Constant high adrenal FDG uptake in PET/CT associated with mitochondrial disease View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2014-09

AUTHORS

Mika H. Martikainen, Ulla Hohenthal, Laura Pirilä, Jukka Kemppainen

ABSTRACT

We describe a patient with the m.3243A>G mitochondrial DNA mutation who developed sepsis caused by Streptococcus constellatus. In the acute phase of illness, abnormally high uptake of (18)F-FDG was observed in both adrenal glands that appeared anatomically normal. In repeated imaging six months later the adrenal uptake had diminished but remained clearly elevated. We did not observe high adrenal FDG uptake as in the patient described here among 30 patients with Staphylococcus aureus sepsis that were investigated with identical imaging protocol. In sepsis, oxygen consumption and metabolic rate are increased compared to normal metabolism. The observed high adrenal FDG uptake during sepsis in this patient probably reflects the acute metabolic stress induced by the infection. Interestingly, in repeated imaging six months later, the adrenal SUVs had diminished but were still abnormally high: this suggests constant high levels of metabolic stress associated with the mitochondrial disorder. More... »

PAGES

863-864

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10545-014-9685-8

DOI

http://dx.doi.org/10.1007/s10545-014-9685-8

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1022434663

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/24554338


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1103", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Clinical Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Adrenal Glands", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "DNA, Mitochondrial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Female", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Fluorodeoxyglucose F18", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Middle Aged", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Mitochondrial Diseases", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radionuclide Imaging", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Radiopharmaceuticals", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Sepsis", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptococcal Infections", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Streptococcus constellatus", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "name": [
            "Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Martikainen", 
        "givenName": "Mika H.", 
        "id": "sg:person.01357556273.17", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357556273.17"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hohenthal", 
        "givenName": "Ulla", 
        "id": "sg:person.01023540424.78", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023540424.78"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Piril\u00e4", 
        "givenName": "Laura", 
        "id": "sg:person.01246356505.48", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246356505.48"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Turku University Hospital", 
          "id": "https://www.grid.ac/institutes/grid.410552.7", 
          "name": [
            "Department of Clinical Physiology and Nuclear Medicine and Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Kemppainen", 
        "givenName": "Jukka", 
        "id": "sg:person.01215160345.52", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215160345.52"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1097/01.rlu.0000159689.00755.7f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005861544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1053/snuc.2002.126035", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014332857"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199307000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028586526"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00003246-199307000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028586526"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2014-09", 
    "datePublishedReg": "2014-09-01", 
    "description": "We describe a patient with the m.3243A>G mitochondrial DNA mutation who developed sepsis caused by Streptococcus constellatus. In the acute phase of illness, abnormally high uptake of (18)F-FDG was observed in both adrenal glands that appeared anatomically normal. In repeated imaging six months later the adrenal uptake had diminished but remained clearly elevated. We did not observe high adrenal FDG uptake as in the patient described here among 30 patients with Staphylococcus aureus sepsis that were investigated with identical imaging protocol. In sepsis, oxygen consumption and metabolic rate are increased compared to normal metabolism. The observed high adrenal FDG uptake during sepsis in this patient probably reflects the acute metabolic stress induced by the infection. Interestingly, in repeated imaging six months later, the adrenal SUVs had diminished but were still abnormally high: this suggests constant high levels of metabolic stress associated with the mitochondrial disorder. ", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10545-014-9685-8", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1090550", 
        "issn": [
          "0141-8955", 
          "1573-2665"
        ], 
        "name": "Journal of Inherited Metabolic Disease", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "5", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "37"
      }
    ], 
    "name": "Constant high adrenal FDG uptake in PET/CT associated with mitochondrial disease", 
    "pagination": "863-864", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "6ae1fe563abf8dc57d1c2c2415de1b7ffe12a5026b8948622d6f3e020671c072"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "24554338"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "7910918"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10545-014-9685-8"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1022434663"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10545-014-9685-8", 
      "https://app.dimensions.ai/details/publication/pub.1022434663"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T01:52", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000481.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10545-014-9685-8"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10545-014-9685-8'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10545-014-9685-8'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10545-014-9685-8'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10545-014-9685-8'


 

This table displays all metadata directly associated to this object as RDF triples.

150 TRIPLES      21 PREDICATES      44 URIs      33 LITERALS      21 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10545-014-9685-8 schema:about N0559af013ffa400b869311be07a9267d
2 N3707893b94a14dd48cdbc435de675f4e
3 N528b85a10a6e4592a65d33bc5164e7f8
4 N62e180c30e9b4a04b62226f8a96ebf7d
5 N68bbb33cdc7c4dc99183a588f9518625
6 N6d9162d5ec81459e9a3bc5e609e159ca
7 N7c8e5cd7d63649138b32e03aa9deeb5e
8 N9ba437d0280b4c4c8be7732585cc0969
9 Nb4596808c4e94ccdaa8f58465321ac51
10 Nb9aff47b0f2d4e49b6772b9551ddd651
11 Nbe2c64f466ba493388b370eb0f0a1247
12 Nff594d834435448d9ec9424cdf75c421
13 anzsrc-for:11
14 anzsrc-for:1103
15 schema:author N69b90b98eb45420c9c998187e024522c
16 schema:citation https://doi.org/10.1053/snuc.2002.126035
17 https://doi.org/10.1097/00003246-199307000-00015
18 https://doi.org/10.1097/01.rlu.0000159689.00755.7f
19 schema:datePublished 2014-09
20 schema:datePublishedReg 2014-09-01
21 schema:description We describe a patient with the m.3243A>G mitochondrial DNA mutation who developed sepsis caused by Streptococcus constellatus. In the acute phase of illness, abnormally high uptake of (18)F-FDG was observed in both adrenal glands that appeared anatomically normal. In repeated imaging six months later the adrenal uptake had diminished but remained clearly elevated. We did not observe high adrenal FDG uptake as in the patient described here among 30 patients with Staphylococcus aureus sepsis that were investigated with identical imaging protocol. In sepsis, oxygen consumption and metabolic rate are increased compared to normal metabolism. The observed high adrenal FDG uptake during sepsis in this patient probably reflects the acute metabolic stress induced by the infection. Interestingly, in repeated imaging six months later, the adrenal SUVs had diminished but were still abnormally high: this suggests constant high levels of metabolic stress associated with the mitochondrial disorder.
22 schema:genre research_article
23 schema:inLanguage en
24 schema:isAccessibleForFree false
25 schema:isPartOf N3ddfbd6ea1f2406d92fded4c069404ca
26 N4c5de41e5cf54835ad0f2fbb115c1bcd
27 sg:journal.1090550
28 schema:name Constant high adrenal FDG uptake in PET/CT associated with mitochondrial disease
29 schema:pagination 863-864
30 schema:productId N5d9582d461dc448f9736dd5852827d5a
31 N8470e993cb1b4ddc9494ad12141b420c
32 Nb171e709c7ff48258f91ad0d273b2480
33 Nb5da19b96e194f09ab44f7ded0efff14
34 Nf79e77d2ba7e4fb2a5f56294083841ce
35 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022434663
36 https://doi.org/10.1007/s10545-014-9685-8
37 schema:sdDatePublished 2019-04-11T01:52
38 schema:sdLicense https://scigraph.springernature.com/explorer/license/
39 schema:sdPublisher Neeefc395842a49b58f8cd4029fd84e0d
40 schema:url http://link.springer.com/10.1007/s10545-014-9685-8
41 sgo:license sg:explorer/license/
42 sgo:sdDataset articles
43 rdf:type schema:ScholarlyArticle
44 N0559af013ffa400b869311be07a9267d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
45 schema:name Adrenal Glands
46 rdf:type schema:DefinedTerm
47 N3707893b94a14dd48cdbc435de675f4e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
48 schema:name Radionuclide Imaging
49 rdf:type schema:DefinedTerm
50 N3732957e60dd48ceac46be085ef304c7 rdf:first sg:person.01023540424.78
51 rdf:rest Na9c3ac6860d149b4b9c6bf0836d9860e
52 N3ddfbd6ea1f2406d92fded4c069404ca schema:volumeNumber 37
53 rdf:type schema:PublicationVolume
54 N4c5de41e5cf54835ad0f2fbb115c1bcd schema:issueNumber 5
55 rdf:type schema:PublicationIssue
56 N528b85a10a6e4592a65d33bc5164e7f8 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
57 schema:name Female
58 rdf:type schema:DefinedTerm
59 N5a69cb97ed3b4df89024f25d93511a01 rdf:first sg:person.01215160345.52
60 rdf:rest rdf:nil
61 N5d9582d461dc448f9736dd5852827d5a schema:name doi
62 schema:value 10.1007/s10545-014-9685-8
63 rdf:type schema:PropertyValue
64 N62e180c30e9b4a04b62226f8a96ebf7d schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
65 schema:name Middle Aged
66 rdf:type schema:DefinedTerm
67 N68bbb33cdc7c4dc99183a588f9518625 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
68 schema:name Fluorodeoxyglucose F18
69 rdf:type schema:DefinedTerm
70 N69b90b98eb45420c9c998187e024522c rdf:first sg:person.01357556273.17
71 rdf:rest N3732957e60dd48ceac46be085ef304c7
72 N6d9162d5ec81459e9a3bc5e609e159ca schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
73 schema:name Mitochondrial Diseases
74 rdf:type schema:DefinedTerm
75 N746aaf83b67045569ddac502afa7b386 schema:name Division of Clinical Neurosciences, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, 20520, Turku, Finland
76 rdf:type schema:Organization
77 N7c8e5cd7d63649138b32e03aa9deeb5e schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
78 schema:name Humans
79 rdf:type schema:DefinedTerm
80 N8470e993cb1b4ddc9494ad12141b420c schema:name dimensions_id
81 schema:value pub.1022434663
82 rdf:type schema:PropertyValue
83 N9ba437d0280b4c4c8be7732585cc0969 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
84 schema:name Radiopharmaceuticals
85 rdf:type schema:DefinedTerm
86 Na9c3ac6860d149b4b9c6bf0836d9860e rdf:first sg:person.01246356505.48
87 rdf:rest N5a69cb97ed3b4df89024f25d93511a01
88 Nb171e709c7ff48258f91ad0d273b2480 schema:name pubmed_id
89 schema:value 24554338
90 rdf:type schema:PropertyValue
91 Nb4596808c4e94ccdaa8f58465321ac51 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name DNA, Mitochondrial
93 rdf:type schema:DefinedTerm
94 Nb5da19b96e194f09ab44f7ded0efff14 schema:name readcube_id
95 schema:value 6ae1fe563abf8dc57d1c2c2415de1b7ffe12a5026b8948622d6f3e020671c072
96 rdf:type schema:PropertyValue
97 Nb9aff47b0f2d4e49b6772b9551ddd651 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Streptococcal Infections
99 rdf:type schema:DefinedTerm
100 Nbe2c64f466ba493388b370eb0f0a1247 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
101 schema:name Streptococcus constellatus
102 rdf:type schema:DefinedTerm
103 Neeefc395842a49b58f8cd4029fd84e0d schema:name Springer Nature - SN SciGraph project
104 rdf:type schema:Organization
105 Nf79e77d2ba7e4fb2a5f56294083841ce schema:name nlm_unique_id
106 schema:value 7910918
107 rdf:type schema:PropertyValue
108 Nff594d834435448d9ec9424cdf75c421 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
109 schema:name Sepsis
110 rdf:type schema:DefinedTerm
111 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
112 schema:name Medical and Health Sciences
113 rdf:type schema:DefinedTerm
114 anzsrc-for:1103 schema:inDefinedTermSet anzsrc-for:
115 schema:name Clinical Sciences
116 rdf:type schema:DefinedTerm
117 sg:journal.1090550 schema:issn 0141-8955
118 1573-2665
119 schema:name Journal of Inherited Metabolic Disease
120 rdf:type schema:Periodical
121 sg:person.01023540424.78 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
122 schema:familyName Hohenthal
123 schema:givenName Ulla
124 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01023540424.78
125 rdf:type schema:Person
126 sg:person.01215160345.52 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
127 schema:familyName Kemppainen
128 schema:givenName Jukka
129 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01215160345.52
130 rdf:type schema:Person
131 sg:person.01246356505.48 schema:affiliation https://www.grid.ac/institutes/grid.410552.7
132 schema:familyName Pirilä
133 schema:givenName Laura
134 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01246356505.48
135 rdf:type schema:Person
136 sg:person.01357556273.17 schema:affiliation N746aaf83b67045569ddac502afa7b386
137 schema:familyName Martikainen
138 schema:givenName Mika H.
139 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01357556273.17
140 rdf:type schema:Person
141 https://doi.org/10.1053/snuc.2002.126035 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014332857
142 rdf:type schema:CreativeWork
143 https://doi.org/10.1097/00003246-199307000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1028586526
144 rdf:type schema:CreativeWork
145 https://doi.org/10.1097/01.rlu.0000159689.00755.7f schema:sameAs https://app.dimensions.ai/details/publication/pub.1005861544
146 rdf:type schema:CreativeWork
147 https://www.grid.ac/institutes/grid.410552.7 schema:alternateName Turku University Hospital
148 schema:name Department of Clinical Physiology and Nuclear Medicine and Turku PET Centre, University of Turku and Turku University Hospital, Turku, Finland
149 Division of Medicine, University of Turku and Turku University Hospital, Turku, Finland
150 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...