Ontology type: schema:ScholarlyArticle
2019-06
AUTHORSJingxin Zhang, Junhua Mai, Feng Li, Jianliang Shen, Guodong Zhang, Jun Li, Louis E Hinkle, Daniel Lin, Xuewu Liu, Zheng Li, Rong-Fu Wang, Elizabeth A Mittendorf, Mauro Ferrari, Haifa Shen
ABSTRACTEffective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based therapeutic dendritic cell vaccine (Nano-DC vaccine) where PSM serves both as the vehicle for antigen peptides and an adjuvant. Here, we analyzed parameters that determined dendritic cell uptake of PSM particles and Nano-DC vaccine accumulation in lymphatic tissues in a murine model of HER2-positive breast cancer. Our study revealed a positive correlation between sphericity of the PSM particles and their cellular uptake by circulating dendritic cells. In addition, the intravenously administered vaccines accumulated more in the spleens and inguinal lymph nodes, while the intradermally inoculated vaccines got enriched in the popliteal lymph nodes. Furthermore, mice with large tumors received more vaccines in the lymph nodes than those with small to medium size tumors. Information from this study will provide guidance on design and optimization of future therapeutic cancer vaccines. More... »
PAGES39
http://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6
DOIhttp://dx.doi.org/10.1007/s10544-019-0397-6
DIMENSIONShttps://app.dimensions.ai/details/publication/pub.1113185268
PUBMEDhttps://www.ncbi.nlm.nih.gov/pubmed/30949852
JSON-LD is the canonical representation for SciGraph data.
TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT
[
{
"@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json",
"about": [
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Immunology",
"type": "DefinedTerm"
},
{
"id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11",
"inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/",
"name": "Medical and Health Sciences",
"type": "DefinedTerm"
}
],
"author": [
{
"affiliation": {
"alternateName": "Xiangya Hospital Central South University",
"id": "https://www.grid.ac/institutes/grid.452223.0",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.",
"Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China."
],
"type": "Organization"
},
"familyName": "Zhang",
"givenName": "Jingxin",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Mai",
"givenName": "Junhua",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.",
"Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Feng",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Wenzhou Medical College",
"id": "https://www.grid.ac/institutes/grid.268099.c",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.",
"State key laboratory of ophthalmology, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, China."
],
"type": "Organization"
},
"familyName": "Shen",
"givenName": "Jianliang",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Zhang",
"givenName": "Guodong",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Xiangya Hospital Central South University",
"id": "https://www.grid.ac/institutes/grid.452223.0",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.",
"Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China."
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Jun",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Hinkle",
"givenName": "Louis E",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Lin",
"givenName": "Daniel",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Liu",
"givenName": "Xuewu",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Li",
"givenName": "Zheng",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Houston Methodist",
"id": "https://www.grid.ac/institutes/grid.63368.38",
"name": [
"Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX, 77030, USA."
],
"type": "Organization"
},
"familyName": "Wang",
"givenName": "Rong-Fu",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Dana-Farber/Brigham and Women's Cancer Center",
"id": "https://www.grid.ac/institutes/grid.417747.6",
"name": [
"Department of Surgery, Brigham and Women's Hospital, Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA, 02115, USA.",
"Breast Oncology Program, Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA, 02115, USA."
],
"type": "Organization"
},
"familyName": "Mittendorf",
"givenName": "Elizabeth A",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cornell University",
"id": "https://www.grid.ac/institutes/grid.5386.8",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. mferrari@houstonmethodist.org.",
"Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. mferrari@houstonmethodist.org."
],
"type": "Organization"
},
"familyName": "Ferrari",
"givenName": "Mauro",
"type": "Person"
},
{
"affiliation": {
"alternateName": "Cornell University",
"id": "https://www.grid.ac/institutes/grid.5386.8",
"name": [
"Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. hshen@houstonmethodist.org.",
"Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. hshen@houstonmethodist.org."
],
"type": "Organization"
},
"familyName": "Shen",
"givenName": "Haifa",
"type": "Person"
}
],
"citation": [
{
"id": "sg:pub.10.1038/leu.2015.343",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1003404089",
"https://doi.org/10.1038/leu.2015.343"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1172/jci11752",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1010749400"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.cell.2015.03.037",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1015607130"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1056/nejmoa1001294",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1017807249"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.celrep.2015.04.009",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1020558562"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.ejogrb.2005.11.015",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1026168819"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.2217/imt.13.169",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1027691653"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nmat4822",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1030847378",
"https://doi.org/10.1038/nmat4822"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1021/nn4035316",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1037388269"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-12-2764",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039705699"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-12-2764",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039705699"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.4049/jimmunol.0903507",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1039959932"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nbt.3506",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1040903815",
"https://doi.org/10.1038/nbt.3506"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/adhm.201100005",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042057132"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/cncr.26574",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1042506743"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2014.04.057",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043813453"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/1078-0432.ccr-10-3126",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1043851469"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/0304-3835(92)90044-v",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1046329806"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047773335",
"https://doi.org/10.1038/ni1223"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/ni1223",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047773335",
"https://doi.org/10.1038/ni1223"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/adfm.201200869",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1047891244"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-065x.2010.00978.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050571439"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1111/j.1600-065x.2010.00978.x",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050571439"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1007/s00276-013-1176-3",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1050703971",
"https://doi.org/10.1007/s00276-013-1176-3"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1002/smll.201201510",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052459353"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.jconrel.2015.09.069",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1052864290"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/science.aaa3828",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1062665141"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1158/0008-5472.can-16-2913",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1084868696"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nnano.2017.52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085051621",
"https://doi.org/10.1038/nnano.2017.52"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/nnano.2017.52",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1085051621",
"https://doi.org/10.1038/nnano.2017.52"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1016/j.smim.2017.09.002",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1091905785"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41563-018-0028-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101324934",
"https://doi.org/10.1038/s41563-018-0028-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41563-018-0028-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101324934",
"https://doi.org/10.1038/s41563-018-0028-2"
],
"type": "CreativeWork"
},
{
"id": "sg:pub.10.1038/s41563-018-0028-2",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1101324934",
"https://doi.org/10.1038/s41563-018-0028-2"
],
"type": "CreativeWork"
},
{
"id": "https://doi.org/10.1126/scitranslmed.aao5931",
"sameAs": [
"https://app.dimensions.ai/details/publication/pub.1103228743"
],
"type": "CreativeWork"
}
],
"datePublished": "2019-06",
"datePublishedReg": "2019-06-01",
"description": "Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based therapeutic dendritic cell vaccine (Nano-DC vaccine) where PSM serves both as the vehicle for antigen peptides and an adjuvant. Here, we analyzed parameters that determined dendritic cell uptake of PSM particles and Nano-DC vaccine accumulation in lymphatic tissues in a murine model of HER2-positive breast cancer. Our study revealed a positive correlation between sphericity of the PSM particles and their cellular uptake by circulating dendritic cells. In addition, the intravenously administered vaccines accumulated more in the spleens and inguinal lymph nodes, while the intradermally inoculated vaccines got enriched in the popliteal lymph nodes. Furthermore, mice with large tumors received more vaccines in the lymph nodes than those with small to medium size tumors. Information from this study will provide guidance on design and optimization of future therapeutic cancer vaccines.",
"genre": "research_article",
"id": "sg:pub.10.1007/s10544-019-0397-6",
"inLanguage": [
"en"
],
"isAccessibleForFree": false,
"isFundedItemOf": [
{
"id": "sg:grant.4729184",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.7615047",
"type": "MonetaryGrant"
},
{
"id": "sg:grant.6376316",
"type": "MonetaryGrant"
}
],
"isPartOf": [
{
"id": "sg:journal.1021020",
"issn": [
"1387-2176",
"1572-8781"
],
"name": "Biomedical Microdevices",
"type": "Periodical"
},
{
"issueNumber": "2",
"type": "PublicationIssue"
},
{
"type": "PublicationVolume",
"volumeNumber": "21"
}
],
"name": "Investigation of parameters that determine Nano-DC vaccine transport.",
"pagination": "39",
"productId": [
{
"name": "pubmed_id",
"type": "PropertyValue",
"value": [
"30949852"
]
},
{
"name": "nlm_unique_id",
"type": "PropertyValue",
"value": [
"100887374"
]
},
{
"name": "doi",
"type": "PropertyValue",
"value": [
"10.1007/s10544-019-0397-6"
]
},
{
"name": "dimensions_id",
"type": "PropertyValue",
"value": [
"pub.1113185268"
]
}
],
"sameAs": [
"https://doi.org/10.1007/s10544-019-0397-6",
"https://app.dimensions.ai/details/publication/pub.1113185268"
],
"sdDataset": "articles",
"sdDatePublished": "2019-04-11T13:56",
"sdLicense": "https://scigraph.springernature.com/explorer/license/",
"sdPublisher": {
"name": "Springer Nature - SN SciGraph project",
"type": "Organization"
},
"sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130814_00000007.jsonl",
"type": "ScholarlyArticle",
"url": "http://link.springer.com/10.1007/s10544-019-0397-6"
}
]Download the RDF metadata as: json-ld nt turtle xml License info
JSON-LD is a popular format for linked data which is fully compatible with JSON.
curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'
N-Triples is a line-based linked data format ideal for batch operations.
curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'
Turtle is a human-readable linked data format.
curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'
RDF/XML is a standard XML format for linked data.
curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'
This table displays all metadata directly associated to this object as RDF triples.
262 TRIPLES
21 PREDICATES
57 URIs
20 LITERALS
8 BLANK NODES