Flow optimization study of a batch microfluidics PET tracer synthesizing device View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2010-11-12

AUTHORS

Arkadij M. Elizarov, Carl Meinhart, Reza Miraghaie, R. Michael van Dam, Jiang Huang, Antoine Daridon, James R. Heath, Hartmuth C. Kolb

ABSTRACT

We present numerical modeling and experimental studies of flow optimization inside a batch microfluidic micro-reactor used for synthesis of human-scale doses of Positron Emission Tomography (PET) tracers. Novel techniques are used for mixing within, and eluting liquid out of, the coin-shaped reaction chamber. Numerical solutions of the general incompressible Navier Stokes equations along with time-dependent elution scalar field equation for the three dimensional coin-shaped geometry were obtained and validated using fluorescence imaging analysis techniques. Utilizing the approach presented in this work, we were able to identify optimized geometrical and operational conditions for the micro-reactor in the absence of radioactive material commonly used in PET related tracer production platforms as well as evaluate the designed and fabricated micro-reactor using numerical and experimental validations. More... »

PAGES

231-242

References to SciGraph publications

  • 2007. Micro-reactors for PET Tracer Labeling in PET CHEMISTRY
  • 2005-07-14. Towards numerical prototyping of labs-on-chip: modeling for integrated microfluidic devices in MICROFLUIDICS AND NANOFLUIDICS
  • 2006-11-11. Rapid circular microfluidic mixer utilizing unbalanced driving force in BIOMEDICAL MICRODEVICES
  • 2008. PET in Oncology in NONE
  • 2008-11-27. Fast and repetitive in-capillary production of [18F]FDG in EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10544-010-9488-0

    DOI

    http://dx.doi.org/10.1007/s10544-010-9488-0

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1019924236

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/21072595


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