Margin status and the risk of local recurrence after breast-conserving treatment of lobular breast cancer View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2007-09

AUTHORS

N. van den Broek, M. J. C. van der Sangen, L. V. van de Poll-Franse, M. W. P. M. van Beek, G. A. P. Nieuwenhuijzen, A. C. Voogd

ABSTRACT

BACKGROUND: Invasive lobular breast carcinoma is known for its multicentricity and is associated with a higher incidence of incomplete excision after breast-conserving therapy. The aim of the study was to examine the influence of positive surgical margins on the local recurrence rate in patients diagnosed with invasive lobular cancer and treated with breast-conserving therapy. METHODS: All 416 women diagnosed with invasive lobular breast cancer and undergoing breast-conserving treatment between 1995 and 2002 were selected from the population-based Eindhoven Cancer Registry. Their medical charts were reviewed and detailed information was collected. RESULTS: The risk of margin involvement was 29% after the first operation and 17% when taking into account the final margin status of the patients undergoing re-excision. During follow-up, 18 patients developed a local recurrence. The 5 year actuarial risk of developing a local recurrence was 3.5% (95% confidence interval 2.5-4.5) and the 8 year risk was 6.4% (95% confidence interval 4.7-8.0). There was no influence of positive surgical margins on the risk of local recurrence, neither in the univariate analysis nor after adjustment for age, tumour size, nodal status and adjuvant systemic treatment. CONCLUSION: Patients with invasive lobular cancer, treated with breast-conservation, have a low risk of local recurrence, despite their high risk of having a microscopically incomplete excision of the tumour. More... »

PAGES

63-68

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-006-9431-5

DOI

http://dx.doi.org/10.1007/s10549-006-9431-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1000970941

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/17115109


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Age Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Carcinoma, Lobular", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mastectomy, Segmental", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Proportional Hazards Models", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Recurrence", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Risk", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Time Factors", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Treatment Outcome", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Maastricht University", 
          "id": "https://www.grid.ac/institutes/grid.5012.6", 
          "name": [
            "Faculty of Medicine, Maastricht University, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van den Broek", 
        "givenName": "N.", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catharina Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.413532.2", 
          "name": [
            "Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van der Sangen", 
        "givenName": "M. J. C.", 
        "id": "sg:person.0647401126.71", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647401126.71"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Eindhoven Cancer Registry", 
          "id": "https://www.grid.ac/institutes/grid.418897.b", 
          "name": [
            "Eindhoven Cancer Registry, Eindhoven, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van de Poll-Franse", 
        "givenName": "L. V.", 
        "id": "sg:person.01106133266.44", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106133266.44"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "name": [
            "Regional Institute of Pathology (PAMM), Eindhoven, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "van Beek", 
        "givenName": "M. W. P. M.", 
        "id": "sg:person.0625613040.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625613040.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Catharina Ziekenhuis", 
          "id": "https://www.grid.ac/institutes/grid.413532.2", 
          "name": [
            "Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Nieuwenhuijzen", 
        "givenName": "G. A. P.", 
        "id": "sg:person.07412540414.15", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07412540414.15"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Maastricht University", 
          "id": "https://www.grid.ac/institutes/grid.5012.6", 
          "name": [
            "Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Voogd", 
        "givenName": "A. C.", 
        "id": "sg:person.01324672026.66", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324672026.66"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/00000658-200006000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008439763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-200006000-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008439763"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/ajcp/78.6.806", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014373321"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/ijc.11032", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014658573"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19890715)64:2<448::aid-cncr2820640218>3.0.co;2-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017201152"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02303750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020307630", 
          "https://doi.org/10.1007/bf02303750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02303750", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020307630", 
          "https://doi.org/10.1007/bf02303750"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021074534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006384407690", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025925662", 
          "https://doi.org/10.1023/a:1006384407690"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19940715)74:2<640::aid-cncr2820740216>3.0.co;2-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027638559"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2168.1997.02540.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027992925"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1200/jco.2005.09.046", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028012420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028624131"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19890415)63:8<1630::aid-cncr2820630833>3.0.co;2-u", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029248102"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02305534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032409021", 
          "https://doi.org/10.1007/bf02305534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/bf02305534", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032409021", 
          "https://doi.org/10.1007/bf02305534"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/1097-0142(19920601)69:11<2789::aid-cncr2820691126>3.0.co;2-j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035497961"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1979.tb03029.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040699247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1365-2559.1979.tb03029.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040699247"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.21921", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045394946"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000171306.74366.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045960085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000171306.74366.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045960085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.sla.0000171306.74366.22", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045960085"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1006359308505", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047360051", 
          "https://doi.org/10.1023/a:1006359308505"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1001/jama.289.11.1421", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048686719"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<113::aid-cncr19>3.0.co;2-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049757054"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800821023", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053178895"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199522240-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053334062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199522240-00012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053334062"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bjs.1800840139", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1054296211"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075201874", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jnci/55.2.231", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1077289701"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2007-09", 
    "datePublishedReg": "2007-09-01", 
    "description": "BACKGROUND: Invasive lobular breast carcinoma is known for its multicentricity and is associated with a higher incidence of incomplete excision after breast-conserving therapy. The aim of the study was to examine the influence of positive surgical margins on the local recurrence rate in patients diagnosed with invasive lobular cancer and treated with breast-conserving therapy.\nMETHODS: All 416 women diagnosed with invasive lobular breast cancer and undergoing breast-conserving treatment between 1995 and 2002 were selected from the population-based Eindhoven Cancer Registry. Their medical charts were reviewed and detailed information was collected.\nRESULTS: The risk of margin involvement was 29% after the first operation and 17% when taking into account the final margin status of the patients undergoing re-excision. During follow-up, 18 patients developed a local recurrence. The 5 year actuarial risk of developing a local recurrence was 3.5% (95% confidence interval 2.5-4.5) and the 8 year risk was 6.4% (95% confidence interval 4.7-8.0). There was no influence of positive surgical margins on the risk of local recurrence, neither in the univariate analysis nor after adjustment for age, tumour size, nodal status and adjuvant systemic treatment.\nCONCLUSION: Patients with invasive lobular cancer, treated with breast-conservation, have a low risk of local recurrence, despite their high risk of having a microscopically incomplete excision of the tumour.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10549-006-9431-5", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "105"
      }
    ], 
    "name": "Margin status and the risk of local recurrence after breast-conserving treatment of lobular breast cancer", 
    "pagination": "63-68", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "04a0774aa3e22aa8285ae1f52dc9a9220b3927c22e2dfcc357d0b0fa20a960c1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "17115109"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "8111104"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-006-9431-5"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1000970941"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-006-9431-5", 
      "https://app.dimensions.ai/details/publication/pub.1000970941"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-10T17:31", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8672_00000509.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10549-006-9431-5"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9431-5'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9431-5'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9431-5'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9431-5'


 

This table displays all metadata directly associated to this object as RDF triples.

247 TRIPLES      21 PREDICATES      68 URIs      35 LITERALS      23 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-006-9431-5 schema:about N301ace49a4b24e55a0f905d63b0052eb
2 N3c49b970f42f4a81aafe6736e7f98108
3 N64af71748c874c63828273ff6a37bed6
4 N8a89ea616dc04daab519311273298bef
5 N8c1c7ba6531b4776850658d842509916
6 N8f49d8c11e7146f6b73d0c5f2292db83
7 Ncb6f2eb5298040dcb5becd1d4f3060d2
8 Nd04023caea644dd997a1b72722f990bd
9 Nd2c2c501c4f54958852f937d10709669
10 Ndec66cad175d4c02888958222f7022ce
11 Ne750697822c7400d94c6081d26bea7f5
12 Ne9947ab1c8aa4675a46cb4ed4c4b8d8e
13 Nf66116a0df0c4538b62d854a2b1fda65
14 Nf954f5ef690d41e1b0fe35125108ed5e
15 anzsrc-for:11
16 anzsrc-for:1112
17 schema:author N77a070a279e84345a9baf96200e745d9
18 schema:citation sg:pub.10.1007/bf02303750
19 sg:pub.10.1007/bf02305534
20 sg:pub.10.1023/a:1006359308505
21 sg:pub.10.1023/a:1006384407690
22 https://app.dimensions.ai/details/publication/pub.1075201874
23 https://doi.org/10.1001/jama.289.11.1421
24 https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<113::aid-cncr19>3.0.co;2-8
25 https://doi.org/10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4
26 https://doi.org/10.1002/1097-0142(19890415)63:8<1630::aid-cncr2820630833>3.0.co;2-u
27 https://doi.org/10.1002/1097-0142(19890715)64:2<448::aid-cncr2820640218>3.0.co;2-7
28 https://doi.org/10.1002/1097-0142(19920601)69:11<2789::aid-cncr2820691126>3.0.co;2-j
29 https://doi.org/10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b
30 https://doi.org/10.1002/1097-0142(19940715)74:2<640::aid-cncr2820740216>3.0.co;2-v
31 https://doi.org/10.1002/bjs.1800821023
32 https://doi.org/10.1002/bjs.1800840139
33 https://doi.org/10.1002/cncr.21921
34 https://doi.org/10.1002/ijc.11032
35 https://doi.org/10.1046/j.1365-2168.1997.02540.x
36 https://doi.org/10.1093/ajcp/78.6.806
37 https://doi.org/10.1093/jnci/55.2.231
38 https://doi.org/10.1097/00000658-199522240-00012
39 https://doi.org/10.1097/00000658-200006000-00012
40 https://doi.org/10.1097/01.sla.0000171306.74366.22
41 https://doi.org/10.1111/j.1365-2559.1979.tb03029.x
42 https://doi.org/10.1200/jco.2005.09.046
43 schema:datePublished 2007-09
44 schema:datePublishedReg 2007-09-01
45 schema:description BACKGROUND: Invasive lobular breast carcinoma is known for its multicentricity and is associated with a higher incidence of incomplete excision after breast-conserving therapy. The aim of the study was to examine the influence of positive surgical margins on the local recurrence rate in patients diagnosed with invasive lobular cancer and treated with breast-conserving therapy. METHODS: All 416 women diagnosed with invasive lobular breast cancer and undergoing breast-conserving treatment between 1995 and 2002 were selected from the population-based Eindhoven Cancer Registry. Their medical charts were reviewed and detailed information was collected. RESULTS: The risk of margin involvement was 29% after the first operation and 17% when taking into account the final margin status of the patients undergoing re-excision. During follow-up, 18 patients developed a local recurrence. The 5 year actuarial risk of developing a local recurrence was 3.5% (95% confidence interval 2.5-4.5) and the 8 year risk was 6.4% (95% confidence interval 4.7-8.0). There was no influence of positive surgical margins on the risk of local recurrence, neither in the univariate analysis nor after adjustment for age, tumour size, nodal status and adjuvant systemic treatment. CONCLUSION: Patients with invasive lobular cancer, treated with breast-conservation, have a low risk of local recurrence, despite their high risk of having a microscopically incomplete excision of the tumour.
46 schema:genre research_article
47 schema:inLanguage en
48 schema:isAccessibleForFree false
49 schema:isPartOf N71ba8d05e9e34902aed21705e2f9da4a
50 Nc3c111ddbd5545ea9020f9b7cf2fe6fd
51 sg:journal.1092777
52 schema:name Margin status and the risk of local recurrence after breast-conserving treatment of lobular breast cancer
53 schema:pagination 63-68
54 schema:productId N7c61fe615c844f07845e3517c5a6ddfa
55 N84d4aa384401406ba60be8a8a31726fe
56 Na3e2e64863974ec19e19914201882f1e
57 Ne7ce66e704a244b19ac21842ed6ee55c
58 Nf2bfae7e5c714c3ba525c72946c415b9
59 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000970941
60 https://doi.org/10.1007/s10549-006-9431-5
61 schema:sdDatePublished 2019-04-10T17:31
62 schema:sdLicense https://scigraph.springernature.com/explorer/license/
63 schema:sdPublisher N32d51f0df42a472f8a4c408e80eed497
64 schema:url http://link.springer.com/10.1007%2Fs10549-006-9431-5
65 sgo:license sg:explorer/license/
66 sgo:sdDataset articles
67 rdf:type schema:ScholarlyArticle
68 N301ace49a4b24e55a0f905d63b0052eb schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
69 schema:name Female
70 rdf:type schema:DefinedTerm
71 N32d51f0df42a472f8a4c408e80eed497 schema:name Springer Nature - SN SciGraph project
72 rdf:type schema:Organization
73 N3c49b970f42f4a81aafe6736e7f98108 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
74 schema:name Mastectomy, Segmental
75 rdf:type schema:DefinedTerm
76 N64af71748c874c63828273ff6a37bed6 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
77 schema:name Aged
78 rdf:type schema:DefinedTerm
79 N6d34c47d6bf54c38b8a7a7fd9fbe8fe0 rdf:first sg:person.0625613040.52
80 rdf:rest Nb410fa11e62549f4bdd1d9e2ff6b7533
81 N71ba8d05e9e34902aed21705e2f9da4a schema:issueNumber 1
82 rdf:type schema:PublicationIssue
83 N77a070a279e84345a9baf96200e745d9 rdf:first Nf29ec867f8eb41faadaa156aa6bd3d79
84 rdf:rest Ne9644729c6774df794619b7c2e200d54
85 N7c61fe615c844f07845e3517c5a6ddfa schema:name dimensions_id
86 schema:value pub.1000970941
87 rdf:type schema:PropertyValue
88 N84d4aa384401406ba60be8a8a31726fe schema:name pubmed_id
89 schema:value 17115109
90 rdf:type schema:PropertyValue
91 N8a89ea616dc04daab519311273298bef schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Treatment Outcome
93 rdf:type schema:DefinedTerm
94 N8c1c7ba6531b4776850658d842509916 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
95 schema:name Age Factors
96 rdf:type schema:DefinedTerm
97 N8f49d8c11e7146f6b73d0c5f2292db83 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Recurrence
99 rdf:type schema:DefinedTerm
100 Na3e2e64863974ec19e19914201882f1e schema:name readcube_id
101 schema:value 04a0774aa3e22aa8285ae1f52dc9a9220b3927c22e2dfcc357d0b0fa20a960c1
102 rdf:type schema:PropertyValue
103 Nb410fa11e62549f4bdd1d9e2ff6b7533 rdf:first sg:person.07412540414.15
104 rdf:rest Ncae2a59af9f74a40a254b311f0b0f324
105 Nc3c111ddbd5545ea9020f9b7cf2fe6fd schema:volumeNumber 105
106 rdf:type schema:PublicationVolume
107 Ncae2a59af9f74a40a254b311f0b0f324 rdf:first sg:person.01324672026.66
108 rdf:rest rdf:nil
109 Ncb6f2eb5298040dcb5becd1d4f3060d2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Time Factors
111 rdf:type schema:DefinedTerm
112 Nd04023caea644dd997a1b72722f990bd schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Humans
114 rdf:type schema:DefinedTerm
115 Nd2c2c501c4f54958852f937d10709669 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
116 schema:name Proportional Hazards Models
117 rdf:type schema:DefinedTerm
118 Ndec66cad175d4c02888958222f7022ce schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
119 schema:name Breast
120 rdf:type schema:DefinedTerm
121 Ndefa87fdc55c4dd08e5f9483ca38d4f6 schema:name Regional Institute of Pathology (PAMM), Eindhoven, The Netherlands
122 rdf:type schema:Organization
123 Ne09f95fcf0c04712858fcf1a65565a4b rdf:first sg:person.01106133266.44
124 rdf:rest N6d34c47d6bf54c38b8a7a7fd9fbe8fe0
125 Ne750697822c7400d94c6081d26bea7f5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
126 schema:name Breast Neoplasms
127 rdf:type schema:DefinedTerm
128 Ne7ce66e704a244b19ac21842ed6ee55c schema:name nlm_unique_id
129 schema:value 8111104
130 rdf:type schema:PropertyValue
131 Ne9644729c6774df794619b7c2e200d54 rdf:first sg:person.0647401126.71
132 rdf:rest Ne09f95fcf0c04712858fcf1a65565a4b
133 Ne9947ab1c8aa4675a46cb4ed4c4b8d8e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
134 schema:name Risk
135 rdf:type schema:DefinedTerm
136 Nf29ec867f8eb41faadaa156aa6bd3d79 schema:affiliation https://www.grid.ac/institutes/grid.5012.6
137 schema:familyName van den Broek
138 schema:givenName N.
139 rdf:type schema:Person
140 Nf2bfae7e5c714c3ba525c72946c415b9 schema:name doi
141 schema:value 10.1007/s10549-006-9431-5
142 rdf:type schema:PropertyValue
143 Nf66116a0df0c4538b62d854a2b1fda65 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
144 schema:name Middle Aged
145 rdf:type schema:DefinedTerm
146 Nf954f5ef690d41e1b0fe35125108ed5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
147 schema:name Carcinoma, Lobular
148 rdf:type schema:DefinedTerm
149 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
150 schema:name Medical and Health Sciences
151 rdf:type schema:DefinedTerm
152 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
153 schema:name Oncology and Carcinogenesis
154 rdf:type schema:DefinedTerm
155 sg:journal.1092777 schema:issn 0167-6806
156 1573-7217
157 schema:name Breast Cancer Research and Treatment
158 rdf:type schema:Periodical
159 sg:person.01106133266.44 schema:affiliation https://www.grid.ac/institutes/grid.418897.b
160 schema:familyName van de Poll-Franse
161 schema:givenName L. V.
162 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01106133266.44
163 rdf:type schema:Person
164 sg:person.01324672026.66 schema:affiliation https://www.grid.ac/institutes/grid.5012.6
165 schema:familyName Voogd
166 schema:givenName A. C.
167 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01324672026.66
168 rdf:type schema:Person
169 sg:person.0625613040.52 schema:affiliation Ndefa87fdc55c4dd08e5f9483ca38d4f6
170 schema:familyName van Beek
171 schema:givenName M. W. P. M.
172 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0625613040.52
173 rdf:type schema:Person
174 sg:person.0647401126.71 schema:affiliation https://www.grid.ac/institutes/grid.413532.2
175 schema:familyName van der Sangen
176 schema:givenName M. J. C.
177 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0647401126.71
178 rdf:type schema:Person
179 sg:person.07412540414.15 schema:affiliation https://www.grid.ac/institutes/grid.413532.2
180 schema:familyName Nieuwenhuijzen
181 schema:givenName G. A. P.
182 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.07412540414.15
183 rdf:type schema:Person
184 sg:pub.10.1007/bf02303750 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020307630
185 https://doi.org/10.1007/bf02303750
186 rdf:type schema:CreativeWork
187 sg:pub.10.1007/bf02305534 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032409021
188 https://doi.org/10.1007/bf02305534
189 rdf:type schema:CreativeWork
190 sg:pub.10.1023/a:1006359308505 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047360051
191 https://doi.org/10.1023/a:1006359308505
192 rdf:type schema:CreativeWork
193 sg:pub.10.1023/a:1006384407690 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025925662
194 https://doi.org/10.1023/a:1006384407690
195 rdf:type schema:CreativeWork
196 https://app.dimensions.ai/details/publication/pub.1075201874 schema:CreativeWork
197 https://doi.org/10.1001/jama.289.11.1421 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048686719
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/(sici)1097-0142(19960101)77:1<113::aid-cncr19>3.0.co;2-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049757054
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/1097-0142(197507)36:1<1::aid-cncr2820360102>3.0.co;2-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028624131
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1002/1097-0142(19890415)63:8<1630::aid-cncr2820630833>3.0.co;2-u schema:sameAs https://app.dimensions.ai/details/publication/pub.1029248102
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1002/1097-0142(19890715)64:2<448::aid-cncr2820640218>3.0.co;2-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017201152
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1002/1097-0142(19920601)69:11<2789::aid-cncr2820691126>3.0.co;2-j schema:sameAs https://app.dimensions.ai/details/publication/pub.1035497961
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1002/1097-0142(19940315)73:6<1673::aid-cncr2820730620>3.0.co;2-b schema:sameAs https://app.dimensions.ai/details/publication/pub.1021074534
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1002/1097-0142(19940715)74:2<640::aid-cncr2820740216>3.0.co;2-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1027638559
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1002/bjs.1800821023 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053178895
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1002/bjs.1800840139 schema:sameAs https://app.dimensions.ai/details/publication/pub.1054296211
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1002/cncr.21921 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045394946
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1002/ijc.11032 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014658573
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1046/j.1365-2168.1997.02540.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1027992925
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1093/ajcp/78.6.806 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014373321
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1093/jnci/55.2.231 schema:sameAs https://app.dimensions.ai/details/publication/pub.1077289701
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1097/00000658-199522240-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053334062
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1097/00000658-200006000-00012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008439763
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1097/01.sla.0000171306.74366.22 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045960085
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1111/j.1365-2559.1979.tb03029.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1040699247
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1200/jco.2005.09.046 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028012420
236 rdf:type schema:CreativeWork
237 https://www.grid.ac/institutes/grid.413532.2 schema:alternateName Catharina Ziekenhuis
238 schema:name Department of Radiotherapy, Catharina Hospital, Eindhoven, The Netherlands
239 Department of Surgery, Catharina Hospital, Eindhoven, The Netherlands
240 rdf:type schema:Organization
241 https://www.grid.ac/institutes/grid.418897.b schema:alternateName Eindhoven Cancer Registry
242 schema:name Eindhoven Cancer Registry, Eindhoven, The Netherlands
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.5012.6 schema:alternateName Maastricht University
245 schema:name Department of Epidemiology, Maastricht University, P.O. Box 616, 6200 MD, Maastricht, The Netherlands
246 Faculty of Medicine, Maastricht University, Maastricht, The Netherlands
247 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...