Coupling tumor growth and bio distribution models View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2019-06

AUTHORS

Raffaella Santagiuliana, Miljan Milosevic, Bogdan Milicevic, Giuseppe Sciumè, Vladimir Simic, Arturas Ziemys, Milos Kojic, Bernhard A. Schrefler

ABSTRACT

We couple a tumor growth model embedded in a microenvironment, with a bio distribution model able to simulate a whole organ. The growth model yields the evolution of tumor cell population, of the differential pressure between cell populations, of porosity of ECM, of consumption of nutrients due to tumor growth, of angiogenesis, and related growth factors as function of the locally available nutrient. The bio distribution model on the other hand operates on a frozen geometry but yields a much refined distribution of nutrient and other molecules. The combination of both models will enable simulating the growth of a tumor in a whole organ, including a realistic distribution of therapeutic agents and allow hence to evaluate the efficacy of these agents. More... »

PAGES

33

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10544-019-0368-y

DOI

http://dx.doi.org/10.1007/s10544-019-0368-y

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1112972165

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/30906958


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