Out-of-plane microtube arrays for drug delivery—liquid flow properties and an application to the nerve block test View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-06

AUTHORS

Kuniharu Takei, Takahiro Kawashima, Takeshi Kawano, Hidekazu Kaneko, Kazuaki Sawada, Makoto Ishida

ABSTRACT

We have proposed fabricating very fine out-of-plane silicon-dioxide microtube arrays using a selective vapor-liquid-solid (VLS) growth technique and microfabrication processes. In this study, we elucidated the liquid-flow properties of microtubes with different inner diameters. Our fabricated microtubes were 0.5 microm in wall thickness; 20 microm in height; and either 2.5 microm, 4.1 microm, 4.6 microm, or 6.4 microm in inner diameter. We determined the relationship between the flow pressure and the liquid flow rate through the microtube. We also conducted a nerve block test, in which a microtube with 4.6 microm inner diameter was used to administer lidocaine solution (Na channel blocker) to the rat sciatic nerve. This successful test represents the first reported use of a microtube for drug delivery to the peripheral nerve of a rat. We conclude that the proposed microtube array and its fabrication process might contribute to developing pharmacological devices. More... »

PAGES

539-545

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10544-008-9259-3

DOI

http://dx.doi.org/10.1007/s10544-008-9259-3

DIMENSIONS

https://app.dimensions.ai/details/publication/pub.1005235979

PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/19051036


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