Polymorphisms in the KDR and POSTN Genes: Association with Breast Cancer Susceptibility and Prognosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-29

AUTHORS

Asta Försti, Qianren Jin, Andrea Altieri, Robert Johansson, Kerstin Wagner, Kerstin Enquist, Ewa Grzybowska, Jolanta Pamula, Wioletta Pekala, Göran Hallmans, Per Lenner, Kari Hemminki

ABSTRACT

Angiogenesis is an important step in the development of cancer. Vascular endothelial growth factor is a major regulator of breast cancer angiogenesis, the effects of which are transmitted through the kinase domain receptor (KDR). Up-regulation of KDR by periostin (POSTN) induces angiogenesis. We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each gene for further analyses. We carried out a case–control study consisting of 412 familial and 912 unselected breast cancer cases together with ethnically and geographically selected controls. Genotype, haplotype and genotype combination analyses were carried out to evaluate their effect on susceptibility to and prognosis of breast cancer. A haplotype in the POSTN gene was associated with an increased risk even after correction for multiple comparisons. Nominal associations between the SNPs and prognostic indicators were also observed. Tumors of the KDR 472His allele carriers were less often progesterone receptor negative according to both genotype and haplotype analyses (OR 0.61, 95%CI 0.40–0.92 and OR 0.60, 95%CI 0.40–0.91, respectively). The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02–3.01 and OR 1.70, 95%CI 1.04–2.78, respectively). The overall and cancer specific survival after 15 years of follow-up was more than 75%, and it did not depend on the genotype. Although a major effect of the SNPs in the KDR and the POSTN genes on breast cancer susceptibility and prognosis was excluded, the effect of the POSTN C-33G SNP on prognosis needs further characterization. More... »

PAGES

83-93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-006-9265-1

DOI

http://dx.doi.org/10.1007/s10549-006-9265-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052050307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16807673


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Oncology and Carcinogenesis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adult", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Aged, 80 and over", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Breast Neoplasms", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Case-Control Studies", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Adhesion Molecules", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Chi-Square Distribution", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Disease-Free Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Gene Frequency", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genetic Predisposition to Disease", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Genotype", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Odds Ratio", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Polymorphism, Genetic", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Prognosis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Vascular Endothelial Growth Factor Receptor-2", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany", 
            "Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "F\u00f6rsti", 
        "givenName": "Asta", 
        "id": "sg:person.01230336622.01", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230336622.01"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Jin", 
        "givenName": "Qianren", 
        "id": "sg:person.01007753724.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007753724.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Altieri", 
        "givenName": "Andrea", 
        "id": "sg:person.01152477135.90", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152477135.90"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Norrlands University Hospital, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.412215.1", 
          "name": [
            "Department of Oncology, Norrlands University Hospital, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Johansson", 
        "givenName": "Robert", 
        "id": "sg:person.01036250535.82", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036250535.82"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany", 
          "id": "http://www.grid.ac/institutes/grid.7497.d", 
          "name": [
            "Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wagner", 
        "givenName": "Kerstin", 
        "id": "sg:person.01301117073.28", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301117073.28"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Public Health and Clinical Medicine/Nutritional Research, Ume\u00e5 University, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.12650.30", 
          "name": [
            "Department of Public Health and Clinical Medicine/Nutritional Research, Ume\u00e5 University, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Enquist", 
        "givenName": "Kerstin", 
        "id": "sg:person.0643342400.87", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643342400.87"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland", 
          "id": "http://www.grid.ac/institutes/grid.418165.f", 
          "name": [
            "Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Grzybowska", 
        "givenName": "Ewa", 
        "id": "sg:person.0770675224.18", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770675224.18"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland", 
          "id": "http://www.grid.ac/institutes/grid.418165.f", 
          "name": [
            "Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pamula", 
        "givenName": "Jolanta", 
        "id": "sg:person.01152051576.08", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152051576.08"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland", 
          "id": "http://www.grid.ac/institutes/grid.418165.f", 
          "name": [
            "Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pekala", 
        "givenName": "Wioletta", 
        "id": "sg:person.01371257214.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371257214.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Norrlands University Hospital, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.412215.1", 
          "name": [
            "Department of Oncology, Norrlands University Hospital, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hallmans", 
        "givenName": "G\u00f6ran", 
        "id": "sg:person.01023564410.54", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023564410.54"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Oncology, Norrlands University Hospital, Ume\u00e5, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.412215.1", 
          "name": [
            "Department of Oncology, Norrlands University Hospital, Ume\u00e5, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lenner", 
        "givenName": "Per", 
        "id": "sg:person.0721051037.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721051037.52"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden", 
          "id": "http://www.grid.ac/institutes/grid.4714.6", 
          "name": [
            "Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany", 
            "Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hemminki", 
        "givenName": "Kari", 
        "id": "sg:person.0726772160.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726772160.17"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nm0603-669", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031340920", 
          "https://doi.org/10.1038/nm0603-669"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1021899904332", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024561400", 
          "https://doi.org/10.1023/a:1021899904332"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1001-117", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010058562", 
          "https://doi.org/10.1038/ng1001-117"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/b:brea.0000004357.92232.cb", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013598070", 
          "https://doi.org/10.1023/b:brea.0000004357.92232.cb"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.onc.1206816", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027528935", 
          "https://doi.org/10.1038/sj.onc.1206816"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ng1474", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1045399696", 
          "https://doi.org/10.1038/ng1474"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00439-002-0902-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1075233260", 
          "https://doi.org/10.1007/s00439-002-0902-4"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1015270324325", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021221270", 
          "https://doi.org/10.1023/a:1015270324325"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2006-06-29", 
    "datePublishedReg": "2006-06-29", 
    "description": "Angiogenesis is an important step in the development of cancer. Vascular endothelial growth factor is a major regulator of breast cancer angiogenesis, the effects of which are transmitted through the kinase domain receptor (KDR). Up-regulation of KDR by periostin (POSTN) induces angiogenesis. We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each gene for further analyses. We carried out a case\u2013control study consisting of 412 familial and 912 unselected breast cancer cases together with ethnically and geographically selected controls. Genotype, haplotype and genotype combination analyses were carried out to evaluate their effect on susceptibility to and prognosis of breast cancer. A haplotype in the POSTN gene was associated with an increased risk even after correction for multiple comparisons. Nominal associations between the SNPs and prognostic indicators were also observed. Tumors of the KDR 472His allele carriers were less often progesterone receptor negative according to both genotype and haplotype analyses (OR 0.61, 95%CI 0.40\u20130.92 and OR 0.60, 95%CI 0.40\u20130.91, respectively). The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02\u20133.01 and OR 1.70, 95%CI 1.04\u20132.78, respectively). The overall and cancer specific survival after 15\u00a0years of follow-up was more than 75%, and it did not depend on the genotype. Although a major effect of the SNPs in the KDR and the POSTN genes on breast cancer susceptibility and prognosis was excluded, the effect of the POSTN C-33G SNP on prognosis needs further characterization.", 
    "genre": "article", 
    "id": "sg:pub.10.1007/s10549-006-9265-1", 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1092777", 
        "issn": [
          "0167-6806", 
          "1573-7217"
        ], 
        "name": "Breast Cancer Research and Treatment", 
        "publisher": "Springer Nature", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "1", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "101"
      }
    ], 
    "keywords": [
      "kinase domain receptor", 
      "breast cancer susceptibility", 
      "single nucleotide polymorphisms", 
      "allele carriers", 
      "POSTN gene", 
      "estrogen receptor-negative tumors", 
      "cancer-specific survival", 
      "receptor-negative tumors", 
      "cancer susceptibility", 
      "case-control study", 
      "vascular endothelial growth factor", 
      "G allele carriers", 
      "breast cancer cases", 
      "breast cancer angiogenesis", 
      "G single nucleotide polymorphism", 
      "endothelial growth factor", 
      "development of cancer", 
      "genotype combination analysis", 
      "specific survival", 
      "negative tumors", 
      "prognostic indicator", 
      "progesterone receptor", 
      "cancer cases", 
      "breast cancer", 
      "cancer angiogenesis", 
      "prognosis", 
      "growth factor", 
      "high grade", 
      "domain receptor", 
      "angiogenesis", 
      "multiple comparisons", 
      "nominal association", 
      "tumors", 
      "cancer", 
      "periostin", 
      "major regulator", 
      "receptors", 
      "haplotype analysis", 
      "nucleotide polymorphisms", 
      "association", 
      "further characterization", 
      "susceptibility", 
      "genotypes", 
      "polymorphism", 
      "genes", 
      "combination analysis", 
      "survival", 
      "effect", 
      "Further analysis", 
      "risk", 
      "major effect", 
      "haplotypes", 
      "grade", 
      "years", 
      "factors", 
      "carriers", 
      "control", 
      "cases", 
      "analysis", 
      "study", 
      "regulator", 
      "important step", 
      "indicators", 
      "development", 
      "correction", 
      "comparison", 
      "characterization", 
      "step"
    ], 
    "name": "Polymorphisms in the KDR and POSTN Genes: Association with Breast Cancer Susceptibility and Prognosis", 
    "pagination": "83-93", 
    "productId": [
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1052050307"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10549-006-9265-1"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "16807673"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10549-006-9265-1", 
      "https://app.dimensions.ai/details/publication/pub.1052050307"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2022-10-01T06:33", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-springernature-scigraph/baseset/20221001/entities/gbq_results/article/article_414.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://doi.org/10.1007/s10549-006-9265-1"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9265-1'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9265-1'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9265-1'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-006-9265-1'


 

This table displays all metadata directly associated to this object as RDF triples.

323 TRIPLES      21 PREDICATES      119 URIs      103 LITERALS      25 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10549-006-9265-1 schema:about N04c7e4854d1c47e0b89d5c359070c8f2
2 N0f2bce884f1c4919ade20b5dd7262397
3 N1edf7c7d92cb4936a08f652d2d397b2e
4 N2224bfdbaa894376b45af3560d70592c
5 N2e1f5df4deab42df90efe068bbab0ac2
6 N39d366f039cf400998ad65ec3faa44a3
7 N51aa1c3a16144b99810423e16f120906
8 N51e862ac23c24d8fa4b094940b353d11
9 N774a8403be9d41028303d8bdba46fda5
10 N7df7e32bac234b84a974503431f985b4
11 N8bfe8d0d5e2d41f1b3a652c917ba2e48
12 N9ce8b23ba1e94f91a14cbbda279a6142
13 Na5bccc3c410d47e59c90aa292274d070
14 Naf3148a4f40b49b5868b7019d0808cd5
15 Nc50fe9f02c654bf2aa449900c0321adf
16 Nda38d783c6734b6f8a6b7940e9c75f94
17 Nf269d0877bc743b2a8afa721bb8f3598
18 Nfd369edc194f4312a135476a16fe7470
19 anzsrc-for:11
20 anzsrc-for:1112
21 schema:author Naac4de17f04945bab25adf7f8de793c9
22 schema:citation sg:pub.10.1007/s00439-002-0902-4
23 sg:pub.10.1023/a:1015270324325
24 sg:pub.10.1023/a:1021899904332
25 sg:pub.10.1023/b:brea.0000004357.92232.cb
26 sg:pub.10.1038/ng1001-117
27 sg:pub.10.1038/ng1474
28 sg:pub.10.1038/nm0603-669
29 sg:pub.10.1038/sj.onc.1206816
30 schema:datePublished 2006-06-29
31 schema:datePublishedReg 2006-06-29
32 schema:description Angiogenesis is an important step in the development of cancer. Vascular endothelial growth factor is a major regulator of breast cancer angiogenesis, the effects of which are transmitted through the kinase domain receptor (KDR). Up-regulation of KDR by periostin (POSTN) induces angiogenesis. We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each gene for further analyses. We carried out a case–control study consisting of 412 familial and 912 unselected breast cancer cases together with ethnically and geographically selected controls. Genotype, haplotype and genotype combination analyses were carried out to evaluate their effect on susceptibility to and prognosis of breast cancer. A haplotype in the POSTN gene was associated with an increased risk even after correction for multiple comparisons. Nominal associations between the SNPs and prognostic indicators were also observed. Tumors of the KDR 472His allele carriers were less often progesterone receptor negative according to both genotype and haplotype analyses (OR 0.61, 95%CI 0.40–0.92 and OR 0.60, 95%CI 0.40–0.91, respectively). The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02–3.01 and OR 1.70, 95%CI 1.04–2.78, respectively). The overall and cancer specific survival after 15 years of follow-up was more than 75%, and it did not depend on the genotype. Although a major effect of the SNPs in the KDR and the POSTN genes on breast cancer susceptibility and prognosis was excluded, the effect of the POSTN C-33G SNP on prognosis needs further characterization.
33 schema:genre article
34 schema:isAccessibleForFree false
35 schema:isPartOf N27382b1b5fb54b37a56b607a763ed7d6
36 Nc57188cb52da4e5aa8449a9eb46e19b5
37 sg:journal.1092777
38 schema:keywords Further analysis
39 G allele carriers
40 G single nucleotide polymorphism
41 POSTN gene
42 allele carriers
43 analysis
44 angiogenesis
45 association
46 breast cancer
47 breast cancer angiogenesis
48 breast cancer cases
49 breast cancer susceptibility
50 cancer
51 cancer angiogenesis
52 cancer cases
53 cancer susceptibility
54 cancer-specific survival
55 carriers
56 case-control study
57 cases
58 characterization
59 combination analysis
60 comparison
61 control
62 correction
63 development
64 development of cancer
65 domain receptor
66 effect
67 endothelial growth factor
68 estrogen receptor-negative tumors
69 factors
70 further characterization
71 genes
72 genotype combination analysis
73 genotypes
74 grade
75 growth factor
76 haplotype analysis
77 haplotypes
78 high grade
79 important step
80 indicators
81 kinase domain receptor
82 major effect
83 major regulator
84 multiple comparisons
85 negative tumors
86 nominal association
87 nucleotide polymorphisms
88 periostin
89 polymorphism
90 progesterone receptor
91 prognosis
92 prognostic indicator
93 receptor-negative tumors
94 receptors
95 regulator
96 risk
97 single nucleotide polymorphisms
98 specific survival
99 step
100 study
101 survival
102 susceptibility
103 tumors
104 vascular endothelial growth factor
105 years
106 schema:name Polymorphisms in the KDR and POSTN Genes: Association with Breast Cancer Susceptibility and Prognosis
107 schema:pagination 83-93
108 schema:productId N4f79e149a1dc4f868d4cb6ba0e20ec09
109 N9bc481ebe7904caa991deb624eafd7ef
110 Na0c28f534eed43d8aead0176ab77f387
111 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052050307
112 https://doi.org/10.1007/s10549-006-9265-1
113 schema:sdDatePublished 2022-10-01T06:33
114 schema:sdLicense https://scigraph.springernature.com/explorer/license/
115 schema:sdPublisher N9b5b59438b804452ba9a10240347036c
116 schema:url https://doi.org/10.1007/s10549-006-9265-1
117 sgo:license sg:explorer/license/
118 sgo:sdDataset articles
119 rdf:type schema:ScholarlyArticle
120 N027d8d882553457aa2b801395e449cf6 rdf:first sg:person.01152051576.08
121 rdf:rest N0884439c594e41cfa23b06b190e9bb50
122 N04c7e4854d1c47e0b89d5c359070c8f2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
123 schema:name Gene Frequency
124 rdf:type schema:DefinedTerm
125 N08535c988f3d40d3bcf16c9d58d97c8d rdf:first sg:person.01301117073.28
126 rdf:rest N45b704341f7047479ecb2c36376c3e63
127 N0884439c594e41cfa23b06b190e9bb50 rdf:first sg:person.01371257214.78
128 rdf:rest N12389d1bf9204d21b370c89cd8008d3f
129 N0f2bce884f1c4919ade20b5dd7262397 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
130 schema:name Disease-Free Survival
131 rdf:type schema:DefinedTerm
132 N12389d1bf9204d21b370c89cd8008d3f rdf:first sg:person.01023564410.54
133 rdf:rest N344e87eeb9e44833ba5704441b4cab4e
134 N1edf7c7d92cb4936a08f652d2d397b2e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
135 schema:name Odds Ratio
136 rdf:type schema:DefinedTerm
137 N2224bfdbaa894376b45af3560d70592c schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
138 schema:name Case-Control Studies
139 rdf:type schema:DefinedTerm
140 N27382b1b5fb54b37a56b607a763ed7d6 schema:issueNumber 1
141 rdf:type schema:PublicationIssue
142 N2e1f5df4deab42df90efe068bbab0ac2 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
143 schema:name Polymorphism, Genetic
144 rdf:type schema:DefinedTerm
145 N344e87eeb9e44833ba5704441b4cab4e rdf:first sg:person.0721051037.52
146 rdf:rest N6cf3da4b72c44f259a47f13dbc9327aa
147 N39d366f039cf400998ad65ec3faa44a3 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
148 schema:name Cell Adhesion Molecules
149 rdf:type schema:DefinedTerm
150 N45b704341f7047479ecb2c36376c3e63 rdf:first sg:person.0643342400.87
151 rdf:rest N8bd8f14d8bbe4a6eb8a1fa8e7b3f4996
152 N4df0e6558c374b77adaf0a1f435fe225 rdf:first sg:person.01152477135.90
153 rdf:rest N7feaf757ceb44f6bae56d20c55eba726
154 N4f79e149a1dc4f868d4cb6ba0e20ec09 schema:name doi
155 schema:value 10.1007/s10549-006-9265-1
156 rdf:type schema:PropertyValue
157 N51aa1c3a16144b99810423e16f120906 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
158 schema:name Adult
159 rdf:type schema:DefinedTerm
160 N51e862ac23c24d8fa4b094940b353d11 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
161 schema:name Humans
162 rdf:type schema:DefinedTerm
163 N6cf3da4b72c44f259a47f13dbc9327aa rdf:first sg:person.0726772160.17
164 rdf:rest rdf:nil
165 N774a8403be9d41028303d8bdba46fda5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
166 schema:name Genotype
167 rdf:type schema:DefinedTerm
168 N7df7e32bac234b84a974503431f985b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
169 schema:name Middle Aged
170 rdf:type schema:DefinedTerm
171 N7feaf757ceb44f6bae56d20c55eba726 rdf:first sg:person.01036250535.82
172 rdf:rest N08535c988f3d40d3bcf16c9d58d97c8d
173 N8bd8f14d8bbe4a6eb8a1fa8e7b3f4996 rdf:first sg:person.0770675224.18
174 rdf:rest N027d8d882553457aa2b801395e449cf6
175 N8bfe8d0d5e2d41f1b3a652c917ba2e48 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
176 schema:name Breast Neoplasms
177 rdf:type schema:DefinedTerm
178 N9b5b59438b804452ba9a10240347036c schema:name Springer Nature - SN SciGraph project
179 rdf:type schema:Organization
180 N9bc481ebe7904caa991deb624eafd7ef schema:name dimensions_id
181 schema:value pub.1052050307
182 rdf:type schema:PropertyValue
183 N9ce8b23ba1e94f91a14cbbda279a6142 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
184 schema:name Aged
185 rdf:type schema:DefinedTerm
186 Na0c28f534eed43d8aead0176ab77f387 schema:name pubmed_id
187 schema:value 16807673
188 rdf:type schema:PropertyValue
189 Na5bccc3c410d47e59c90aa292274d070 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
190 schema:name Genetic Predisposition to Disease
191 rdf:type schema:DefinedTerm
192 Naac4de17f04945bab25adf7f8de793c9 rdf:first sg:person.01230336622.01
193 rdf:rest Nebac9f6bbbea4ea1bd64fb1ab8632791
194 Naf3148a4f40b49b5868b7019d0808cd5 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
195 schema:name Vascular Endothelial Growth Factor Receptor-2
196 rdf:type schema:DefinedTerm
197 Nc50fe9f02c654bf2aa449900c0321adf schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
198 schema:name Chi-Square Distribution
199 rdf:type schema:DefinedTerm
200 Nc57188cb52da4e5aa8449a9eb46e19b5 schema:volumeNumber 101
201 rdf:type schema:PublicationVolume
202 Nda38d783c6734b6f8a6b7940e9c75f94 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
203 schema:name Aged, 80 and over
204 rdf:type schema:DefinedTerm
205 Nebac9f6bbbea4ea1bd64fb1ab8632791 rdf:first sg:person.01007753724.48
206 rdf:rest N4df0e6558c374b77adaf0a1f435fe225
207 Nf269d0877bc743b2a8afa721bb8f3598 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
208 schema:name Prognosis
209 rdf:type schema:DefinedTerm
210 Nfd369edc194f4312a135476a16fe7470 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
211 schema:name Female
212 rdf:type schema:DefinedTerm
213 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
214 schema:name Medical and Health Sciences
215 rdf:type schema:DefinedTerm
216 anzsrc-for:1112 schema:inDefinedTermSet anzsrc-for:
217 schema:name Oncology and Carcinogenesis
218 rdf:type schema:DefinedTerm
219 sg:journal.1092777 schema:issn 0167-6806
220 1573-7217
221 schema:name Breast Cancer Research and Treatment
222 schema:publisher Springer Nature
223 rdf:type schema:Periodical
224 sg:person.01007753724.48 schema:affiliation grid-institutes:grid.4714.6
225 schema:familyName Jin
226 schema:givenName Qianren
227 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01007753724.48
228 rdf:type schema:Person
229 sg:person.01023564410.54 schema:affiliation grid-institutes:grid.412215.1
230 schema:familyName Hallmans
231 schema:givenName Göran
232 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023564410.54
233 rdf:type schema:Person
234 sg:person.01036250535.82 schema:affiliation grid-institutes:grid.412215.1
235 schema:familyName Johansson
236 schema:givenName Robert
237 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036250535.82
238 rdf:type schema:Person
239 sg:person.01152051576.08 schema:affiliation grid-institutes:grid.418165.f
240 schema:familyName Pamula
241 schema:givenName Jolanta
242 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152051576.08
243 rdf:type schema:Person
244 sg:person.01152477135.90 schema:affiliation grid-institutes:grid.7497.d
245 schema:familyName Altieri
246 schema:givenName Andrea
247 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01152477135.90
248 rdf:type schema:Person
249 sg:person.01230336622.01 schema:affiliation grid-institutes:grid.4714.6
250 schema:familyName Försti
251 schema:givenName Asta
252 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01230336622.01
253 rdf:type schema:Person
254 sg:person.01301117073.28 schema:affiliation grid-institutes:grid.7497.d
255 schema:familyName Wagner
256 schema:givenName Kerstin
257 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01301117073.28
258 rdf:type schema:Person
259 sg:person.01371257214.78 schema:affiliation grid-institutes:grid.418165.f
260 schema:familyName Pekala
261 schema:givenName Wioletta
262 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01371257214.78
263 rdf:type schema:Person
264 sg:person.0643342400.87 schema:affiliation grid-institutes:grid.12650.30
265 schema:familyName Enquist
266 schema:givenName Kerstin
267 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0643342400.87
268 rdf:type schema:Person
269 sg:person.0721051037.52 schema:affiliation grid-institutes:grid.412215.1
270 schema:familyName Lenner
271 schema:givenName Per
272 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0721051037.52
273 rdf:type schema:Person
274 sg:person.0726772160.17 schema:affiliation grid-institutes:grid.4714.6
275 schema:familyName Hemminki
276 schema:givenName Kari
277 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0726772160.17
278 rdf:type schema:Person
279 sg:person.0770675224.18 schema:affiliation grid-institutes:grid.418165.f
280 schema:familyName Grzybowska
281 schema:givenName Ewa
282 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0770675224.18
283 rdf:type schema:Person
284 sg:pub.10.1007/s00439-002-0902-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1075233260
285 https://doi.org/10.1007/s00439-002-0902-4
286 rdf:type schema:CreativeWork
287 sg:pub.10.1023/a:1015270324325 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021221270
288 https://doi.org/10.1023/a:1015270324325
289 rdf:type schema:CreativeWork
290 sg:pub.10.1023/a:1021899904332 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024561400
291 https://doi.org/10.1023/a:1021899904332
292 rdf:type schema:CreativeWork
293 sg:pub.10.1023/b:brea.0000004357.92232.cb schema:sameAs https://app.dimensions.ai/details/publication/pub.1013598070
294 https://doi.org/10.1023/b:brea.0000004357.92232.cb
295 rdf:type schema:CreativeWork
296 sg:pub.10.1038/ng1001-117 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010058562
297 https://doi.org/10.1038/ng1001-117
298 rdf:type schema:CreativeWork
299 sg:pub.10.1038/ng1474 schema:sameAs https://app.dimensions.ai/details/publication/pub.1045399696
300 https://doi.org/10.1038/ng1474
301 rdf:type schema:CreativeWork
302 sg:pub.10.1038/nm0603-669 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031340920
303 https://doi.org/10.1038/nm0603-669
304 rdf:type schema:CreativeWork
305 sg:pub.10.1038/sj.onc.1206816 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027528935
306 https://doi.org/10.1038/sj.onc.1206816
307 rdf:type schema:CreativeWork
308 grid-institutes:grid.12650.30 schema:alternateName Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, Umeå, Sweden
309 schema:name Department of Public Health and Clinical Medicine/Nutritional Research, Umeå University, Umeå, Sweden
310 rdf:type schema:Organization
311 grid-institutes:grid.412215.1 schema:alternateName Department of Oncology, Norrlands University Hospital, Umeå, Sweden
312 schema:name Department of Oncology, Norrlands University Hospital, Umeå, Sweden
313 rdf:type schema:Organization
314 grid-institutes:grid.418165.f schema:alternateName Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland
315 schema:name Department of Molecular Biology, Centre of Oncology, Maria Sklodowska-Curie Institute, Gliwice, Poland
316 rdf:type schema:Organization
317 grid-institutes:grid.4714.6 schema:alternateName Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
318 schema:name Department of Biosciences at Novum, Karolinska Institute, Huddinge, Sweden
319 Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany
320 rdf:type schema:Organization
321 grid-institutes:grid.7497.d schema:alternateName Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany
322 schema:name Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), 69120, Heidelberg, Germany
323 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...