Mitochondrial diabetes is associated with insulin resistance in subcutaneous adipose tissue but not with increased liver fat content View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2011-12

AUTHORS

Markus M. Lindroos, Ronald Borra, Nina Mononen, Terho Lehtimäki, Kirsi A. Virtanen, Virva Lepomäki, Letizia Guiducci, Patricia Iozzo, Kari Majamaa, Pirjo Nuutila

ABSTRACT

We recently showed that patients with mitochondrial diabetes are insulin resistant in skeletal muscle before the decline in insulin secretion is observed. In this study, we further evaluate whether insulin resistance is associated with increased ectopic fat accumulation and altered adipose and hepatic tissue insulin sensitivity. We studied 15 nonobese patients with the m.3243A > G mutation. Five were without diabetes (group 1), three had newly diagnosed diabetes (group 2), and seven had previously diagnosed diabetes (group 3). Thirteen healthy volunteers of similar age and body mass index (BMI) served as controls. Insulin-stimulated glucose uptake was measured with positron emission tomography using 2- [(18)F]-fluoro-2-deoxyglucose during euglycemic hyperinsulinemia. Fat masses and liver fat content were measured with magnetic resonance imaging and spectroscopy. Compared with controls, insulin-stimulated glucose uptake in adipose tissue was decreased by ∼50% in all groups with the m.3243A > G mutation. In addition, fat masses were not different, but insulin-mediated suppression of lipolysis and adiponectin metabolism were blunted in patients with the m.3243A > G mutation. Hepatic fat content was normal (<5.6%) in 80% of patients and significantly elevated in one case only. Hepatic glucose metabolism in patients with m.3243A > G did not differ from that of controls. In conclusion, m.3243A > G mutation affects subcutaneous adipose tissue metabolism. This seems to occur before aberrant liver metabolism, if any, can be observed or before beta-cell failure results in mitochondrial diabetes. More... »

PAGES

1205-1212

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10545-011-9338-0

DOI

http://dx.doi.org/10.1007/s10545-011-9338-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1014660491

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/21556834


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Download the RDF metadata as:  json-ld nt turtle xml License info

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RDF/XML is a standard XML format for linked data.

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296 schema:name Department of Clinical Medicine, Neurology, University of Oulu, Oulu, Finland
297 Department of Neurology, University of Turku and Turku University Hospital, Turku, Finland
298 Medical Imaging Centre of Southwest Finland, Turku University Hospital, Turku, Finland
299 Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, FIN-20521, Turku, Finland
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301 https://www.grid.ac/institutes/grid.412330.7 schema:alternateName Tampere University Hospital
302 schema:name Laboratory of Atherosclerosis Genetics, Department of Clinical Chemistry, Centre of Laboratory Medicine, Tampere University Hospital, Tampere, Finland
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305 schema:name Institute of Clinical Physiology, National Research Council (CNR), Pisa, Italy
306 Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, FIN-20521, Turku, Finland
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309 schema:name Turku PET Centre, University of Turku and Turku University Hospital, P.O. Box 52, FIN-20521, Turku, Finland
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