A microfabricated platform for establishing oxygen gradients in 3-D constructs View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2013-06

AUTHORS

Shawn C. Oppegard, David T. Eddington

ABSTRACT

Oxygen gradients are increasingly implicated in a number of biological processes, including stem cell differentiation and cancer metastasis. Unfortunately, the current in vitro tools designed to mimic conditions found in vivo lack application flexibility, simplicity in operation, and precise spatial control that most researchers require for widespread dissemination. The novel microfluidic-based device presented here addresses all the above concerns, offering a simple platform for enhanced control over the oxygen microenvironment exposed to three-dimensional cell-seeded constructs. The device utilizes an oxygen diffusion membrane approach to establish a gradient across a construct sandwiched between two continually perfused microfluidic networks. The device is capable of forming steady-state gradients at both the conditions tested-0 % to 5 % O₂ and 0 % to 21 % O₂-but a wide variety of profiles within the construct are possible. Cell viability with two model cell lines was also tested, with no adverse effects relative to the control. More... »

PAGES

407-414

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10544-013-9737-0

DOI

http://dx.doi.org/10.1007/s10544-013-9737-0

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1048841248

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/23344840


Indexing Status Check whether this publication has been indexed by Scopus and Web Of Science using the SN Indexing Status Tool
Incoming Citations Browse incoming citations for this publication using opencitations.net

JSON-LD is the canonical representation for SciGraph data.

TIP: You can open this SciGraph record using an external JSON-LD service: JSON-LD Playground Google SDTT

[
  {
    "@context": "https://springernature.github.io/scigraph/jsonld/sgcontext.json", 
    "about": [
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/0601", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biochemistry and Cell Biology", 
        "type": "DefinedTerm"
      }, 
      {
        "id": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/06", 
        "inDefinedTermSet": "http://purl.org/au-research/vocabulary/anzsrc-for/2008/", 
        "name": "Biological Sciences", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Biomimetics", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Line", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Cell Survival", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Humans", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Membranes, Artificial", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Microtechnology", 
        "type": "DefinedTerm"
      }, 
      {
        "inDefinedTermSet": "https://www.nlm.nih.gov/mesh/", 
        "name": "Oxygen", 
        "type": "DefinedTerm"
      }
    ], 
    "author": [
      {
        "affiliation": {
          "alternateName": "University of Illinois at Chicago", 
          "id": "https://www.grid.ac/institutes/grid.185648.6", 
          "name": [
            "Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Oppegard", 
        "givenName": "Shawn C.", 
        "id": "sg:person.01311732004.32", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311732004.32"
        ], 
        "type": "Person"
      }, 
      {
        "affiliation": {
          "alternateName": "University of Illinois at Chicago", 
          "id": "https://www.grid.ac/institutes/grid.185648.6", 
          "name": [
            "Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA"
          ], 
          "type": "Organization"
        }, 
        "familyName": "Eddington", 
        "givenName": "David T.", 
        "id": "sg:person.01311673353.61", 
        "sameAs": [
          "https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311673353.61"
        ], 
        "type": "Person"
      }
    ], 
    "citation": [
      {
        "id": "sg:pub.10.1038/nmat2022", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1000577233", 
          "https://doi.org/10.1038/nmat2022"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c004856a", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1001151825"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.bioeng.3.1.335", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1002076643"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3791/1695", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1003859529"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2008.08.008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004258846"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004610862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2004-0342", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1004610862"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2006.05.012", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005830628"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-04-0289", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1005994791"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/bp034024w", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1008593996"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1634/stemcells.2007-0197", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1012042218"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1080/095530000138259", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013293806"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0704-804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013407263", 
          "https://doi.org/10.1038/nbt0704-804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nbt0704-804", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1013407263", 
          "https://doi.org/10.1038/nbt0704-804"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.cellbio.15.1.551", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1014138125"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.0701152104", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016402226"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1158/0008-5472.can-03-2958", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1016925612"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1073/pnas.92.12.5510", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1017639394"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b508097e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018813839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b508097e", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018813839"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.bbamcr.2004.04.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1018975589"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0270-9139(03)80278-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1019677506"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/28867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020992380", 
          "https://doi.org/10.1038/28867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/28867", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1020992380", 
          "https://doi.org/10.1038/28867"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1371/journal.pone.0006891", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1021933661"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2009.05.041", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022149104"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0092-8674(00)81405-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1022398043"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1041330213", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1023484271"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1152/ajplung.90445.2008", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024101538"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/b920401f", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1024353594"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9062-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025544837", 
          "https://doi.org/10.1007/s10555-007-9062-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9062-2", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025544837", 
          "https://doi.org/10.1007/s10555-007-9062-2"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/nm0297-177", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1025563287", 
          "https://doi.org/10.1038/nm0297-177"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.tice.2008.12.007", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1026056886"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1146/annurev.arplant.48.1.223", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027018774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/j.biomaterials.2008.02.005", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1027507625"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031578783", 
          "https://doi.org/10.1038/bjc.1998.148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/bjc.1998.148", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1031578783", 
          "https://doi.org/10.1038/bjc.1998.148"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035902317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.20571", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1035902317"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0002-9440(10)63540-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1037986283"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9063-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038320638", 
          "https://doi.org/10.1007/s10555-007-9063-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10555-007-9063-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1038320638", 
          "https://doi.org/10.1007/s10555-007-9063-1"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/jcp.1081", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1040410009"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10544-006-9005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041598067", 
          "https://doi.org/10.1007/s10544-006-9005-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10544-006-9005-7", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1041598067", 
          "https://doi.org/10.1007/s10544-006-9005-7"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.284.5411.143", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042379237"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042694570", 
          "https://doi.org/10.1038/sj.bjc.6601047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6601047", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1042694570", 
          "https://doi.org/10.1038/sj.bjc.6601047"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1002/bit.10569", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1047436462"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10544-009-9294-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050866401", 
          "https://doi.org/10.1007/s10544-009-9294-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10544-009-9294-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050866401", 
          "https://doi.org/10.1007/s10544-009-9294-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1007/s10544-009-9294-8", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1050866401", 
          "https://doi.org/10.1007/s10544-009-9294-8"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051263178", 
          "https://doi.org/10.1038/sj.bjc.6690586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "sg:pub.10.1038/sj.bjc.6690586", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051263178", 
          "https://doi.org/10.1038/sj.bjc.6690586"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1016/s0006-2952(02)01168-1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1051930639"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c004660d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052805743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1039/c004660d", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1052805743"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac202300g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055002137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1021/ac202300g", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1055002137"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/108497801753354267", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059207684"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.2006.0251", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059313592"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tea.2009.0670", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059315484"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1089/ten.tec.2010.0241", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1059317406"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199807000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199807000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1097/00000658-199807000-00002", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1060134811"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1126/science.1147949", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1062456443"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883911506066934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063856774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1177/0883911506066934", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1063856774"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.1667/rr3491.1", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1068196587"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://doi.org/10.3892/ijmm.12.5.693", 
        "sameAs": [
          "https://app.dimensions.ai/details/publication/pub.1071505544"
        ], 
        "type": "CreativeWork"
      }, 
      {
        "id": "https://app.dimensions.ai/details/publication/pub.1074687338", 
        "type": "CreativeWork"
      }
    ], 
    "datePublished": "2013-06", 
    "datePublishedReg": "2013-06-01", 
    "description": "Oxygen gradients are increasingly implicated in a number of biological processes, including stem cell differentiation and cancer metastasis. Unfortunately, the current in vitro tools designed to mimic conditions found in vivo lack application flexibility, simplicity in operation, and precise spatial control that most researchers require for widespread dissemination. The novel microfluidic-based device presented here addresses all the above concerns, offering a simple platform for enhanced control over the oxygen microenvironment exposed to three-dimensional cell-seeded constructs. The device utilizes an oxygen diffusion membrane approach to establish a gradient across a construct sandwiched between two continually perfused microfluidic networks. The device is capable of forming steady-state gradients at both the conditions tested-0 % to 5 % O\u2082 and 0 % to 21 % O\u2082-but a wide variety of profiles within the construct are possible. Cell viability with two model cell lines was also tested, with no adverse effects relative to the control.", 
    "genre": "research_article", 
    "id": "sg:pub.10.1007/s10544-013-9737-0", 
    "inLanguage": [
      "en"
    ], 
    "isAccessibleForFree": true, 
    "isFundedItemOf": [
      {
        "id": "sg:grant.2699098", 
        "type": "MonetaryGrant"
      }, 
      {
        "id": "sg:grant.3097467", 
        "type": "MonetaryGrant"
      }
    ], 
    "isPartOf": [
      {
        "id": "sg:journal.1021020", 
        "issn": [
          "1387-2176", 
          "1572-8781"
        ], 
        "name": "Biomedical Microdevices", 
        "type": "Periodical"
      }, 
      {
        "issueNumber": "3", 
        "type": "PublicationIssue"
      }, 
      {
        "type": "PublicationVolume", 
        "volumeNumber": "15"
      }
    ], 
    "name": "A microfabricated platform for establishing oxygen gradients in 3-D constructs", 
    "pagination": "407-414", 
    "productId": [
      {
        "name": "readcube_id", 
        "type": "PropertyValue", 
        "value": [
          "e8abd33bce019ee2588968197447d284bd404f3ff7ff8df80d07df40d5c3ba6d"
        ]
      }, 
      {
        "name": "pubmed_id", 
        "type": "PropertyValue", 
        "value": [
          "23344840"
        ]
      }, 
      {
        "name": "nlm_unique_id", 
        "type": "PropertyValue", 
        "value": [
          "100887374"
        ]
      }, 
      {
        "name": "doi", 
        "type": "PropertyValue", 
        "value": [
          "10.1007/s10544-013-9737-0"
        ]
      }, 
      {
        "name": "dimensions_id", 
        "type": "PropertyValue", 
        "value": [
          "pub.1048841248"
        ]
      }
    ], 
    "sameAs": [
      "https://doi.org/10.1007/s10544-013-9737-0", 
      "https://app.dimensions.ai/details/publication/pub.1048841248"
    ], 
    "sdDataset": "articles", 
    "sdDatePublished": "2019-04-11T02:03", 
    "sdLicense": "https://scigraph.springernature.com/explorer/license/", 
    "sdPublisher": {
      "name": "Springer Nature - SN SciGraph project", 
      "type": "Organization"
    }, 
    "sdSource": "s3://com-uberresearch-data-dimensions-target-20181106-alternative/cleanup/v134/2549eaecd7973599484d7c17b260dba0a4ecb94b/merge/v9/a6c9fde33151104705d4d7ff012ea9563521a3ce/jats-lookup/v90/0000000001_0000000264/records_8700_00000516.jsonl", 
    "type": "ScholarlyArticle", 
    "url": "http://link.springer.com/10.1007%2Fs10544-013-9737-0"
  }
]
 

Download the RDF metadata as:  json-ld nt turtle xml License info

HOW TO GET THIS DATA PROGRAMMATICALLY:

JSON-LD is a popular format for linked data which is fully compatible with JSON.

curl -H 'Accept: application/ld+json' 'https://scigraph.springernature.com/pub.10.1007/s10544-013-9737-0'

N-Triples is a line-based linked data format ideal for batch operations.

curl -H 'Accept: application/n-triples' 'https://scigraph.springernature.com/pub.10.1007/s10544-013-9737-0'

Turtle is a human-readable linked data format.

curl -H 'Accept: text/turtle' 'https://scigraph.springernature.com/pub.10.1007/s10544-013-9737-0'

RDF/XML is a standard XML format for linked data.

curl -H 'Accept: application/rdf+xml' 'https://scigraph.springernature.com/pub.10.1007/s10544-013-9737-0'


 

This table displays all metadata directly associated to this object as RDF triples.

283 TRIPLES      21 PREDICATES      91 URIs      28 LITERALS      16 BLANK NODES

Subject Predicate Object
1 sg:pub.10.1007/s10544-013-9737-0 schema:about N2acc652864274e6880680ce20f44b280
2 N30eea495fb5c4de1addcdd2f919de426
3 N511ffa83eecd410d87c95f070777b730
4 N7cfcaab741024d3ea5aef0d7f52fd9b4
5 N82edd1173e454287b2ae778f83312497
6 Naeeca72355d54727b9cc4c41654c4ce4
7 Nbb7f213b182f4d87bed9dbb22dc68980
8 anzsrc-for:06
9 anzsrc-for:0601
10 schema:author Nad469e14fae04b1fb91e234d8a9ce5ac
11 schema:citation sg:pub.10.1007/s10544-006-9005-7
12 sg:pub.10.1007/s10544-009-9294-8
13 sg:pub.10.1007/s10555-007-9062-2
14 sg:pub.10.1007/s10555-007-9063-1
15 sg:pub.10.1038/28867
16 sg:pub.10.1038/bjc.1998.148
17 sg:pub.10.1038/nbt0704-804
18 sg:pub.10.1038/nm0297-177
19 sg:pub.10.1038/nmat2022
20 sg:pub.10.1038/sj.bjc.6601047
21 sg:pub.10.1038/sj.bjc.6690586
22 https://app.dimensions.ai/details/publication/pub.1074687338
23 https://doi.org/10.1002/bit.10569
24 https://doi.org/10.1002/jcp.1041330213
25 https://doi.org/10.1002/jcp.1081
26 https://doi.org/10.1002/jcp.20571
27 https://doi.org/10.1016/j.bbamcr.2004.04.007
28 https://doi.org/10.1016/j.biomaterials.2006.05.012
29 https://doi.org/10.1016/j.biomaterials.2008.02.005
30 https://doi.org/10.1016/j.biomaterials.2008.08.008
31 https://doi.org/10.1016/j.biomaterials.2009.05.041
32 https://doi.org/10.1016/j.tice.2008.12.007
33 https://doi.org/10.1016/s0002-9440(10)63540-7
34 https://doi.org/10.1016/s0006-2952(02)01168-1
35 https://doi.org/10.1016/s0092-8674(00)81405-1
36 https://doi.org/10.1016/s0270-9139(03)80278-1
37 https://doi.org/10.1021/ac202300g
38 https://doi.org/10.1021/bp034024w
39 https://doi.org/10.1039/b508097e
40 https://doi.org/10.1039/b920401f
41 https://doi.org/10.1039/c004660d
42 https://doi.org/10.1039/c004856a
43 https://doi.org/10.1073/pnas.0701152104
44 https://doi.org/10.1073/pnas.92.12.5510
45 https://doi.org/10.1080/095530000138259
46 https://doi.org/10.1089/108497801753354267
47 https://doi.org/10.1089/ten.2006.0251
48 https://doi.org/10.1089/ten.tea.2009.0670
49 https://doi.org/10.1089/ten.tec.2010.0241
50 https://doi.org/10.1097/00000658-199807000-00002
51 https://doi.org/10.1126/science.1147949
52 https://doi.org/10.1126/science.284.5411.143
53 https://doi.org/10.1146/annurev.arplant.48.1.223
54 https://doi.org/10.1146/annurev.bioeng.3.1.335
55 https://doi.org/10.1146/annurev.cellbio.15.1.551
56 https://doi.org/10.1152/ajplung.90445.2008
57 https://doi.org/10.1158/0008-5472.can-03-2958
58 https://doi.org/10.1158/0008-5472.can-04-0289
59 https://doi.org/10.1177/0883911506066934
60 https://doi.org/10.1371/journal.pone.0006891
61 https://doi.org/10.1634/stemcells.2004-0342
62 https://doi.org/10.1634/stemcells.2007-0197
63 https://doi.org/10.1667/rr3491.1
64 https://doi.org/10.3791/1695
65 https://doi.org/10.3892/ijmm.12.5.693
66 schema:datePublished 2013-06
67 schema:datePublishedReg 2013-06-01
68 schema:description Oxygen gradients are increasingly implicated in a number of biological processes, including stem cell differentiation and cancer metastasis. Unfortunately, the current in vitro tools designed to mimic conditions found in vivo lack application flexibility, simplicity in operation, and precise spatial control that most researchers require for widespread dissemination. The novel microfluidic-based device presented here addresses all the above concerns, offering a simple platform for enhanced control over the oxygen microenvironment exposed to three-dimensional cell-seeded constructs. The device utilizes an oxygen diffusion membrane approach to establish a gradient across a construct sandwiched between two continually perfused microfluidic networks. The device is capable of forming steady-state gradients at both the conditions tested-0 % to 5 % O₂ and 0 % to 21 % O₂-but a wide variety of profiles within the construct are possible. Cell viability with two model cell lines was also tested, with no adverse effects relative to the control.
69 schema:genre research_article
70 schema:inLanguage en
71 schema:isAccessibleForFree true
72 schema:isPartOf N419172ab56464b28a8d5fff4a6d99b66
73 N7a5638c632064054a59297fc9acafb6a
74 sg:journal.1021020
75 schema:name A microfabricated platform for establishing oxygen gradients in 3-D constructs
76 schema:pagination 407-414
77 schema:productId N2b692f4a2a6f46d1a21f5e4cc2abc70b
78 Ncc696e4eded94d2eb1642600a411f249
79 Ne1d00d2a22024445964cc6a5ec90a9d2
80 Ne856acd1c2b74b34a0eb569fc672031a
81 Nf7d68fa844544794aad2c09a005ed148
82 schema:sameAs https://app.dimensions.ai/details/publication/pub.1048841248
83 https://doi.org/10.1007/s10544-013-9737-0
84 schema:sdDatePublished 2019-04-11T02:03
85 schema:sdLicense https://scigraph.springernature.com/explorer/license/
86 schema:sdPublisher Ne3ec9ea6167546d3876f6ef5bb2f0f21
87 schema:url http://link.springer.com/10.1007%2Fs10544-013-9737-0
88 sgo:license sg:explorer/license/
89 sgo:sdDataset articles
90 rdf:type schema:ScholarlyArticle
91 N2acc652864274e6880680ce20f44b280 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
92 schema:name Cell Survival
93 rdf:type schema:DefinedTerm
94 N2b692f4a2a6f46d1a21f5e4cc2abc70b schema:name readcube_id
95 schema:value e8abd33bce019ee2588968197447d284bd404f3ff7ff8df80d07df40d5c3ba6d
96 rdf:type schema:PropertyValue
97 N30eea495fb5c4de1addcdd2f919de426 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
98 schema:name Humans
99 rdf:type schema:DefinedTerm
100 N364bc1fae92948829cb9264c24872ea9 rdf:first sg:person.01311673353.61
101 rdf:rest rdf:nil
102 N419172ab56464b28a8d5fff4a6d99b66 schema:issueNumber 3
103 rdf:type schema:PublicationIssue
104 N511ffa83eecd410d87c95f070777b730 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
105 schema:name Biomimetics
106 rdf:type schema:DefinedTerm
107 N7a5638c632064054a59297fc9acafb6a schema:volumeNumber 15
108 rdf:type schema:PublicationVolume
109 N7cfcaab741024d3ea5aef0d7f52fd9b4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
110 schema:name Cell Line
111 rdf:type schema:DefinedTerm
112 N82edd1173e454287b2ae778f83312497 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
113 schema:name Membranes, Artificial
114 rdf:type schema:DefinedTerm
115 Nad469e14fae04b1fb91e234d8a9ce5ac rdf:first sg:person.01311732004.32
116 rdf:rest N364bc1fae92948829cb9264c24872ea9
117 Naeeca72355d54727b9cc4c41654c4ce4 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
118 schema:name Microtechnology
119 rdf:type schema:DefinedTerm
120 Nbb7f213b182f4d87bed9dbb22dc68980 schema:inDefinedTermSet https://www.nlm.nih.gov/mesh/
121 schema:name Oxygen
122 rdf:type schema:DefinedTerm
123 Ncc696e4eded94d2eb1642600a411f249 schema:name dimensions_id
124 schema:value pub.1048841248
125 rdf:type schema:PropertyValue
126 Ne1d00d2a22024445964cc6a5ec90a9d2 schema:name nlm_unique_id
127 schema:value 100887374
128 rdf:type schema:PropertyValue
129 Ne3ec9ea6167546d3876f6ef5bb2f0f21 schema:name Springer Nature - SN SciGraph project
130 rdf:type schema:Organization
131 Ne856acd1c2b74b34a0eb569fc672031a schema:name doi
132 schema:value 10.1007/s10544-013-9737-0
133 rdf:type schema:PropertyValue
134 Nf7d68fa844544794aad2c09a005ed148 schema:name pubmed_id
135 schema:value 23344840
136 rdf:type schema:PropertyValue
137 anzsrc-for:06 schema:inDefinedTermSet anzsrc-for:
138 schema:name Biological Sciences
139 rdf:type schema:DefinedTerm
140 anzsrc-for:0601 schema:inDefinedTermSet anzsrc-for:
141 schema:name Biochemistry and Cell Biology
142 rdf:type schema:DefinedTerm
143 sg:grant.2699098 http://pending.schema.org/fundedItem sg:pub.10.1007/s10544-013-9737-0
144 rdf:type schema:MonetaryGrant
145 sg:grant.3097467 http://pending.schema.org/fundedItem sg:pub.10.1007/s10544-013-9737-0
146 rdf:type schema:MonetaryGrant
147 sg:journal.1021020 schema:issn 1387-2176
148 1572-8781
149 schema:name Biomedical Microdevices
150 rdf:type schema:Periodical
151 sg:person.01311673353.61 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
152 schema:familyName Eddington
153 schema:givenName David T.
154 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311673353.61
155 rdf:type schema:Person
156 sg:person.01311732004.32 schema:affiliation https://www.grid.ac/institutes/grid.185648.6
157 schema:familyName Oppegard
158 schema:givenName Shawn C.
159 schema:sameAs https://app.dimensions.ai/discover/publication?and_facet_researcher=ur.01311732004.32
160 rdf:type schema:Person
161 sg:pub.10.1007/s10544-006-9005-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1041598067
162 https://doi.org/10.1007/s10544-006-9005-7
163 rdf:type schema:CreativeWork
164 sg:pub.10.1007/s10544-009-9294-8 schema:sameAs https://app.dimensions.ai/details/publication/pub.1050866401
165 https://doi.org/10.1007/s10544-009-9294-8
166 rdf:type schema:CreativeWork
167 sg:pub.10.1007/s10555-007-9062-2 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025544837
168 https://doi.org/10.1007/s10555-007-9062-2
169 rdf:type schema:CreativeWork
170 sg:pub.10.1007/s10555-007-9063-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1038320638
171 https://doi.org/10.1007/s10555-007-9063-1
172 rdf:type schema:CreativeWork
173 sg:pub.10.1038/28867 schema:sameAs https://app.dimensions.ai/details/publication/pub.1020992380
174 https://doi.org/10.1038/28867
175 rdf:type schema:CreativeWork
176 sg:pub.10.1038/bjc.1998.148 schema:sameAs https://app.dimensions.ai/details/publication/pub.1031578783
177 https://doi.org/10.1038/bjc.1998.148
178 rdf:type schema:CreativeWork
179 sg:pub.10.1038/nbt0704-804 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013407263
180 https://doi.org/10.1038/nbt0704-804
181 rdf:type schema:CreativeWork
182 sg:pub.10.1038/nm0297-177 schema:sameAs https://app.dimensions.ai/details/publication/pub.1025563287
183 https://doi.org/10.1038/nm0297-177
184 rdf:type schema:CreativeWork
185 sg:pub.10.1038/nmat2022 schema:sameAs https://app.dimensions.ai/details/publication/pub.1000577233
186 https://doi.org/10.1038/nmat2022
187 rdf:type schema:CreativeWork
188 sg:pub.10.1038/sj.bjc.6601047 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042694570
189 https://doi.org/10.1038/sj.bjc.6601047
190 rdf:type schema:CreativeWork
191 sg:pub.10.1038/sj.bjc.6690586 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051263178
192 https://doi.org/10.1038/sj.bjc.6690586
193 rdf:type schema:CreativeWork
194 https://app.dimensions.ai/details/publication/pub.1074687338 schema:CreativeWork
195 https://doi.org/10.1002/bit.10569 schema:sameAs https://app.dimensions.ai/details/publication/pub.1047436462
196 rdf:type schema:CreativeWork
197 https://doi.org/10.1002/jcp.1041330213 schema:sameAs https://app.dimensions.ai/details/publication/pub.1023484271
198 rdf:type schema:CreativeWork
199 https://doi.org/10.1002/jcp.1081 schema:sameAs https://app.dimensions.ai/details/publication/pub.1040410009
200 rdf:type schema:CreativeWork
201 https://doi.org/10.1002/jcp.20571 schema:sameAs https://app.dimensions.ai/details/publication/pub.1035902317
202 rdf:type schema:CreativeWork
203 https://doi.org/10.1016/j.bbamcr.2004.04.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1018975589
204 rdf:type schema:CreativeWork
205 https://doi.org/10.1016/j.biomaterials.2006.05.012 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005830628
206 rdf:type schema:CreativeWork
207 https://doi.org/10.1016/j.biomaterials.2008.02.005 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027507625
208 rdf:type schema:CreativeWork
209 https://doi.org/10.1016/j.biomaterials.2008.08.008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004258846
210 rdf:type schema:CreativeWork
211 https://doi.org/10.1016/j.biomaterials.2009.05.041 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022149104
212 rdf:type schema:CreativeWork
213 https://doi.org/10.1016/j.tice.2008.12.007 schema:sameAs https://app.dimensions.ai/details/publication/pub.1026056886
214 rdf:type schema:CreativeWork
215 https://doi.org/10.1016/s0002-9440(10)63540-7 schema:sameAs https://app.dimensions.ai/details/publication/pub.1037986283
216 rdf:type schema:CreativeWork
217 https://doi.org/10.1016/s0006-2952(02)01168-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1051930639
218 rdf:type schema:CreativeWork
219 https://doi.org/10.1016/s0092-8674(00)81405-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1022398043
220 rdf:type schema:CreativeWork
221 https://doi.org/10.1016/s0270-9139(03)80278-1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1019677506
222 rdf:type schema:CreativeWork
223 https://doi.org/10.1021/ac202300g schema:sameAs https://app.dimensions.ai/details/publication/pub.1055002137
224 rdf:type schema:CreativeWork
225 https://doi.org/10.1021/bp034024w schema:sameAs https://app.dimensions.ai/details/publication/pub.1008593996
226 rdf:type schema:CreativeWork
227 https://doi.org/10.1039/b508097e schema:sameAs https://app.dimensions.ai/details/publication/pub.1018813839
228 rdf:type schema:CreativeWork
229 https://doi.org/10.1039/b920401f schema:sameAs https://app.dimensions.ai/details/publication/pub.1024353594
230 rdf:type schema:CreativeWork
231 https://doi.org/10.1039/c004660d schema:sameAs https://app.dimensions.ai/details/publication/pub.1052805743
232 rdf:type schema:CreativeWork
233 https://doi.org/10.1039/c004856a schema:sameAs https://app.dimensions.ai/details/publication/pub.1001151825
234 rdf:type schema:CreativeWork
235 https://doi.org/10.1073/pnas.0701152104 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016402226
236 rdf:type schema:CreativeWork
237 https://doi.org/10.1073/pnas.92.12.5510 schema:sameAs https://app.dimensions.ai/details/publication/pub.1017639394
238 rdf:type schema:CreativeWork
239 https://doi.org/10.1080/095530000138259 schema:sameAs https://app.dimensions.ai/details/publication/pub.1013293806
240 rdf:type schema:CreativeWork
241 https://doi.org/10.1089/108497801753354267 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059207684
242 rdf:type schema:CreativeWork
243 https://doi.org/10.1089/ten.2006.0251 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059313592
244 rdf:type schema:CreativeWork
245 https://doi.org/10.1089/ten.tea.2009.0670 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059315484
246 rdf:type schema:CreativeWork
247 https://doi.org/10.1089/ten.tec.2010.0241 schema:sameAs https://app.dimensions.ai/details/publication/pub.1059317406
248 rdf:type schema:CreativeWork
249 https://doi.org/10.1097/00000658-199807000-00002 schema:sameAs https://app.dimensions.ai/details/publication/pub.1060134811
250 rdf:type schema:CreativeWork
251 https://doi.org/10.1126/science.1147949 schema:sameAs https://app.dimensions.ai/details/publication/pub.1062456443
252 rdf:type schema:CreativeWork
253 https://doi.org/10.1126/science.284.5411.143 schema:sameAs https://app.dimensions.ai/details/publication/pub.1042379237
254 rdf:type schema:CreativeWork
255 https://doi.org/10.1146/annurev.arplant.48.1.223 schema:sameAs https://app.dimensions.ai/details/publication/pub.1027018774
256 rdf:type schema:CreativeWork
257 https://doi.org/10.1146/annurev.bioeng.3.1.335 schema:sameAs https://app.dimensions.ai/details/publication/pub.1002076643
258 rdf:type schema:CreativeWork
259 https://doi.org/10.1146/annurev.cellbio.15.1.551 schema:sameAs https://app.dimensions.ai/details/publication/pub.1014138125
260 rdf:type schema:CreativeWork
261 https://doi.org/10.1152/ajplung.90445.2008 schema:sameAs https://app.dimensions.ai/details/publication/pub.1024101538
262 rdf:type schema:CreativeWork
263 https://doi.org/10.1158/0008-5472.can-03-2958 schema:sameAs https://app.dimensions.ai/details/publication/pub.1016925612
264 rdf:type schema:CreativeWork
265 https://doi.org/10.1158/0008-5472.can-04-0289 schema:sameAs https://app.dimensions.ai/details/publication/pub.1005994791
266 rdf:type schema:CreativeWork
267 https://doi.org/10.1177/0883911506066934 schema:sameAs https://app.dimensions.ai/details/publication/pub.1063856774
268 rdf:type schema:CreativeWork
269 https://doi.org/10.1371/journal.pone.0006891 schema:sameAs https://app.dimensions.ai/details/publication/pub.1021933661
270 rdf:type schema:CreativeWork
271 https://doi.org/10.1634/stemcells.2004-0342 schema:sameAs https://app.dimensions.ai/details/publication/pub.1004610862
272 rdf:type schema:CreativeWork
273 https://doi.org/10.1634/stemcells.2007-0197 schema:sameAs https://app.dimensions.ai/details/publication/pub.1012042218
274 rdf:type schema:CreativeWork
275 https://doi.org/10.1667/rr3491.1 schema:sameAs https://app.dimensions.ai/details/publication/pub.1068196587
276 rdf:type schema:CreativeWork
277 https://doi.org/10.3791/1695 schema:sameAs https://app.dimensions.ai/details/publication/pub.1003859529
278 rdf:type schema:CreativeWork
279 https://doi.org/10.3892/ijmm.12.5.693 schema:sameAs https://app.dimensions.ai/details/publication/pub.1071505544
280 rdf:type schema:CreativeWork
281 https://www.grid.ac/institutes/grid.185648.6 schema:alternateName University of Illinois at Chicago
282 schema:name Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA
283 rdf:type schema:Organization
 




Preview window. Press ESC to close (or click here)


...