Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06

AUTHORS

Simone Pisano, Matteo Giustiniani, Lewis Francis, Deyarina Gonzalez, Lavinia Margarit, I. Martin Sheldon, Donatella Paolino, Massimo Fresta, R. Steven Conlan, Gareth D. Healey

ABSTRACT

Infections of the female reproductive tract are a major cause of morbidity and mortality in humans, requiring significant investment to sustain treatment and representing a major challenge to health. The increasing prevalence of bacterial resistance, and an almost complete absence of new antibiotic therapies for the past five decades, mean there is a desperate need for novel approaches to the treatment of bacterial infections. Within the present study, we demonstrate the effective ex vivo treatment of bacterial infection of the female reproductive tract using a controlled-release, liquid crystal-based platform. Liquid crystal encapsulation of ciprofloxacin significantly enhanced its bactericidal efficacy and reduced cell toxicity. Liquid crystal structures are low-cost, simple to manufacture and provide a sustained-release profile of encapsulated ciprofloxacin. Treatment of Escherichia coli infected reproductive tract epithelial cells and whole organ cultures with liquid crystal encapsulated ciprofloxacin proved to be an effective strategy for reducing bacterial load and reproductive tract inflammatory responses to infection. These data suggest that such an approach could provide an efficacious treatment modality for enhancing the effectiveness of current antibiotic therapies. More... »

PAGES

36

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10544-019-0385-x

DOI

http://dx.doi.org/10.1007/s10544-019-0385-x

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1113055618

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30923927


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/1107", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Immunology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/11", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Medical and Health Sciences", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "Swansea University", 
          "id": "https://www.grid.ac/institutes/grid.4827.9", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Pisano", 
        "givenName": "Simone", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Magna Graecia University", 
          "id": "https://www.grid.ac/institutes/grid.411489.1", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Catanzaro \u201cMagna Graecia\u201d, Viale \u201cS. Venuta\u201d, 88100, Catanzaro, Italy", 
            "Inter-Regional Research Center for Food Safety & Health, University of Catanzaro \u201cMagna Gr\u00e6cia\u201d, Viale \u201cS. Venuta\u201d, 88100, Catanzaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Giustiniani", 
        "givenName": "Matteo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swansea University", 
          "id": "https://www.grid.ac/institutes/grid.4827.9", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Francis", 
        "givenName": "Lewis", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swansea University", 
          "id": "https://www.grid.ac/institutes/grid.4827.9", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Gonzalez", 
        "givenName": "Deyarina", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Princess of Wales Hospital", 
          "id": "https://www.grid.ac/institutes/grid.415249.f", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK", 
            "Obstetrics & Gynecology Department Princess of Wales Hospital, Abertawe Bro Morannwg University Health Board, Coity Road, CF31 1RQ, Bridgend, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Margarit", 
        "givenName": "Lavinia", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swansea University", 
          "id": "https://www.grid.ac/institutes/grid.4827.9", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Sheldon", 
        "givenName": "I. Martin", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Magna Graecia University", 
          "id": "https://www.grid.ac/institutes/grid.411489.1", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Catanzaro \u201cMagna Graecia\u201d, Viale \u201cS. Venuta\u201d, 88100, Catanzaro, Italy", 
            "Inter-Regional Research Center for Food Safety & Health, University of Catanzaro \u201cMagna Gr\u00e6cia\u201d, Viale \u201cS. Venuta\u201d, 88100, Catanzaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Paolino", 
        "givenName": "Donatella", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Magna Graecia University", 
          "id": "https://www.grid.ac/institutes/grid.411489.1", 
          "name": [
            "Department of Clinical and Experimental Medicine, University of Catanzaro \u201cMagna Graecia\u201d, Viale \u201cS. Venuta\u201d, 88100, Catanzaro, Italy", 
            "Inter-Regional Research Center for Food Safety & Health, University of Catanzaro \u201cMagna Gr\u00e6cia\u201d, Viale \u201cS. Venuta\u201d, 88100, Catanzaro, Italy"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Fresta", 
        "givenName": "Massimo", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swansea University", 
          "id": "https://www.grid.ac/institutes/grid.4827.9", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Conlan", 
        "givenName": "R. Steven", 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "Swansea University", 
          "id": "https://www.grid.ac/institutes/grid.4827.9", 
          "name": [
            "Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Healey", 
        "givenName": "Gareth D.", 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "https://doi.org/10.1093/jac/dkl265", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000389782"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2004.11.034", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000697846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.39.12.2752", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001026399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c2sm25249j", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001134056"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.molstruc.2011.03.056", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002257903"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2005/892058", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004718413"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.chroma.2015.09.075", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005044495"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.it.2011.01.003", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1006280399"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/10.5.368", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008156313"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/j.1875-9114.1988.tb04058.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008672365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c5cp03797b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1009772173"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.2165/00002512-199404020-00007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013032333", 
          "https://doi.org/10.2165/00002512-199404020-00007"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2014.05.052", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013211463"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0012906", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013408164"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2012.01106.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014190504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2005.11.031", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014730272"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jconrel.2011.03.033", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015303606"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s40005-014-0165-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1015307572", 
          "https://doi.org/10.1007/s40005-014-0165-9"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1023/a:1016036908947", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016051168", 
          "https://doi.org/10.1023/a:1016036908947"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0010197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017291896"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0378-5173(96)04649-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017358333"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bi5000564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019343088"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/428290", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021262252"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/1477-7827-7-55", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021739964", 
          "https://doi.org/10.1186/1477-7827-7-55"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1155/2014/815981", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022332510"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/2049-2618-1-29", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022588888", 
          "https://doi.org/10.1186/2049-2618-1-29"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/ar1917", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024845291", 
          "https://doi.org/10.1186/ar1917"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.coi.2007.09.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025154962"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/physiolgenomics.00064.2009", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025497139"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/00016340600578357", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025976420"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0009192", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026099328"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijmm.2014.04.006", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026556631"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1128/aac.00068-15", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026853698"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006250-200107000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027330709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00006250-200107000-00015", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027330709"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s1461-5347(00)00296-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027397922"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/03009734.2014.898717", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027831154"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1439-0531.2012.02104.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1028724040"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.fertnstert.2004.01.025", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029067516"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/516221", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1029815421"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.jri.2016.07.002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030097609"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0169-409x(01)00108-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1030359269"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0082599", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032731187"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000175142.79347.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032745963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/01.aog.0000175142.79347.12", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032745963"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1517/14740338.2013.796362", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1032906093"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1111/j.1600-0897.2011.00970.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035133232"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3390/molecules21010062", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035146742"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-07-0564", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038341927"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3201/eid2004.131288", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038652569"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1086/318710", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038680990"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e3182a4690b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040478527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/gme.0b013e3182a4690b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040478527"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3109/13625187.2014.980501", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040987794"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fphys.2015.00164", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041489351"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2005.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041818369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2005.05.022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041818369"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0731-7085(01)00414-9", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042043159"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1211/jpp.62.06.0005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042341191"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkm238", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1043753504"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1046/j.1365-2672.2000.01017.x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1044696616"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/dkh448", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1046271365"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ogc.2005.12.013", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047602188"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.113.115972", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047764023"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.ijpharm.2006.03.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1048185361"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.109.077370", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1049879441"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0140-6736(07)60729-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052791134"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-9524-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053148296", 
          "https://doi.org/10.1007/978-1-4614-9524-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/978-1-4614-9524-6", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053148296", 
          "https://doi.org/10.1007/978-1-4614-9524-6"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1095/biolreprod.111.092718", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053289170"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/0022-1759(83)90303-4", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1053705634"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la303801b", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056157075"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la801645x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056163121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/la801645x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1056163121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/apc.1999.13.747", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059228404"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/cid/ciw864", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059468306"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1093/jac/26.suppl_d.31", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059732878"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2005-1113", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064247697"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1210/en.2013-1822", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1064252138"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1366/0003702953963490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065264121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1366/0003702953963490", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1065264121"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1530/rep-14-0230", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1067717877"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.2527/jas1979.4951261x", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1070898882"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4103/2277-9175.124626", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1072248156"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1075834965", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4049/jimmunol.1501080", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1079195644"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1079452282", 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pmed.1002366", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1090899743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/s41467-017-00901-0", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1092119323", 
          "https://doi.org/10.1038/s41467-017-00901-0"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.4018/978-1-5225-0751-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1096035592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2017.11.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099618177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.actbio.2017.11.057", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1099618177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1186/s40168-018-0418-3", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1100860502", 
          "https://doi.org/10.1186/s40168-018-0418-3"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmed.2018.00181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104536832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3389/fmed.2018.00181", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1104536832"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1106393110", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2019-06", 
    "datePublishedReg": "2019-06-01", 
    "description": "Infections of the female reproductive tract are a major cause of morbidity and mortality in humans, requiring significant investment to sustain treatment and representing a major challenge to health. The increasing prevalence of bacterial resistance, and an almost complete absence of new antibiotic therapies for the past five decades, mean there is a desperate need for novel approaches to the treatment of bacterial infections. Within the present study, we demonstrate the effective ex vivo treatment of bacterial infection of the female reproductive tract using a controlled-release, liquid crystal-based platform. Liquid crystal encapsulation of ciprofloxacin significantly enhanced its bactericidal efficacy and reduced cell toxicity. Liquid crystal structures are low-cost, simple to manufacture and provide a sustained-release profile of encapsulated ciprofloxacin. Treatment of Escherichia coli infected reproductive tract epithelial cells and whole organ cultures with liquid crystal encapsulated ciprofloxacin proved to be an effective strategy for reducing bacterial load and reproductive tract inflammatory responses to infection. These data suggest that such an approach could provide an efficacious treatment modality for enhancing the effectiveness of current antibiotic therapies.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10544-019-0385-x", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": false, 
    "isPartOf": [
      {
        "id": "sg:journal.1021020", 
        "issn": [
          "1387-2176", 
          "1572-8781"
        ], 
        "name": "Biomedical Microdevices", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "2", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "21"
      }
    ], 
    "name": "Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract", 
    "pagination": "36", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "7f943dd3f7ee65d0b49934d7331474a92bf32142f885ca463c8ab6b8bec2fea9"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "30923927"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100887374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10544-019-0385-x"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1113055618"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10544-019-0385-x", 
      "https://app.dimensions.ai/details/publication/pub.1113055618"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T13:19", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000368_0000000368/records_78956_00000001.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "https://link.springer.com/10.1007%2Fs10544-019-0385-x"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0385-x'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0385-x'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0385-x'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10544-019-0385-x'


 

This table displays all metadata directly associated to this object as RDF triples.

397 TRIPLES      21 PREDICATES      116 URIs      21 LITERALS      9 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10544-019-0385-x schema:about anzsrc-for:11
2 anzsrc-for:1107
3 schema:author N53deb54dc76141f1afa3a627ce920c49
4 schema:citation sg:pub.10.1007/978-1-4614-9524-6
5 sg:pub.10.1007/s40005-014-0165-9
6 sg:pub.10.1023/a:1016036908947
7 sg:pub.10.1038/s41467-017-00901-0
8 sg:pub.10.1186/1477-7827-7-55
9 sg:pub.10.1186/2049-2618-1-29
10 sg:pub.10.1186/ar1917
11 sg:pub.10.1186/s40168-018-0418-3
12 sg:pub.10.2165/00002512-199404020-00007
13 https://app.dimensions.ai/details/publication/pub.1075834965
14 https://app.dimensions.ai/details/publication/pub.1079452282
15 https://app.dimensions.ai/details/publication/pub.1106393110
16 https://doi.org/10.1002/j.1875-9114.1988.tb04058.x
17 https://doi.org/10.1016/0022-1759(83)90303-4
18 https://doi.org/10.1016/0378-5173(96)04649-2
19 https://doi.org/10.1016/j.actbio.2017.11.057
20 https://doi.org/10.1016/j.biomaterials.2005.11.031
21 https://doi.org/10.1016/j.chroma.2015.09.075
22 https://doi.org/10.1016/j.coi.2007.09.002
23 https://doi.org/10.1016/j.fertnstert.2004.01.025
24 https://doi.org/10.1016/j.ijmm.2014.04.006
25 https://doi.org/10.1016/j.ijpharm.2005.05.022
26 https://doi.org/10.1016/j.ijpharm.2006.03.012
27 https://doi.org/10.1016/j.it.2011.01.003
28 https://doi.org/10.1016/j.jconrel.2004.11.034
29 https://doi.org/10.1016/j.jconrel.2011.03.033
30 https://doi.org/10.1016/j.jconrel.2014.05.052
31 https://doi.org/10.1016/j.jri.2016.07.002
32 https://doi.org/10.1016/j.molstruc.2011.03.056
33 https://doi.org/10.1016/j.ogc.2005.12.013
34 https://doi.org/10.1016/s0140-6736(07)60729-6
35 https://doi.org/10.1016/s0169-409x(01)00108-9
36 https://doi.org/10.1016/s0731-7085(01)00414-9
37 https://doi.org/10.1016/s1461-5347(00)00296-0
38 https://doi.org/10.1021/bi5000564
39 https://doi.org/10.1021/la303801b
40 https://doi.org/10.1021/la801645x
41 https://doi.org/10.1039/c2sm25249j
42 https://doi.org/10.1039/c5cp03797b
43 https://doi.org/10.1046/j.1365-2672.2000.01017.x
44 https://doi.org/10.1080/00016340600578357
45 https://doi.org/10.1086/318710
46 https://doi.org/10.1086/428290
47 https://doi.org/10.1086/516221
48 https://doi.org/10.1089/apc.1999.13.747
49 https://doi.org/10.1093/cid/ciw864
50 https://doi.org/10.1093/jac/10.5.368
51 https://doi.org/10.1093/jac/26.suppl_d.31
52 https://doi.org/10.1093/jac/dkh448
53 https://doi.org/10.1093/jac/dkl265
54 https://doi.org/10.1093/jac/dkm238
55 https://doi.org/10.1095/biolreprod.109.077370
56 https://doi.org/10.1095/biolreprod.111.092718
57 https://doi.org/10.1095/biolreprod.113.115972
58 https://doi.org/10.1097/00006250-200107000-00015
59 https://doi.org/10.1097/01.aog.0000175142.79347.12
60 https://doi.org/10.1097/gme.0b013e3182a4690b
61 https://doi.org/10.1111/j.1439-0531.2012.02104.x
62 https://doi.org/10.1111/j.1600-0897.2011.00970.x
63 https://doi.org/10.1111/j.1600-0897.2012.01106.x
64 https://doi.org/10.1128/aac.00068-15
65 https://doi.org/10.1128/aac.39.12.2752
66 https://doi.org/10.1152/physiolgenomics.00064.2009
67 https://doi.org/10.1155/2005/892058
68 https://doi.org/10.1155/2014/815981
69 https://doi.org/10.1210/en.2005-1113
70 https://doi.org/10.1210/en.2013-1822
71 https://doi.org/10.1211/jpp.62.06.0005
72 https://doi.org/10.1366/0003702953963490
73 https://doi.org/10.1371/journal.pmed.1002366
74 https://doi.org/10.1371/journal.pone.0009192
75 https://doi.org/10.1371/journal.pone.0010197
76 https://doi.org/10.1371/journal.pone.0012906
77 https://doi.org/10.1371/journal.pone.0082599
78 https://doi.org/10.1517/14740338.2013.796362
79 https://doi.org/10.1530/rep-07-0564
80 https://doi.org/10.1530/rep-14-0230
81 https://doi.org/10.2527/jas1979.4951261x
82 https://doi.org/10.3109/03009734.2014.898717
83 https://doi.org/10.3109/13625187.2014.980501
84 https://doi.org/10.3201/eid2004.131288
85 https://doi.org/10.3389/fmed.2018.00181
86 https://doi.org/10.3389/fphys.2015.00164
87 https://doi.org/10.3390/molecules21010062
88 https://doi.org/10.4018/978-1-5225-0751-2
89 https://doi.org/10.4049/jimmunol.1501080
90 https://doi.org/10.4103/2277-9175.124626
91 schema:datePublished 2019-06
92 schema:datePublishedReg 2019-06-01
93 schema:description Infections of the female reproductive tract are a major cause of morbidity and mortality in humans, requiring significant investment to sustain treatment and representing a major challenge to health. The increasing prevalence of bacterial resistance, and an almost complete absence of new antibiotic therapies for the past five decades, mean there is a desperate need for novel approaches to the treatment of bacterial infections. Within the present study, we demonstrate the effective ex vivo treatment of bacterial infection of the female reproductive tract using a controlled-release, liquid crystal-based platform. Liquid crystal encapsulation of ciprofloxacin significantly enhanced its bactericidal efficacy and reduced cell toxicity. Liquid crystal structures are low-cost, simple to manufacture and provide a sustained-release profile of encapsulated ciprofloxacin. Treatment of Escherichia coli infected reproductive tract epithelial cells and whole organ cultures with liquid crystal encapsulated ciprofloxacin proved to be an effective strategy for reducing bacterial load and reproductive tract inflammatory responses to infection. These data suggest that such an approach could provide an efficacious treatment modality for enhancing the effectiveness of current antibiotic therapies.
94 schema:genre research_article
95 schema:inLanguage en
96 schema:isAccessibleForFree false
97 schema:isPartOf N1cf25d84b8a34c9ea1add97f7dcc1d2d
98 Nbdf5dfb2a51b453fbbf3a19b14a63cf2
99 sg:journal.1021020
100 schema:name Liquid crystal delivery of ciprofloxacin to treat infections of the female reproductive tract
101 schema:pagination 36
102 schema:productId N2178332547ca41959cdd4ecfa3ae5d9c
103 N27d64874ab6a40c8bbcf128fca6377a2
104 N2fcd3a3128e842ad970480b2bbc8e9b5
105 N57a666d9968c4be1b99652ef96752024
106 N5da4514647374781a08fc93503cd1a11
107 schema:sameAs https://app.dimensions.ai/details/publication/pub.1113055618
108 https://doi.org/10.1007/s10544-019-0385-x
109 schema:sdDatePublished 2019-04-11T13:19
110 schema:sdLicense https://scigraph.springernature.com/explorer/license/
111 schema:sdPublisher N1092e8ba8f184d349605a66e008fbcde
112 schema:url https://link.springer.com/10.1007%2Fs10544-019-0385-x
113 sgo:license sg:explorer/license/
114 sgo:sdDataset articles
115 rdf:type schema:ScholarlyArticle
116 N05c6afe7a3e9442f953796c60ac1651d schema:affiliation https://www.grid.ac/institutes/grid.411489.1
117 schema:familyName Fresta
118 schema:givenName Massimo
119 rdf:type schema:Person
120 N093646852d73487dab160edf76a674b7 schema:affiliation https://www.grid.ac/institutes/grid.4827.9
121 schema:familyName Conlan
122 schema:givenName R. Steven
123 rdf:type schema:Person
124 N1092e8ba8f184d349605a66e008fbcde schema:name Springer Nature - SN SciGraph project
125 rdf:type schema:Organization
126 N197ec423b7f9478b9a7cb6dd9db53e7b rdf:first Na9029eed17564556abf6222ac693b8ba
127 rdf:rest Nb776107b3e674b9981096e528749c801
128 N1cf25d84b8a34c9ea1add97f7dcc1d2d schema:issueNumber 2
129 rdf:type schema:PublicationIssue
130 N2178332547ca41959cdd4ecfa3ae5d9c schema:name pubmed_id
131 schema:value 30923927
132 rdf:type schema:PropertyValue
133 N21d5246105c9433cb48f438db13b2008 rdf:first N8840d5fd405d4dae8f6d95f0ea418a83
134 rdf:rest N6d5dd3ea91d84efaa998341e764a7cc7
135 N27d64874ab6a40c8bbcf128fca6377a2 schema:name doi
136 schema:value 10.1007/s10544-019-0385-x
137 rdf:type schema:PropertyValue
138 N2fcd3a3128e842ad970480b2bbc8e9b5 schema:name readcube_id
139 schema:value 7f943dd3f7ee65d0b49934d7331474a92bf32142f885ca463c8ab6b8bec2fea9
140 rdf:type schema:PropertyValue
141 N37a80c68602848b9a41968e876837f53 rdf:first N05c6afe7a3e9442f953796c60ac1651d
142 rdf:rest N488cd9000b214db5905568f4bcb445f4
143 N488cd9000b214db5905568f4bcb445f4 rdf:first N093646852d73487dab160edf76a674b7
144 rdf:rest Nd4e790a4e5f949698f20b7c97c3450f9
145 N53deb54dc76141f1afa3a627ce920c49 rdf:first Nccac916d027048c4871fd33fcf034c71
146 rdf:rest N81c9bf0b42c843c9a697bd710484e3c3
147 N57a666d9968c4be1b99652ef96752024 schema:name dimensions_id
148 schema:value pub.1113055618
149 rdf:type schema:PropertyValue
150 N5da4514647374781a08fc93503cd1a11 schema:name nlm_unique_id
151 schema:value 100887374
152 rdf:type schema:PropertyValue
153 N633c2b058bb741eab942ceb0af881bdc schema:affiliation https://www.grid.ac/institutes/grid.4827.9
154 schema:familyName Francis
155 schema:givenName Lewis
156 rdf:type schema:Person
157 N6d5dd3ea91d84efaa998341e764a7cc7 rdf:first Nb14e8370fefa4df78d6a7e4759948f40
158 rdf:rest N37a80c68602848b9a41968e876837f53
159 N81c9bf0b42c843c9a697bd710484e3c3 rdf:first Na3f39b9bf24548f7bd7d2a08965189ff
160 rdf:rest Nb16d31133f3a47608c60f3e9148fb4e3
161 N8840d5fd405d4dae8f6d95f0ea418a83 schema:affiliation https://www.grid.ac/institutes/grid.4827.9
162 schema:familyName Sheldon
163 schema:givenName I. Martin
164 rdf:type schema:Person
165 Na3f39b9bf24548f7bd7d2a08965189ff schema:affiliation https://www.grid.ac/institutes/grid.411489.1
166 schema:familyName Giustiniani
167 schema:givenName Matteo
168 rdf:type schema:Person
169 Na9029eed17564556abf6222ac693b8ba schema:affiliation https://www.grid.ac/institutes/grid.4827.9
170 schema:familyName Gonzalez
171 schema:givenName Deyarina
172 rdf:type schema:Person
173 Nb14e8370fefa4df78d6a7e4759948f40 schema:affiliation https://www.grid.ac/institutes/grid.411489.1
174 schema:familyName Paolino
175 schema:givenName Donatella
176 rdf:type schema:Person
177 Nb16d31133f3a47608c60f3e9148fb4e3 rdf:first N633c2b058bb741eab942ceb0af881bdc
178 rdf:rest N197ec423b7f9478b9a7cb6dd9db53e7b
179 Nb776107b3e674b9981096e528749c801 rdf:first Nb7826f4352974ad6b02c33d5a2a82d44
180 rdf:rest N21d5246105c9433cb48f438db13b2008
181 Nb7826f4352974ad6b02c33d5a2a82d44 schema:affiliation https://www.grid.ac/institutes/grid.415249.f
182 schema:familyName Margarit
183 schema:givenName Lavinia
184 rdf:type schema:Person
185 Nbdf5dfb2a51b453fbbf3a19b14a63cf2 schema:volumeNumber 21
186 rdf:type schema:PublicationVolume
187 Nccac916d027048c4871fd33fcf034c71 schema:affiliation https://www.grid.ac/institutes/grid.4827.9
188 schema:familyName Pisano
189 schema:givenName Simone
190 rdf:type schema:Person
191 Nd4e790a4e5f949698f20b7c97c3450f9 rdf:first Nd51d834430d541ad890b043141a017de
192 rdf:rest rdf:nil
193 Nd51d834430d541ad890b043141a017de schema:affiliation https://www.grid.ac/institutes/grid.4827.9
194 schema:familyName Healey
195 schema:givenName Gareth D.
196 rdf:type schema:Person
197 anzsrc-for:11 schema:inDefinedTermSet anzsrc-for:
198 schema:name Medical and Health Sciences
199 rdf:type schema:DefinedTerm
200 anzsrc-for:1107 schema:inDefinedTermSet anzsrc-for:
201 schema:name Immunology
202 rdf:type schema:DefinedTerm
203 sg:journal.1021020 schema:issn 1387-2176
204 1572-8781
205 schema:name Biomedical Microdevices
206 rdf:type schema:Periodical
207 sg:pub.10.1007/978-1-4614-9524-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053148296
208 https://doi.org/10.1007/978-1-4614-9524-6
209 rdf:type schema:CreativeWork
210 sg:pub.10.1007/s40005-014-0165-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015307572
211 https://doi.org/10.1007/s40005-014-0165-9
212 rdf:type schema:CreativeWork
213 sg:pub.10.1023/a:1016036908947 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016051168
214 https://doi.org/10.1023/a:1016036908947
215 rdf:type schema:CreativeWork
216 sg:pub.10.1038/s41467-017-00901-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1092119323
217 https://doi.org/10.1038/s41467-017-00901-0
218 rdf:type schema:CreativeWork
219 sg:pub.10.1186/1477-7827-7-55 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021739964
220 https://doi.org/10.1186/1477-7827-7-55
221 rdf:type schema:CreativeWork
222 sg:pub.10.1186/2049-2618-1-29 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022588888
223 https://doi.org/10.1186/2049-2618-1-29
224 rdf:type schema:CreativeWork
225 sg:pub.10.1186/ar1917 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024845291
226 https://doi.org/10.1186/ar1917
227 rdf:type schema:CreativeWork
228 sg:pub.10.1186/s40168-018-0418-3 schema:sameAs https://app.dimensions.ai/details/publication/pub.1100860502
229 https://doi.org/10.1186/s40168-018-0418-3
230 rdf:type schema:CreativeWork
231 sg:pub.10.2165/00002512-199404020-00007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013032333
232 https://doi.org/10.2165/00002512-199404020-00007
233 rdf:type schema:CreativeWork
234 https://app.dimensions.ai/details/publication/pub.1075834965 schema:CreativeWork
235 https://app.dimensions.ai/details/publication/pub.1079452282 schema:CreativeWork
236 https://app.dimensions.ai/details/publication/pub.1106393110 schema:CreativeWork
237 https://doi.org/10.1002/j.1875-9114.1988.tb04058.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1008672365
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1016/0022-1759(83)90303-4 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053705634
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1016/0378-5173(96)04649-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017358333
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1016/j.actbio.2017.11.057 schema:sameAs https://app.dimensions.ai/details/publication/pub.1099618177
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1016/j.biomaterials.2005.11.031 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014730272
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1016/j.chroma.2015.09.075 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005044495
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1016/j.coi.2007.09.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025154962
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1016/j.fertnstert.2004.01.025 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029067516
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1016/j.ijmm.2014.04.006 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026556631
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1016/j.ijpharm.2005.05.022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041818369
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1016/j.ijpharm.2006.03.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048185361
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1016/j.it.2011.01.003 schema:sameAs https://app.dimensions.ai/details/publication/pub.1006280399
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1016/j.jconrel.2004.11.034 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000697846
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1016/j.jconrel.2011.03.033 schema:sameAs https://app.dimensions.ai/details/publication/pub.1015303606
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1016/j.jconrel.2014.05.052 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013211463
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1016/j.jri.2016.07.002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030097609
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1016/j.molstruc.2011.03.056 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002257903
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1016/j.ogc.2005.12.013 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047602188
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1016/s0140-6736(07)60729-6 schema:sameAs https://app.dimensions.ai/details/publication/pub.1052791134
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1016/s0169-409x(01)00108-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1030359269
276 rdf:type schema:CreativeWork
277 https://doi.org/10.1016/s0731-7085(01)00414-9 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042043159
278 rdf:type schema:CreativeWork
279 https://doi.org/10.1016/s1461-5347(00)00296-0 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027397922
280 rdf:type schema:CreativeWork
281 https://doi.org/10.1021/bi5000564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019343088
282 rdf:type schema:CreativeWork
283 https://doi.org/10.1021/la303801b schema:sameAs https://app.dimensions.ai/details/publication/pub.1056157075
284 rdf:type schema:CreativeWork
285 https://doi.org/10.1021/la801645x schema:sameAs https://app.dimensions.ai/details/publication/pub.1056163121
286 rdf:type schema:CreativeWork
287 https://doi.org/10.1039/c2sm25249j schema:sameAs https://app.dimensions.ai/details/publication/pub.1001134056
288 rdf:type schema:CreativeWork
289 https://doi.org/10.1039/c5cp03797b schema:sameAs https://app.dimensions.ai/details/publication/pub.1009772173
290 rdf:type schema:CreativeWork
291 https://doi.org/10.1046/j.1365-2672.2000.01017.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1044696616
292 rdf:type schema:CreativeWork
293 https://doi.org/10.1080/00016340600578357 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025976420
294 rdf:type schema:CreativeWork
295 https://doi.org/10.1086/318710 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038680990
296 rdf:type schema:CreativeWork
297 https://doi.org/10.1086/428290 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021262252
298 rdf:type schema:CreativeWork
299 https://doi.org/10.1086/516221 schema:sameAs https://app.dimensions.ai/details/publication/pub.1029815421
300 rdf:type schema:CreativeWork
301 https://doi.org/10.1089/apc.1999.13.747 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059228404
302 rdf:type schema:CreativeWork
303 https://doi.org/10.1093/cid/ciw864 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059468306
304 rdf:type schema:CreativeWork
305 https://doi.org/10.1093/jac/10.5.368 schema:sameAs https://app.dimensions.ai/details/publication/pub.1008156313
306 rdf:type schema:CreativeWork
307 https://doi.org/10.1093/jac/26.suppl_d.31 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059732878
308 rdf:type schema:CreativeWork
309 https://doi.org/10.1093/jac/dkh448 schema:sameAs https://app.dimensions.ai/details/publication/pub.1046271365
310 rdf:type schema:CreativeWork
311 https://doi.org/10.1093/jac/dkl265 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000389782
312 rdf:type schema:CreativeWork
313 https://doi.org/10.1093/jac/dkm238 schema:sameAs https://app.dimensions.ai/details/publication/pub.1043753504
314 rdf:type schema:CreativeWork
315 https://doi.org/10.1095/biolreprod.109.077370 schema:sameAs https://app.dimensions.ai/details/publication/pub.1049879441
316 rdf:type schema:CreativeWork
317 https://doi.org/10.1095/biolreprod.111.092718 schema:sameAs https://app.dimensions.ai/details/publication/pub.1053289170
318 rdf:type schema:CreativeWork
319 https://doi.org/10.1095/biolreprod.113.115972 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047764023
320 rdf:type schema:CreativeWork
321 https://doi.org/10.1097/00006250-200107000-00015 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027330709
322 rdf:type schema:CreativeWork
323 https://doi.org/10.1097/01.aog.0000175142.79347.12 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032745963
324 rdf:type schema:CreativeWork
325 https://doi.org/10.1097/gme.0b013e3182a4690b schema:sameAs https://app.dimensions.ai/details/publication/pub.1040478527
326 rdf:type schema:CreativeWork
327 https://doi.org/10.1111/j.1439-0531.2012.02104.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1028724040
328 rdf:type schema:CreativeWork
329 https://doi.org/10.1111/j.1600-0897.2011.00970.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1035133232
330 rdf:type schema:CreativeWork
331 https://doi.org/10.1111/j.1600-0897.2012.01106.x schema:sameAs https://app.dimensions.ai/details/publication/pub.1014190504
332 rdf:type schema:CreativeWork
333 https://doi.org/10.1128/aac.00068-15 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026853698
334 rdf:type schema:CreativeWork
335 https://doi.org/10.1128/aac.39.12.2752 schema:sameAs https://app.dimensions.ai/details/publication/pub.1001026399
336 rdf:type schema:CreativeWork
337 https://doi.org/10.1152/physiolgenomics.00064.2009 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025497139
338 rdf:type schema:CreativeWork
339 https://doi.org/10.1155/2005/892058 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004718413
340 rdf:type schema:CreativeWork
341 https://doi.org/10.1155/2014/815981 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022332510
342 rdf:type schema:CreativeWork
343 https://doi.org/10.1210/en.2005-1113 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064247697
344 rdf:type schema:CreativeWork
345 https://doi.org/10.1210/en.2013-1822 schema:sameAs https://app.dimensions.ai/details/publication/pub.1064252138
346 rdf:type schema:CreativeWork
347 https://doi.org/10.1211/jpp.62.06.0005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042341191
348 rdf:type schema:CreativeWork
349 https://doi.org/10.1366/0003702953963490 schema:sameAs https://app.dimensions.ai/details/publication/pub.1065264121
350 rdf:type schema:CreativeWork
351 https://doi.org/10.1371/journal.pmed.1002366 schema:sameAs https://app.dimensions.ai/details/publication/pub.1090899743
352 rdf:type schema:CreativeWork
353 https://doi.org/10.1371/journal.pone.0009192 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026099328
354 rdf:type schema:CreativeWork
355 https://doi.org/10.1371/journal.pone.0010197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017291896
356 rdf:type schema:CreativeWork
357 https://doi.org/10.1371/journal.pone.0012906 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013408164
358 rdf:type schema:CreativeWork
359 https://doi.org/10.1371/journal.pone.0082599 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032731187
360 rdf:type schema:CreativeWork
361 https://doi.org/10.1517/14740338.2013.796362 schema:sameAs https://app.dimensions.ai/details/publication/pub.1032906093
362 rdf:type schema:CreativeWork
363 https://doi.org/10.1530/rep-07-0564 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038341927
364 rdf:type schema:CreativeWork
365 https://doi.org/10.1530/rep-14-0230 schema:sameAs https://app.dimensions.ai/details/publication/pub.1067717877
366 rdf:type schema:CreativeWork
367 https://doi.org/10.2527/jas1979.4951261x schema:sameAs https://app.dimensions.ai/details/publication/pub.1070898882
368 rdf:type schema:CreativeWork
369 https://doi.org/10.3109/03009734.2014.898717 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027831154
370 rdf:type schema:CreativeWork
371 https://doi.org/10.3109/13625187.2014.980501 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040987794
372 rdf:type schema:CreativeWork
373 https://doi.org/10.3201/eid2004.131288 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038652569
374 rdf:type schema:CreativeWork
375 https://doi.org/10.3389/fmed.2018.00181 schema:sameAs https://app.dimensions.ai/details/publication/pub.1104536832
376 rdf:type schema:CreativeWork
377 https://doi.org/10.3389/fphys.2015.00164 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041489351
378 rdf:type schema:CreativeWork
379 https://doi.org/10.3390/molecules21010062 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035146742
380 rdf:type schema:CreativeWork
381 https://doi.org/10.4018/978-1-5225-0751-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1096035592
382 rdf:type schema:CreativeWork
383 https://doi.org/10.4049/jimmunol.1501080 schema:sameAs https://app.dimensions.ai/details/publication/pub.1079195644
384 rdf:type schema:CreativeWork
385 https://doi.org/10.4103/2277-9175.124626 schema:sameAs https://app.dimensions.ai/details/publication/pub.1072248156
386 rdf:type schema:CreativeWork
387 https://www.grid.ac/institutes/grid.411489.1 schema:alternateName Magna Graecia University
388 schema:name Department of Clinical and Experimental Medicine, University of Catanzaro “Magna Graecia”, Viale “S. Venuta”, 88100, Catanzaro, Italy
389 Inter-Regional Research Center for Food Safety & Health, University of Catanzaro “Magna Græcia”, Viale “S. Venuta”, 88100, Catanzaro, Italy
390 rdf:type schema:Organization
391 https://www.grid.ac/institutes/grid.415249.f schema:alternateName Princess of Wales Hospital
392 schema:name Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK
393 Obstetrics & Gynecology Department Princess of Wales Hospital, Abertawe Bro Morannwg University Health Board, Coity Road, CF31 1RQ, Bridgend, UK
394 rdf:type schema:Organization
395 https://www.grid.ac/institutes/grid.4827.9 schema:alternateName Swansea University
396 schema:name Institute of Life Science, Swansea University Medical School, Swansea University, SA2 8PP, Swansea, UK
397 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...