Plasma metals as potential biomarkers in dementia: a case–control study in patients with sporadic Alzheimer’s disease View Full Text


Ontology type: schema:ScholarlyArticle      Open Access: True


Article Info

DATE

2018-03-07

AUTHORS

Jingshu Xu, Stephanie J. Church, Stefano Patassini, Paul Begley, Katherine A. B. Kellett, Emma R. L. C. Vardy, Richard D. Unwin, Nigel M. Hooper, Garth J. S. Cooper

ABSTRACT

Sporadic Alzheimer’s disease (AD) is a neurodegenerative disorder that causes the most prevalent form of age-related dementia but its pathogenesis remains obscure. Altered regulation of metals, particularly pan-cerebral copper deficiency, and more regionally-localized perturbation of other metals, are prominent in AD brain although data on how these CNS perturbations are reflected in the peripheral bloodstream are inconsistent to date. To assess the potential use of metal dysregulation to generate biomarkers in AD, we performed a case–control study of seven essential metals and selenium, measured by inductively coupled plasma mass-spectrometry, in samples from AD and matched control cases. Metals were sodium, potassium, calcium, magnesium, iron, zinc, and copper. In the whole study-group and in female participants, plasma metal levels did not differ between cases and controls. In males by contrast, there was moderate evidence that zinc levels trended towards increase in AD [10.8 (10.2–11.5)] µmol/L, mean (± 95% CI; P = 0.021) compared with controls [10.2 (9.6–10.4)]. Thus alterations in plasma zinc levels differed between genders in AD. In correlational analysis, there was evidence for an increased number of ‘strong’ metal co-regulations in AD cases and differential co-modulations of metal pairs: copper-sodium (Rcontrol = − 0.03, RAD = 0.65; P = 0.009), and copper-calcium (Rcontrol = − 0.01, RAD = 0.65; P = 0.01) were significant in AD males, potentially consistent with reported evidence for dysregulation of copper in severely damaged brain regions in AD. In conclusion, our data suggest that the measurement of metals co-regulation in plasma may provide a useful representation of those metal perturbations taking place in the AD brain and therefore might be useful as plasma-based biomarkers.Graphical Abstract More... »

PAGES

267-276

References to SciGraph publications

Identifiers

URI

http://scigraph.springernature.com/pub.10.1007/s10534-018-0089-3

DOI

http://dx.doi.org/10.1007/s10534-018-0089-3

DIMENSIONS

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PUBMED

https://www.ncbi.nlm.nih.gov/pubmed/29516299


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46 calcium
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53 copper
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71 levels
72 magnesium
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75 measurement of metals
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77 metal dysregulation
78 metal levels
79 metal pairs
80 metal perturbation
81 metals
82 moderate evidence
83 neurodegenerative disorders
84 number
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87 pathogenesis
88 patients
89 peripheral bloodstream
90 perturbations
91 place
92 plasma
93 plasma metals
94 plasma zinc levels
95 plasma-based biomarkers
96 potassium
97 potential biomarkers
98 potential use
99 prevalent form
100 region
101 regulation
102 reported evidence
103 representation
104 samples
105 selenium
106 sodium
107 sporadic Alzheimer's disease
108 study
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110 useful representation
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