Investigation of parameters that determine Nano-DC vaccine transport. View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06

AUTHORS

Jingxin Zhang, Junhua Mai, Feng Li, Jianliang Shen, Guodong Zhang, Jun Li, Louis E Hinkle, Daniel Lin, Xuewu Liu, Zheng Li, Rong-Fu Wang, Elizabeth A Mittendorf, Mauro Ferrari, Haifa Shen

ABSTRACT

Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based therapeutic dendritic cell vaccine (Nano-DC vaccine) where PSM serves both as the vehicle for antigen peptides and an adjuvant. Here, we analyzed parameters that determined dendritic cell uptake of PSM particles and Nano-DC vaccine accumulation in lymphatic tissues in a murine model of HER2-positive breast cancer. Our study revealed a positive correlation between sphericity of the PSM particles and their cellular uptake by circulating dendritic cells. In addition, the intravenously administered vaccines accumulated more in the spleens and inguinal lymph nodes, while the intradermally inoculated vaccines got enriched in the popliteal lymph nodes. Furthermore, mice with large tumors received more vaccines in the lymph nodes than those with small to medium size tumors. Information from this study will provide guidance on design and optimization of future therapeutic cancer vaccines. More... »

PAGES

39

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6

DOI

http://dx.doi.org/10.1007/s10544-019-0397-6

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113185268

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30949852


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Xiangya Hospital Central South University", 
          "id": "https://www.grid.ac/institutes/grid.452223.0", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.", 
            "Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Jingxin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mai", 
        "givenName": "Junhua", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.", 
            "Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Feng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Wenzhou Medical College", 
          "id": "https://www.grid.ac/institutes/grid.268099.c", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.", 
            "State key laboratory of ophthalmology, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Jianliang", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Zhang", 
        "givenName": "Guodong", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Xiangya Hospital Central South University", 
          "id": "https://www.grid.ac/institutes/grid.452223.0", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.", 
            "Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Jun", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Hinkle", 
        "givenName": "Louis E", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Lin", 
        "givenName": "Daniel", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Liu", 
        "givenName": "Xuewu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Li", 
        "givenName": "Zheng", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Houston Methodist", 
          "id": "https://www.grid.ac/institutes/grid.63368.38", 
          "name": [
            "Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX, 77030, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Wang", 
        "givenName": "Rong-Fu", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Dana-Farber/Brigham and Women's Cancer Center", 
          "id": "https://www.grid.ac/institutes/grid.417747.6", 
          "name": [
            "Department of Surgery, Brigham and Women's Hospital, Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA, 02115, USA.", 
            "Breast Oncology Program, Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA, 02115, USA."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Mittendorf", 
        "givenName": "Elizabeth A", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. mferrari@houstonmethodist.org.", 
            "Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. mferrari@houstonmethodist.org."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Ferrari", 
        "givenName": "Mauro", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Cornell University", 
          "id": "https://www.grid.ac/institutes/grid.5386.8", 
          "name": [
            "Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. hshen@houstonmethodist.org.", 
            "Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. hshen@houstonmethodist.org."
          ], 
          "type": "Organization"
        }, 
        "familyName": "Shen", 
        "givenName": "Haifa", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/leu.2015.343", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003404089", 
          "https://doi.org/10.1038/leu.2015.343"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1172/jci11752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1010749400"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.cell.2015.03.037", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015607130"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1056/nejmoa1001294", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017807249"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.celrep.2015.04.009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020558562"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ejogrb.2005.11.015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026168819"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2217/imt.13.169", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027691653"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nmat4822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030847378", 
          "https://doi.org/10.1038/nmat4822"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/nn4035316", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037388269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039705699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-12-2764", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039705699"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.0903507", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1039959932"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt.3506", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040903815", 
          "https://doi.org/10.1038/nbt.3506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adhm.201100005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042057132"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/cncr.26574", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042506743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2014.04.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043813453"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/1078-0432.ccr-10-3126", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043851469"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0304-3835(92)90044-v", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046329806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047773335", 
          "https://doi.org/10.1038/ni1223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/ni1223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047773335", 
          "https://doi.org/10.1038/ni1223"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/adfm.201200869", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047891244"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2010.00978.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050571439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-065x.2010.00978.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050571439"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s00276-013-1176-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050703971", 
          "https://doi.org/10.1007/s00276-013-1176-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/smll.201201510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052459353"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2015.09.069", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052864290"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.aaa3828", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062665141"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-16-2913", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1084868696"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2017.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085051621", 
          "https://doi.org/10.1038/nnano.2017.52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nnano.2017.52", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1085051621", 
          "https://doi.org/10.1038/nnano.2017.52"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.smim.2017.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1091905785"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41563-018-0028-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101324934", 
          "https://doi.org/10.1038/s41563-018-0028-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41563-018-0028-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101324934", 
          "https://doi.org/10.1038/s41563-018-0028-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41563-018-0028-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1101324934", 
          "https://doi.org/10.1038/s41563-018-0028-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/scitranslmed.aao5931", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1103228743"
        ], 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-06", 
    "datePublishedReg": "2019-06-01", 
    "description": "Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based therapeutic dendritic cell vaccine (Nano-DC vaccine) where PSM serves both as the vehicle for antigen peptides and an adjuvant. Here, we analyzed parameters that determined dendritic cell uptake of PSM particles and Nano-DC vaccine accumulation in lymphatic tissues in a murine model of HER2-positive breast cancer. Our study revealed a positive correlation between sphericity of the PSM particles and their cellular uptake by circulating dendritic cells. In addition, the intravenously administered vaccines accumulated more in the spleens and inguinal lymph nodes, while the intradermally inoculated vaccines got enriched in the popliteal lymph nodes. Furthermore, mice with large tumors received more vaccines in the lymph nodes than those with small to medium size tumors. Information from this study will provide guidance on design and optimization of future therapeutic cancer vaccines.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10544-019-0397-6", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.4729184", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.7615047", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.6376316", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021020", 
        "issn": [
          "1387-2176", 
          "1572-8781"
        ], 
        "name": "Biomedical Microdevices", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Investigation of parameters that determine Nano-DC vaccine transport.", 
    "pagination": "39", 
    "productId": [
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30949852"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100887374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10544-019-0397-6"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113185268"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10544-019-0397-6", 
      "https://app.dimensions.ai/details/publication/pub.1113185268"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:56", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000371_0000000371/records_130814_00000007.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007/s10544-019-0397-6"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0397-6'


 

This table displays all metadata directly associated to this object as RDF triples.

262 TRIPLES      21 PREDICATES      57 URIs      20 LITERALS      8 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10544-019-0397-6 schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N861a85aac222497d9348019a0f0743fd
4 schema:citation sg:pub.10.1007/s00276-013-1176-3
5 sg:pub.10.1038/leu.2015.343
6 sg:pub.10.1038/nbt.3506
7 sg:pub.10.1038/ni1223
8 sg:pub.10.1038/nmat4822
9 sg:pub.10.1038/nnano.2017.52
10 sg:pub.10.1038/s41563-018-0028-2
11 https://doi.org/10.1002/adfm.201200869
12 https://doi.org/10.1002/adhm.201100005
13 https://doi.org/10.1002/cncr.26574
14 https://doi.org/10.1002/smll.201201510
15 https://doi.org/10.1016/0304-3835(92)90044-v
16 https://doi.org/10.1016/j.cell.2015.03.037
17 https://doi.org/10.1016/j.celrep.2015.04.009
18 https://doi.org/10.1016/j.ejogrb.2005.11.015
19 https://doi.org/10.1016/j.jconrel.2014.04.057
20 https://doi.org/10.1016/j.jconrel.2015.09.069
21 https://doi.org/10.1016/j.smim.2017.09.002
22 https://doi.org/10.1021/nn4035316
23 https://doi.org/10.1056/nejmoa1001294
24 https://doi.org/10.1111/j.1600-065x.2010.00978.x
25 https://doi.org/10.1126/science.aaa3828
26 https://doi.org/10.1126/scitranslmed.aao5931
27 https://doi.org/10.1158/0008-5472.can-16-2913
28 https://doi.org/10.1158/1078-0432.ccr-10-3126
29 https://doi.org/10.1158/1078-0432.ccr-12-2764
30 https://doi.org/10.1172/jci11752
31 https://doi.org/10.2217/imt.13.169
32 https://doi.org/10.4049/jimmunol.0903507
33 schema:datePublished 2019-06
34 schema:datePublishedReg 2019-06-01
35 schema:description Effective migration of dendritic cells into the lymphatic system organs is the prerequisite for a functional dendritic cell vaccine. We have previously developed a porous silicon microparticle (PSM)-based therapeutic dendritic cell vaccine (Nano-DC vaccine) where PSM serves both as the vehicle for antigen peptides and an adjuvant. Here, we analyzed parameters that determined dendritic cell uptake of PSM particles and Nano-DC vaccine accumulation in lymphatic tissues in a murine model of HER2-positive breast cancer. Our study revealed a positive correlation between sphericity of the PSM particles and their cellular uptake by circulating dendritic cells. In addition, the intravenously administered vaccines accumulated more in the spleens and inguinal lymph nodes, while the intradermally inoculated vaccines got enriched in the popliteal lymph nodes. Furthermore, mice with large tumors received more vaccines in the lymph nodes than those with small to medium size tumors. Information from this study will provide guidance on design and optimization of future therapeutic cancer vaccines.
36 schema:genre research_article
37 schema:inLanguage en
38 schema:isAccessibleForFree false
39 schema:isPartOf N49b5a3b6b0124af8b57f886482b03633
40 N9e3b87858ca445299fc9774e8e900784
41 sg:journal.1021020
42 schema:name Investigation of parameters that determine Nano-DC vaccine transport.
43 schema:pagination 39
44 schema:productId N2b7d082258054ff087fa885f9c04ca81
45 N447800424791478bb85dd5a75dfa7ce8
46 Ncf3f254dd7c24e678fcd6318800da560
47 Nf545f98da9fb498eb87e33ff3c11eb9c
48 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113185268
49 https://doi.org/10.1007/s10544-019-0397-6
50 schema:sdDatePublished 2019-04-11T13:56
51 schema:sdLicense https://scigraph.springernature.com/explorer/license/
52 schema:sdPublisher Nd1281fede7044a85b73d4d37c4096345
53 schema:url http://link.springer.com/10.1007/s10544-019-0397-6
54 sgo:license sg:explorer/license/
55 sgo:sdDataset articles
56 rdf:type schema:ScholarlyArticle
57 N0631cfb6644240e09adc426cfa73cdb6 rdf:first Nd8e2c13b81884bc0afc21770bb1467a4
58 rdf:rest N3e5889afbd7c455cad3ba4cdc21245ab
59 N0a3af3c8ac5842cf9bc267931d6dd100 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
60 schema:familyName Li
61 schema:givenName Zheng
62 rdf:type schema:Person
63 N0d9112f23a904a1bb8d56d859a48c2f1 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
64 schema:familyName Lin
65 schema:givenName Daniel
66 rdf:type schema:Person
67 N20e3b314d2bf43419ba2f9c917bb6f25 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
68 schema:familyName Liu
69 schema:givenName Xuewu
70 rdf:type schema:Person
71 N240df13a80744a338064a0753353b84e schema:affiliation https://www.grid.ac/institutes/grid.63368.38
72 schema:familyName Wang
73 schema:givenName Rong-Fu
74 rdf:type schema:Person
75 N2649c05ccad14f84838359a687d61a91 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
76 schema:familyName Shen
77 schema:givenName Haifa
78 rdf:type schema:Person
79 N2a4501faca704e9caa4649d5d1ad484f rdf:first N0d9112f23a904a1bb8d56d859a48c2f1
80 rdf:rest Nf767fb81e9474f638b49cfb3d589cf73
81 N2b7d082258054ff087fa885f9c04ca81 schema:name dimensions_id
82 schema:value pub.1113185268
83 rdf:type schema:PropertyValue
84 N2f847aa649a648d78875df88ed4adb87 rdf:first N8002c1d56eb440738f5419ae52b29fac
85 rdf:rest N891411ca1a284f7193a40c8e515db033
86 N3e5889afbd7c455cad3ba4cdc21245ab rdf:first N4501631b8b8c484fb3ea9ebaa33d6853
87 rdf:rest Nef410135675a408cb91f6bade04e40ba
88 N443b697846604e2d9299ccc2499eec27 rdf:first N772c75f521a84cb89dfa57a6448cb2fb
89 rdf:rest Nf798b23349294774822289c16a7dc095
90 N447800424791478bb85dd5a75dfa7ce8 schema:name doi
91 schema:value 10.1007/s10544-019-0397-6
92 rdf:type schema:PropertyValue
93 N4501631b8b8c484fb3ea9ebaa33d6853 schema:affiliation https://www.grid.ac/institutes/grid.452223.0
94 schema:familyName Li
95 schema:givenName Jun
96 rdf:type schema:Person
97 N49b5a3b6b0124af8b57f886482b03633 schema:volumeNumber 21
98 rdf:type schema:PublicationVolume
99 N4f61dc3712724ff391216229082709d5 rdf:first N0a3af3c8ac5842cf9bc267931d6dd100
100 rdf:rest Nf0172736872c4922a7c07740df06b75a
101 N6f3411623e654103a7b9862cae934168 rdf:first N2649c05ccad14f84838359a687d61a91
102 rdf:rest rdf:nil
103 N772c75f521a84cb89dfa57a6448cb2fb schema:affiliation https://www.grid.ac/institutes/grid.63368.38
104 schema:familyName Mai
105 schema:givenName Junhua
106 rdf:type schema:Person
107 N8002c1d56eb440738f5419ae52b29fac schema:affiliation https://www.grid.ac/institutes/grid.417747.6
108 schema:familyName Mittendorf
109 schema:givenName Elizabeth A
110 rdf:type schema:Person
111 N861a85aac222497d9348019a0f0743fd rdf:first N8f7bab150c84459d9d78788781ff7d59
112 rdf:rest N443b697846604e2d9299ccc2499eec27
113 N891411ca1a284f7193a40c8e515db033 rdf:first Ncd2e6ebc26be490abc8c59e878d05b17
114 rdf:rest N6f3411623e654103a7b9862cae934168
115 N8f7bab150c84459d9d78788781ff7d59 schema:affiliation https://www.grid.ac/institutes/grid.452223.0
116 schema:familyName Zhang
117 schema:givenName Jingxin
118 rdf:type schema:Person
119 N9e3b87858ca445299fc9774e8e900784 schema:issueNumber 2
120 rdf:type schema:PublicationIssue
121 Na0dbc2a4bcb9447ead0f4c84080ffbde schema:affiliation https://www.grid.ac/institutes/grid.63368.38
122 schema:familyName Hinkle
123 schema:givenName Louis E
124 rdf:type schema:Person
125 Nb43a8e105d074923ab77af6274a39b14 rdf:first Nba9fe477ccd948b0bd6ddf299ff179bb
126 rdf:rest N0631cfb6644240e09adc426cfa73cdb6
127 Nba9fe477ccd948b0bd6ddf299ff179bb schema:affiliation https://www.grid.ac/institutes/grid.268099.c
128 schema:familyName Shen
129 schema:givenName Jianliang
130 rdf:type schema:Person
131 Nc646c35e044d4077b9b6ea71112bfbc7 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
132 schema:familyName Li
133 schema:givenName Feng
134 rdf:type schema:Person
135 Ncd2e6ebc26be490abc8c59e878d05b17 schema:affiliation https://www.grid.ac/institutes/grid.5386.8
136 schema:familyName Ferrari
137 schema:givenName Mauro
138 rdf:type schema:Person
139 Ncf3f254dd7c24e678fcd6318800da560 schema:name nlm_unique_id
140 schema:value 100887374
141 rdf:type schema:PropertyValue
142 Nd1281fede7044a85b73d4d37c4096345 schema:name Springer Nature - SN SciGraph project
143 rdf:type schema:Organization
144 Nd8e2c13b81884bc0afc21770bb1467a4 schema:affiliation https://www.grid.ac/institutes/grid.63368.38
145 schema:familyName Zhang
146 schema:givenName Guodong
147 rdf:type schema:Person
148 Nef410135675a408cb91f6bade04e40ba rdf:first Na0dbc2a4bcb9447ead0f4c84080ffbde
149 rdf:rest N2a4501faca704e9caa4649d5d1ad484f
150 Nf0172736872c4922a7c07740df06b75a rdf:first N240df13a80744a338064a0753353b84e
151 rdf:rest N2f847aa649a648d78875df88ed4adb87
152 Nf545f98da9fb498eb87e33ff3c11eb9c schema:name pubmed_id
153 schema:value 30949852
154 rdf:type schema:PropertyValue
155 Nf767fb81e9474f638b49cfb3d589cf73 rdf:first N20e3b314d2bf43419ba2f9c917bb6f25
156 rdf:rest N4f61dc3712724ff391216229082709d5
157 Nf798b23349294774822289c16a7dc095 rdf:first Nc646c35e044d4077b9b6ea71112bfbc7
158 rdf:rest Nb43a8e105d074923ab77af6274a39b14
159 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
160 schema:name Medical and Health Sciences
161 rdf:type schema:DefinedTerm
162 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
163 schema:name Immunology
164 rdf:type schema:DefinedTerm
165 sg:grant.4729184 http://pending.schema.org/fundedItem sg:pub.10.1007/s10544-019-0397-6
166 rdf:type schema:MonetaryGrant
167 sg:grant.6376316 http://pending.schema.org/fundedItem sg:pub.10.1007/s10544-019-0397-6
168 rdf:type schema:MonetaryGrant
169 sg:grant.7615047 http://pending.schema.org/fundedItem sg:pub.10.1007/s10544-019-0397-6
170 rdf:type schema:MonetaryGrant
171 sg:journal.1021020 schema:issn 1387-2176
172 1572-8781
173 schema:name Biomedical Microdevices
174 rdf:type schema:Periodical
175 sg:pub.10.1007/s00276-013-1176-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050703971
176 https://doi.org/10.1007/s00276-013-1176-3
177 rdf:type schema:CreativeWork
178 sg:pub.10.1038/leu.2015.343 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003404089
179 https://doi.org/10.1038/leu.2015.343
180 rdf:type schema:CreativeWork
181 sg:pub.10.1038/nbt.3506 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040903815
182 https://doi.org/10.1038/nbt.3506
183 rdf:type schema:CreativeWork
184 sg:pub.10.1038/ni1223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047773335
185 https://doi.org/10.1038/ni1223
186 rdf:type schema:CreativeWork
187 sg:pub.10.1038/nmat4822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030847378
188 https://doi.org/10.1038/nmat4822
189 rdf:type schema:CreativeWork
190 sg:pub.10.1038/nnano.2017.52 schema:sameAs https://app.dimensions.ai/details/publication/pub.1085051621
191 https://doi.org/10.1038/nnano.2017.52
192 rdf:type schema:CreativeWork
193 sg:pub.10.1038/s41563-018-0028-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1101324934
194 https://doi.org/10.1038/s41563-018-0028-2
195 rdf:type schema:CreativeWork
196 https://doi.org/10.1002/adfm.201200869 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047891244
197 rdf:type schema:CreativeWork
198 https://doi.org/10.1002/adhm.201100005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042057132
199 rdf:type schema:CreativeWork
200 https://doi.org/10.1002/cncr.26574 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042506743
201 rdf:type schema:CreativeWork
202 https://doi.org/10.1002/smll.201201510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052459353
203 rdf:type schema:CreativeWork
204 https://doi.org/10.1016/0304-3835(92)90044-v schema:sameAs https://app.dimensions.ai/details/publication/pub.1046329806
205 rdf:type schema:CreativeWork
206 https://doi.org/10.1016/j.cell.2015.03.037 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015607130
207 rdf:type schema:CreativeWork
208 https://doi.org/10.1016/j.celrep.2015.04.009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020558562
209 rdf:type schema:CreativeWork
210 https://doi.org/10.1016/j.ejogrb.2005.11.015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026168819
211 rdf:type schema:CreativeWork
212 https://doi.org/10.1016/j.jconrel.2014.04.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043813453
213 rdf:type schema:CreativeWork
214 https://doi.org/10.1016/j.jconrel.2015.09.069 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052864290
215 rdf:type schema:CreativeWork
216 https://doi.org/10.1016/j.smim.2017.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1091905785
217 rdf:type schema:CreativeWork
218 https://doi.org/10.1021/nn4035316 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037388269
219 rdf:type schema:CreativeWork
220 https://doi.org/10.1056/nejmoa1001294 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017807249
221 rdf:type schema:CreativeWork
222 https://doi.org/10.1111/j.1600-065x.2010.00978.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1050571439
223 rdf:type schema:CreativeWork
224 https://doi.org/10.1126/science.aaa3828 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062665141
225 rdf:type schema:CreativeWork
226 https://doi.org/10.1126/scitranslmed.aao5931 schema:sameAs https://app.dimensions.ai/details/publication/pub.1103228743
227 rdf:type schema:CreativeWork
228 https://doi.org/10.1158/0008-5472.can-16-2913 schema:sameAs https://app.dimensions.ai/details/publication/pub.1084868696
229 rdf:type schema:CreativeWork
230 https://doi.org/10.1158/1078-0432.ccr-10-3126 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043851469
231 rdf:type schema:CreativeWork
232 https://doi.org/10.1158/1078-0432.ccr-12-2764 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039705699
233 rdf:type schema:CreativeWork
234 https://doi.org/10.1172/jci11752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1010749400
235 rdf:type schema:CreativeWork
236 https://doi.org/10.2217/imt.13.169 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027691653
237 rdf:type schema:CreativeWork
238 https://doi.org/10.4049/jimmunol.0903507 schema:sameAs https://app.dimensions.ai/details/publication/pub.1039959932
239 rdf:type schema:CreativeWork
240 https://www.grid.ac/institutes/grid.268099.c schema:alternateName Wenzhou Medical College
241 schema:name Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
242 State key laboratory of ophthalmology, School of Biomedical Engineering, Wenzhou Medical University, Wenzhou, 325035, China.
243 rdf:type schema:Organization
244 https://www.grid.ac/institutes/grid.417747.6 schema:alternateName Dana-Farber/Brigham and Women's Cancer Center
245 schema:name Breast Oncology Program, Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA, 02115, USA.
246 Department of Surgery, Brigham and Women's Hospital, Dana-Farber/ Brigham and Women's Cancer Center, Boston, MA, 02115, USA.
247 rdf:type schema:Organization
248 https://www.grid.ac/institutes/grid.452223.0 schema:alternateName Xiangya Hospital Central South University
249 schema:name Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
250 Xiangya Hospital of Central South University, Changsha, 410000, Hunan, China.
251 rdf:type schema:Organization
252 https://www.grid.ac/institutes/grid.5386.8 schema:alternateName Cornell University
253 schema:name Department of Cell and Developmental Biology, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. hshen@houstonmethodist.org.
254 Department of Medicine, Weill Cornell Medical College, 1300 York Avenue, New York, NY, 10065, USA. mferrari@houstonmethodist.org.
255 Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. hshen@houstonmethodist.org.
256 Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA. mferrari@houstonmethodist.org.
257 rdf:type schema:Organization
258 https://www.grid.ac/institutes/grid.63368.38 schema:alternateName Houston Methodist
259 schema:name Center for Bioenergetics, Houston Methodist Research Institute, Houston, TX, 77030, USA.
260 Center for Inflammation and Epigenetics, Houston Methodist Research Institute, Houston, TX, 77030, USA.
261 Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, 77030, USA.
262 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...