Ontology type: schema:ScholarlyArticle
2005-04
AUTHORSSun Young Rha, Yong Hwa Moon, Hei Chul Jeung, Yong Tae Kim, Joo Hyuk Sohn, Woo Ick Yang, Chang Ok Suh, Gwi Eon Kim, Jae Kyung Roh, Hyun Cheol Chung
ABSTRACTPurposesWe evaluated the efficacy and tolerability of gemcitabine monotherapy in heavily pretreated, breast cancer patients as salvage chemotherapy.MethodsA weekly infusion of gemcitabine at 850 mg/m2for 30 min, for 3 of every 4 weeks, was introduced in advanced breast cancer patients who had failed previous doxorubicin and taxane based chemotherapy. There was no dose modification, and the treatment was delayed until the leukopenia was recovered with G-CSF support. The efficacy was evaluated every three cycles and the treatment was continued until either disease progression or 12 cycles.ResultsOf 41 enrolled patients, 38 were evaluable with a median age of 47. Total 178 cycles of gemcitabine was administered and the relative dose intensity was 89. The toxicity was mild with 12 of grade III neutropenia and 14 of grade III/IV thrombocytopenia without clinical symptoms. The response rate was 20 (8/38), comprising two complete and six partial responses. The median response duration and overall survival were 9 (2–25) and 11 months, respectively. The overall survival of 12 months was better in the third line patients than the 7 months in the fourth line treatment group.ConclusionGemcitabine monotherapy is effective and safe as salvage treatment in heavily pretreated, breast cancer patients. More... »
PAGES215-221
http://scigraph.springernature.com/pub.10.1007/s10549-004-2468-4
DOIhttp://dx.doi.org/10.1007/s10549-004-2468-4
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1027872686
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/15830134
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1112",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Oncology and Carcinogenesis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Adult",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Antimetabolites, Antineoplastic",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Breast Neoplasms",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Deoxycytidine",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Female",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Granulocyte Colony-Stimulating Factor",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Humans",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Infusions, Intravenous",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Middle Aged",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Neoplasm Metastasis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Salvage Therapy",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Survival Analysis",
"type": "DefinedTerm"
},
{
"inDefinedTermSet": "https://www.nlm.nih.gov/mesh/",
"name": "Treatment Outcome",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea",
"Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Rha",
"givenName": "Sun Young",
"id": "sg:person.01036404665.54",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01036404665.54"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea",
"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Moon",
"givenName": "Yong Hwa",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Jeung",
"givenName": "Hei Chul",
"id": "sg:person.01043564241.87",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01043564241.87"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Yong Tae",
"id": "sg:person.01013045214.98",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01013045214.98"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Sohn",
"givenName": "Joo Hyuk",
"id": "sg:person.0661267733.85",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0661267733.85"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Pathology, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Pathology, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Yang",
"givenName": "Woo Ick",
"id": "sg:person.016025552634.33",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016025552634.33"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Suh",
"givenName": "Chang Ok",
"id": "sg:person.016501460022.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016501460022.74"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Radiation Oncology, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Kim",
"givenName": "Gwi Eon",
"id": "sg:person.01311370625.22",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311370625.22"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea",
"Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea",
"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Roh",
"givenName": "Jae Kyung",
"id": "sg:person.0767622633.82",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.0767622633.82"
],
"type": "Person"
},
{
"affiliation": {
"alternateName": "Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea",
"id": "http://www.grid.ac/institutes/grid.15444.30",
"name": [
"Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul, Korea",
"Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, Korea",
"Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea",
"Yonsei Cancer Center, Yonsei University College of Medicine, Seoul, Korea"
],
"type": "Organization"
},
"familyName": "Chung",
"givenName": "Hyun Cheol",
"id": "sg:person.016554426212.74",
"sameAs": [
"https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.016554426212.74"
],
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1007/s004320050210",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1023164289",
"https://doi.org/10.1007/s004320050210"
],
"type": "CreativeWork"
}
],
"datePublished": "2005-04",
"datePublishedReg": "2005-04-01",
"description": "PurposesWe evaluated the efficacy and tolerability of gemcitabine monotherapy in heavily pretreated, breast cancer patients as salvage chemotherapy.MethodsA weekly infusion of gemcitabine at 850\u00a0mg/m2for 30\u00a0min, for 3 of every 4\u00a0weeks, was introduced in advanced breast cancer patients who had failed previous doxorubicin and taxane based chemotherapy. There was no dose modification, and the treatment was delayed until the leukopenia was recovered with G-CSF support. The efficacy was evaluated every three cycles and the treatment was continued until either disease progression or 12 cycles.ResultsOf 41 enrolled patients, 38 were evaluable with a median age of 47. Total 178 cycles of gemcitabine was administered and the relative dose intensity was 89. The toxicity was mild with 12 of grade III neutropenia and 14 of grade III/IV thrombocytopenia without clinical symptoms. The response rate was 20 (8/38), comprising two complete and six partial responses. The median response duration and overall survival were 9 (2\u201325) and 11\u00a0months, respectively. The overall survival of 12\u00a0months was better in the third line patients than the 7\u00a0months in the fourth line treatment group.ConclusionGemcitabine monotherapy is effective and safe as salvage treatment in heavily pretreated, breast cancer patients.",
"genre": "article",
"id": "sg:pub.10.1007/s10549-004-2468-4",
"inLanguage": "en",
"isAccessibleForFree": false,
"isPartOf": [
{
"id": "sg:journal.1092777",
"issn": [
"0167-6806",
"1573-7217"
],
"name": "Breast Cancer Research and Treatment",
"publisher": "Springer Nature",
"type": "Periodical"
},
{
"issueNumber": "3",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "90"
}
],
"keywords": [
"breast cancer patients",
"cancer patients",
"salvage chemotherapy",
"gemcitabine monotherapy",
"overall survival",
"grade III/IV thrombocytopenia",
"advanced breast cancer patients",
"cycles of gemcitabine",
"relative dose intensity",
"grade III neutropenia",
"median response duration",
"third-line patients",
"G-CSF support",
"metastatic breast cancer",
"previous doxorubicin",
"salvage treatment",
"weekly infusions",
"dose modification",
"dose intensity",
"partial response",
"median age",
"clinical symptoms",
"disease progression",
"line patients",
"breast cancer",
"response duration",
"treatment groups",
"patients",
"response rate",
"monotherapy",
"chemotherapy",
"months",
"gemcitabine",
"treatment",
"efficacy",
"survival",
"PurposesWe",
"tolerability",
"leukopenia",
"neutropenia",
"thrombocytopenia",
"infusion",
"taxanes",
"symptoms",
"cancer",
"progression",
"weeks",
"age",
"doxorubicin",
"toxicity",
"duration",
"group",
"min",
"response",
"rate",
"cycle",
"support",
"modification",
"intensity"
],
"name": "Gemcitabine monotherapy as salvage chemotherapy in heavily pretreated metastatic breast cancer",
"pagination": "215-221",
"productId": [
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1027872686"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10549-004-2468-4"
]
},
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"15830134"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10549-004-2468-4",
"https://app.dimensions.ai/details/publication/pub.1027872686"
],
"sdDataset": "articles",
"sdDatePublished": "2022-05-20T07:23",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-springernature-scigraph/baseset/20220519/entities/gbq_results/article/article_409.jsonl",
"type": "ScholarlyArticle",
"url": "https://doi.org/10.1007/s10549-004-2468-4"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10549-004-2468-4'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10549-004-2468-4'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10549-004-2468-4'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10549-004-2468-4'
This table displays all metadata directly associated to this object as RDF triples.
250 TRIPLES
22 PREDICATES
101 URIs
92 LITERALS
21 BLANK NODES