in epidermal growth factor receptor and insulin-like growth factor receptor signalling: implication for Gefitinib (\u2018Iressa\u2019) response and resistance",
"pagination": "79-91",
"productId": [
{
"name": "readcube_id",
"type": "PropertyValue",
"value": [
"b4938c5dd138362866ba2deb74e0ae8b2b1ba404c4c846a0ad712bbed267b9c1"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"17902048"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"8111104"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10549-007-9763-9"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1037907096"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10549-007-9763-9",
"https://app.dimensions.ai/details/publication/pub.1037907096"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T14:31",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000373_0000000373/records_13096_00000001.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s10549-007-9763-9"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-007-9763-9'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-007-9763-9'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-007-9763-9'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-007-9763-9'
This table displays all metadata directly associated to this object as RDF triples.
312 TRIPLES
21 PREDICATES
90 URIs
41 LITERALS
29 BLANK NODES