Copper(II) complexes of methimazole, an anti Grave’s disease drug. Synthesis, characterization and its potential biological behavior as alkaline phosphatase inhibitor View Full Text


Ontology type: schema:ScholarlyArticle     


Article Info

DATE

2009-12-11

AUTHORS

Nora M. Urquiza, Silvia G. Manca, María A. Moyano, Raquel Arrieta Dellmans, Luis Lezama, Teófilo Rojo, Luciana G. Naso, Patricia A. M. Williams, Evelina G. Ferrer

ABSTRACT

Methimazole (MeimzH) is an anti-thyroid drug and the first choice for patients with Grave’s disease. Two new copper(II) complexes of this drug: [Cu(MeimzH)2(NO3)2].0.5H2O and [Cu(MeimzH)2(H2O)2](NO3)2·H2O were synthesized and characterized by elemental analysis, dissolution behavior, thermogravimetric analysis and UV-vis, diffuse reflectance, FTIR and EPR spectroscopies. As it is known that copper(II) cation can act as an inhibitor of alkaline phosphatase (ALP), the inhibitory effect of methimazole and its copper(II) complexes on ALP activity has also been investigated. More... »

PAGES

255-264

References to SciGraph publications

  • 2006-07-05. Synthesis, characterization, antitumoral and osteogenic activities of quercetin vanadyl(IV) complexes in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 2001-12. On the interaction of the vanadyl(IV) cation with lactose in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 2007-12-21. Antioxidant effects of the VO(IV) hesperidin complex and its role in cancer chemoprevention in JBIC JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
  • 1994-06. Vanadium compounds in BIOLOGICAL TRACE ELEMENT RESEARCH
  • 2004-04. Methimazole upregulates T-cell-derived cytokines without improving the existing Th1/Th2 imbalance in Graves’ disease in JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
  • Identifiers

    URI

    http://scigraph.springernature.com/pub.10.1007/s10534-009-9283-7

    DOI

    http://dx.doi.org/10.1007/s10534-009-9283-7

    DIMENSIONS

    https://app.dimensions.ai/details/publication/pub.1026224015

    PUBMED

    https://www.ncbi.nlm.nih.gov/pubmed/20012553


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