Polymorphisms in the KDR and POSTN Genes: Association with Breast Cancer Susceptibility and Prognosis View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2006-06-29

AUTHORS

Asta Försti, Qianren Jin, Andrea Altieri, Robert Johansson, Kerstin Wagner, Kerstin Enquist, Ewa Grzybowska, Jolanta Pamula, Wioletta Pekala, Göran Hallmans, Per Lenner, Kari Hemminki

ABSTRACT

Angiogenesis is an important step in the development of cancer. Vascular endothelial growth factor is a major regulator of breast cancer angiogenesis, the effects of which are transmitted through the kinase domain receptor (KDR). Up-regulation of KDR by periostin (POSTN) induces angiogenesis. We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each gene for further analyses. We carried out a case–control study consisting of 412 familial and 912 unselected breast cancer cases together with ethnically and geographically selected controls. Genotype, haplotype and genotype combination analyses were carried out to evaluate their effect on susceptibility to and prognosis of breast cancer. A haplotype in the POSTN gene was associated with an increased risk even after correction for multiple comparisons. Nominal associations between the SNPs and prognostic indicators were also observed. Tumors of the KDR 472His allele carriers were less often progesterone receptor negative according to both genotype and haplotype analyses (OR 0.61, 95%CI 0.40–0.92 and OR 0.60, 95%CI 0.40–0.91, respectively). The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02–3.01 and OR 1.70, 95%CI 1.04–2.78, respectively). The overall and cancer specific survival after 15 years of follow-up was more than 75%, and it did not depend on the genotype. Although a major effect of the SNPs in the KDR and the POSTN genes on breast cancer susceptibility and prognosis was excluded, the effect of the POSTN C-33G SNP on prognosis needs further characterization. More... »

PAGES

83-93

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10549-006-9265-1

DOI

http://dx.doi.org/10.1007/s10549-006-9265-1

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1052050307

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/16807673


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32 schema:description Angiogenesis is an important step in the development of cancer. Vascular endothelial growth factor is a major regulator of breast cancer angiogenesis, the effects of which are transmitted through the kinase domain receptor (KDR). Up-regulation of KDR by periostin (POSTN) induces angiogenesis. We screened the KDR and the POSTN genes for published single nucleotide polymorphisms (SNPs) and chose two SNPs in each gene for further analyses. We carried out a case–control study consisting of 412 familial and 912 unselected breast cancer cases together with ethnically and geographically selected controls. Genotype, haplotype and genotype combination analyses were carried out to evaluate their effect on susceptibility to and prognosis of breast cancer. A haplotype in the POSTN gene was associated with an increased risk even after correction for multiple comparisons. Nominal associations between the SNPs and prognostic indicators were also observed. Tumors of the KDR 472His allele carriers were less often progesterone receptor negative according to both genotype and haplotype analyses (OR 0.61, 95%CI 0.40–0.92 and OR 0.60, 95%CI 0.40–0.91, respectively). The POSTN -33G allele carriers had more often high grade and estrogen receptor negative tumors (OR 1.75, 95%CI 1.02–3.01 and OR 1.70, 95%CI 1.04–2.78, respectively). The overall and cancer specific survival after 15 years of follow-up was more than 75%, and it did not depend on the genotype. Although a major effect of the SNPs in the KDR and the POSTN genes on breast cancer susceptibility and prognosis was excluded, the effect of the POSTN C-33G SNP on prognosis needs further characterization.
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38 schema:keywords Further analysis
39 G allele carriers
40 G single nucleotide polymorphism
41 POSTN gene
42 allele carriers
43 analysis
44 angiogenesis
45 association
46 breast cancer
47 breast cancer angiogenesis
48 breast cancer cases
49 breast cancer susceptibility
50 cancer
51 cancer angiogenesis
52 cancer cases
53 cancer susceptibility
54 cancer-specific survival
55 carriers
56 case-control study
57 cases
58 characterization
59 combination analysis
60 comparison
61 control
62 correction
63 development
64 development of cancer
65 domain receptor
66 effect
67 endothelial growth factor
68 estrogen receptor-negative tumors
69 factors
70 further characterization
71 genes
72 genotype combination analysis
73 genotypes
74 grade
75 growth factor
76 haplotype analysis
77 haplotypes
78 high grade
79 important step
80 indicators
81 kinase domain receptor
82 major effect
83 major regulator
84 multiple comparisons
85 negative tumors
86 nominal association
87 nucleotide polymorphisms
88 periostin
89 polymorphism
90 progesterone receptor
91 prognosis
92 prognostic indicator
93 receptor-negative tumors
94 receptors
95 regulator
96 risk
97 single nucleotide polymorphisms
98 specific survival
99 step
100 study
101 survival
102 susceptibility
103 tumors
104 vascular endothelial growth factor
105 years
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