Coherence and Consciousness: Study of Fronto-Parietal Gamma Synchrony in Patients with Disorders of Consciousness View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-07-29

AUTHORS

Marianna Cavinato, Clara Genna, Paolo Manganotti, Emanuela Formaggio, Silvia Francesca Storti, Stefania Campostrini, Chiara Arcaro, Emanuela Casanova, Valeria Petrone, Roberto Piperno, Francesco Piccione

ABSTRACT

Evaluation of consciousness needs to be supported by the evidence of brain activation during external stimulation in patients with unresponsive wakefulness syndrome (UWS). Assessment of patients should include techniques that do not depend on overt motor responses and allow an objective investigation of the spontaneous patterns of brain activity. In particular, electroencephalography (EEG) coherence allows to easily measure functional relationships between pairs of neocortical regions and seems to be closely correlated with cognitive or behavioral measures. Here, we show the contribution of higher order associative cortices of patients with disorder of consciousness (N = 26) in response to simple sensory stimuli, such as visual, auditory and noxious stimulation. In all stimulus modalities an increase of short-range parietal and long-range fronto-parietal coherences in gamma frequencies were seen in the controls and minimally conscious patients. By contrast, UWS patients showed no significant modifications in the EEG patterns after stimulation. Our results suggest that UWS patients can not activate associative cortical networks, suggesting a lack of information integration. In fact, fronto-parietal circuits result to be connectively disrupted, conversely to patients that exhibit some form of consciousness. In the light of this, EEG coherence can be considered a powerful tool to quantify the involvement of cognitive processing giving information about the integrity of fronto-parietal network. This measure can represent a new neurophysiological marker of unconsciousness and help in determining an accurate diagnosis and rehabilitative intervention in each patient. More... »

PAGES

570-579

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10548-014-0383-5

DOI

http://dx.doi.org/10.1007/s10548-014-0383-5

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1001751106

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/25070585


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33 schema:description Evaluation of consciousness needs to be supported by the evidence of brain activation during external stimulation in patients with unresponsive wakefulness syndrome (UWS). Assessment of patients should include techniques that do not depend on overt motor responses and allow an objective investigation of the spontaneous patterns of brain activity. In particular, electroencephalography (EEG) coherence allows to easily measure functional relationships between pairs of neocortical regions and seems to be closely correlated with cognitive or behavioral measures. Here, we show the contribution of higher order associative cortices of patients with disorder of consciousness (N = 26) in response to simple sensory stimuli, such as visual, auditory and noxious stimulation. In all stimulus modalities an increase of short-range parietal and long-range fronto-parietal coherences in gamma frequencies were seen in the controls and minimally conscious patients. By contrast, UWS patients showed no significant modifications in the EEG patterns after stimulation. Our results suggest that UWS patients can not activate associative cortical networks, suggesting a lack of information integration. In fact, fronto-parietal circuits result to be connectively disrupted, conversely to patients that exhibit some form of consciousness. In the light of this, EEG coherence can be considered a powerful tool to quantify the involvement of cognitive processing giving information about the integrity of fronto-parietal network. This measure can represent a new neurophysiological marker of unconsciousness and help in determining an accurate diagnosis and rehabilitative intervention in each patient.
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40 schema:keywords EEG coherence
41 EEG patterns
42 Fronto-Parietal Gamma Synchrony
43 UWS patients
44 accurate diagnosis
45 activation
46 activity
47 assessment
48 assessment of patients
49 associative cortex
50 associative cortical networks
51 behavioral measures
52 brain activation
53 brain activity
54 circuit
55 cognitive processing
56 coherence
57 conscious patients
58 consciousness
59 contrast
60 contribution
61 control
62 cortex
63 cortical networks
64 diagnosis
65 disorders
66 disorders of consciousness
67 electroencephalography (EEG) coherence
68 evaluation
69 evaluation of consciousness
70 evidence
71 external stimulation
72 fact
73 form
74 forms of consciousness
75 frequency
76 fronto-parietal circuits
77 fronto-parietal coherence
78 fronto-parietal network
79 functional relationship
80 gamma frequencies
81 gamma synchrony
82 help
83 higher order associative cortices
84 increase
85 information
86 information integration
87 integration
88 integrity
89 intervention
90 investigation
91 involvement
92 lack
93 light
94 long-range fronto-parietal coherences
95 markers
96 measures
97 modalities
98 modification
99 motor response
100 neocortical regions
101 network
102 neurophysiological markers
103 new neurophysiological marker
104 noxious stimulation
105 objective investigation
106 order associative cortices
107 overt motor responses
108 pairs
109 patients
110 patterns
111 powerful tool
112 processing
113 region
114 rehabilitative interventions
115 relationship
116 response
117 results
118 sensory stimuli
119 significant modification
120 simple sensory stimuli
121 spontaneous patterns
122 stimulation
123 stimuli
124 stimulus modality
125 study
126 synchrony
127 syndrome
128 technique
129 tool
130 unconsciousness
131 unresponsive wakefulness syndrome
132 wakefulness syndrome
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